ENSG00000138758

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264893 ENSG00000138758 HEK293_OSMI2_6hA HEK293_TMG_6hB SEPTIN11 protein_coding protein_coding 33.80375 12.2604 50.77051 2.898207 2.417064 2.049092 26.299534 10.78103 39.734249 2.694812 1.959767 1.880914 0.82439167 0.8722 0.7826333 -0.08956667 1.588872e-01 3.44033e-17 FALSE TRUE
MSTRG.25010.12 ENSG00000138758 HEK293_OSMI2_6hA HEK293_TMG_6hB SEPTIN11 protein_coding   33.80375 12.2604 50.77051 2.898207 2.417064 2.049092 5.206458 0.00000 8.516636 0.000000 1.083193 9.735833 0.09573333 0.0000 0.1677000 0.16770000 3.440330e-17 3.44033e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138758 E001 0.3228314 0.3993205162 1.000000e+00   4 76949102 76949174 73 + 0.126 0.000 -9.368
ENSG00000138758 E002 0.4950181 0.0217681645 1.064966e-01   4 76949751 76949751 1 + 0.067 0.350 2.885
ENSG00000138758 E003 0.9712551 0.0161772949 2.402544e-02   4 76949752 76949761 10 + 0.126 0.542 2.886
ENSG00000138758 E004 1.3272228 0.0136386611 9.848812e-02   4 76949762 76949765 4 + 0.223 0.542 1.885
ENSG00000138758 E005 7.8785860 0.1392053839 5.807644e-01 7.576622e-01 4 76949766 76949808 43 + 0.838 0.960 0.462
ENSG00000138758 E006 21.9476494 0.0429481632 7.489896e-01 8.661427e-01 4 76949809 76949835 27 + 1.262 1.329 0.235
ENSG00000138758 E007 21.9406349 0.0377564981 8.368639e-01 9.177027e-01 4 76949836 76949836 1 + 1.265 1.317 0.183
ENSG00000138758 E008 34.1369657 0.0149338650 7.035806e-01 8.378974e-01 4 76949837 76949861 25 + 1.464 1.459 -0.018
ENSG00000138758 E009 68.6917964 0.0088131641 2.267575e-01 4.614597e-01 4 76949862 76949930 69 + 1.771 1.722 -0.165
ENSG00000138758 E010 0.3040503 0.0274424043 1.000000e+00   4 76959228 76959252 25 + 0.126 0.000 -12.219
ENSG00000138758 E011 0.0000000       4 76972390 76972590 201 +      
ENSG00000138758 E012 0.3503582 0.0457103923 3.659555e-01   4 76973010 76973070 61 + 0.067 0.210 1.885
ENSG00000138758 E013 0.4644705 0.0217681645 5.704495e-03   4 76974478 76974807 330 + 0.000 0.456 14.358
ENSG00000138758 E014 0.0000000       4 76985024 76985123 100 +      
ENSG00000138758 E015 0.1723744 0.0673505027 1.293320e-01   4 76987788 76987808 21 + 0.000 0.210 12.226
ENSG00000138758 E016 0.4514866 0.0217681645 6.590993e-01   4 76987809 76987870 62 + 0.126 0.209 0.883
ENSG00000138758 E017 3.1305806 0.0077581026 2.254998e-01 4.599233e-01 4 76995781 76995938 158 + 0.503 0.727 0.990
ENSG00000138758 E018 142.9835936 0.0003483471 6.747662e-05 1.075869e-03 4 76996425 76996539 115 + 2.099 1.984 -0.386
ENSG00000138758 E019 90.1773027 0.0004251181 1.546755e-03 1.393868e-02 4 77005601 77005609 9 + 1.901 1.786 -0.385
ENSG00000138758 E020 238.6044276 0.0003369219 1.316960e-06 3.608423e-05 4 77005610 77005796 187 + 2.318 2.210 -0.360
ENSG00000138758 E021 0.1426347 0.0326026137 1.000000e+00   4 77009780 77009987 208 + 0.067 0.000 -11.139
ENSG00000138758 E022 262.9518200 0.0043382231 2.012499e-03 1.714938e-02 4 77011735 77011921 187 + 2.358 2.258 -0.332
ENSG00000138758 E023 126.7986972 0.0034370393 1.291490e-03 1.209800e-02 4 77014856 77014870 15 + 2.049 1.921 -0.428
ENSG00000138758 E024 256.0755764 0.0003004614 7.531332e-06 1.639735e-04 4 77014871 77015017 147 + 2.345 2.253 -0.307
ENSG00000138758 E025 200.6299087 0.0002163111 2.352445e-04 3.060593e-03 4 77019165 77019261 97 + 2.237 2.157 -0.266
ENSG00000138758 E026 115.4327706 0.0003381305 2.314524e-02 1.064086e-01 4 77020502 77020531 30 + 1.995 1.937 -0.193
ENSG00000138758 E027 276.9434578 0.0005315420 5.090070e-02 1.818090e-01 4 77020532 77020670 139 + 2.364 2.346 -0.063
ENSG00000138758 E028 7.6452514 0.2373324750 6.938114e-01 8.315582e-01 4 77020671 77021639 969 + 0.870 0.828 -0.165
ENSG00000138758 E029 222.8184406 0.0009856764 2.908240e-01 5.314447e-01 4 77028629 77028716 88 + 2.266 2.266 -0.001
ENSG00000138758 E030 182.0609396 0.0022482103 5.149836e-01 7.116498e-01 4 77028717 77028761 45 + 2.178 2.185 0.023
ENSG00000138758 E031 216.6836556 0.0003369102 6.342181e-01 7.930843e-01 4 77030783 77030896 114 + 2.250 2.270 0.067
ENSG00000138758 E032 142.8095237 0.0130075826 8.806243e-01 9.415684e-01 4 77030897 77030970 74 + 2.073 2.085 0.041
ENSG00000138758 E033 12.2294127 0.0277740111 2.051899e-01 4.361360e-01 4 77030971 77032158 1188 + 1.002 1.182 0.652
ENSG00000138758 E034 358.1684217 0.0006850093 4.592165e-01 6.726236e-01 4 77034497 77034923 427 + 2.470 2.486 0.054
ENSG00000138758 E035 182.5379828 0.0003074997 4.925791e-01 6.957025e-01 4 77034924 77035020 97 + 2.179 2.191 0.043
ENSG00000138758 E036 1148.4472442 0.0005644244 9.307550e-01 9.673652e-01 4 77035021 77036769 1749 + 2.969 3.005 0.119
ENSG00000138758 E037 94.6635751 0.0017671538 1.117286e-02 6.309345e-02 4 77036770 77036772 3 + 1.860 2.009 0.500
ENSG00000138758 E038 151.3263868 0.0003427927 1.028594e-03 1.013278e-02 4 77036773 77036837 65 + 2.064 2.207 0.479
ENSG00000138758 E039 1159.7066340 0.0075290267 2.217628e-04 2.913540e-03 4 77036838 77038615 1778 + 2.935 3.113 0.592
ENSG00000138758 E040 6.0169501 0.0045279077 1.152944e-03 1.107070e-02 4 77039073 77039326 254 + 0.639 1.085 1.732
ENSG00000138758 E041 7.3321171 0.0117921551 3.858534e-08 1.582390e-06 4 77039743 77040384 642 + 0.566 1.279 2.745