ENSG00000138246

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260818 ENSG00000138246 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAJC13 protein_coding protein_coding 7.867658 3.711898 14.74619 0.9149284 0.4091229 1.98721 6.0105626 3.025213 12.319340 0.7387533 0.44116882 2.022226 0.6789167 0.8165667 0.8352 0.01863333 9.149309e-01 1.241789e-05 FALSE TRUE
ENST00000509279 ENSG00000138246 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAJC13 protein_coding nonsense_mediated_decay 7.867658 3.711898 14.74619 0.9149284 0.4091229 1.98721 0.6674534 0.509333 0.000000 0.2566915 0.00000000 -5.698588 0.1489292 0.1100667 0.0000 -0.11006667 5.711736e-02 1.241789e-05   FALSE
MSTRG.23696.2 ENSG00000138246 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAJC13 protein_coding   7.867658 3.711898 14.74619 0.9149284 0.4091229 1.98721 0.6440352 0.000000 1.013595 0.0000000 0.05959422 6.677502 0.1070750 0.0000000 0.0689 0.06890000 1.241789e-05 1.241789e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138246 E001 12.0288129 0.0027654199 9.582713e-01 9.810252e-01 3 132417502 132417699 198 + 1.037 1.069 0.119
ENSG00000138246 E002 11.8579610 0.0029249418 8.642659e-01 9.327576e-01 3 132417700 132417707 8 + 1.023 1.069 0.167
ENSG00000138246 E003 11.7153264 0.0030987449 8.182048e-01 9.070080e-01 3 132417708 132417708 1 + 1.017 1.069 0.192
ENSG00000138246 E004 18.5642976 0.0018805223 4.295691e-01 6.507007e-01 3 132417709 132417760 52 + 1.221 1.173 -0.173
ENSG00000138246 E005 28.5812567 0.0021311592 7.448149e-04 7.817956e-03 3 132434538 132434618 81 + 1.432 1.154 -0.973
ENSG00000138246 E006 29.8248835 0.0012078839 4.166895e-04 4.894077e-03 3 132446475 132446550 76 + 1.452 1.173 -0.977
ENSG00000138246 E007 51.1311894 0.0008444437 7.390550e-05 1.161901e-03 3 132447321 132447470 150 + 1.673 1.440 -0.799
ENSG00000138246 E008 28.4859079 0.0027840540 6.846419e-02 2.216443e-01 3 132447898 132447939 42 + 1.410 1.285 -0.436
ENSG00000138246 E009 65.3820182 0.0006484025 3.339210e-06 8.140608e-05 3 132450647 132450847 201 + 1.777 1.530 -0.841
ENSG00000138246 E010 68.9486071 0.0017605650 1.570655e-08 7.050840e-07 3 132453298 132453504 207 + 1.808 1.478 -1.122
ENSG00000138246 E011 51.6731077 0.0056362704 3.817716e-04 4.556761e-03 3 132453599 132453694 96 + 1.674 1.430 -0.835
ENSG00000138246 E012 50.3774087 0.0099048890 2.742264e-03 2.181934e-02 3 132454066 132454157 92 + 1.660 1.440 -0.753
ENSG00000138246 E013 35.9041302 0.0013340080 2.619416e-03 2.108832e-02 3 132456235 132456293 59 + 1.518 1.313 -0.708
ENSG00000138246 E014 49.2934944 0.0008275774 5.747508e-04 6.351657e-03 3 132456294 132456401 108 + 1.650 1.450 -0.685
ENSG00000138246 E015 39.8792093 0.0009550884 5.794050e-02 1.981581e-01 3 132456501 132456580 80 + 1.545 1.440 -0.362
ENSG00000138246 E016 59.9514447 0.0006302215 1.705975e-02 8.568119e-02 3 132456663 132456832 170 + 1.721 1.611 -0.373
ENSG00000138246 E017 45.5234655 0.0092821102 1.234902e-01 3.212609e-01 3 132457269 132457368 100 + 1.606 1.503 -0.353
ENSG00000138246 E018 0.1779838 0.0408036339 1.000000e+00   3 132457369 132458349 981 + 0.066 0.000 -8.087
