ENSG00000139116

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000541463 ENSG00000139116 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF21A protein_coding protein_coding 6.430341 2.76582 12.18149 0.5138071 0.4756754 2.134889 0.1493358 0.0000000 0.7243885 0.0000000 0.2108659 6.198472 0.01467083 0.00000000 0.06033333 0.06033333 0.01609468 0.01609468 FALSE TRUE
ENST00000544797 ENSG00000139116 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF21A protein_coding protein_coding 6.430341 2.76582 12.18149 0.5138071 0.4756754 2.134889 1.2436985 0.3791043 2.1357118 0.2156842 0.6324644 2.463228 0.13359167 0.14956667 0.17173333 0.02216667 0.93688523 0.01609468 FALSE TRUE
ENST00000551264 ENSG00000139116 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF21A protein_coding protein_coding 6.430341 2.76582 12.18149 0.5138071 0.4756754 2.134889 1.4357768 1.3744009 2.0409847 0.3661000 0.7360056 0.567055 0.35002917 0.47993333 0.16326667 -0.31666667 0.08860434 0.01609468 FALSE TRUE
MSTRG.7117.1 ENSG00000139116 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF21A protein_coding   6.430341 2.76582 12.18149 0.5138071 0.4756754 2.134889 0.7016178 0.3610789 0.9653222 0.1815831 0.2455317 1.394153 0.15991667 0.15673333 0.07976667 -0.07696667 0.97326605 0.01609468 FALSE TRUE
MSTRG.7117.6 ENSG00000139116 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF21A protein_coding   6.430341 2.76582 12.18149 0.5138071 0.4756754 2.134889 2.0665053 0.3107448 4.9610818 0.1764269 0.4817974 3.954062 0.22471250 0.09526667 0.41113333 0.31586667 0.16741815 0.01609468 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000139116 E001 0.0000000       12 39293228 39293228 1 -      
ENSG00000139116 E002 0.0000000       12 39293229 39293230 2 -      
ENSG00000139116 E003 37.7472307 0.0252480867 4.264592e-03 3.062980e-02 12 39293231 39293606 376 - 1.412 1.694 0.966
ENSG00000139116 E004 28.7910608 0.0013618711 8.737935e-04 8.881388e-03 12 39293607 39293729 123 - 1.312 1.555 0.839
ENSG00000139116 E005 99.5049403 0.0022895079 3.371953e-05 5.962466e-04 12 39293730 39294278 549 - 1.856 2.043 0.627
ENSG00000139116 E006 43.9300606 0.0010129360 2.775371e-02 1.205634e-01 12 39294279 39294386 108 - 1.520 1.656 0.466
ENSG00000139116 E007 36.0136229 0.0017116842 1.672650e-01 3.869266e-01 12 39294387 39294423 37 - 1.451 1.547 0.329
ENSG00000139116 E008 50.4096410 0.0009196928 1.306065e-01 3.327429e-01 12 39294424 39294517 94 - 1.592 1.681 0.302
ENSG00000139116 E009 65.5375102 0.0007884908 1.387076e-02 7.383403e-02 12 39301480 39301679 200 - 1.695 1.820 0.425
ENSG00000139116 E010 65.1624870 0.0010252138 2.246369e-01 4.589681e-01 12 39302965 39303135 171 - 1.704 1.769 0.218
ENSG00000139116 E011 53.8128019 0.0008203051 2.617710e-01 5.008590e-01 12 39304821 39304938 118 - 1.623 1.687 0.219
ENSG00000139116 E012 58.4634221 0.0007318503 4.159231e-01 6.404849e-01 12 39307565 39307729 165 - 1.665 1.710 0.153
ENSG00000139116 E013 59.7139572 0.0007331885 9.083638e-01 9.563519e-01 12 39309586 39309751 166 - 1.682 1.675 -0.025
ENSG00000139116 E014 24.2183493 0.0014314063 2.698636e-01 5.098064e-01 12 39309752 39309766 15 - 1.285 1.377 0.319
ENSG00000139116 E015 0.2027342 0.0357653621 9.399215e-02   12 39311415 39311416 2 - 0.000 0.224 14.037
ENSG00000139116 E016 48.3924644 0.0011270559 2.577773e-01 4.965518e-01 12 39311417 39311553 137 - 1.580 1.649 0.235
ENSG00000139116 E017 2.0747652 0.0110950405 7.026499e-01 8.372528e-01 12 39311554 39312826 1273 - 0.407 0.479 0.375
ENSG00000139116 E018 0.1614157 0.0336913395 1.000000e+00   12 39315229 39315240 12 - 0.063 0.000 -9.840
ENSG00000139116 E019 0.1614157 0.0336913395 1.000000e+00   12 39315241 39315243 3 - 0.063 0.000 -9.840
ENSG00000139116 E020 0.9986097 0.1017645415 4.251809e-01   12 39315932 39315970 39 - 0.211 0.369 1.094
ENSG00000139116 E021 18.0028623 0.0022560070 1.967464e-01 4.254727e-01 12 39318073 39318201 129 - 1.161 1.281 0.427
ENSG00000139116 E022 41.5104866 0.0021121821 8.032930e-01 8.982480e-01 12 39319906 39319989 84 - 1.529 1.546 0.058
