ENSG00000138594

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308580 ENSG00000138594 HEK293_OSMI2_6hA HEK293_TMG_6hB TMOD3 protein_coding protein_coding 7.405582 2.329362 13.25547 0.4681656 0.716584 2.503489 1.49219445 0.62238460 2.456051 0.17209649 0.03741134 1.963328 0.29007500 0.25686667 0.1865667 -0.07030000 5.683561e-01 1.537028e-07 FALSE TRUE
ENST00000558666 ENSG00000138594 HEK293_OSMI2_6hA HEK293_TMG_6hB TMOD3 protein_coding processed_transcript 7.405582 2.329362 13.25547 0.4681656 0.716584 2.503489 0.04079277 0.07463059 0.000000 0.07463059 0.00000000 -3.081179 0.01215417 0.05313333 0.0000000 -0.05313333 6.717488e-01 1.537028e-07   FALSE
MSTRG.10816.3 ENSG00000138594 HEK293_OSMI2_6hA HEK293_TMG_6hB TMOD3 protein_coding   7.405582 2.329362 13.25547 0.4681656 0.716584 2.503489 4.32236968 1.46854183 7.812094 0.33645131 0.68034519 2.403380 0.52837083 0.62456667 0.5872333 -0.03733333 8.627399e-01 1.537028e-07 TRUE TRUE
MSTRG.10816.5 ENSG00000138594 HEK293_OSMI2_6hA HEK293_TMG_6hB TMOD3 protein_coding   7.405582 2.329362 13.25547 0.4681656 0.716584 2.503489 1.10176870 0.00000000 2.558355 0.00000000 0.29357076 8.004701 0.08826250 0.00000000 0.1949333 0.19493333 1.537028e-07 1.537028e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138594 E001 0.0000000       15 51829628 51829636 9 +      
ENSG00000138594 E002 0.8274031 0.0173894078 1.000000000   15 51829637 51829652 16 + 0.210 0.223 0.113
ENSG00000138594 E003 20.4878466 0.0171012683 0.169955734 0.39040163 15 51829653 51829782 130 + 1.254 1.177 -0.272
ENSG00000138594 E004 22.2299346 0.0215567777 0.041670093 0.15906269 15 51829783 51829836 54 + 1.297 1.137 -0.568
ENSG00000138594 E005 1.1480216 0.0150680981 0.646921941   15 51834994 51835058 65 + 0.286 0.223 -0.472
ENSG00000138594 E006 67.8061231 0.0178902889 0.074570967 0.23392944 15 51862811 51863010 200 + 1.747 1.687 -0.205
ENSG00000138594 E007 68.9397955 0.0009405340 0.039355964 0.15311328 15 51869217 51869373 157 + 1.758 1.721 -0.124
ENSG00000138594 E008 0.0000000       15 51875026 51875270 245 +      
ENSG00000138594 E009 39.7651175 0.7308206152 0.531204893 0.72289892 15 51887589 51887711 123 + 1.496 1.564 0.233
ENSG00000138594 E010 43.9924949 0.0092723855 0.696591738 0.83338475 15 51889056 51889145 90 + 1.552 1.585 0.113
ENSG00000138594 E011 58.3719236 0.0009033370 0.001723438 0.01518598 15 51893815 51893945 131 + 1.698 1.586 -0.381
ENSG00000138594 E012 65.8097516 0.0170476779 0.081233105 0.24731182 15 51896419 51896526 108 + 1.734 1.678 -0.190
ENSG00000138594 E013 77.8664320 0.0046795955 0.044272251 0.16578713 15 51900155 51900298 144 + 1.805 1.772 -0.112
ENSG00000138594 E014 0.0000000       15 51901266 51901492 227 +      
ENSG00000138594 E015 63.7424276 0.0007427837 0.213631983 0.44592518 15 51901892 51902036 145 + 1.715 1.721 0.021
ENSG00000138594 E016 38.4929138 0.7126772424 0.454640867 0.66924479 15 51908776 51908862 87 + 1.462 1.617 0.530
ENSG00000138594 E017 25.7305219 0.5630014160 0.361785087 0.59711381 15 51908863 51908876 14 + 1.289 1.462 0.597
ENSG00000138594 E018 286.8785695 0.0682639645 0.131077559 0.33352788 15 51908877 51911013 2137 + 2.319 2.487 0.560
ENSG00000138594 E019 32.6179220 0.0747822395 0.404940089 0.63219957 15 51911014 51911039 26 + 1.378 1.582 0.700
ENSG00000138594 E020 49.9846636 0.0396811326 0.190696197 0.41777956 15 51911040 51911152 113 + 1.549 1.786 0.807
ENSG00000138594 E021 153.4226655 0.0490806895 0.987926000 0.99580268 15 51911153 51915725 4573 + 2.063 2.167 0.348
ENSG00000138594 E022 1.3413898 0.0575999528 0.798182183   15 51916015 51916133 119 + 0.286 0.371 0.532
ENSG00000138594 E023 0.0000000       15 51921494 51921495 2 +      
ENSG00000138594 E024 0.4536995 0.1137163922 0.629225188   15 51921496 51921508 13 + 0.118 0.221 1.097
ENSG00000138594 E025 0.4536995 0.1137163922 0.629225188   15 51921509 51921616 108 + 0.118 0.221 1.097
ENSG00000138594 E026 0.1308682 0.0326491905 0.118928119   15 51924392 51924578 187 + 0.000 0.222 12.395
ENSG00000138594 E027 0.3040503 0.0244411696 1.000000000   15 51929433 51929454 22 + 0.117 0.000 -9.212
ENSG00000138594 E028 0.0000000       15 51931031 51931051 21 +      
ENSG00000138594 E029 0.3337900 0.0575245055 0.338698312   15 51931052 51931133 82 + 0.063 0.223 2.112
ENSG00000138594 E030 0.9116329 0.2368269486 0.014392477   15 51931134 51931308 175 + 0.063 0.578 4.163
ENSG00000138594 E031 0.0000000       15 51933977 51934202 226 +      
ENSG00000138594 E032 0.0000000       15 51934203 51934249 47 +      
ENSG00000138594 E033 0.7381610 0.0172671820 0.065890103   15 51934250 51934354 105 + 0.117 0.478 2.693
ENSG00000138594 E034 0.5885118 0.0365872625 0.211419768   15 51936630 51937054 425 + 0.117 0.369 2.112
ENSG00000138594 E035 0.2735028 0.0274424043 0.341601429   15 51946990 51947295 306 + 0.063 0.222 2.109