ENSG00000139697

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267176 ENSG00000139697 HEK293_OSMI2_6hA HEK293_TMG_6hB SBNO1 protein_coding protein_coding 7.834456 3.592676 15.73661 0.865893 0.8395286 2.127901 1.1852149 1.27958630 0.8640177 0.17675425 0.8640177 -0.5611740 0.22478333 0.380333333 0.05176667 -0.32856667 1.173735e-01 7.353016e-09 FALSE TRUE
ENST00000420886 ENSG00000139697 HEK293_OSMI2_6hA HEK293_TMG_6hB SBNO1 protein_coding protein_coding 7.834456 3.592676 15.73661 0.865893 0.8395286 2.127901 1.1891224 1.46163011 0.8829149 0.53637545 0.8829149 -0.7208206 0.29927917 0.400333333 0.05363333 -0.34670000 1.340677e-01 7.353016e-09 FALSE TRUE
ENST00000602398 ENSG00000139697 HEK293_OSMI2_6hA HEK293_TMG_6hB SBNO1 protein_coding protein_coding 7.834456 3.592676 15.73661 0.865893 0.8395286 2.127901 0.4144961 0.00000000 0.7945271 0.00000000 0.7945271 6.3300691 0.04958333 0.000000000 0.05650000 0.05650000 1.000000e+00 7.353016e-09 FALSE TRUE
MSTRG.8240.11 ENSG00000139697 HEK293_OSMI2_6hA HEK293_TMG_6hB SBNO1 protein_coding   7.834456 3.592676 15.73661 0.865893 0.8395286 2.127901 0.4663777 0.02814659 1.0563741 0.02814659 0.5318717 4.8050155 0.03878750 0.007166667 0.07003333 0.06286667 7.127590e-01 7.353016e-09 FALSE TRUE
MSTRG.8240.12 ENSG00000139697 HEK293_OSMI2_6hA HEK293_TMG_6hB SBNO1 protein_coding   7.834456 3.592676 15.73661 0.865893 0.8395286 2.127901 0.6871891 0.00000000 2.4720509 0.00000000 0.1823235 7.9553889 0.05257917 0.000000000 0.15936667 0.15936667 7.353016e-09 7.353016e-09 FALSE TRUE
MSTRG.8240.5 ENSG00000139697 HEK293_OSMI2_6hA HEK293_TMG_6hB SBNO1 protein_coding   7.834456 3.592676 15.73661 0.865893 0.8395286 2.127901 2.1490080 0.65906792 6.6069500 0.55063513 0.5232936 3.3059418 0.18820417 0.157600000 0.41890000 0.26130000 4.959805e-01 7.353016e-09 TRUE TRUE
MSTRG.8240.6 ENSG00000139697 HEK293_OSMI2_6hA HEK293_TMG_6hB SBNO1 protein_coding   7.834456 3.592676 15.73661 0.865893 0.8395286 2.127901 0.5228838 0.00000000 1.0344532 0.00000000 0.1040964 6.7066040 0.04049167 0.000000000 0.06653333 0.06653333 7.884004e-05 7.353016e-09 TRUE TRUE
MSTRG.8240.7 ENSG00000139697 HEK293_OSMI2_6hA HEK293_TMG_6hB SBNO1 protein_coding   7.834456 3.592676 15.73661 0.865893 0.8395286 2.127901 0.7089126 0.00000000 1.3766544 0.00000000 0.7381773 7.1154645 0.05484583 0.000000000 0.08293333 0.08293333 4.959805e-01 7.353016e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000139697 E001 24.8493760 0.118358860 1.469305e-07 5.242053e-06 12 123289109 123289334 226 - 0.812 1.875 3.754
ENSG00000139697 E002 30.1722151 0.240844014 1.525917e-04 2.129475e-03 12 123289335 123289421 87 - 0.925 1.944 3.552
ENSG00000139697 E003 285.1816022 1.427899232 1.202535e-01 3.162544e-01 12 123289422 123294432 5011 - 2.017 2.849 2.778