ENSG00000139116 E023 30.2015813 0.0011785600 1.352141e-01 3.400487e-01 12 39319990 39320013 24 - 1.373 1.485 0.384
ENSG00000139116 E024 6.3078966 0.0044579990 3.304189e-02 1.361827e-01 12 39321348 39322667 1320 - 0.701 0.988 1.116
ENSG00000139116 E025 65.0913670 0.0006296899 7.141129e-02 2.276146e-01 12 39322668 39322882 215 - 1.700 1.793 0.315
ENSG00000139116 E026 33.0526464 0.0010637091 3.912622e-03 2.865504e-02 12 39325839 39325893 55 - 1.387 1.586 0.683
ENSG00000139116 E027 35.6440101 0.0013688907 1.859937e-03 1.612436e-02 12 39326264 39326324 61 - 1.422 1.629 0.710
ENSG00000139116 E028 1.2659058 0.0139510352 1.445072e-01   12 39330052 39330241 190 - 0.350 0.000 -12.839
ENSG00000139116 E029 6.4701516 0.0095360902 5.474206e-01 7.344220e-01 12 39330242 39330262 21 - 0.798 0.701 -0.391
ENSG00000139116 E030 56.7199057 0.0009091500 6.103592e-01 7.771592e-01 12 39330746 39330911 166 - 1.653 1.681 0.095
ENSG00000139116 E031 47.2851170 0.0009698843 9.387717e-01 9.716752e-01 12 39331690 39331791 102 - 1.582 1.586 0.015
ENSG00000139116 E032 0.2027342 0.0357653621 9.399215e-02   12 39331931 39332213 283 - 0.000 0.224 14.037
ENSG00000139116 E033 68.5253161 0.0005689172 2.417660e-01 4.785080e-01 12 39332214 39332408 195 - 1.752 1.687 -0.220
ENSG00000139116 E034 54.3849365 0.0010178597 2.435469e-01 4.805599e-01 12 39332591 39332744 154 - 1.659 1.586 -0.248
ENSG00000139116 E035 43.3159516 0.0008679154 7.635837e-01 8.748167e-01 12 39332893 39333036 144 - 1.551 1.530 -0.072
ENSG00000139116 E036 31.9779284 0.0053434959 3.116032e-01 5.519930e-01 12 39333037 39333107 71 - 1.439 1.351 -0.305
ENSG00000139116 E037 30.5640049 0.0014931120 3.669927e-01 6.015084e-01 12 39333212 39333280 69 - 1.414 1.339 -0.261
ENSG00000139116 E038 40.5030658 0.0010604852 8.481314e-01 9.239053e-01 12 39337096 39337203 108 - 1.518 1.503 -0.049
ENSG00000139116 E039 0.1426347 0.0318923567 1.000000e+00   12 39337204 39337541 338 - 0.063 0.000 -9.838
ENSG00000139116 E040 51.3065126 0.0018112249 6.998091e-01 8.355035e-01 12 39340165 39340364 200 - 1.620 1.594 -0.088
ENSG00000139116 E041 49.4168889 0.0007744480 4.102289e-01 6.361638e-01 12 39340906 39341094 189 - 1.609 1.555 -0.185
ENSG00000139116 E042 40.9195808 0.0011932957 2.253615e-02 1.043592e-01 12 39341505 39341622 118 - 1.549 1.377 -0.593
ENSG00000139116 E043 36.3553522 0.0505655645 2.039668e-02 9.730119e-02 12 39342034 39342124 91 - 1.516 1.185 -1.152
ENSG00000139116 E044 0.3206185 0.0274424043 1.000000e+00   12 39346466 39346504 39 - 0.117 0.000 -10.839
ENSG00000139116 E045 44.9508376 0.0010483874 2.493685e-02 1.120334e-01 12 39351777 39351980 204 - 1.586 1.424 -0.555
ENSG00000139116 E046 0.0000000       12 39356600 39356831 232 -      
ENSG00000139116 E047 32.6264149 0.0019252048 1.831709e-02 9.007797e-02 12 39356832 39356895 64 - 1.454 1.250 -0.709
ENSG00000139116 E048 22.4379564 0.0102067861 4.544142e-02 1.686716e-01 12 39357248 39357250 3 - 1.300 1.071 -0.815
ENSG00000139116 E049 58.6887759 0.0007632605 7.921064e-06 1.715352e-04 12 39357251 39357437 187 - 1.715 1.412 -1.033
ENSG00000139116 E050 58.5324273 0.0006318028 3.418352e-06 8.313259e-05 12 39358178 39358373 196 - 1.716 1.401 -1.077
ENSG00000139116 E051 39.5811845 0.0009712892 1.959480e-03 1.679668e-02 12 39363098 39363213 116 - 1.542 1.297 -0.846
ENSG00000139116 E052 48.5104043 0.0096535760 3.728560e-02 1.476909e-01 12 39366350 39366517 168 - 1.620 1.444 -0.600
ENSG00000139116 E053 37.9572144 0.0158807516 7.111888e-01 8.425621e-01 12 39367030 39367164 135 - 1.499 1.462 -0.126
ENSG00000139116 E054 0.0000000       12 39367165 39367188 24 -      
ENSG00000139116 E055 35.8003926 0.0014027309 4.691421e-01 6.794689e-01 12 39367883 39368032 150 - 1.479 1.423 -0.192
ENSG00000139116 E056 42.9304970 0.0212321993 2.000790e-02 9.590994e-02 12 39369729 39369911 183 - 1.579 1.328 -0.864
ENSG00000139116 E057 37.8101209 0.0009563145 1.276938e-03 1.198681e-02 12 39370039 39370261 223 - 1.528 1.266 -0.906
ENSG00000139116 E058 13.8068155 0.0049094170 8.170390e-02 2.482102e-01 12 39442927 39443390 464 - 1.107 0.887 -0.815