ENSG00000138496

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000462315 ENSG00000138496 HEK293_OSMI2_6hA HEK293_TMG_6hB PARP9 protein_coding protein_coding 0.3577958 0.4347207 0.2586373 0.09611564 0.0307165 -0.7272402 0.13393497 0.24103789 0.02463414 0.03645137 0.009375936 -2.8576386 0.36114167 0.5747000 0.08893333 -0.48576667 0.0213921 0.0213921 FALSE TRUE
ENST00000471785 ENSG00000138496 HEK293_OSMI2_6hA HEK293_TMG_6hB PARP9 protein_coding protein_coding 0.3577958 0.4347207 0.2586373 0.09611564 0.0307165 -0.7272402 0.08733036 0.00000000 0.15593289 0.00000000 0.080840890 4.0525280 0.29671250 0.0000000 0.61146667 0.61146667 0.3955678 0.0213921 FALSE TRUE
ENST00000477522 ENSG00000138496 HEK293_OSMI2_6hA HEK293_TMG_6hB PARP9 protein_coding protein_coding 0.3577958 0.4347207 0.2586373 0.09611564 0.0307165 -0.7272402 0.05423762 0.14213689 0.07807024 0.07847085 0.078070235 -0.7886436 0.13712500 0.2702667 0.29960000 0.02933333 0.9149402 0.0213921 FALSE TRUE
ENST00000492382 ENSG00000138496 HEK293_OSMI2_6hA HEK293_TMG_6hB PARP9 protein_coding protein_coding 0.3577958 0.4347207 0.2586373 0.09611564 0.0307165 -0.7272402 0.03600711 0.03424373 0.00000000 0.03424373 0.000000000 -2.1454729 0.08316250 0.1263667 0.00000000 -0.12636667 0.9494480 0.0213921 FALSE TRUE
ENST00000682323 ENSG00000138496 HEK293_OSMI2_6hA HEK293_TMG_6hB PARP9 protein_coding protein_coding 0.3577958 0.4347207 0.2586373 0.09611564 0.0307165 -0.7272402 0.02945314 0.00000000 0.00000000 0.00000000 0.000000000 0.0000000 0.08515417 0.0000000 0.00000000 0.00000000   0.0213921 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138496 E001 0.0000000       3 122527924 122527958 35 -      
ENSG00000138496 E002 0.1308682 0.032649190 1.000000e+00   3 122527959 122527960 2 - 0.000 0.076 8.846
ENSG00000138496 E003 0.1308682 0.032649190 1.000000e+00   3 122527961 122528004 44 - 0.000 0.076 10.703
ENSG00000138496 E004 5.1346587 0.007757352 2.655194e-01 5.048994e-01 3 122528005 122528743 739 - 0.842 0.718 -0.495
ENSG00000138496 E005 18.3704147 0.010814053 7.394959e-08 2.832922e-06 3 122531773 122536167 4395 - 0.726 1.326 2.222
ENSG00000138496 E006 3.8885817 0.007025665 6.134017e-01 7.792162e-01 3 122536168 122536342 175 - 0.568 0.668 0.438
ENSG00000138496 E007 0.0000000       3 122536343 122536933 591 -      
ENSG00000138496 E008 3.9939594 0.018228744 6.931476e-01 8.311497e-01 3 122536934 122537073 140 - 0.680 0.632 -0.207
ENSG00000138496 E009 5.9488039 0.004989514 7.692423e-02 2.386436e-01 3 122540472 122540852 381 - 0.933 0.735 -0.773
ENSG00000138496 E010 2.2103512 0.019751429 4.657540e-01 6.771231e-01 3 122545432 122545489 58 - 0.568 0.464 -0.500
ENSG00000138496 E011 0.2617363 0.036666396 7.416647e-01   3 122545490 122546003 514 - 0.000 0.141 11.550
ENSG00000138496 E012 1.7871992 0.014639708 5.172768e-01 7.131763e-01 3 122550584 122550600 17 - 0.500 0.404 -0.494
ENSG00000138496 E013 4.0788999 0.007868011 2.670224e-01 5.066290e-01 3 122550601 122550802 202 - 0.768 0.630 -0.576
ENSG00000138496 E014 3.3355047 0.022482749 2.180362e-01 4.510770e-01 3 122552418 122552639 222 - 0.727 0.543 -0.797
ENSG00000138496 E015 5.3974428 0.008133366 8.193478e-02 2.486314e-01 3 122555286 122555863 578 - 0.904 0.702 -0.797
ENSG00000138496 E016 2.2847564 0.145588008 1.379294e-01 3.443469e-01 3 122555864 122556121 258 - 0.675 0.400 -1.299
ENSG00000138496 E017 0.0000000       3 122558329 122558401 73 -      
ENSG00000138496 E018 0.0000000       3 122558402 122558433 32 -      
ENSG00000138496 E019 0.4043710 0.031745422 7.223546e-01   3 122558434 122558467 34 - 0.187 0.141 -0.492
ENSG00000138496 E020 0.6672048 0.021768165 2.818397e-01   3 122559606 122559709 104 - 0.000 0.248 12.365
ENSG00000138496 E021 0.0000000       3 122564111 122564242 132 -      
ENSG00000138496 E022 0.0000000       3 122564243 122564244 2 -      
ENSG00000138496 E023 0.0000000       3 122564245 122564253 9 -      
ENSG00000138496 E024 0.0000000       3 122564254 122564300 47 -      
ENSG00000138496 E025 0.0000000       3 122564301 122564315 15 -      
ENSG00000138496 E026 0.3336024 0.027442404 7.245900e-01   3 122564439 122564577 139 - 0.000 0.142 11.562