ENSG00000139436

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320063 ENSG00000139436 HEK293_OSMI2_6hA HEK293_TMG_6hB GIT2 protein_coding protein_coding 11.12295 10.89318 13.14908 0.3057762 0.5995368 0.2713098 0.2605676 0.0000000 0.7570869 0.0000000 0.1373705 6.2613181 0.02209167 0.00000000 0.05736667 0.0573666667 3.122633e-08 3.122633e-08 FALSE TRUE
ENST00000355312 ENSG00000139436 HEK293_OSMI2_6hA HEK293_TMG_6hB GIT2 protein_coding protein_coding 11.12295 10.89318 13.14908 0.3057762 0.5995368 0.2713098 4.2398566 5.1015656 2.2147691 0.6168579 1.1334090 -1.2001097 0.40726250 0.46993333 0.16136667 -0.3085666667 5.930434e-01 3.122633e-08 FALSE TRUE
ENST00000361006 ENSG00000139436 HEK293_OSMI2_6hA HEK293_TMG_6hB GIT2 protein_coding protein_coding 11.12295 10.89318 13.14908 0.3057762 0.5995368 0.2713098 1.7935636 1.8006681 3.3810137 1.1556441 0.9215555 0.9051945 0.15607083 0.15986667 0.26463333 0.1047666667 8.232019e-01 3.122633e-08 FALSE TRUE
ENST00000457474 ENSG00000139436 HEK293_OSMI2_6hA HEK293_TMG_6hB GIT2 protein_coding protein_coding 11.12295 10.89318 13.14908 0.3057762 0.5995368 0.2713098 0.3750218 0.7797188 0.0000000 0.3921581 0.0000000 -6.3032671 0.04207083 0.07366667 0.00000000 -0.0736666667 3.091527e-01 3.122633e-08 FALSE TRUE
ENST00000550480 ENSG00000139436 HEK293_OSMI2_6hA HEK293_TMG_6hB GIT2 protein_coding retained_intron 11.12295 10.89318 13.14908 0.3057762 0.5995368 0.2713098 0.8718161 0.8041639 0.9822354 0.3791285 0.1619474 0.2853632 0.07510833 0.07470000 0.07426667 -0.0004333333 9.622235e-01 3.122633e-08   FALSE
ENST00000551209 ENSG00000139436 HEK293_OSMI2_6hA HEK293_TMG_6hB GIT2 protein_coding protein_coding 11.12295 10.89318 13.14908 0.3057762 0.5995368 0.2713098 0.9079561 0.5436801 1.3856490 0.3274774 0.4892739 1.3338116 0.07416667 0.04840000 0.10350000 0.0551000000 7.380731e-01 3.122633e-08 FALSE TRUE
MSTRG.7995.9 ENSG00000139436 HEK293_OSMI2_6hA HEK293_TMG_6hB GIT2 protein_coding   11.12295 10.89318 13.14908 0.3057762 0.5995368 0.2713098 0.3182418 0.0000000 1.1043839 0.0000000 0.6326400 6.8001025 0.02421667 0.00000000 0.08803333 0.0880333333 3.487841e-01 3.122633e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000139436 E001 189.7825390 0.9600853937 2.224828e-01 4.564451e-01 12 109929804 109930786 983 - 2.025 2.407 1.275
ENSG00000139436 E002 46.7993204 0.1698656514 1.912111e-02 9.287277e-02 12 109930787 109930875 89 - 1.377 1.821 1.515
ENSG00000139436 E003 45.2503747 0.2165268895 6.096754e-02 2.049546e-01 12 109930876 109930950 75 - 1.412 1.792 1.293
ENSG00000139436 E004 69.6386333 0.3470850420 7.481232e-02 2.344371e-01 12 109930951 109931153 203 - 1.578 1.980 1.359
ENSG00000139436 E005 193.7324551 0.0051269140 7.084727e-07 2.105986e-05 12 109931154 109932254 1101 - 2.124 2.384 0.870
ENSG00000139436 E006 40.4297845 0.0705583680 4.510491e-01 6.663761e-01 12 109932255 109932316 62 - 1.618 1.609 -0.031
