ENSG00000139117

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331366 ENSG00000139117 HEK293_OSMI2_6hA HEK293_TMG_6hB CPNE8 protein_coding protein_coding 4.259302 0.873996 7.171537 0.2257473 0.4868623 3.022181 3.0303835 0.8245809 5.316871 0.2051444 0.1045143 2.674165 0.7888708 0.9552 0.7502333 -0.2049667 0.232705461 0.004287039 FALSE TRUE
ENST00000360449 ENSG00000139117 HEK293_OSMI2_6hA HEK293_TMG_6hB CPNE8 protein_coding protein_coding 4.259302 0.873996 7.171537 0.2257473 0.4868623 3.022181 0.8232371 0.0000000 1.351831 0.0000000 0.3826057 7.089404 0.1077167 0.0000 0.1829333 0.1829333 0.004287039 0.004287039 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000139117 E001 0.0000000       12 38646822 38647093 272 -      
ENSG00000139117 E002 0.4458772 0.022011131 0.0373684878   12 38652203 38652357 155 - 0.047 0.451 3.999
ENSG00000139117 E003 57.9506778 0.932028940 0.2167721448 0.449606682 12 38652358 38653370 1013 - 1.498 1.938 1.491
ENSG00000139117 E004 33.0950628 0.705286981 0.1322742276 0.335371185 12 38653371 38653833 463 - 1.245 1.755 1.755
ENSG00000139117 E005 18.2696600 0.659220804 0.3338781801 0.572469021 12 38653834 38653961 128 - 1.051 1.374 1.147
ENSG00000139117 E006 19.7475805 0.166806034 0.0923924179 0.268179349 12 38653962 38654070 109 - 1.066 1.467 1.413
ENSG00000139117 E007 14.5042382 0.058376598 0.1052537986 0.291106411 12 38670729 38670756 28 - 0.957 1.317 1.293
ENSG00000139117 E008 15.7926815 0.031247549 0.0785646846 0.241912257 12 38670757 38670802 46 - 0.995 1.338 1.228
ENSG00000139117 E009 0.1426347 0.033506315 1.0000000000   12 38670803 38670995 193 - 0.047 0.000 -8.507
ENSG00000139117 E010 18.6344923 0.002885359 0.0176614093 0.087861075 12 38675717 38675774 58 - 1.060 1.408 1.231
ENSG00000139117 E011 21.8250174 0.002372461 0.4754653215 0.683823839 12 38677452 38677554 103 - 1.150 1.342 0.676
ENSG00000139117 E012 0.3393995 0.027217742 1.0000000000   12 38679578 38679678 101 - 0.089 0.000 -9.511
ENSG00000139117 E013 22.6159856 0.004329189 0.4727507667 0.681984977 12 38685490 38685617 128 - 1.163 1.359 0.687
ENSG00000139117 E014 0.1308682 0.032649190 0.0594777766   12 38685618 38685694 77 - 0.000 0.281 14.469
ENSG00000139117 E015 32.7956417 0.032487873 0.6371225745 0.795114001 12 38693657 38693838 182 - 1.328 1.407 0.275
ENSG00000139117 E016 20.2535636 0.015817386 0.3152706317 0.555350225 12 38702875 38702921 47 - 1.140 1.139 -0.001
ENSG00000139117 E017 0.0000000       12 38720653 38721222 570 -      
ENSG00000139117 E018 15.0401350 0.041655787 0.2345928339 0.470379461 12 38723772 38723833 62 - 1.028 0.963 -0.241
ENSG00000139117 E019 12.3017812 0.019033084 0.5018883814 0.702132441 12 38724846 38724899 54 - 0.943 0.963 0.073
ENSG00000139117 E020 0.3206185 0.026131912 1.0000000000   12 38726359 38726594 236 - 0.089 0.000 -9.509
ENSG00000139117 E021 21.1763811 0.002307115 0.2806231480 0.520839188 12 38730283 38730358 76 - 1.163 1.167 0.011
ENSG00000139117 E022 21.2324869 0.001894496 0.1060237318 0.292383352 12 38760847 38760888 42 - 1.170 1.109 -0.218
ENSG00000139117 E023 28.4044230 0.016218410 0.0596308048 0.201931886 12 38762112 38762216 105 - 1.290 1.193 -0.342
ENSG00000139117 E024 21.2647164 0.033321858 0.1419043005 0.350299283 12 38767635 38767690 56 - 1.170 1.105 -0.233
ENSG00000139117 E025 23.3955867 0.007768168 0.0127808229 0.069553217 12 38767691 38767738 48 - 1.218 1.042 -0.630
ENSG00000139117 E026 26.3017660 0.032280771 0.0031261275 0.024171942 12 38776238 38776301 64 - 1.274 0.962 -1.124
ENSG00000139117 E027 30.0315336 0.006293365 0.0001198973 0.001737165 12 38829379 38829455 77 - 1.331 1.005 -1.165
ENSG00000139117 E028 24.1033896 0.009591089 0.0018935336 0.016362127 12 38839916 38839955 40 - 1.236 0.964 -0.984
ENSG00000139117 E029 27.3152878 0.007956492 0.0036483314 0.027185790 12 38848559 38848662 104 - 1.285 1.076 -0.742
ENSG00000139117 E030 16.5334775 0.002609213 0.0759497406 0.236665894 12 38873004 38873050 47 - 1.073 0.964 -0.401
ENSG00000139117 E031 14.4448505 0.006866582 0.0258672883 0.114876059 12 38874471 38874511 41 - 1.025 0.811 -0.809
ENSG00000139117 E032 16.9907116 0.002196319 0.0011305131 0.010894741 12 38905437 38905591 155 - 1.102 0.745 -1.351
ENSG00000139117 E033 1.0842675 0.324061372 0.3530674228   12 38906142 38906269 128 - 0.166 0.463 2.030
ENSG00000139117 E034 0.0000000       12 38907319 38907430 112 -