ENSG00000138468

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314261 ENSG00000138468 HEK293_OSMI2_6hA HEK293_TMG_6hB SENP7 protein_coding protein_coding 3.281476 1.219167 6.194032 0.1855348 0.2991404 2.335525 0.2660686 0.00000000 0.4962194 0.00000000 0.14092802 5.6616910 0.11483750 0.00000000 0.08230000 0.082300000 0.07144462 0.01440664 FALSE TRUE
ENST00000348610 ENSG00000138468 HEK293_OSMI2_6hA HEK293_TMG_6hB SENP7 protein_coding protein_coding 3.281476 1.219167 6.194032 0.1855348 0.2991404 2.335525 0.9842140 0.04180623 1.7561821 0.04180623 0.27888452 5.0913648 0.18598750 0.03486667 0.28183333 0.246966667 0.03520030 0.01440664 FALSE TRUE
ENST00000366089 ENSG00000138468 HEK293_OSMI2_6hA HEK293_TMG_6hB SENP7 protein_coding protein_coding 3.281476 1.219167 6.194032 0.1855348 0.2991404 2.335525 0.4135209 0.49699680 0.2628425 0.09093517 0.14427144 -0.8939082 0.24259167 0.40336667 0.04033333 -0.363033333 0.03855579 0.01440664   FALSE
ENST00000394085 ENSG00000138468 HEK293_OSMI2_6hA HEK293_TMG_6hB SENP7 protein_coding protein_coding 3.281476 1.219167 6.194032 0.1855348 0.2991404 2.335525 0.2659376 0.15146648 0.6152808 0.11635412 0.18601375 1.9532696 0.07481667 0.10900000 0.09996667 -0.009033333 0.98327851 0.01440664 FALSE TRUE
ENST00000394094 ENSG00000138468 HEK293_OSMI2_6hA HEK293_TMG_6hB SENP7 protein_coding protein_coding 3.281476 1.219167 6.194032 0.1855348 0.2991404 2.335525 0.6195760 0.03634942 1.1205115 0.03634942 0.04018572 4.6082806 0.14749583 0.03030000 0.18216667 0.151866667 0.09817270 0.01440664 FALSE TRUE
ENST00000394095 ENSG00000138468 HEK293_OSMI2_6hA HEK293_TMG_6hB SENP7 protein_coding protein_coding 3.281476 1.219167 6.194032 0.1855348 0.2991404 2.335525 0.1975404 0.38805130 0.4228759 0.01731172 0.21886373 0.1209992 0.11612083 0.33693333 0.06996667 -0.266966667 0.31153536 0.01440664 FALSE TRUE
MSTRG.23359.5 ENSG00000138468 HEK293_OSMI2_6hA HEK293_TMG_6hB SENP7 protein_coding   3.281476 1.219167 6.194032 0.1855348 0.2991404 2.335525 0.3547255 0.01312999 1.1624569 0.01312999 0.27360125 5.6636266 0.06356250 0.01093333 0.18470000 0.173766667 0.01440664 0.01440664 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138468 E001 0.2027342 0.047621531 0.0555421704   3 101324205 101324272 68 - 0.000 0.263 12.776
ENSG00000138468 E002 37.2158736 0.034971551 0.0006180872 0.006736632 3 101324273 101325539 1267 - 1.348 1.709 1.238
ENSG00000138468 E003 28.1962610 0.001761451 0.0158982570 0.081410255 3 101325540 101325866 327 - 1.275 1.488 0.740
ENSG00000138468 E004 35.0762048 0.001245420 0.0409055605 0.157048018 3 101325867 101326080 214 - 1.373 1.543 0.585
ENSG00000138468 E005 29.5423144 0.004638040 0.5799718069 0.757157425 3 101327666 101327816 151 - 1.317 1.384 0.233
ENSG00000138468 E006 18.6110691 0.002165012 0.5885821317 0.762740800 3 101328478 101328546 69 - 1.144 1.100 -0.158
