ENSG00000138600

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261854 ENSG00000138600 HEK293_OSMI2_6hA HEK293_TMG_6hB SPPL2A protein_coding protein_coding 9.848932 2.210415 17.62399 0.1904123 1.236762 2.989457 1.85409209 0.3930180 3.352346 0.01932678 0.03416153 3.060552 0.175845833 0.1794333 0.1921667 0.01273333 9.515694e-01 5.77662e-12 FALSE TRUE
ENST00000558414 ENSG00000138600 HEK293_OSMI2_6hA HEK293_TMG_6hB SPPL2A protein_coding protein_coding 9.848932 2.210415 17.62399 0.1904123 1.236762 2.989457 1.26496431 0.0000000 4.971544 0.00000000 0.66110477 8.960449 0.097429167 0.0000000 0.2798667 0.27986667 5.776620e-12 5.77662e-12 FALSE FALSE
ENST00000558934 ENSG00000138600 HEK293_OSMI2_6hA HEK293_TMG_6hB SPPL2A protein_coding protein_coding 9.848932 2.210415 17.62399 0.1904123 1.236762 2.989457 0.37514119 0.0000000 1.223559 0.00000000 1.22355896 6.946683 0.061304167 0.0000000 0.0610000 0.06100000 1.000000e+00 5.77662e-12 FALSE TRUE
ENST00000559293 ENSG00000138600 HEK293_OSMI2_6hA HEK293_TMG_6hB SPPL2A protein_coding processed_transcript 9.848932 2.210415 17.62399 0.1904123 1.236762 2.989457 0.02779223 0.1378341 0.000000 0.06922412 0.00000000 -3.885907 0.008816667 0.0633000 0.0000000 -0.06330000 1.289807e-02 5.77662e-12   FALSE
MSTRG.10794.2 ENSG00000138600 HEK293_OSMI2_6hA HEK293_TMG_6hB SPPL2A protein_coding   9.848932 2.210415 17.62399 0.1904123 1.236762 2.989457 5.71899878 1.5905226 6.868870 0.27753331 0.89688992 2.103629 0.600166667 0.7098667 0.4000333 -0.30983333 1.897741e-01 5.77662e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138600 E001 190.9231666 0.0003347774 6.014818e-07 0.000018237 15 50702266 50707442 5177 - 2.170 2.006 -0.550
ENSG00000138600 E002 7.1605065 0.0446215229 2.011215e-01 0.431103318 15 50707443 50707447 5 - 0.751 0.964 0.822
ENSG00000138600 E003 75.4236829 0.0073743346 4.957640e-02 0.178600173 15 50707448 50707874 427 - 1.726 1.858 0.445
ENSG00000138600 E004 72.3141564 0.0005922669 1.842166e-01 0.409456122 15 50719940 50720100 161 - 1.718 1.801 0.278
ENSG00000138600 E005 32.3586411 0.0010914283 3.907258e-01 0.620962869 15 50722124 50722140 17 - 1.379 1.458 0.274
ENSG00000138600 E006 34.1020346 0.0011681373 7.007625e-01 0.836142571 15 50722141 50722172 32 - 1.415 1.397 -0.062
ENSG00000138600 E007 27.5895851 0.0014377096 8.926454e-01 0.947915301 15 50722173 50722201 29 - 1.325 1.327 0.004
ENSG00000138600 E008 49.5120435 0.0035164418 6.223529e-01 0.785439818 15 50725221 50725323 103 - 1.562 1.609 0.159
ENSG00000138600 E009 1.0288969 0.5983118169 1.560095e-01   15 50725324 50725519 196 - 0.108 0.612 3.450
ENSG00000138600 E010 1.1993187 0.4980517915 5.114542e-01   15 50725916 50726072 157 - 0.235 0.403 1.091
ENSG00000138600 E011 5.4403742 0.0134579689 8.131917e-01 0.904155767 15 50726073 50726126 54 - 0.690 0.739 0.204
ENSG00000138600 E012 2.7227564 0.0435488892 2.386097e-02 0.108674375 15 50726127 50726320 194 - 0.379 0.794 1.905
ENSG00000138600 E013 37.7472027 0.0040773065 8.728361e-01 0.937513481 15 50726321 50726377 57 - 1.453 1.479 0.089
ENSG00000138600 E014 52.2622283 0.0049447207 5.621732e-01 0.744799841 15 50730965 50731039 75 - 1.597 1.567 -0.102
ENSG00000138600 E015 63.3351551 0.0008574512 7.364106e-01 0.858223422 15 50732603 50732684 82 - 1.670 1.703 0.111
ENSG00000138600 E016 60.9963842 0.0011315573 9.006675e-01 0.952212280 15 50736101 50736202 102 - 1.655 1.676 0.070
ENSG00000138600 E017 57.5221740 0.0007574080 1.864909e-01 0.412434675 15 50736644 50736740 97 - 1.619 1.709 0.307
ENSG00000138600 E018 78.2859923 0.0016213164 4.366104e-01 0.656191226 15 50739680 50739828 149 - 1.769 1.740 -0.099
ENSG00000138600 E019 45.8841770 0.0061615114 7.010108e-01 0.836250270 15 50747495 50747503 9 - 1.539 1.522 -0.058
ENSG00000138600 E020 81.6552289 0.0021330892 1.803793e-01 0.404480847 15 50747504 50747628 125 - 1.791 1.728 -0.212
ENSG00000138600 E021 0.1779838 0.0342739032 1.000000e+00   15 50747997 50748112 116 - 0.057 0.000 -7.956
ENSG00000138600 E022 62.0758919 0.0015585030 4.464628e-01 0.663080556 15 50748113 50748202 90 - 1.674 1.640 -0.115
ENSG00000138600 E023 70.0869530 0.0143657897 6.077787e-01 0.775398163 15 50748688 50748870 183 - 1.726 1.695 -0.105
ENSG00000138600 E024 32.6081500 0.2093927698 4.344909e-01 0.654578760 15 50749636 50749742 107 - 1.377 1.491 0.393
ENSG00000138600 E025 7.5845592 0.3357698842 8.752515e-02 0.259144176 15 50749743 50749746 4 - 0.723 1.132 1.551
ENSG00000138600 E026 0.1614157 0.0329437117 1.000000e+00   15 50764507 50764561 55 - 0.057 0.000 -7.951
ENSG00000138600 E027 13.0225716 0.1277880831 1.675552e-02 0.084573410 15 50765468 50765711 244 - 0.924 1.353 1.540