ENSG00000138448

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261023 ENSG00000138448 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGAV protein_coding protein_coding 6.468072 0.9344391 11.68011 0.2801959 0.4140942 3.629687 2.8580868 0.58275156 4.3066339 0.29144834 1.118030977 2.864407 0.3716417 0.5327333 0.37303333 -0.15970000 0.93539371 0.00235846 FALSE TRUE
ENST00000374907 ENSG00000138448 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGAV protein_coding protein_coding 6.468072 0.9344391 11.68011 0.2801959 0.4140942 3.629687 0.1100422 0.00000000 0.2241851 0.00000000 0.002204775 4.549577 0.0729250 0.0000000 0.01923333 0.01923333 0.54018062 0.00235846 FALSE TRUE
ENST00000433736 ENSG00000138448 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGAV protein_coding protein_coding 6.468072 0.9344391 11.68011 0.2801959 0.4140942 3.629687 0.5356928 0.18624602 2.0571072 0.10582751 1.148727350 3.396878 0.1978292 0.2195000 0.17150000 -0.04800000 0.97215310 0.00235846 FALSE TRUE
ENST00000496477 ENSG00000138448 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGAV protein_coding retained_intron 6.468072 0.9344391 11.68011 0.2801959 0.4140942 3.629687 0.3718281 0.00000000 0.8848459 0.00000000 0.442453877 6.483567 0.0292000 0.0000000 0.07430000 0.07430000 0.72971131 0.00235846 FALSE FALSE
MSTRG.19630.1 ENSG00000138448 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGAV protein_coding   6.468072 0.9344391 11.68011 0.2801959 0.4140942 3.629687 0.8837228 0.09440731 1.3500679 0.09440731 0.409753257 3.703384 0.1540458 0.1985333 0.11826667 -0.08026667 0.83290002 0.00235846 FALSE TRUE
MSTRG.19630.4 ENSG00000138448 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGAV protein_coding   6.468072 0.9344391 11.68011 0.2801959 0.4140942 3.629687 1.4927011 0.00000000 2.5988146 0.00000000 0.665001298 8.027251 0.1237458 0.0000000 0.22100000 0.22100000 0.00235846 0.00235846 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138448 E001 4.3108963 0.0086272718 7.891368e-01 8.899471e-01 2 186590034 186590055 22 + 0.530 0.617 0.393
ENSG00000138448 E002 5.1854151 0.0156947952 9.916660e-01 9.975701e-01 2 186590056 186590079 24 + 0.590 0.617 0.123
ENSG00000138448 E003 9.9413832 0.0457938582 3.933855e-01 6.230557e-01 2 186590080 186590297 218 + 0.800 0.973 0.659
ENSG00000138448 E004 23.5293494 0.0020005634 9.778857e-01 9.907244e-01 2 186590298 186590523 226 + 1.154 1.194 0.144
ENSG00000138448 E005 0.0000000       2 186600205 186600381 177 +      
ENSG00000138448 E006 33.9040515 0.0128098332 1.629938e-01 3.812056e-01 2 186602021 186602151 131 + 1.320 1.193 -0.448
ENSG00000138448 E007 27.9021555 0.0029887361 6.203890e-01 7.840820e-01 2 186622339 186622430 92 + 1.233 1.222 -0.039
ENSG00000138448 E008 30.9378520 0.0014596867 1.421654e-01 3.506654e-01 2 186625473 186625587 115 + 1.283 1.164 -0.422
ENSG00000138448 E009 14.1046119 0.0024797670 8.150526e-01 9.052793e-01 2 186630797 186630799 3 + 0.962 0.971 0.034
ENSG00000138448 E010 23.2948874 0.0049465864 3.701723e-01 6.041107e-01 2 186630800 186630858 59 + 1.163 1.096 -0.240
ENSG00000138448 E011 23.8701575 0.0022468804 4.952368e-01 6.976560e-01 2 186633329 186633374 46 + 1.169 1.131 -0.133
ENSG00000138448 E012 48.2738915 0.0009145662 4.200241e-01 6.436658e-01 2 186636082 186636207 126 + 1.457 1.433 -0.083
ENSG00000138448 E013 32.0248755 0.0010969633 7.599421e-01 8.725133e-01 2 186637065 186637109 45 + 1.284 1.297 0.047
