ENSG00000139734

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377908 ENSG00000139734 HEK293_OSMI2_6hA HEK293_TMG_6hB DIAPH3 protein_coding protein_coding 11.50545 3.771598 19.02065 1.073447 0.89359 2.331257 3.0975637 0.1337328 5.869906 0.1337328 0.3694823 5.354332 0.1637458 0.02693333 0.3091667 0.2822333 3.300818e-02 7.404989e-09 FALSE TRUE
ENST00000400324 ENSG00000139734 HEK293_OSMI2_6hA HEK293_TMG_6hB DIAPH3 protein_coding protein_coding 11.50545 3.771598 19.02065 1.073447 0.89359 2.331257 7.3035616 3.5098869 11.619754 1.0134406 0.2487851 1.724220 0.7064792 0.92643333 0.6129333 -0.3135000 7.404989e-09 7.404989e-09 FALSE TRUE
ENST00000649952 ENSG00000139734 HEK293_OSMI2_6hA HEK293_TMG_6hB DIAPH3 protein_coding processed_transcript 11.50545 3.771598 19.02065 1.073447 0.89359 2.331257 0.3049899 0.0000000 0.000000 0.0000000 0.0000000 0.000000 0.0733875 0.00000000 0.0000000 0.0000000   7.404989e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000139734 E001 9.9198167 0.4053011424 0.218663574 0.45179416 13 59665583 59665691 109 - 0.841 1.238 1.456
ENSG00000139734 E002 136.8422972 1.4064312643 0.337412024 0.57577847 13 59665692 59666583 892 - 1.934 2.319 1.287
ENSG00000139734 E003 65.0817321 0.8835683648 0.217057652 0.44992208 13 59666584 59666740 157 - 1.609 2.011 1.356
ENSG00000139734 E004 66.0317906 0.9152705432 0.277820129 0.51788946 13 59666741 59666846 106 - 1.643 1.969 1.102
ENSG00000139734 E005 0.0000000       13 59695252 59695445 194 -      
ENSG00000139734 E006 0.1723744 0.1901336189 0.124235166   13 59696026 59696193 168 - 0.000 0.220 13.061
ENSG00000139734 E007 0.1779838 0.0712273106 1.000000000   13 59750839 59751021 183 - 0.064 0.000 -9.008
ENSG00000139734 E008 0.3447487 1.0729169339 0.149775067   13 59774059 59774162 104 - 0.000 0.371 14.097
ENSG00000139734 E009 0.0000000       13 59774163 59774188 26 -      
ENSG00000139734 E010 48.7198730 0.1386930944 0.146511506 0.35719344 13 59774189 59774248 60 - 1.543 1.783 0.813
ENSG00000139734 E011 75.5234537 0.0006953676 0.001410583 0.01297527 13 59774728 59774823 96 - 1.748 1.948 0.674
ENSG00000139734 E012 95.6191510 0.0171216743 0.942182030 0.97336208 13 59810788 59810923 136 - 1.873 1.952 0.265
ENSG00000139734 E013 110.5995610 0.0178037594 0.101385520 0.28433453 13 59833107 59833271 165 - 1.964 1.896 -0.227
ENSG00000139734 E014 4.5419287 0.1139787023 0.594072871 0.76638979 13 59837675 59839323 1649 - 0.626 0.755 0.540
ENSG00000139734 E015 101.2768812 0.0129710697 0.207487414 0.43880669 13 59839324 59839448 125 - 1.919 1.896 -0.076
ENSG00000139734 E016 0.0000000       13 59861254 59861406 153 -      
ENSG00000139734 E017 95.0083302 0.0089723640 0.191108441 0.41832114 13 59861407 59861536 130 - 1.892 1.871 -0.071
ENSG00000139734 E018 117.4991128 0.0137948575 0.462574855 0.67486684 13 59879229 59879468 240 - 1.975 1.987 0.040
ENSG00000139734 E019 71.7726987 0.0136767963 0.398398848 0.62696033 13 59911735 59911836 102 - 1.767 1.761 -0.020
ENSG00000139734 E020 73.2030360 0.0088190415 0.732990696 0.85599273 13 59916155 59916249 95 - 1.772 1.797 0.086
ENSG00000139734 E021 82.9903915 0.0023205287 0.397781510 0.62659378 13 59924775 59924870 96 - 1.830 1.842 0.042
ENSG00000139734 E022 90.8428836 0.0052820139 0.045176114 0.16805273 13 59969944 59970058 115 - 1.880 1.821 -0.197
ENSG00000139734 E023 117.9469660 0.0107149060 0.264459250 0.50368763 13 59970852 59971160 309 - 1.982 1.970 -0.041
ENSG00000139734 E024 78.0378509 0.0143900577 0.613977427 0.77953143 13 59974352 59974456 105 - 1.799 1.806 0.023
ENSG00000139734 E025 73.5097681 0.0126759496 0.282167004 0.52252249 13 59980795 59980859 65 - 1.780 1.751 -0.099
ENSG00000139734 E026 95.1506920 0.0068031622 0.004143654 0.02995992 13 59983769 59983887 119 - 1.908 1.786 -0.412
ENSG00000139734 E027 86.1975663 0.0050766135 0.031453119 0.13163770 13 59991158 59991274 117 - 1.860 1.794 -0.224
ENSG00000139734 E028 81.8190943 0.0020663018 0.144438156 0.35405997 13 59992068 59992186 119 - 1.832 1.813 -0.065
ENSG00000139734 E029 68.7927255 0.0006038551 0.644938907 0.80016439 13 59992473 59992583 111 - 1.738 1.814 0.257
ENSG00000139734 E030 59.0640164 0.0006543411 0.979904370 0.99175601 13 60008544 60008649 106 - 1.676 1.727 0.175
ENSG00000139734 E031 69.8585260 0.0005216320 0.187063124 0.41311793 13 60010533 60010669 137 - 1.762 1.748 -0.049
ENSG00000139734 E032 0.0000000       13 60013049 60013209 161 -      
ENSG00000139734 E033 47.9317890 0.0007616010 0.042093691 0.16015407 13 60015913 60015982 70 - 1.613 1.536 -0.262
ENSG00000139734 E034 55.5067492 0.0809632542 0.757818163 0.87128541 13 60016071 60016145 75 - 1.662 1.646 -0.053
ENSG00000139734 E035 59.9820229 0.2304256594 0.754436188 0.86937469 13 60042690 60042820 131 - 1.689 1.693 0.011
ENSG00000139734 E036 49.8236233 0.0110050030 0.174267009 0.39621579 13 60093628 60093732 105 - 1.627 1.566 -0.207
ENSG00000139734 E037 54.5482936 0.0056049434 0.050913961 0.18184491 13 60112010 60112186 177 - 1.667 1.582 -0.289
ENSG00000139734 E038 17.9517055 0.0019932182 0.318734016 0.55852535 13 60132957 60132989 33 - 1.198 1.149 -0.174
ENSG00000139734 E039 55.5124179 0.0411925536 0.373612642 0.60703427 13 60163587 60163928 342 - 1.671 1.599 -0.245