ENSG00000138668

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000352301 ENSG00000138668 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPD protein_coding protein_coding 580.5872 650.7761 463.5683 162.191 19.1755 -0.4893704 61.97945 84.560199 51.92091 23.455451 3.723107 -0.70355593 0.10813750 0.12713333 0.11273333 -0.01440000 8.393753e-01 2.592035e-09 FALSE TRUE
ENST00000353341 ENSG00000138668 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPD protein_coding protein_coding 580.5872 650.7761 463.5683 162.191 19.1755 -0.4893704 225.70100 289.756838 124.41407 72.658139 1.059383 -1.21962684 0.38185000 0.44470000 0.26930000 -0.17540000 2.592035e-09 2.592035e-09 FALSE TRUE
ENST00000507010 ENSG00000138668 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPD protein_coding protein_coding 580.5872 650.7761 463.5683 162.191 19.1755 -0.4893704 26.58429 5.679851 38.97379 3.102983 2.496425 2.77641142 0.04808333 0.01093333 0.08393333 0.07300000 4.591102e-01 2.592035e-09 FALSE FALSE
ENST00000509263 ENSG00000138668 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPD protein_coding protein_coding 580.5872 650.7761 463.5683 162.191 19.1755 -0.4893704 143.75578 157.148673 149.76448 35.124464 7.769970 -0.06943006 0.25703750 0.24643333 0.32293333 0.07650000 4.808215e-02 2.592035e-09 FALSE FALSE
MSTRG.25007.12 ENSG00000138668 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPD protein_coding   580.5872 650.7761 463.5683 162.191 19.1755 -0.4893704 79.17421 81.723915 34.50287 28.147364 2.698439 -1.24380057 0.12450833 0.11653333 0.07420000 -0.04233333 4.351593e-01 2.592035e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138668 E001 82.1427195 0.7437972992 0.9166444057 0.960488322 4 82352498 82353075 578 - 2.044 1.791 -0.854
ENSG00000138668 E002 56.1957656 0.6372560005 0.9837306761 0.993695543 4 82353076 82353332 257 - 1.891 1.622 -0.910
ENSG00000138668 E003 94.0965106 0.6853394564 0.6164174655 0.781342046 4 82353333 82353455 123 - 1.964 1.934 -0.099
ENSG00000138668 E004 148.8309960 1.0791848147 0.6382800350 0.795915997 4 82353456 82353648 193 - 2.153 2.135 -0.062
ENSG00000138668 E005 70.7414620 0.5775153221 0.5869243809 0.761558076 4 82353649 82353665 17 - 1.830 1.817 -0.042
ENSG00000138668 E006 83.2275068 0.6553363573 0.6515461513 0.804523028 4 82353666 82353710 45 - 1.930 1.873 -0.192
ENSG00000138668 E007 56.8815740 0.5845967927 0.8478890999 0.923783581 4 82353711 82353715 5 - 1.836 1.670 -0.562
ENSG00000138668 E008 87.4059000 0.7264968519 0.8091560969 0.901679927 4 82353716 82353741 26 - 2.018 1.855 -0.549
ENSG00000138668 E009 82.0886733 0.6996080686 0.7913166770 0.891209990 4 82353742 82353750 9 - 1.979 1.836 -0.481
ENSG00000138668 E010 123.4960950 1.0657938525 0.7594487722 0.872227159 4 82353751 82353828 78 - 2.142 2.019 -0.412
ENSG00000138668 E011 80.3785875 0.5773042935 0.4649436774 0.676538486 4 82353829 82353833 5 - 1.844 1.890 0.156
ENSG00000138668 E012 3295.7630978 1.9688537143 0.4902785688 0.694191025 4 82353834 82354154 321 - 3.327 3.537 0.698
ENSG00000138668 E013 328.4779127 1.7612672881 0.6884040387 0.828092870 4 82354155 82354846 692 - 2.819 2.166 -2.177
ENSG00000138668 E014 77.4085845 1.3154077146 0.6062739776 0.774391830 4 82354847 82354894 48 - 2.196 1.544 -2.199
