ENSG00000139746

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267229 ENSG00000139746 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM26 protein_coding protein_coding 34.38694 23.16919 62.79262 6.146342 3.26008 1.437995 7.310553 7.0870105 13.976884 2.3383254 1.6425356 0.9787912 0.20188750 0.29083333 0.22566667 -0.06516667 7.178081e-01 6.026555e-09 FALSE TRUE
ENST00000438724 ENSG00000139746 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM26 protein_coding protein_coding 34.38694 23.16919 62.79262 6.146342 3.26008 1.437995 3.217868 2.0772088 6.412704 0.5048134 0.4617413 1.6216058 0.09276667 0.09286667 0.10340000 0.01053333 9.288701e-01 6.026555e-09 FALSE TRUE
ENST00000449987 ENSG00000139746 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM26 protein_coding protein_coding 34.38694 23.16919 62.79262 6.146342 3.26008 1.437995 3.993007 4.4860951 4.112761 0.9409927 2.1067933 -0.1250616 0.17932917 0.20286667 0.06220000 -0.14066667 6.463614e-01 6.026555e-09 FALSE TRUE
MSTRG.8946.1 ENSG00000139746 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM26 protein_coding   34.38694 23.16919 62.79262 6.146342 3.26008 1.437995 4.178134 0.0000000 7.904467 0.0000000 2.4497678 9.6283484 0.08060833 0.00000000 0.12243333 0.12243333 6.026555e-09 6.026555e-09 FALSE TRUE
MSTRG.8946.22 ENSG00000139746 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM26 protein_coding   34.38694 23.16919 62.79262 6.146342 3.26008 1.437995 2.854558 1.5981248 6.084066 0.5053436 0.6491963 1.9220258 0.08995833 0.06853333 0.09793333 0.02940000 6.309486e-01 6.026555e-09 TRUE TRUE
MSTRG.8946.3 ENSG00000139746 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM26 protein_coding   34.38694 23.16919 62.79262 6.146342 3.26008 1.437995 2.555712 0.5752359 4.922490 0.3474158 1.1537573 3.0752260 0.05317083 0.02800000 0.07700000 0.04900000 6.250457e-01 6.026555e-09 TRUE TRUE
MSTRG.8946.37 ENSG00000139746 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM26 protein_coding   34.38694 23.16919 62.79262 6.146342 3.26008 1.437995 2.671045 1.1278363 5.943146 0.3326102 0.3983102 2.3873594 0.06113750 0.05120000 0.09513333 0.04393333 2.135974e-01 6.026555e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000139746 E001 96.018513 1.2961166526 4.689978e-01 0.6793851356 13 79311824 79312197 374 - 1.891 2.050 0.533
ENSG00000139746 E002 114.820062 1.3642325553 4.993024e-01 0.7003257859 13 79312198 79312319 122 - 1.975 2.114 0.465
ENSG00000139746 E003 226.959265 1.6047736189 5.684236e-01 0.7491112220 13 79312320 79312799 480 - 2.284 2.379 0.315
ENSG00000139746 E004 124.639614 1.4244708830 6.134474e-01 0.7792523676 13 79312800 79313233 434 - 2.047 2.073 0.088
ENSG00000139746 E005 154.164788 1.5123562412 6.753299e-01 0.8197634315 13 79313234 79313606 373 - 2.154 2.126 -0.093
ENSG00000139746 E006 87.034862 1.3027028943 6.010795e-01 0.7708734521 13 79313607 79313789 183 - 1.893 1.919 0.087
ENSG00000139746 E007 127.281502 1.4317539952 6.099007e-01 0.7768214694 13 79313790 79314177 388 - 2.055 2.085 0.101
ENSG00000139746 E008 118.251916 1.4165520415 6.195437e-01 0.7835268804 13 79314178 79314551 374 - 2.026 2.047 0.069
ENSG00000139746 E009 46.434362 0.8963961244 6.266819e-01 0.7883050760 13 79314552 79314552 1 - 1.640 1.612 -0.094
ENSG00000139746 E010 56.975376 0.9413324018 5.636333e-01 0.7458419277 13 79314553 79314606 54 - 1.714 1.733 0.067
ENSG00000139746 E011 42.850697 0.8445903366 6.047694e-01 0.7733625295 13 79314607 79314613 7 - 1.606 1.579 -0.093
ENSG00000139746 E012 115.546545 1.4127709044 6.511143e-01 0.8042892101 13 79314614 79314735 122 - 2.026 2.012 -0.045
ENSG00000139746 E013 53.788081 0.8994972881 5.908396e-01 0.7642784867 13 79314736 79314737 2 - 1.690 1.707 0.055
ENSG00000139746 E014 191.434371 1.5589358038 6.219519e-01 0.7851187846 13 79314738 79314990 253 - 2.227 2.270 0.142
ENSG00000139746 E015 52.580651 0.8888505388 6.116491e-01 0.7780018427 13 79314991 79314993 3 - 1.685 1.685 0.000
ENSG00000139746 E016 56.279527 0.1125881762 9.316295e-01 0.9679246385 13 79318821 79318867 47 - 1.733 1.670 -0.212
ENSG00000139746 E017 40.326091 0.0867689388 5.512492e-01 0.7371950365 13 79318868 79318876 9 - 1.612 1.465 -0.500