ENSG00000138468 E007 16.1458606 0.002090706 0.3814425769 0.613428356 3 101328646 101328689 44 - 1.095 1.005 -0.328
ENSG00000138468 E008 16.7101713 0.002686751 0.0529280213 0.186535412 3 101330334 101330386 53 - 1.120 0.882 -0.879
ENSG00000138468 E009 20.1759152 0.002637547 0.0210958197 0.099662152 3 101331985 101332109 125 - 1.196 0.927 -0.981
ENSG00000138468 E010 19.5633168 0.002024591 0.4686648610 0.679130951 3 101332770 101332862 93 - 1.164 1.100 -0.228
ENSG00000138468 E011 3.6747507 0.039311985 0.1162804423 0.309588360 3 101332863 101333269 407 - 0.480 0.778 1.307
ENSG00000138468 E012 3.3468280 0.014053517 0.9369759583 0.970691022 3 101337129 101337508 380 - 0.513 0.542 0.135
ENSG00000138468 E013 18.5241056 0.009849380 0.3373283812 0.575703556 3 101337509 101337631 123 - 1.142 1.039 -0.372
ENSG00000138468 E014 14.2151146 0.002549400 0.8021557317 0.897577851 3 101340095 101340211 117 - 1.023 1.071 0.172
ENSG00000138468 E015 1.1368026 0.100565325 0.0731219502   3 101340212 101340425 214 - 0.176 0.546 2.336
ENSG00000138468 E016 17.5026143 0.003811332 0.5748225184 0.753555045 3 101341646 101341779 134 - 1.099 1.178 0.283
ENSG00000138468 E017 27.1329797 0.001476325 0.0060734280 0.040093596 3 101343686 101343954 269 - 1.319 1.039 -0.999
ENSG00000138468 E018 0.1614157 0.033561989 0.8849338208   3 101347326 101347718 393 - 0.051 0.000 -7.381
ENSG00000138468 E019 23.4194660 0.007083400 0.3152029195 0.555265507 3 101347872 101348051 180 - 1.247 1.153 -0.333
ENSG00000138468 E020 10.7953805 0.042868455 0.5782779475 0.756015024 3 101351618 101351651 34 - 0.914 1.005 0.340
ENSG00000138468 E021 21.0095351 0.021054183 0.5530543846 0.738421872 3 101361715 101361861 147 - 1.196 1.130 -0.237
ENSG00000138468 E022 21.3261707 0.001628927 0.0235876496 0.107814109 3 101364834 101364991 158 - 1.220 0.968 -0.911
ENSG00000138468 E023 27.8807576 0.001863351 0.0048336037 0.033712148 3 101366430 101366769 340 - 1.327 1.039 -1.027
ENSG00000138468 E024 18.5364444 0.002035491 0.0205529894 0.097865423 3 101367830 101368011 182 - 1.164 0.882 -1.035
ENSG00000138468 E025 18.0527319 0.002468006 0.7320380749 0.855422919 3 101372008 101372126 119 - 1.124 1.178 0.193
ENSG00000138468 E026 15.7814865 0.002279983 0.6738965705 0.818840788 3 101398861 101399055 195 - 1.063 1.128 0.234
ENSG00000138468 E027 20.4697296 0.002146935 0.7579732692 0.871315082 3 101417593 101417790 198 - 1.174 1.223 0.173
ENSG00000138468 E028 20.1048557 0.001966620 0.5307701956 0.722581523 3 101458955 101459052 98 - 1.178 1.128 -0.181
ENSG00000138468 E029 16.6141373 0.002062728 0.3183157179 0.558202224 3 101493873 101493968 96 - 1.077 1.201 0.447
ENSG00000138468 E030 10.5831559 0.002904639 0.9947718479 0.998956948 3 101501070 101501119 50 - 0.912 0.927 0.057
ENSG00000138468 E031 11.0100644 0.002918652 0.3864761560 0.617700585 3 101513091 101513241 151 - 0.912 1.039 0.472