ENSG00000138246 E019 36.9034829 0.0031601792 3.604907e-02 1.443620e-01 3 132460250 132460357 108 + 1.523 1.387 -0.471
ENSG00000138246 E020 46.2564915 0.0008189782 9.555218e-02 2.740161e-01 3 132461050 132461205 156 + 1.608 1.529 -0.268
ENSG00000138246 E021 31.9503786 0.0221832057 3.106676e-01 5.511580e-01 3 132462467 132462523 57 + 1.454 1.370 -0.289
ENSG00000138246 E022 42.8187022 0.0009110825 1.966824e-01 4.254009e-01 3 132463696 132463817 122 + 1.571 1.513 -0.198
ENSG00000138246 E023 1.8927875 0.0100683367 3.155814e-02 1.319374e-01 3 132465951 132465994 44 + 0.474 0.000 -11.670
ENSG00000138246 E024 41.8957688 0.0009428466 9.414421e-04 9.432917e-03 3 132465995 132466070 76 + 1.586 1.375 -0.723
ENSG00000138246 E025 45.2511114 0.0007793892 4.802768e-06 1.111502e-04 3 132466299 132466394 96 + 1.630 1.327 -1.044
ENSG00000138246 E026 51.6475312 0.0033643621 1.183123e-05 2.422199e-04 3 132467170 132467313 144 + 1.685 1.397 -0.987
ENSG00000138246 E027 0.0000000       3 132467314 132467346 33 +      
ENSG00000138246 E028 44.8372703 0.0009731681 1.208555e-05 2.470395e-04 3 132473145 132473227 83 + 1.627 1.339 -0.989
ENSG00000138246 E029 0.5067846 0.0217681645 6.239747e-01   3 132474256 132474383 128 + 0.124 0.213 0.942
ENSG00000138246 E030 62.4425076 0.0007082527 9.158691e-06 1.944439e-04 3 132474932 132475085 154 + 1.760 1.521 -0.811
ENSG00000138246 E031 56.1659018 0.0008872987 4.255097e-02 1.613805e-01 3 132477789 132477892 104 + 1.690 1.597 -0.315
ENSG00000138246 E032 55.3291758 0.0006502658 1.162546e-01 3.095585e-01 3 132477981 132478140 160 + 1.681 1.617 -0.216
ENSG00000138246 E033 34.0357054 0.0126036862 2.312425e-02 1.063493e-01 3 132479227 132479289 63 + 1.494 1.311 -0.633
ENSG00000138246 E034 43.6016513 0.0069388661 1.282697e-02 6.974625e-02 3 132480369 132480470 102 + 1.596 1.428 -0.577
ENSG00000138246 E035 52.1219950 0.0008078904 1.176113e-02 6.548986e-02 3 132482226 132482330 105 + 1.666 1.537 -0.437
ENSG00000138246 E036 71.3531491 0.0006732797 8.076477e-02 2.463743e-01 3 132483375 132483577 203 + 1.785 1.723 -0.212
ENSG00000138246 E037 2.0595524 0.0133742825 5.782912e-01 7.560212e-01 3 132484363 132484488 126 + 0.449 0.355 -0.518
ENSG00000138246 E038 0.0000000       3 132484489 132484493 5 +      
ENSG00000138246 E039 42.9337108 0.0008224769 3.315555e-01 5.704049e-01 3 132484588 132484672 85 + 1.565 1.530 -0.122
ENSG00000138246 E040 65.4653959 0.0005976561 7.810641e-01 8.853231e-01 3 132488298 132488452 155 + 1.734 1.748 0.046
ENSG00000138246 E041 42.9519331 0.0010160763 7.298443e-01 8.541465e-01 3 132488976 132489021 46 + 1.555 1.561 0.018
ENSG00000138246 E042 57.3824815 0.0007122375 8.128482e-01 9.039140e-01 3 132490897 132491051 155 + 1.670 1.712 0.142
ENSG00000138246 E043 63.5990862 0.0007792374 4.615852e-01 6.742630e-01 3 132492414 132492615 202 + 1.725 1.712 -0.041
ENSG00000138246 E044 50.8622460 0.0030263067 1.200309e-01 3.158939e-01 3 132494144 132494259 116 + 1.643 1.568 -0.255
ENSG00000138246 E045 47.2525547 0.0017886119 5.065797e-01 7.053398e-01 3 132495088 132495166 79 + 1.581 1.649 0.234
