ENSG00000138376

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260947 ENSG00000138376 HEK293_OSMI2_6hA HEK293_TMG_6hB BARD1 protein_coding protein_coding 6.505006 0.9807917 15.11717 0.1500676 1.485264 3.932417 3.38853277 0.84665040 6.41469927 0.14683192 0.26081620 2.9068505 0.69176250 0.85850000 0.437200000 -0.4213000 0.03651640 0.01185132 FALSE TRUE
ENST00000455743 ENSG00000138376 HEK293_OSMI2_6hA HEK293_TMG_6hB BARD1 protein_coding nonsense_mediated_decay 6.505006 0.9807917 15.11717 0.1500676 1.485264 3.932417 0.63191390 0.04385873 1.99302318 0.04385873 1.12277585 5.2168550 0.06145833 0.03530000 0.148266667 0.1129667 0.86744204 0.01185132 FALSE TRUE
ENST00000465841 ENSG00000138376 HEK293_OSMI2_6hA HEK293_TMG_6hB BARD1 protein_coding retained_intron 6.505006 0.9807917 15.11717 0.1500676 1.485264 3.932417 0.55437148 0.00000000 3.44038960 0.00000000 1.72430346 8.4306155 0.03525417 0.00000000 0.207333333 0.2073333 0.60952492 0.01185132   FALSE
ENST00000617164 ENSG00000138376 HEK293_OSMI2_6hA HEK293_TMG_6hB BARD1 protein_coding protein_coding 6.505006 0.9807917 15.11717 0.1500676 1.485264 3.932417 1.12713513 0.00000000 1.83181073 0.00000000 0.93962721 7.5249810 0.09729167 0.00000000 0.110500000 0.1105000 0.67711209 0.01185132 FALSE TRUE
ENST00000650978 ENSG00000138376 HEK293_OSMI2_6hA HEK293_TMG_6hB BARD1 protein_coding nonsense_mediated_decay 6.505006 0.9807917 15.11717 0.1500676 1.485264 3.932417 0.07049861 0.06669051 0.07849155 0.02510076 0.01789276 0.2064916 0.02814167 0.07356667 0.005066667 -0.0685000 0.01185132 0.01185132 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138376 E001 163.5529889 1.505945253 0.341820939 0.57954358 2 214725646 214728423 2778 - 1.949 2.327 1.264
ENSG00000138376 E002 20.0455645 0.563970948 0.281803795 0.52212406 2 214728424 214728537 114 - 1.074 1.428 1.246
ENSG00000138376 E003 9.8318255 0.204562436 0.026360986 0.11636637 2 214728538 214728552 15 - 0.756 1.288 1.971
ENSG00000138376 E004 8.4079684 0.191058854 0.043665492 0.16428087 2 214728553 214728561 9 - 0.713 1.183 1.772
ENSG00000138376 E005 8.5811506 0.225766486 0.076896478 0.23859081 2 214728562 214728570 9 - 0.730 1.158 1.616
ENSG00000138376 E006 11.1258099 0.282763310 0.071338360 0.22744568 2 214728571 214728584 14 - 0.816 1.299 1.770
ENSG00000138376 E007 21.4994495 0.590278984 0.302388331 0.54297067 2 214728585 214728674 90 - 1.103 1.454 1.233
ENSG00000138376 E008 13.7624604 0.496811495 0.548287418 0.73510294 2 214728675 214728675 1 - 0.957 1.148 0.698
ENSG00000138376 E009 13.6198258 0.493039078 0.539067485 0.72836536 2 214728676 214728676 1 - 0.952 1.148 0.716
ENSG00000138376 E010 15.8742942 0.581186268 0.577924582 0.75576876 2 214728677 214728703 27 - 1.010 1.214 0.734
ENSG00000138376 E011 45.7178113 0.819060120 0.494935085 0.69738277 2 214728704 214729008 305 - 1.445 1.618 0.591
ENSG00000138376 E012 1.5578137 0.192096014 0.309930580 0.55041978 2 214730235 214730280 46 - 0.321 0.001 -9.488
ENSG00000138376 E013 33.9107937 0.001199469 0.994779782 0.99895695 2 214730411 214730508 98 - 1.337 1.452 0.397
ENSG00000138376 E014 0.8439712 0.154110024 0.687836966   2 214730908 214731145 238 - 0.159 0.291 1.107
ENSG00000138376 E015 35.6773694 0.044729822 0.039608844 0.15373398 2 214745067 214745159 93 - 1.378 1.227 -0.529
ENSG00000138376 E016 0.0000000       2 214745712 214745721 10 -      
ENSG00000138376 E017 51.3916347 0.076794689 0.018126956 0.08944113 2 214745722 214745854 133 - 1.537 1.294 -0.840
ENSG00000138376 E018 42.6493859 0.072844243 0.014599495 0.07659471 2 214752447 214752555 109 - 1.459 1.187 -0.949
ENSG00000138376 E019 55.5552139 0.025464186 0.027066642 0.11851062 2 214767482 214767654 173 - 1.560 1.453 -0.367
ENSG00000138376 E020 39.4838342 0.025778397 0.158980006 0.37523146 2 214769232 214769312 81 - 1.410 1.374 -0.124
ENSG00000138376 E021 1.7210104 0.012198908 0.232770943 0.46833955 2 214769313 214770845 1533 - 0.275 0.582 1.674
ENSG00000138376 E022 73.6683959 0.038989303 0.274491338 0.51445693 2 214780560 214780896 337 - 1.668 1.675 0.024
ENSG00000138376 E023 27.9154656 0.042552198 0.112410727 0.30314944 2 214780897 214780967 71 - 1.273 1.177 -0.339
ENSG00000138376 E024 93.9767684 0.041476834 0.004789123 0.03347203 2 214780968 214781509 542 - 1.789 1.605 -0.623
ENSG00000138376 E025 34.9353588 0.079435517 0.130404937 0.33245898 2 214792297 214792445 149 - 1.366 1.250 -0.406
ENSG00000138376 E026 2.3006725 0.197698819 0.128870474 0.33000347 2 214796794 214797060 267 - 0.410 0.001 -10.005
ENSG00000138376 E027 23.6422140 0.002298325 0.310558523 0.55104515 2 214797061 214797117 57 - 1.199 1.206 0.026
ENSG00000138376 E028 28.1604450 0.020900330 0.522597984 0.71676122 2 214809412 214809683 272 - 1.260 1.317 0.199