ENSG00000139697 E004 3.3910426 0.225931974 4.131874e-02 1.581659e-01 12 123294433 123294461 29 - 0.373 0.936 2.489
ENSG00000139697 E005 4.0693937 0.227602747 1.309186e-02 7.082327e-02 12 123294462 123294507 46 - 0.373 1.048 2.904
ENSG00000139697 E006 166.2333199 1.434433412 4.417634e-01 6.599442e-01 12 123294508 123295594 1087 - 2.028 2.404 1.258
ENSG00000139697 E007 51.0077563 0.773129470 3.244775e-01 5.637847e-01 12 123295595 123295690 96 - 1.527 1.891 1.234
ENSG00000139697 E008 44.0095798 0.721136563 2.929245e-01 5.336003e-01 12 123295691 123295760 70 - 1.459 1.837 1.286
ENSG00000139697 E009 39.2491884 0.682160361 2.939791e-01 5.346185e-01 12 123295761 123295806 46 - 1.408 1.793 1.312
ENSG00000139697 E010 52.4191969 0.801072690 3.839805e-01 6.155760e-01 12 123295807 123295896 90 - 1.560 1.868 1.043
ENSG00000139697 E011 73.5768463 0.932576926 4.997844e-01 7.006000e-01 12 123295897 123296050 154 - 1.731 1.963 0.783
ENSG00000139697 E012 100.7109030 0.014093136 9.912039e-01 9.973528e-01 12 123297978 123298171 194 - 1.893 2.049 0.526
ENSG00000139697 E013 56.4863445 0.005354091 7.941131e-01 8.927904e-01 12 123302824 123302900 77 - 1.645 1.802 0.531
ENSG00000139697 E014 74.0747984 0.010337007 7.887264e-01 8.897474e-01 12 123304582 123304719 138 - 1.758 1.915 0.529
ENSG00000139697 E015 71.2524953 0.014775210 5.190866e-01 7.144129e-01 12 123309310 123309402 93 - 1.749 1.885 0.459
ENSG00000139697 E016 74.2436923 0.003131433 1.998046e-01 4.294189e-01 12 123309489 123309583 95 - 1.778 1.885 0.359
ENSG00000139697 E017 75.9603255 0.005134469 7.199716e-02 2.288022e-01 12 123309710 123309856 147 - 1.797 1.870 0.245
ENSG00000139697 E018 54.3836885 0.003147491 5.052157e-03 3.490671e-02 12 123311055 123311129 75 - 1.666 1.664 -0.007
ENSG00000139697 E019 51.5736149 0.012709929 1.431032e-01 3.521394e-01 12 123313620 123313719 100 - 1.627 1.695 0.230
ENSG00000139697 E020 65.4307968 0.015085358 3.665389e-01 6.011471e-01 12 123315373 123315444 72 - 1.717 1.825 0.362
ENSG00000139697 E021 80.2720766 0.018498537 7.796693e-02 2.407402e-01 12 123315548 123315660 113 - 1.822 1.860 0.127
ENSG00000139697 E022 85.1676750 0.003880962 3.451820e-05 6.081502e-04 12 123317221 123317356 136 - 1.870 1.820 -0.169
ENSG00000139697 E023 84.1783154 0.011705892 2.435506e-03 1.991741e-02 12 123319900 123320031 132 - 1.862 1.828 -0.115
ENSG00000139697 E024 87.7014605 0.010292831 6.019622e-02 2.032740e-01 12 123320432 123320607 176 - 1.861 1.910 0.163
ENSG00000139697 E025 73.7873300 0.012490988 7.684513e-03 4.787787e-02 12 123320699 123320866 168 - 1.802 1.777 -0.085
ENSG00000139697 E026 80.8240673 0.014310874 3.263947e-03 2.497743e-02 12 123321535 123321732 198 - 1.844 1.805 -0.131