ENSG00000138246 E046 57.6860457 0.0009037315 2.751922e-01 5.152174e-01 3 132496528 132496663 136 + 1.664 1.752 0.299
ENSG00000138246 E047 87.5479646 0.0017539100 4.085029e-01 6.348669e-01 3 132499126 132499310 185 + 1.843 1.913 0.235
ENSG00000138246 E048 60.8147839 0.0261624131 5.397541e-01 7.288035e-01 3 132499734 132499808 75 + 1.704 1.697 -0.023
ENSG00000138246 E049 68.1589093 0.0006017454 8.043934e-01 8.988454e-01 3 132500794 132500913 120 + 1.751 1.767 0.054
ENSG00000138246 E050 75.9878282 0.0005659874 9.543495e-01 9.790649e-01 3 132502289 132502468 180 + 1.794 1.820 0.087
ENSG00000138246 E051 74.9969848 0.0005549258 1.486493e-01 3.603618e-01 3 132503214 132503381 168 + 1.802 1.758 -0.151
ENSG00000138246 E052 66.9542983 0.0109519760 1.996401e-01 4.292007e-01 3 132505302 132505415 114 + 1.757 1.695 -0.208
ENSG00000138246 E053 71.0008467 0.0050522750 9.662154e-01 9.850080e-01 3 132507237 132507353 117 + 1.764 1.793 0.098
ENSG00000138246 E054 85.0776856 0.0009799672 1.554213e-01 3.700661e-01 3 132511067 132511244 178 + 1.828 1.923 0.320
ENSG00000138246 E055 64.5471687 0.0040371298 3.221899e-02 1.338698e-01 3 132513008 132513099 92 + 1.691 1.844 0.516
ENSG00000138246 E056 66.3576661 0.0005971142 4.019597e-01 6.300109e-01 3 132514571 132514670 100 + 1.727 1.799 0.240
ENSG00000138246 E057 0.9938080 0.0151745916 7.803033e-01   3 132514671 132514816 146 + 0.261 0.213 -0.383
ENSG00000138246 E058 67.2426114 0.0007114459 8.057169e-01 8.995356e-01 3 132516422 132516496 75 + 1.739 1.781 0.139
ENSG00000138246 E059 76.6519311 0.0005455657 8.830267e-03 5.306378e-02 3 132516704 132516816 113 + 1.767 1.916 0.503
ENSG00000138246 E060 79.8758648 0.0004925513 1.416845e-02 7.501803e-02 3 132522828 132522972 145 + 1.791 1.929 0.467
ENSG00000138246 E061 51.3940522 0.0014106975 7.200691e-02 2.288168e-01 3 132522973 132522997 25 + 1.607 1.738 0.442
ENSG00000138246 E062 59.6935503 0.0027424954 1.852292e-02 9.079574e-02 3 132523157 132523199 43 + 1.661 1.820 0.537
ENSG00000138246 E063 96.0697234 0.0005442599 1.223664e-04 1.766760e-03 3 132523540 132523713 174 + 1.855 2.040 0.621
ENSG00000138246 E064 2.0567920 0.0115282971 1.755371e-01 3.978676e-01 3 132523714 132524017 304 + 0.474 0.213 -1.647
ENSG00000138246 E065 121.6158957 0.0020832828 1.973269e-05 3.780901e-04 3 132525610 132525789 180 + 1.949 2.151 0.676
ENSG00000138246 E066 103.5247320 0.0007951857 9.428317e-07 2.698711e-05 3 132526141 132526281 141 + 1.874 2.096 0.747
ENSG00000138246 E067 47.9317431 0.0007964652 4.303688e-05 7.324766e-04 3 132528189 132528201 13 + 1.539 1.794 0.866
ENSG00000138246 E068 77.2383869 0.0024486948 9.823514e-15 1.441883e-12 3 132528202 132528332 131 + 1.696 2.088 1.320
ENSG00000138246 E069 63.6869419 0.0714222938 1.256363e-02 6.869262e-02 3 132530998 132531097 100 + 1.627 1.973 1.167
ENSG00000138246 E070 0.4514866 0.0217681645 6.290634e-01   3 132537158 132537266 109 + 0.124 0.212 0.937
ENSG00000138246 E071 153.3282582 1.0978596896 2.638322e-01 5.030999e-01 3 132538176 132539032 857 + 1.975 2.388 1.382