ENSG00000139218

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369367 ENSG00000139218 HEK293_OSMI2_6hA HEK293_TMG_6hB SCAF11 protein_coding protein_coding 24.75132 11.31255 43.22922 2.555667 1.480041 1.933141 7.7435327 3.0072410 13.475048 0.7526521 0.24371146 2.160059 0.30583333 0.2622667 0.31283333 0.05056667 6.342186e-01 6.688688e-23 FALSE TRUE
ENST00000395453 ENSG00000139218 HEK293_OSMI2_6hA HEK293_TMG_6hB SCAF11 protein_coding protein_coding 24.75132 11.31255 43.22922 2.555667 1.480041 1.933141 1.7192099 0.3734551 2.664826 0.1323252 0.13107113 2.802316 0.07745833 0.0318000 0.06176667 0.02996667 2.547144e-01 6.688688e-23   FALSE
ENST00000547950 ENSG00000139218 HEK293_OSMI2_6hA HEK293_TMG_6hB SCAF11 protein_coding retained_intron 24.75132 11.31255 43.22922 2.555667 1.480041 1.933141 0.9031564 2.1665826 0.000000 0.6627945 0.00000000 -7.765921 0.06667500 0.1850333 0.00000000 -0.18503333 6.688688e-23 6.688688e-23 FALSE TRUE
ENST00000549162 ENSG00000139218 HEK293_OSMI2_6hA HEK293_TMG_6hB SCAF11 protein_coding protein_coding 24.75132 11.31255 43.22922 2.555667 1.480041 1.933141 5.9272623 1.2440326 12.660315 0.3322523 0.75014746 3.336806 0.16413750 0.1073000 0.29236667 0.18506667 1.018594e-08 6.688688e-23 FALSE TRUE
ENST00000550629 ENSG00000139218 HEK293_OSMI2_6hA HEK293_TMG_6hB SCAF11 protein_coding processed_transcript 24.75132 11.31255 43.22922 2.555667 1.480041 1.933141 1.6862707 1.6288538 1.806223 0.2062063 0.22939940 0.148254 0.09857917 0.1629333 0.04223333 -0.12070000 2.795156e-02 6.688688e-23 FALSE TRUE
ENST00000550893 ENSG00000139218 HEK293_OSMI2_6hA HEK293_TMG_6hB SCAF11 protein_coding protein_coding 24.75132 11.31255 43.22922 2.555667 1.480041 1.933141 2.3122216 1.6226634 3.634248 0.6533386 0.08804638 1.158394 0.12407917 0.1350667 0.08426667 -0.05080000 5.687594e-01 6.688688e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000139218 E001 51.1291662 0.0278926479 1.088502e-04 0.0016042060 12 45919131 45919309 179 - 1.510 1.878 1.248
ENSG00000139218 E002 445.9870818 0.0049247595 5.989509e-06 0.0001346514 12 45919310 45921408 2099 - 2.504 2.677 0.577
ENSG00000139218 E003 109.6700413 0.0033616414 1.830010e-01 0.4078341465 12 45921409 45921864 456 - 1.922 1.999 0.257
ENSG00000139218 E004 99.9531190 0.0006239180 5.699036e-01 0.7502130316 12 45921865 45922047 183 - 1.901 1.890 -0.039
ENSG00000139218 E005 89.1908915 0.0004896342 9.229846e-01 0.9638069569 12 45922048 45922194 147 - 1.848 1.858 0.034
ENSG00000139218 E006 11.7659432 0.0028301912 3.166864e-02 0.1322398564 12 45922356 45922462 107 - 0.957 1.205 0.898
ENSG00000139218 E007 131.4433592 0.0039540794 5.332559e-04 0.0059786832 12 45922463 45922582 120 - 1.978 2.147 0.568
ENSG00000139218 E008 96.8362606 0.0005632643 2.926940e-04 0.0036562094 12 45922936 45922983 48 - 1.849 2.018 0.567
ENSG00000139218 E009 145.9360830 0.0003823584 1.936409e-03 0.0166428889 12 45922984 45923154 171 - 2.036 2.160 0.414
ENSG00000139218 E010 134.6892549 0.0003350755 9.665162e-03 0.0566788991 12 45924728 45924946 219 - 2.003 2.112 0.367
ENSG00000139218 E011 125.7434520 0.0004969702 2.596650e-03 0.0209405442 12 45924947 45925074 128 - 1.967 2.096 0.434
ENSG00000139218 E012 144.2858811 0.0012955413 3.369365e-03 0.0255867113 12 45926142 45926291 150 - 2.027 2.152 0.419
ENSG00000139218 E013 250.5568126 0.0002161530 2.363881e-04 0.0030721774 12 45926292 45926715 424 - 2.270 2.383 0.378
