ENSG00000138867

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435822 ENSG00000138867 HEK293_OSMI2_6hA HEK293_TMG_6hB GUCD1 protein_coding protein_coding 71.96213 95.33124 32.36379 13.14951 1.248847 -1.558274 39.7890757 61.28924 18.141599 9.003187 2.0806727 -1.755773 0.581891667 0.6414000 0.56666667 -0.07473333 8.392485e-01 3.460542e-22 FALSE TRUE
ENST00000490922 ENSG00000138867 HEK293_OSMI2_6hA HEK293_TMG_6hB GUCD1 protein_coding processed_transcript 71.96213 95.33124 32.36379 13.14951 1.248847 -1.558274 13.8896764 10.38085 0.000000 1.228868 0.0000000 -10.021098 0.122775000 0.1111333 0.00000000 -0.11113333 3.460542e-22 3.460542e-22   FALSE
ENST00000493099 ENSG00000138867 HEK293_OSMI2_6hA HEK293_TMG_6hB GUCD1 protein_coding processed_transcript 71.96213 95.33124 32.36379 13.14951 1.248847 -1.558274 0.2858576 0.00000 2.286861 0.000000 2.2868609 7.843520 0.008204167 0.0000000 0.06563333 0.06563333 8.002307e-01 3.460542e-22 FALSE FALSE
ENST00000621833 ENSG00000138867 HEK293_OSMI2_6hA HEK293_TMG_6hB GUCD1 protein_coding protein_coding 71.96213 95.33124 32.36379 13.14951 1.248847 -1.558274 13.2545481 17.07146 8.761627 3.658956 0.9638955 -0.961515 0.201587500 0.1747000 0.27003333 0.09533333 2.428815e-01 3.460542e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138867 E001 0.6368449 0.018937642 0.63977158   22 24540423 24540437 15 - 0.001 0.215 9.084
ENSG00000138867 E002 1.2146877 0.014380327 0.25220521   22 24540438 24540441 4 - 0.001 0.327 9.894
ENSG00000138867 E003 204.2524689 0.394710822 0.44474715 0.66194245 22 24540442 24540531 90 - 2.166 2.221 0.186
ENSG00000138867 E004 406.4751466 0.786044383 0.36224784 0.59753601 22 24540532 24540613 82 - 2.364 2.537 0.577
ENSG00000138867 E005 282.2680850 0.420245810 0.25513015 0.49372100 22 24540614 24540619 6 - 2.197 2.381 0.613
ENSG00000138867 E006 493.2096248 0.894058865 0.40894149 0.63518375 22 24540620 24540704 85 - 2.472 2.617 0.482
ENSG00000138867 E007 980.2863362 1.179879450 0.44612143 0.66280864 22 24540705 24540973 269 - 2.769 2.915 0.484
ENSG00000138867 E008 494.2186650 0.903432022 0.41951985 0.64327034 22 24540974 24541062 89 - 2.482 2.616 0.448
ENSG00000138867 E009 1461.6710244 1.372948229 0.51469571 0.71147196 22 24541063 24541967 905 - 2.976 3.082 0.354
ENSG00000138867 E010 760.4911527 1.075076291 0.42955384 0.65068926 22 24541968 24542397 430 - 2.658 2.805 0.487
ENSG00000138867 E011 585.2659408 0.991085961 0.45067012 0.66615222 22 24542398 24542686 289 - 2.571 2.686 0.383
ENSG00000138867 E012 336.7738821 0.819870330 0.53276740 0.72404781 22 24542687 24542755 69 - 2.398 2.434 0.119
ENSG00000138867 E013 322.1560486 0.772077906 0.48590423 0.69119620 22 24542756 24542829 74 - 2.351 2.421 0.233
ENSG00000138867 E014 338.0638398 0.750131912 0.41867848 0.64261781 22 24542830 24542933 104 - 2.329 2.450 0.401
ENSG00000138867 E015 456.9187588 0.878260593 0.42943410 0.65059676 22 24542934 24543097 164 - 2.456 2.581 0.414
ENSG00000138867 E016 17.0122437 0.003450649 0.85122069 0.92570492 22 24543098 24543100 3 - 1.146 1.182 0.130
ENSG00000138867 E017 384.3841902 0.014055291 0.05887270 0.20020704 22 24543842 24543954 113 - 2.497 2.482 -0.047
ENSG00000138867 E018 270.3630875 0.073902340 0.12156377 0.31832489 22 24543955 24544044 90 - 2.382 2.319 -0.209
ENSG00000138867 E019 192.9348519 0.115617825 0.15119800 0.36406672 22 24544045 24544083 39 - 2.261 2.166 -0.317
ENSG00000138867 E020 149.6768120 0.124903375 0.18014096 0.40418404 22 24546914 24546916 3 - 2.148 2.058 -0.303
ENSG00000138867 E021 305.8482346 0.170735684 0.19104816 0.41822153 22 24546917 24547005 89 - 2.476 2.360 -0.388
ENSG00000138867 E022 7.7210912 0.078858583 0.01084489 0.06170718 22 24547006 24547390 385 - 1.105 0.755 -1.324
ENSG00000138867 E023 2.9277329 0.397492689 0.53811727 0.72772357 22 24547716 24547772 57 - 0.563 0.501 -0.295
ENSG00000138867 E024 5.0467263 0.234263442 0.75950436 0.87226151 22 24547773 24547907 135 - 0.559 0.722 0.700
ENSG00000138867 E025 403.6127840 0.168753724 0.22121760 0.45495411 22 24547908 24548073 166 - 2.577 2.486 -0.302
ENSG00000138867 E026 246.7025450 0.165914478 0.33280112 0.57143981 22 24548917 24549001 85 - 2.328 2.283 -0.150
ENSG00000138867 E027 129.3618514 0.185036933 0.73705151 0.85862718 22 24554949 24555053 105 - 1.828 2.049 0.742
ENSG00000138867 E028 86.8900293 0.156475003 0.45454858 0.66914705 22 24555054 24555136 83 - 1.583 1.888 1.031
ENSG00000138867 E029 11.5708943 0.029714830 0.42527638 0.64747302 22 24555137 24555182 46 - 0.836 1.042 0.773
ENSG00000138867 E030 155.7060337 0.276303957 0.16002931 0.37682553 22 24555615 24555935 321 - 2.285 2.032 -0.848