ENSG00000138448 E014 33.4640691 0.0032888326 3.309594e-01 5.698521e-01 2 186638277 186638320 44 + 1.308 1.248 -0.209
ENSG00000138448 E015 31.5135156 0.0017128110 8.189676e-01 9.074330e-01 2 186638409 186638465 57 + 1.274 1.341 0.231
ENSG00000138448 E016 26.3354092 0.0457119290 5.394085e-01 7.285571e-01 2 186640915 186640967 53 + 1.195 1.298 0.362
ENSG00000138448 E017 31.6090996 0.9580303826 7.250756e-01 8.511642e-01 2 186641386 186641588 203 + 1.282 1.249 -0.112
ENSG00000138448 E018 34.1538729 0.0180697673 7.858653e-02 2.419471e-01 2 186646686 186646877 192 + 1.327 1.132 -0.690
ENSG00000138448 E019 18.4405326 0.0043806879 1.277070e-02 6.951370e-02 2 186649840 186649885 46 + 1.081 0.714 -1.404
ENSG00000138448 E020 29.5484206 0.0013895219 7.845808e-04 8.150225e-03 2 186651982 186652089 108 + 1.277 0.862 -1.514
ENSG00000138448 E021 27.0478451 0.0047388780 4.219559e-02 1.604196e-01 2 186654650 186654708 59 + 1.235 1.017 -0.785
ENSG00000138448 E022 47.5296847 0.0027268944 8.080913e-03 4.969131e-02 2 186656247 186656401 155 + 1.467 1.248 -0.761
ENSG00000138448 E023 48.8538327 0.0007842693 8.270824e-02 2.501150e-01 2 186659038 186659175 138 + 1.471 1.361 -0.380
ENSG00000138448 E024 38.7751036 0.0018730785 5.864242e-02 1.997359e-01 2 186663768 186663835 68 + 1.373 1.222 -0.529
ENSG00000138448 E025 56.1938703 0.0007082781 4.101632e-02 1.573559e-01 2 186664494 186664641 148 + 1.527 1.399 -0.442
ENSG00000138448 E026 43.2281907 0.0009530825 9.616319e-01 9.828370e-01 2 186665126 186665218 93 + 1.401 1.450 0.168
ENSG00000138448 E027 36.7873502 0.0712340011 7.754591e-01 8.820313e-01 2 186666704 186666783 80 + 1.329 1.428 0.342
ENSG00000138448 E028 40.9807739 0.0066727266 7.723839e-01 8.800778e-01 2 186667150 186667230 81 + 1.383 1.399 0.055
ENSG00000138448 E029 1.5533880 0.0125412434 3.741768e-01 6.074646e-01 2 186667648 186667670 23 + 0.300 0.000 -10.772
ENSG00000138448 E030 46.8460305 0.0083572475 9.182030e-01 9.613326e-01 2 186667671 186667776 106 + 1.436 1.494 0.197
ENSG00000138448 E031 0.7249894 0.0228689384 7.195908e-02   2 186667777 186668020 244 + 0.113 0.489 2.805
ENSG00000138448 E032 0.4820342 0.0213405351 1.000000e+00   2 186668524 186668761 238 + 0.113 0.000 -9.180
ENSG00000138448 E033 31.8389068 0.0235134611 5.432584e-01 7.313913e-01 2 186668762 186668844 83 + 1.284 1.245 -0.135
ENSG00000138448 E034 24.7561807 0.0018041457 6.511443e-01 8.042904e-01 2 186668845 186668876 32 + 1.174 1.164 -0.036
ENSG00000138448 E035 26.0571300 0.0014567829 3.348646e-01 5.734440e-01 2 186668877 186668920 44 + 1.202 1.132 -0.251
ENSG00000138448 E036 39.3674609 0.0019912184 5.177961e-02 1.839424e-01 2 186669701 186669814 114 + 1.380 1.222 -0.553
ENSG00000138448 E037 0.1426347 0.0326747416 6.007976e-01   2 186669815 186669957 143 + 0.041 0.000 -7.616
ENSG00000138448 E038 42.1206634 0.0009641367 3.548690e-01 5.916272e-01 2 186675604 186675717 114 + 1.401 1.361 -0.140
ENSG00000138448 E039 40.8322207 0.0009863942 7.356759e-01 8.577267e-01 2 186675820 186675927 108 + 1.384 1.399 0.051
ENSG00000138448 E040 0.4820342 0.0213405351 1.000000e+00   2 186675928 186676283 356 + 0.113 0.000 -9.180
ENSG00000138448 E041 46.6530478 0.0012300139 8.605837e-01 9.306409e-01 2 186676813 186676935 123 + 1.436 1.496 0.206
ENSG00000138448 E042 376.6721116 0.0051525753 2.525783e-10 1.646588e-08 2 186677197 186680901 3705 + 2.304 2.558 0.845