ENSG00000139687

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267163 ENSG00000139687 HEK293_OSMI2_6hA HEK293_TMG_6hB RB1 protein_coding protein_coding 12.22313 4.796436 19.71829 1.123948 0.454782 2.037227 10.8002338 3.097457 19.1979554 0.7511113 0.38421280 2.627898 0.7417750 0.6440333 0.9737667 0.3297333 3.152423e-20 1.180768e-20 FALSE TRUE
ENST00000531171 ENSG00000139687 HEK293_OSMI2_6hA HEK293_TMG_6hB RB1 protein_coding processed_transcript 12.22313 4.796436 19.71829 1.123948 0.454782 2.037227 0.9561022 1.485753 0.1234258 0.3714890 0.04364398 -3.486762 0.1960167 0.3106333 0.0064000 -0.3042333 1.180768e-20 1.180768e-20   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000139687 E001 0.7930990 0.1406046783 9.198387e-01   13 48303744 48303746 3 + 0.203 0.230 0.228
ENSG00000139687 E002 0.7930990 0.1406046783 9.198387e-01   13 48303747 48303750 4 + 0.203 0.230 0.228
ENSG00000139687 E003 1.6196943 0.0121572692 9.798039e-02 2.782310e-01 13 48303751 48303774 24 + 0.276 0.581 1.665
ENSG00000139687 E004 41.9824823 0.0622189592 9.352915e-01 9.698129e-01 13 48303775 48304049 275 + 1.525 1.487 -0.130
ENSG00000139687 E005 68.2804681 0.0030176792 2.209928e-03 1.846205e-02 13 48307280 48307406 127 + 1.754 1.550 -0.694
ENSG00000139687 E006 0.7732728 0.6422644733 6.748765e-01   13 48333017 48333216 200 + 0.194 0.239 0.382
ENSG00000139687 E007 75.9089623 0.0005561438 6.997578e-04 7.441603e-03 13 48342599 48342714 116 + 1.801 1.606 -0.660
ENSG00000139687 E008 84.7602724 0.0010614765 8.383814e-03 5.108592e-02 13 48345080 48345199 120 + 1.843 1.701 -0.482
ENSG00000139687 E009 63.8934240 0.0006664190 2.060836e-01 4.371220e-01 13 48347825 48347863 39 + 1.710 1.636 -0.252
ENSG00000139687 E010 71.3628519 0.0005331526 7.578530e-04 7.923955e-03 13 48348956 48349023 68 + 1.775 1.575 -0.678
ENSG00000139687 E011 86.8451883 0.0034145914 9.940086e-06 2.086079e-04 13 48360017 48360127 111 + 1.868 1.590 -0.939
ENSG00000139687 E012 0.0000000       13 48360128 48360737 610 +      
ENSG00000139687 E013 84.4547357 0.0020200246 3.249886e-03 2.490435e-02 13 48362815 48362957 143 + 1.843 1.676 -0.565
ENSG00000139687 E014 43.5069323 0.0008554949 5.126516e-01 7.099424e-01 13 48364894 48364971 78 + 1.541 1.495 -0.156
ENSG00000139687 E015 68.1334326 0.0036920855 5.665390e-01 7.476732e-01 13 48367494 48367603 110 + 1.733 1.694 -0.129
ENSG00000139687 E016 83.7609839 0.0008241623 4.834397e-02 1.757908e-01 13 48368527 48368604 78 + 1.830 1.725 -0.356
ENSG00000139687 E017 91.0142278 0.0004182504 6.608970e-02 2.162909e-01 13 48373405 48373492 88 + 1.864 1.774 -0.305
ENSG00000139687 E018 99.6990659 0.0004340195 9.985310e-04 9.902682e-03 13 48376918 48377034 117 + 1.914 1.753 -0.544
ENSG00000139687 E019 56.9770209 0.0007923096 1.804447e-01 4.045849e-01 13 48379594 48379650 57 + 1.665 1.583 -0.280
ENSG00000139687 E020 48.4289796 0.0008213860 8.738902e-02 2.589723e-01 13 48380053 48380084 32 + 1.601 1.485 -0.396
ENSG00000139687 E021 68.1696335 0.0006374486 3.476267e-02 1.409886e-01 13 48380165 48380241 77 + 1.744 1.621 -0.415
ENSG00000139687 E022 34.4106045 0.0010258979 1.754451e-01 3.977441e-01 13 48381247 48381249 3 + 1.453 1.345 -0.374
ENSG00000139687 E023 92.4580675 0.0004583488 2.512249e-02 1.126078e-01 13 48381250 48381443 194 + 1.874 1.763 -0.373
ENSG00000139687 E024 0.1426347 0.0327104018 1.000000e+00   13 48444828 48445221 394 + 0.060 0.000 -7.839
ENSG00000139687 E025 75.2118985 0.0004830856 1.781597e-01 4.014141e-01 13 48452993 48453111 119 + 1.779 1.707 -0.243
ENSG00000139687 E026 89.2279068 0.0005192810 4.109930e-01 6.368079e-01 13 48456204 48456349 146 + 1.831 1.870 0.134
ENSG00000139687 E027 108.7614865 0.0005380773 4.188779e-01 6.427793e-01 13 48459688 48459833 146 + 1.930 1.894 -0.119
ENSG00000139687 E028 90.1616072 0.0005487347 5.566200e-01 7.409224e-01 13 48463731 48463835 105 + 1.846 1.818 -0.095
ENSG00000139687 E029 84.9328371 0.0006856732 3.234715e-01 5.627987e-01 13 48464998 48465111 114 + 1.813 1.862 0.165
ENSG00000139687 E030 104.6611371 0.0004941444 2.513994e-01 4.894673e-01 13 48465205 48465368 164 + 1.899 1.949 0.170
ENSG00000139687 E031 52.0690721 0.0011146007 1.601647e-01 3.770580e-01 13 48473360 48473390 31 + 1.590 1.676 0.295
ENSG00000139687 E032 2.3164168 0.0154189023 6.920829e-01 8.303773e-01 13 48476400 48476446 47 + 0.420 0.494 0.379
ENSG00000139687 E033 2.1440425 0.0100150306 8.526505e-01 9.265227e-01 13 48476447 48476522 76 + 0.419 0.382 -0.207
ENSG00000139687 E034 2.3765866 0.0300592262 3.744515e-01 6.077010e-01 13 48476523 48476700 178 + 0.419 0.582 0.799
ENSG00000139687 E035 105.4754015 0.0004301090 2.131503e-01 4.454238e-01 13 48476701 48476843 143 + 1.904 1.959 0.184
ENSG00000139687 E036 75.8300267 0.0005635622 1.279582e-01 3.285864e-01 13 48477355 48477404 50 + 1.758 1.836 0.262
ENSG00000139687 E037 0.3228314 0.4705868897 1.000000e+00   13 48479979 48479997 19 + 0.113 0.001 -7.617
ENSG00000139687 E038 516.1419255 0.0002004023 7.153981e-39 1.104464e-35 13 48479998 48481890 1893 + 2.549 2.770 0.736
ENSG00000139687 E039 0.0000000       13 48599302 48599436 135 +