ENSG00000139746 E018 33.646725 0.0462952358 7.663810e-01 0.8764368681 13 79318877 79318879 3 - 1.518 1.452 -0.226
ENSG00000139746 E019 74.642162 0.0271287643 3.803918e-01 0.6125063014 13 79318880 79319534 655 - 1.854 1.773 -0.270
ENSG00000139746 E020 176.250633 0.0002984780 9.656737e-04 0.0096359127 13 79319535 79319953 419 - 2.174 2.285 0.369
ENSG00000139746 E021 482.299476 0.0161902482 2.461746e-02 0.1110358358 13 79319954 79320710 757 - 2.588 2.748 0.536
ENSG00000139746 E022 52.085133 0.0076050933 8.553722e-01 0.9278217683 13 79321234 79321301 68 - 1.684 1.681 -0.012
ENSG00000139746 E023 35.553865 0.0012268793 1.084841e-01 0.2965012031 13 79322208 79322348 141 - 1.548 1.454 -0.321
ENSG00000139746 E024 353.705543 0.0013855045 2.105867e-04 0.0027904541 13 79322349 79322462 114 - 2.474 2.590 0.389
ENSG00000139746 E025 275.918548 0.0005127676 1.739288e-03 0.0152907373 13 79334344 79334430 87 - 2.374 2.468 0.312
ENSG00000139746 E026 2.514060 0.0095949595 2.724577e-02 0.1190275500 13 79334431 79334488 58 - 0.603 0.182 -2.535
ENSG00000139746 E027 4.456344 0.1074798919 3.283527e-01 0.5673805331 13 79336456 79336535 80 - 0.740 0.554 -0.803
ENSG00000139746 E028 402.792248 0.0090096761 1.589276e-01 0.3751467562 13 79337102 79337302 201 - 2.536 2.622 0.287
ENSG00000139746 E029 312.794725 0.0105069002 5.396447e-01 0.7287452067 13 79341123 79341227 105 - 2.437 2.490 0.176
ENSG00000139746 E030 388.847317 0.0120352306 7.497382e-01 0.8666190118 13 79342664 79342831 168 - 2.534 2.576 0.138
ENSG00000139746 E031 284.441295 0.0085487597 9.353594e-01 0.9698572165 13 79344248 79344322 75 - 2.404 2.433 0.096
ENSG00000139746 E032 342.124572 0.0106187420 6.203145e-01 0.7840337136 13 79344669 79344794 126 - 2.478 2.525 0.158
ENSG00000139746 E033 31.363289 0.0251969876 6.798424e-01 0.8225823123 13 79353153 79353224 72 - 1.444 1.509 0.224
ENSG00000139746 E034 301.528286 0.0120276782 5.328998e-01 0.7241166204 13 79354439 79354561 123 - 2.419 2.480 0.205
ENSG00000139746 E035 106.289311 0.0069684870 3.655674e-01 0.6004002385 13 79354562 79354570 9 - 1.967 2.032 0.217
ENSG00000139746 E036 309.672502 0.0074148810 8.462328e-01 0.9228671851 13 79355220 79355384 165 - 2.440 2.471 0.104
ENSG00000139746 E037 267.577946 0.0054791823 8.511115e-01 0.9256524527 13 79358274 79358433 160 - 2.380 2.405 0.082
ENSG00000139746 E038 259.118903 0.0155179570 7.218141e-01 0.8491727087 13 79359575 79359686 112 - 2.364 2.393 0.099
ENSG00000139746 E039 338.488215 0.0105685922 2.535566e-01 0.4918639943 13 79365578 79365718 141 - 2.501 2.449 -0.173
ENSG00000139746 E040 16.736238 0.0023428006 3.790389e-01 0.6114416961 13 79365719 79365733 15 - 1.177 1.270 0.328
ENSG00000139746 E041 1.138468 0.0145974473 1.000000e+00   13 79365760 79366054 295 - 0.302 0.309 0.048
ENSG00000139746 E042 289.968249 0.0119630510 1.428012e-01 0.3516470910 13 79366055 79366195 141 - 2.438 2.371 -0.222
ENSG00000139746 E043 33.143681 0.0013623341 4.961407e-01 0.6982665764 13 79366196 79366225 30 - 1.501 1.470 -0.107
ENSG00000139746 E044 350.369498 0.0148828479 4.085646e-02 0.1569340106 13 79366633 79366872 240 - 2.527 2.431 -0.321
ENSG00000139746 E045 424.694720 0.0074016464 3.248480e-02 0.1346612194 13 79368730 79368990 261 - 2.606 2.526 -0.268
ENSG00000139746 E046 395.495418 0.0077113819 1.663340e-01 0.3856966422 13 79370945 79371159 215 - 2.568 2.516 -0.172
ENSG00000139746 E047 134.639846 0.0121522394 1.003805e-01 0.2824722755 13 79371160 79371162 3 - 2.113 2.017 -0.321
ENSG00000139746 E048 243.577402 0.0061228957 3.300427e-02 0.1360681010 13 79371842 79371930 89 - 2.368 2.283 -0.284
ENSG00000139746 E049 1.525155 0.0192729746 3.218101e-01 0.5612694980 13 79376217 79377378 1162 - 0.302 0.489 1.053
ENSG00000139746 E050 258.215192 0.0015699889 1.029947e-06 0.0000291466 13 79377379 79377515 137 - 2.408 2.270 -0.461
ENSG00000139746 E051 230.157224 0.0017932629 4.023721e-04 0.0047538639 13 79378789 79378907 119 - 2.349 2.246 -0.342
ENSG00000139746 E052 148.097092 0.0018028708 5.054524e-04 0.0057298860 13 79405704 79405741 38 - 2.162 2.042 -0.404
ENSG00000139746 E053 193.801878 0.0047544789 9.960773e-03 0.0579980887 13 79405742 79406061 320 - 2.273 2.171 -0.342
ENSG00000139746 E054 160.648802 0.0155590050 5.758812e-02 0.1973641392 13 79406062 79406477 416 - 2.197 2.076 -0.406