ENSG00000139436 E007 72.0739895 0.0837332818 7.880673e-01 8.893975e-01 12 109932317 109932614 298 - 1.826 1.887 0.205
ENSG00000139436 E008 86.7379649 0.0006093573 7.459892e-02 2.339757e-01 12 109932615 109932972 358 - 1.863 1.994 0.440
ENSG00000139436 E009 30.0146911 0.2491971851 4.532279e-01 6.681295e-01 12 109932973 109932977 5 - 1.438 1.526 0.303
ENSG00000139436 E010 41.0930064 0.3098100458 3.228429e-01 5.621581e-01 12 109932978 109933037 60 - 1.528 1.683 0.529
ENSG00000139436 E011 29.7295136 0.2180081663 3.572400e-01 5.934535e-01 12 109933038 109933056 19 - 1.396 1.544 0.508
ENSG00000139436 E012 35.6428367 0.2492139377 2.743648e-01 5.143220e-01 12 109933057 109933095 39 - 1.451 1.632 0.621
ENSG00000139436 E013 31.0423356 0.2158062091 3.022116e-01 5.428365e-01 12 109933096 109933111 16 - 1.405 1.568 0.560
ENSG00000139436 E014 44.7351194 0.3074165242 2.476562e-01 4.854758e-01 12 109933112 109933190 79 - 1.531 1.736 0.698
ENSG00000139436 E015 26.2785409 0.1512341852 2.648398e-01 5.041607e-01 12 109934022 109934036 15 - 1.319 1.508 0.653
ENSG00000139436 E016 22.0277643 0.1192270758 3.157527e-01 5.557612e-01 12 109934037 109934039 3 - 1.259 1.427 0.587
ENSG00000139436 E017 33.4862903 0.2621802192 3.899645e-01 6.204381e-01 12 109934040 109934085 46 - 1.457 1.589 0.451
ENSG00000139436 E018 74.9821616 0.0014114185 8.538888e-02 2.553352e-01 12 109938380 109938534 155 - 1.889 1.877 -0.041
ENSG00000139436 E019 45.8305790 0.0290807386 3.392468e-02 1.386535e-01 12 109938535 109938568 34 - 1.728 1.613 -0.392
ENSG00000139436 E020 5.8769442 0.3154815774 4.501959e-01 6.658330e-01 12 109938569 109938808 240 - 0.857 0.808 -0.190
ENSG00000139436 E021 5.8064198 0.4239113238 4.184413e-01 6.424577e-01 12 109938809 109939022 214 - 0.876 0.780 -0.378
ENSG00000139436 E022 62.6761096 0.0408366441 2.835656e-01 5.240153e-01 12 109939165 109939239 75 - 1.807 1.794 -0.041
ENSG00000139436 E023 35.1429903 0.0368252098 2.873670e-01 5.281436e-01 12 109939240 109939247 8 - 1.563 1.544 -0.066
ENSG00000139436 E024 10.0097499 0.1727373592 3.267093e-01 5.658839e-01 12 109939248 109939685 438 - 1.085 1.000 -0.312
ENSG00000139436 E025 15.7162677 0.3029837706 6.591255e-01 8.094725e-01 12 109939754 109940501 748 - 1.181 1.250 0.247
ENSG00000139436 E026 6.4508404 0.2430293379 7.359783e-01 8.579309e-01 12 109942842 109943021 180 - 0.827 0.897 0.268
ENSG00000139436 E027 34.4715478 0.0020695147 9.757804e-01 9.896854e-01 12 109945260 109945349 90 - 1.509 1.571 0.212
ENSG00000139436 E028 43.7099248 0.0768625719 4.835937e-01 6.894915e-01 12 109947256 109947321 66 - 1.643 1.649 0.022
ENSG00000139436 E029 73.1257347 0.0400425482 2.500708e-01 4.880031e-01 12 109947322 109947504 183 - 1.876 1.860 -0.052
ENSG00000139436 E030 1.1416042 0.0165392302 9.313669e-01   12 109947505 109948061 557 - 0.318 0.334 0.103
