ENSG00000139737

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267219 ENSG00000139737 HEK293_OSMI2_6hA HEK293_TMG_6hB SLAIN1 protein_coding protein_coding 36.74381 15.85726 58.31889 2.572957 3.174201 1.878158 12.557111 3.9979316 23.0503226 2.2200810 2.4451667 2.5244829 0.35887917 0.27813333 0.39546667 0.11733333 0.89484265 0.01713045 FALSE  
ENST00000358679 ENSG00000139737 HEK293_OSMI2_6hA HEK293_TMG_6hB SLAIN1 protein_coding protein_coding 36.74381 15.85726 58.31889 2.572957 3.174201 1.878158 1.849243 2.2086966 3.9509627 1.6456607 1.9795855 0.8361387 0.05402500 0.11733333 0.06986667 -0.04746667 1.00000000 0.01713045 FALSE  
ENST00000418532 ENSG00000139737 HEK293_OSMI2_6hA HEK293_TMG_6hB SLAIN1 protein_coding protein_coding 36.74381 15.85726 58.31889 2.572957 3.174201 1.878158 5.462672 2.3116380 4.3917269 0.3574982 0.1719396 0.9229266 0.15095000 0.14740000 0.07603333 -0.07136667 0.01713045 0.01713045 FALSE  
ENST00000442759 ENSG00000139737 HEK293_OSMI2_6hA HEK293_TMG_6hB SLAIN1 protein_coding protein_coding 36.74381 15.85726 58.31889 2.572957 3.174201 1.878158 9.236609 1.9633036 17.6309955 1.2296348 1.8102728 3.1602471 0.19400000 0.10510000 0.30096667 0.19586667 0.58702497 0.01713045 FALSE  
ENST00000446759 ENSG00000139737 HEK293_OSMI2_6hA HEK293_TMG_6hB SLAIN1 protein_coding protein_coding 36.74381 15.85726 58.31889 2.572957 3.174201 1.878158 2.662724 0.5473159 5.1600100 0.5473159 0.7415420 3.2135999 0.06320000 0.05080000 0.09000000 0.03920000 0.38259798 0.01713045 FALSE  
MSTRG.8899.4 ENSG00000139737 HEK293_OSMI2_6hA HEK293_TMG_6hB SLAIN1 protein_coding   36.74381 15.85726 58.31889 2.572957 3.174201 1.878158 1.347068 1.0678063 0.4166261 0.5465967 0.4166261 -1.3370539 0.04573333 0.05786667 0.00670000 -0.05116667 0.53847429 0.01713045 FALSE  
MSTRG.8899.9 ENSG00000139737 HEK293_OSMI2_6hA HEK293_TMG_6hB SLAIN1 protein_coding   36.74381 15.85726 58.31889 2.572957 3.174201 1.878158 2.817041 3.2340967 2.6404203 0.5779514 1.9741993 -0.2915956 0.10867500 0.20380000 0.04256667 -0.16123333 0.39933057 0.01713045    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000139737 E001 26.9405928 0.0012991590 9.822418e-11 6.967721e-09 13 77697687 77697887 201 + 1.226 1.671 1.536
ENSG00000139737 E002 19.4582357 0.0048483864 3.545371e-06 8.576717e-05 13 77697888 77697928 41 + 1.122 1.511 1.363
ENSG00000139737 E003 21.6532796 0.0585009074 6.581474e-03 4.261259e-02 13 77697929 77698162 234 + 1.178 1.541 1.262
ENSG00000139737 E004 0.8148287 0.0169966098 1.223967e-02   13 77698163 77698203 41 + 0.075 0.506 3.551
ENSG00000139737 E005 6.1000351 0.0052135150 3.371016e-02 1.380891e-01 13 77698204 77698269 66 + 0.711 0.993 1.092
ENSG00000139737 E006 22.1107967 0.0018579822 1.904106e-03 1.643178e-02 13 77698270 77698422 153 + 1.235 1.481 0.853
ENSG00000139737 E007 65.7619443 0.0092176216 6.743552e-01 8.191123e-01 13 77698423 77698539 117 + 1.776 1.761 -0.050
ENSG00000139737 E008 2.8999393 0.0085282786 8.367896e-01 9.176791e-01 13 77698881 77698881 1 + 0.537 0.576 0.178
ENSG00000139737 E009 5.2970879 0.0054308915 1.838823e-01 4.089663e-01 13 77698882 77699019 138 + 0.695 0.883 0.747
ENSG00000139737 E010 2.0536850 0.0125061341 5.578813e-01 7.417641e-01 13 77699020 77699057 38 + 0.399 0.507 0.556
ENSG00000139737 E011 3.1071153 0.0074485837 9.530618e-01 9.784947e-01 13 77699058 77699223 166 + 0.561 0.576 0.067
ENSG00000139737 E012 4.6602046 0.0081823168 2.814749e-04 3.542645e-03 13 77706690 77706806 117 + 0.513 1.017 2.058
ENSG00000139737 E013 95.7044532 0.0105271942 1.542785e-01 3.683787e-01 13 77719532 77719597 66 + 1.952 1.869 -0.278
ENSG00000139737 E014 127.2139696 0.0013580532 4.990472e-03 3.457337e-02 13 77719598 77719671 74 + 2.077 1.972 -0.351
ENSG00000139737 E015 0.0000000       13 77741160 77741199 40 +      
ENSG00000139737 E016 0.0000000       13 77741200 77741218 19 +      
ENSG00000139737 E017 0.6081007 0.0217983718 2.718973e-01   13 77741219 77741355 137 + 0.244 0.000 -9.376
ENSG00000139737 E018 1.0845253 0.0550755139 5.007838e-01   13 77741356 77741440 85 + 0.327 0.191 -1.023
ENSG00000139737 E019 0.0000000       13 77741538 77741618 81 +      
ENSG00000139737 E020 0.0000000       13 77742749 77742787 39 +      
ENSG00000139737 E021 17.1884750 0.0019040113 4.531169e-01 6.680413e-01 13 77743016 77743056 41 + 1.185 1.258 0.259
ENSG00000139737 E022 18.5653338 0.0019923040 2.105572e-01 4.424936e-01 13 77743057 77743104 48 + 1.206 1.320 0.400
ENSG00000139737 E023 23.7982064 0.0016426137 1.225953e-01 3.198929e-01 13 77743105 77743165 61 + 1.306 1.431 0.433
ENSG00000139737 E024 0.0000000       13 77743166 77743462 297 +      
ENSG00000139737 E025 213.3334566 0.0005045051 6.949807e-04 7.401926e-03 13 77744283 77744432 150 + 2.295 2.205 -0.304
ENSG00000139737 E026 0.6072928 0.0193874923 3.033180e-01   13 77744433 77744516 84 + 0.139 0.323 1.553
ENSG00000139737 E027 386.7017587 0.0001670461 8.468033e-05 1.301654e-03 13 77746514 77746855 342 + 2.548 2.478 -0.235
ENSG00000139737 E028 0.4514866 0.0217681645 7.608671e-01   13 77746856 77746858 3 + 0.139 0.191 0.551
ENSG00000139737 E029 229.8997105 0.0007241377 7.811743e-01 8.853834e-01 13 77753203 77753358 156 + 2.308 2.306 -0.004
ENSG00000139737 E030 302.6944407 0.0001987782 7.095106e-01 8.414814e-01 13 77760828 77761110 283 + 2.421 2.435 0.048
ENSG00000139737 E031 521.0351005 0.0044361611 2.685853e-01 5.082622e-01 13 77763145 77764242 1098 + 2.649 2.686 0.123