ENSG00000139218 E014 886.3246032 0.0009950249 3.553681e-05 0.0006231252 12 45926716 45928652 1937 - 2.853 2.785 -0.225
ENSG00000139218 E015 131.3065333 0.0008638689 2.378858e-03 0.0195577439 12 45928653 45928783 131 - 2.037 1.922 -0.387
ENSG00000139218 E016 96.3601324 0.0004288009 2.811222e-02 0.1215928934 12 45928784 45928859 76 - 1.900 1.810 -0.302
ENSG00000139218 E017 3.1276276 0.0272951511 4.186672e-01 0.6426128356 12 45928860 45929965 1106 - 0.496 0.647 0.688
ENSG00000139218 E018 1.5158259 0.1547979799 1.486079e-01 0.3603078262 12 45930950 45931505 556 - 0.397 0.001 -10.102
ENSG00000139218 E019 108.6270555 0.0006887202 7.024919e-03 0.0447618506 12 45931506 45931612 107 - 1.955 1.845 -0.369
ENSG00000139218 E020 108.1645863 0.0005209566 7.203683e-03 0.0456031848 12 45933131 45933232 102 - 1.953 1.845 -0.362
ENSG00000139218 E021 107.0304281 0.0006835799 3.874992e-04 0.0046097329 12 45934176 45934285 110 - 1.955 1.801 -0.519
ENSG00000139218 E022 90.7861756 0.0006547675 1.670777e-03 0.0148169047 12 45934447 45934505 59 - 1.881 1.735 -0.493
ENSG00000139218 E023 0.1426347 0.0332644210 1.000000e+00   12 45934506 45934510 5 - 0.061 0.000 -7.599
ENSG00000139218 E024 0.6841482 0.3662327189 2.314303e-01   12 45934976 45935083 108 - 0.117 0.378 2.173
ENSG00000139218 E025 1.0429489 0.1168536680 1.000000e+00   12 45945084 45945248 165 - 0.247 0.228 -0.154
ENSG00000139218 E026 99.0669819 0.0028563861 1.388584e-03 0.0128173426 12 45945249 45945310 62 - 1.919 1.756 -0.552
ENSG00000139218 E027 63.7050443 0.0080711161 1.931458e-02 0.0935529595 12 45945311 45945313 3 - 1.729 1.562 -0.568
ENSG00000139218 E028 114.9708721 0.0019627896 2.146053e-04 0.0028370640 12 45948437 45948529 93 - 1.985 1.814 -0.575
ENSG00000139218 E029 61.9500004 0.0018567635 1.548012e-02 0.0798760644 12 45948530 45948537 8 - 1.717 1.578 -0.471
ENSG00000139218 E030 91.7737504 0.0008311361 7.041929e-03 0.0448293731 12 45951650 45951727 78 - 1.883 1.761 -0.409
ENSG00000139218 E031 1.0263808 0.3062703109 1.000000e+00   12 45951728 45951752 25 - 0.248 0.230 -0.141
ENSG00000139218 E032 1.7719527 0.1820036407 5.793143e-01 0.7566713008 12 45953828 45953857 30 - 0.369 0.480 0.594
ENSG00000139218 E033 7.9160658 0.0062299847 4.317280e-02 0.1630015706 12 45954734 45956192 1459 - 0.895 0.572 -1.325
ENSG00000139218 E034 2.1192921 0.0103924035 2.708245e-01 0.5107466913 12 45960162 45960214 53 - 0.451 0.226 -1.417
ENSG00000139218 E035 17.0965320 0.0080279302 5.361450e-01 0.7264132586 12 45960455 45960984 530 - 1.144 1.222 0.280
ENSG00000139218 E036 33.7839806 0.0010274492 5.458501e-02 0.1904197224 12 45960985 45961322 338 - 1.460 1.319 -0.490
ENSG00000139218 E037 1.7737355 0.0121989077 3.833083e-01 0.6149761650 12 45961407 45961695 289 - 0.402 0.226 -1.156
ENSG00000139218 E038 0.7721051 0.0209354611 1.000000e+00   12 45961696 45961699 4 - 0.206 0.226 0.166
ENSG00000139218 E039 126.2595398 0.0004683754 1.116388e-03 0.0107925512 12 45961700 45961857 158 - 2.018 1.893 -0.420
ENSG00000139218 E040 77.7166410 0.0006794067 1.377183e-01 0.3440334635 12 45964107 45964188 82 - 1.803 1.740 -0.213
ENSG00000139218 E041 13.5609149 0.0026664453 1.495286e-01 0.3615849843 12 45974190 45975734 1545 - 1.094 0.930 -0.601
ENSG00000139218 E042 0.0000000       12 45987422 45987467 46 -      
ENSG00000139218 E043 74.0149092 0.0006082914 6.714128e-02 0.2187110858 12 45990353 45990811 459 - 1.785 1.701 -0.285
ENSG00000139218 E044 5.9341616 0.1988829627 1.177030e-02 0.0655216231 12 45991885 45992218 334 - 0.581 1.132 2.158