ENSG00000139645

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267116 ENSG00000139645 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD52 protein_coding protein_coding 30.29565 44.78596 24.12948 6.116328 1.308108 -0.8919736 23.907266 33.238491 20.2203161 5.057040 0.752663 -0.716770 0.7988333 0.7401333 0.8401333 0.1000000 0.2699782446 2.77915e-05 FALSE TRUE
MSTRG.7458.7 ENSG00000139645 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD52 protein_coding   30.29565 44.78596 24.12948 6.116328 1.308108 -0.8919736 4.168274 9.206416 0.8704651 1.667336 0.261318 -3.387868 0.1213667 0.2040333 0.0360000 -0.1680333 0.0000277915 2.77915e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000139645 E001 0.1308682 0.0326491905 1.000000e+00   12 56229854 56229878 25 - 0.001 0.090 7.612
ENSG00000139645 E002 0.5668842 0.4282341146 9.226037e-01   12 56237172 56237223 52 - 0.163 0.171 0.089
ENSG00000139645 E003 11.8718058 0.0035435537 4.099184e-03 2.972022e-02 12 56237807 56237835 29 - 0.809 1.188 1.408
ENSG00000139645 E004 58.8771465 0.0591309709 8.551351e-03 5.183894e-02 12 56237836 56237891 56 - 1.469 1.846 1.279
ENSG00000139645 E005 116.2018784 0.0032761847 6.127213e-12 5.493884e-10 12 56237892 56237968 77 - 1.753 2.143 1.308
ENSG00000139645 E006 5014.9917840 0.0011548721 1.708689e-20 5.373604e-18 12 56237969 56243237 5269 - 3.571 3.717 0.486
ENSG00000139645 E007 239.6157792 0.0003013151 7.924345e-01 8.918645e-01 12 56243238 56243392 155 - 2.319 2.379 0.198
ENSG00000139645 E008 225.8110557 0.0002431311 8.682338e-02 2.579217e-01 12 56243785 56243876 92 - 2.327 2.335 0.027
ENSG00000139645 E009 225.7711586 0.0002553143 2.330542e-01 4.686778e-01 12 56244051 56244133 83 - 2.318 2.339 0.071
ENSG00000139645 E010 247.2130028 0.0002522267 5.543927e-02 1.923285e-01 12 56244353 56244435 83 - 2.369 2.375 0.017
ENSG00000139645 E011 305.0119159 0.0002642700 5.164081e-02 1.836107e-01 12 56244652 56244797 146 - 2.458 2.466 0.027
ENSG00000139645 E012 230.6760083 0.0003148282 1.934889e-03 1.663182e-02 12 56244906 56244989 84 - 2.361 2.334 -0.089
ENSG00000139645 E013 213.7339087 0.0002962115 5.116041e-02 1.824718e-01 12 56245103 56245190 88 - 2.309 2.310 0.002
ENSG00000139645 E014 291.5437295 0.0001921125 7.152880e-01 8.451171e-01 12 56245377 56245596 220 - 2.415 2.459 0.147
ENSG00000139645 E015 206.7336160 0.0004340888 1.768216e-01 3.994952e-01 12 56247493 56247610 118 - 2.287 2.302 0.049
ENSG00000139645 E016 208.7552401 0.0005182051 1.323238e-01 3.354574e-01 12 56247687 56247774 88 - 2.295 2.306 0.036
ENSG00000139645 E017 271.7715984 0.0005255519 3.614521e-01 5.968949e-01 12 56248023 56248224 202 - 2.395 2.425 0.101
ENSG00000139645 E018 170.1932440 0.0003377193 2.555401e-01 4.941989e-01 12 56248495 56248566 72 - 2.198 2.217 0.063
ENSG00000139645 E019 194.9481483 0.0006464655 4.147706e-01 6.396440e-01 12 56248759 56248870 112 - 2.250 2.278 0.094
ENSG00000139645 E020 200.3822236 0.0002634030 2.287420e-04 2.987667e-03 12 56252015 56252095 81 - 2.313 2.267 -0.154