ENSG00000138668 E015 180.6585045 1.5106968455 0.7293533843 0.853867985 4 82354895 82355001 107 - 2.546 1.936 -2.041
ENSG00000138668 E016 162.9928701 1.6716185321 0.5360706442 0.726371184 4 82355002 82355248 247 - 2.550 1.788 -2.551
ENSG00000138668 E017 60.9752235 0.8725145599 0.6477741693 0.802063014 4 82355249 82355303 55 - 2.066 1.493 -1.939
ENSG00000138668 E018 3066.0311065 1.9480968729 0.4875371431 0.692335521 4 82355304 82355401 98 - 3.299 3.505 0.686
ENSG00000138668 E019 30.5082129 0.5928507495 0.6625463053 0.811478859 4 82355402 82356536 1135 - 1.724 1.270 -1.561
ENSG00000138668 E020 684.1169731 1.5156316698 0.4754801730 0.683836970 4 82356537 82356553 17 - 2.676 2.846 0.565
ENSG00000138668 E021 1526.2832204 1.7801992882 0.5453001911 0.732903171 4 82356554 82356683 130 - 3.057 3.184 0.420
ENSG00000138668 E022 10.4033243 0.0067582268 0.1758332652 0.398239712 4 82356684 82356795 112 - 0.913 1.067 0.570
ENSG00000138668 E023 3615.7946944 2.0390109910 0.5582410787 0.742015879 4 82356796 82356895 100 - 3.430 3.559 0.430
ENSG00000138668 E024 3295.3430859 0.0344156492 0.3389454470 0.577026813 4 82357313 82357402 90 - 3.452 3.496 0.148
ENSG00000138668 E025 2354.5248401 0.0005807726 0.2416005981 0.478378200 4 82357403 82357436 34 - 3.324 3.344 0.066
ENSG00000138668 E026 1744.4180347 0.0008813612 0.9397739660 0.972108280 4 82357437 82357444 8 - 3.202 3.210 0.028
ENSG00000138668 E027 29.1451444 0.1317342412 0.2215635672 0.455345802 4 82357445 82358658 1214 - 1.589 1.360 -0.788
ENSG00000138668 E028 3572.8360323 0.0113139128 0.3724975889 0.606083546 4 82358659 82358757 99 - 3.533 3.511 -0.073
ENSG00000138668 E029 3244.8158935 0.0199918828 0.1100738354 0.299132178 4 82358758 82358820 63 - 3.531 3.449 -0.273
ENSG00000138668 E030 9.2431468 0.0049158636 0.0014127650 0.012990416 4 82358821 82358842 22 - 1.187 0.837 -1.292
ENSG00000138668 E031 2949.8497662 0.0248859079 0.0542861563 0.189754609 4 82359471 82359515 45 - 3.515 3.394 -0.401
ENSG00000138668 E032 4408.0123252 0.0309225028 0.1517390581 0.364857378 4 82359516 82359639 124 - 3.672 3.578 -0.310
ENSG00000138668 E033 2064.3168598 0.0269512884 0.2497043533 0.487551722 4 82371528 82371584 57 - 3.330 3.256 -0.245
ENSG00000138668 E034 7.9411377 0.0458735853 0.0001192258 0.001729629 4 82373119 82373150 32 - 1.226 0.653 -2.180
ENSG00000138668 E035 1949.5849163 0.0303487283 0.2600849670 0.499057204 4 82373446 82373486 41 - 3.306 3.231 -0.250
ENSG00000138668 E036 1227.6793536 0.0417221661 0.5522754709 0.737874997 4 82373487 82373624 138 - 3.001 3.076 0.248
ENSG00000138668 E037 1305.8743818 0.0468084033 0.6055565181 0.773879444 4 82373625 82373737 113 - 3.029 3.102 0.242
ENSG00000138668 E038 1337.2534925 0.0485939154 0.7622686934 0.873971927 4 82373738 82373777 40 - 3.057 3.106 0.161
ENSG00000138668 E039 1599.5865449 0.0452257240 0.7503115817 0.866939479 4 82373778 82374063 286 - 3.133 3.184 0.169
ENSG00000138668 E040 39.8889898 0.0009400330 0.6882804129 0.827989792 4 82374119 82374155 37 - 1.595 1.571 -0.080
ENSG00000138668 E041 6.2198902 0.0058868974 0.7837981155 0.886859358 4 82374156 82374297 142 - 0.859 0.822 -0.142
ENSG00000138668 E042 0.9596762 0.0167431421 0.9116898714   4 82374298 82375206 909 - 0.292 0.271 -0.144