ENSG00000138386

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337386 ENSG00000138386 HEK293_OSMI2_6hA HEK293_TMG_6hB NAB1 protein_coding protein_coding 6.227528 2.31228 9.927913 0.1121195 0.4211268 2.097401 0.7121131 0.4579727 1.260617 0.1302980 0.1870245 1.441033 0.13075000 0.1990000 0.1266667 -0.0723333333 0.69588418 0.01545753 FALSE TRUE
ENST00000409581 ENSG00000138386 HEK293_OSMI2_6hA HEK293_TMG_6hB NAB1 protein_coding protein_coding 6.227528 2.31228 9.927913 0.1121195 0.4211268 2.097401 1.5559861 0.7948050 3.024243 0.1816646 0.4836706 1.914626 0.21164583 0.3377000 0.3033000 -0.0344000000 0.94277883 0.01545753 FALSE TRUE
ENST00000409641 ENSG00000138386 HEK293_OSMI2_6hA HEK293_TMG_6hB NAB1 protein_coding protein_coding 6.227528 2.31228 9.927913 0.1121195 0.4211268 2.097401 0.4099151 0.2120294 1.091720 0.1744679 0.1771781 2.310934 0.09647083 0.0995000 0.1114667 0.0119666667 0.80920946 0.01545753 FALSE TRUE
ENST00000434473 ENSG00000138386 HEK293_OSMI2_6hA HEK293_TMG_6hB NAB1 protein_coding protein_coding 6.227528 2.31228 9.927913 0.1121195 0.4211268 2.097401 0.8555697 0.2991393 1.254752 0.1393353 0.1736362 2.032525 0.17491250 0.1256333 0.1253667 -0.0002666667 0.97234732 0.01545753 FALSE TRUE
MSTRG.19676.10 ENSG00000138386 HEK293_OSMI2_6hA HEK293_TMG_6hB NAB1 protein_coding   6.227528 2.31228 9.927913 0.1121195 0.4211268 2.097401 1.0632916 0.0000000 1.339261 0.0000000 0.5489353 7.076025 0.16421250 0.0000000 0.1380000 0.1380000000 0.01545753 0.01545753 FALSE TRUE
MSTRG.19676.9 ENSG00000138386 HEK293_OSMI2_6hA HEK293_TMG_6hB NAB1 protein_coding   6.227528 2.31228 9.927913 0.1121195 0.4211268 2.097401 0.2741736 0.3285081 0.000000 0.1743290 0.0000000 -5.081118 0.04717083 0.1453333 0.0000000 -0.1453333333 0.14282490 0.01545753 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138386 E001 0.0000000       2 190646746 190646858 113 +      
ENSG00000138386 E002 0.3032425 0.024441170 0.041595967   2 190648876 190648894 19 + 0.000 0.319 11.360
ENSG00000138386 E003 0.3032425 0.024441170 0.041595967   2 190648895 190648897 3 + 0.000 0.319 13.276
ENSG00000138386 E004 0.3032425 0.024441170 0.041595967   2 190648898 190648914 17 + 0.000 0.319 13.276
ENSG00000138386 E005 0.6370325 0.019859352 0.047653481   2 190648915 190648958 44 + 0.076 0.420 3.087
ENSG00000138386 E006 0.9161448 0.015890315 0.235579066   2 190648959 190648971 13 + 0.197 0.419 1.499
ENSG00000138386 E007 0.0000000       2 190649070 190649082 13 +      
ENSG00000138386 E008 4.3746635 0.102865395 0.617967112 0.78243669 2 190649083 190649217 135 + 0.654 0.764 0.455
ENSG00000138386 E009 14.0608792 0.018417843 0.230533033 0.46574759 2 190649218 190649360 143 + 1.078 1.225 0.527
ENSG00000138386 E010 2.4368060 0.034577545 0.067134552 0.21871109 2 190649831 190649845 15 + 0.403 0.725 1.496
ENSG00000138386 E011 6.1771820 0.022117102 0.008716021 0.05255391 2 190649846 190649872 27 + 0.684 1.052 1.423
ENSG00000138386 E012 10.7742346 0.002945543 0.009345512 0.05528557 2 190649873 190649982 110 + 0.928 1.210 1.024
ENSG00000138386 E013 1.6044975 0.038316466 0.618565895 0.78285575 2 190653725 190653726 2 + 0.404 0.319 -0.503
ENSG00000138386 E014 2.2056333 0.063386011 0.945844019 0.97530735 2 190653727 190653730 4 + 0.466 0.498 0.158
ENSG00000138386 E015 2.3836172 0.118723925 0.922683008 0.96365170 2 190653731 190653738 8 + 0.496 0.496 0.000
ENSG00000138386 E016 2.7770294 0.255323133 0.781859396 0.88571615 2 190653739 190653780 42 + 0.547 0.551 0.017
ENSG00000138386 E017 10.9352248 0.005035052 0.967520533 0.98568841 2 190655977 190656153 177 + 1.032 1.053 0.075
ENSG00000138386 E018 0.4161375 0.104967111 0.789511555   2 190656154 190656159 6 + 0.140 0.187 0.502
ENSG00000138386 E019 2.6084564 0.206841676 0.573838024 0.75288157 2 190659059 190659157 99 + 0.469 0.627 0.735
ENSG00000138386 E020 29.1897602 0.054652230 0.466092362 0.67731831 2 190659158 190659276 119 + 1.446 1.366 -0.277
ENSG00000138386 E021 94.7825468 0.022664693 0.068515180 0.22176708 2 190659277 190659829 553 + 1.957 1.835 -0.410
ENSG00000138386 E022 30.4049610 0.004640594 0.001264437 0.01189313 2 190659830 190659856 27 + 1.498 1.251 -0.857
ENSG00000138386 E023 50.5175893 0.010590716 0.033151012 0.13645695 2 190659857 190659995 139 + 1.690 1.555 -0.461
ENSG00000138386 E024 45.6827775 0.001089224 0.239624328 0.47621732 2 190670326 190670459 134 + 1.633 1.579 -0.184
ENSG00000138386 E025 25.6841717 0.042666305 0.582833193 0.75889776 2 190673101 190673152 52 + 1.361 1.430 0.241
ENSG00000138386 E026 23.2534501 0.096614396 0.104878449 0.29042693 2 190683738 190683827 90 + 1.261 1.499 0.826
ENSG00000138386 E027 12.9607880 0.395929763 0.261932522 0.50103025 2 190685476 190685478 3 + 1.022 1.258 0.846
ENSG00000138386 E028 41.8999498 0.791094794 0.383606306 0.61524380 2 190685479 190685638 160 + 1.529 1.698 0.577
ENSG00000138386 E029 37.9194497 0.088399530 0.400860882 0.62898277 2 190687201 190687317 117 + 1.515 1.600 0.292
ENSG00000138386 E030 282.4151379 0.002373986 0.791458113 0.89129835 2 190690245 190692766 2522 + 2.398 2.406 0.026