ENSG00000139697 E027 53.2149117 0.002007093 7.306149e-02 2.309567e-01 12 123323680 123323831 152 - 1.642 1.707 0.220
ENSG00000139697 E028 60.4450509 0.009780027 1.950529e-01 4.234296e-01 12 123325502 123325599 98 - 1.689 1.774 0.287
ENSG00000139697 E029 81.2188352 0.010946068 2.599312e-02 1.152962e-01 12 123326152 123326334 183 - 1.832 1.854 0.073
ENSG00000139697 E030 69.7471201 0.007388659 3.696863e-03 2.745135e-02 12 123327426 123327579 154 - 1.775 1.760 -0.051
ENSG00000139697 E031 67.8799805 0.003220156 3.920699e-06 9.343600e-05 12 123327707 123327812 106 - 1.783 1.685 -0.333
ENSG00000139697 E032 72.4877607 0.013865047 1.981820e-05 3.792637e-04 12 123327892 123328027 136 - 1.822 1.664 -0.535
ENSG00000139697 E033 74.6408901 0.014567585 3.884345e-05 6.720847e-04 12 123328734 123328895 162 - 1.832 1.682 -0.507
ENSG00000139697 E034 52.4371780 0.008617653 4.475686e-06 1.045926e-04 12 123330419 123330509 91 - 1.685 1.512 -0.587
ENSG00000139697 E035 54.5843604 0.018040318 2.001777e-05 3.823934e-04 12 123331242 123331326 85 - 1.707 1.503 -0.695
ENSG00000139697 E036 37.4289556 0.027430616 2.205112e-04 2.898924e-03 12 123331327 123331375 49 - 1.552 1.309 -0.839
ENSG00000139697 E037 57.5754059 0.017994816 3.960617e-05 6.820848e-04 12 123334053 123334213 161 - 1.728 1.534 -0.661
ENSG00000139697 E038 46.7575285 0.012196613 7.120045e-06 1.561197e-04 12 123336395 123336488 94 - 1.642 1.432 -0.718
ENSG00000139697 E039 24.4742765 0.001752479 4.801835e-05 8.036483e-04 12 123336489 123336491 3 - 1.369 1.176 -0.677
ENSG00000139697 E040 51.9085078 0.006675376 9.581874e-09 4.526349e-07 12 123340988 123341088 101 - 1.693 1.433 -0.887
ENSG00000139697 E041 82.3161240 0.028082785 5.953862e-05 9.673773e-04 12 123345258 123345567 310 - 1.883 1.661 -0.751
ENSG00000139697 E042 8.4607045 0.011935668 1.820054e-01 4.065866e-01 12 123345568 123345570 3 - 0.913 0.886 -0.105
ENSG00000139697 E043 15.8771913 0.027055845 5.946436e-03 3.947741e-02 12 123348029 123348034 6 - 1.187 0.981 -0.748
ENSG00000139697 E044 29.6057150 0.012664560 1.391442e-04 1.970071e-03 12 123348035 123348133 99 - 1.445 1.242 -0.706
ENSG00000139697 E045 30.7703431 0.011597400 9.638516e-02 2.754188e-01 12 123350310 123350441 132 - 1.429 1.457 0.095
ENSG00000139697 E046 1.6253243 0.247903685 6.306792e-02 2.095785e-01 12 123357809 123357852 44 - 0.450 0.001 -9.989
ENSG00000139697 E047 0.0000000       12 123357853 123357917 65 -      
ENSG00000139697 E048 13.7731576 0.484807064 6.222342e-01 7.853504e-01 12 123364701 123364763 63 - 1.060 1.215 0.558
ENSG00000139697 E049 9.5391303 0.324326250 5.418489e-01 7.304030e-01 12 123364764 123364847 84 - 0.910 1.089 0.662
ENSG00000139697 E050 0.4952057 0.307451710 8.020966e-01   12 123383627 123383718 92 - 0.128 0.208 0.840