ENSG00000139436 E031 16.9701679 0.1034582293 6.500690e-01 8.036037e-01 12 109948062 109948846 785 - 1.310 1.207 -0.365
ENSG00000139436 E032 1.0360046 0.0307965916 1.262574e-03   12 109950694 109951166 473 - 0.545 0.000 -14.870
ENSG00000139436 E033 41.7614786 0.0038303855 2.463820e-02 1.110836e-01 12 109951167 109951211 45 - 1.668 1.599 -0.236
ENSG00000139436 E034 57.0964664 0.0020831679 1.338761e-02 7.197888e-02 12 109951212 109951316 105 - 1.805 1.742 -0.211
ENSG00000139436 E035 0.1308682 0.0322950858 7.166797e-01   12 109952680 109953091 412 - 0.000 0.110 11.404
ENSG00000139436 E036 83.7946629 0.2673530246 6.114225e-01 7.778555e-01 12 109953092 109953234 143 - 1.919 1.931 0.041
ENSG00000139436 E037 0.3641499 0.0290868149 7.986671e-01   12 109953235 109954550 1316 - 0.133 0.111 -0.311
ENSG00000139436 E038 76.9887955 0.0005155868 8.679187e-05 1.327622e-03 12 109959847 109959958 112 - 1.946 1.848 -0.330
ENSG00000139436 E039 68.4311009 0.0104400626 4.945168e-04 5.624562e-03 12 109961278 109961375 98 - 1.914 1.770 -0.485
ENSG00000139436 E040 45.6050796 0.0455229714 4.825723e-02 1.756123e-01 12 109961613 109961650 38 - 1.730 1.608 -0.415
ENSG00000139436 E041 36.6259498 0.0416058164 3.380647e-02 1.383405e-01 12 109961651 109961685 35 - 1.645 1.507 -0.469
ENSG00000139436 E042 33.6373494 0.0170230996 3.632454e-03 2.710225e-02 12 109965526 109965574 49 - 1.624 1.455 -0.579
ENSG00000139436 E043 15.8123884 0.0025663497 1.305321e-02 7.065779e-02 12 109965575 109965577 3 - 1.302 1.147 -0.548
ENSG00000139436 E044 0.1426347 0.0304619412 3.407817e-01   12 109967314 109967319 6 - 0.133 0.000 -12.068
ENSG00000139436 E045 34.9442632 0.0012519148 3.247247e-02 1.346232e-01 12 109967458 109967503 46 - 1.600 1.531 -0.235
ENSG00000139436 E046 49.7333303 0.4750754340 6.238333e-01 7.864919e-01 12 109980952 109981046 95 - 1.709 1.697 -0.041
ENSG00000139436 E047 0.1426347 0.0304619412 3.407817e-01   12 109981047 109983180 2134 - 0.133 0.000 -12.068
ENSG00000139436 E048 59.9413707 0.3701145863 6.906228e-01 8.294810e-01 12 109983373 109983503 131 - 1.796 1.772 -0.083
ENSG00000139436 E049 48.6258072 0.4904393360 7.286434e-01 8.533939e-01 12 109983608 109983694 87 - 1.726 1.666 -0.203
ENSG00000139436 E050 56.2978458 0.0024538997 2.613681e-04 3.336816e-03 12 109988963 109989068 106 - 1.832 1.706 -0.426
ENSG00000139436 E051 57.9077629 0.0123472484 2.526031e-03 2.050467e-02 12 109989690 109989802 113 - 1.837 1.708 -0.434
ENSG00000139436 E052 53.9010139 0.0758139902 2.073192e-01 4.385979e-01 12 109991627 109991760 134 - 1.776 1.701 -0.257
ENSG00000139436 E053 0.3337900 0.0312291250 8.004610e-01   12 109991761 109992088 328 - 0.133 0.110 -0.313
ENSG00000139436 E054 0.3032425 0.0274424043 3.387497e-01   12 109996099 109996172 74 - 0.000 0.198 12.406
ENSG00000139436 E055 33.4766368 0.0709964681 3.297943e-01 5.687398e-01 12 109996173 109996389 217 - 1.554 1.516 -0.130