ENSG00000139645 E021 153.3686303 0.0002961863 2.730825e-04 3.458727e-03 12 56252175 56252228 54 - 2.206 2.148 -0.193
ENSG00000139645 E022 157.7679199 0.0005363653 2.955110e-06 7.343366e-05 12 56252229 56252315 87 - 2.239 2.147 -0.306
ENSG00000139645 E023 170.9226299 0.0003310934 3.764671e-09 1.940297e-07 12 56252502 56252570 69 - 2.289 2.173 -0.389
ENSG00000139645 E024 215.7203739 0.0005068729 2.205112e-08 9.584815e-07 12 56252780 56252897 118 - 2.378 2.282 -0.322
ENSG00000139645 E025 185.5279792 0.0002833216 1.380402e-03 1.276193e-02 12 56253004 56253086 83 - 2.275 2.238 -0.121
ENSG00000139645 E026 215.4967415 0.0011120517 2.749739e-04 3.477576e-03 12 56253288 56253402 115 - 2.350 2.292 -0.193
ENSG00000139645 E027 187.2667475 0.0014755377 1.395606e-04 1.975543e-03 12 56253722 56253800 79 - 2.299 2.225 -0.245
ENSG00000139645 E028 129.7206646 0.0003628858 2.296997e-07 7.783545e-06 12 56254067 56254086 20 - 2.167 2.051 -0.390
ENSG00000139645 E029 234.0275587 0.0019711592 7.811805e-06 1.693851e-04 12 56254087 56254229 143 - 2.407 2.315 -0.307
ENSG00000139645 E030 151.1686000 0.0002832141 6.146731e-03 4.045171e-02 12 56254230 56254279 50 - 2.181 2.149 -0.106
ENSG00000139645 E031 196.8020871 0.0003492014 2.037402e-05 3.880638e-04 12 56254578 56254720 143 - 2.315 2.250 -0.215
ENSG00000139645 E032 141.0067009 0.0037458753 1.105286e-04 1.625140e-03 12 56254865 56254952 88 - 2.203 2.088 -0.386
ENSG00000139645 E033 5.5999273 0.1859666539 3.124422e-01 5.527531e-01 12 56254953 56255084 132 - 0.890 0.739 -0.591
ENSG00000139645 E034 2.1225777 0.1768418460 3.227807e-01 5.621288e-01 12 56255194 56255322 129 - 0.280 0.549 1.484
ENSG00000139645 E035 3.0333733 0.0259634547 6.099862e-01 7.768703e-01 12 56255323 56255539 217 - 0.621 0.574 -0.210
ENSG00000139645 E036 3.6757780 0.0268184512 1.325300e-01 3.358006e-01 12 56255540 56255783 244 - 0.776 0.575 -0.852
ENSG00000139645 E037 179.2944861 0.0049012142 1.324700e-04 1.891729e-03 12 56255784 56255984 201 - 2.308 2.190 -0.394
ENSG00000139645 E038 12.7904063 0.1583951507 2.932991e-01 5.340352e-01 12 56255985 56257014 1030 - 1.202 1.063 -0.499
ENSG00000139645 E039 134.8724171 0.0031846685 5.202509e-05 8.609488e-04 12 56257015 56257085 71 - 2.185 2.070 -0.386
ENSG00000139645 E040 2.7971952 0.0217715271 1.992656e-01 4.288212e-01 12 56257086 56257282 197 - 0.665 0.487 -0.807
ENSG00000139645 E041 133.1967258 0.0043704117 3.767784e-04 4.504761e-03 12 56257283 56257361 79 - 2.174 2.067 -0.358
ENSG00000139645 E042 2.9328650 0.0085558199 4.881421e-01 6.927601e-01 12 56257362 56257518 157 - 0.621 0.547 -0.331
ENSG00000139645 E043 7.6071099 0.1353868877 3.619233e-01 5.972956e-01 12 56257519 56257827 309 - 0.988 0.862 -0.477
ENSG00000139645 E044 109.3212425 0.0064206422 3.795674e-03 2.799534e-02 12 56257828 56257911 84 - 2.084 1.981 -0.345
ENSG00000139645 E045 76.9224095 0.0038120398 8.745442e-01 9.384837e-01 12 56258243 56258419 177 - 1.840 1.882 0.144