ENSG00000138182

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260753 ENSG00000138182 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF20B protein_coding protein_coding 9.80993 2.547715 20.39722 0.3285662 0.6458974 2.996152 5.9876362 1.07432835 13.6059686 0.23791292 2.9668289 3.650426 0.44363750 0.41890000 0.66000000 0.2411000 5.638746e-01 4.594927e-12 FALSE TRUE
ENST00000371728 ENSG00000138182 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF20B protein_coding protein_coding 9.80993 2.547715 20.39722 0.3285662 0.6458974 2.996152 0.6534385 0.06081872 1.6399407 0.06081872 0.3491175 4.542140 0.08375417 0.01923333 0.08163333 0.0624000 4.116254e-01 4.594927e-12 FALSE TRUE
ENST00000478929 ENSG00000138182 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF20B protein_coding processed_transcript 9.80993 2.547715 20.39722 0.3285662 0.6458974 2.996152 0.8815229 1.41256805 0.4531193 0.19205708 0.1167229 -1.619042 0.33302500 0.56186667 0.02250000 -0.5393667 4.594927e-12 4.594927e-12 FALSE TRUE
MSTRG.4355.2 ENSG00000138182 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF20B protein_coding   9.80993 2.547715 20.39722 0.3285662 0.6458974 2.996152 2.1519468 0.00000000 4.4162500 0.00000000 2.2113162 8.789941 0.12886667 0.00000000 0.22283333 0.2228333 5.187302e-01 4.594927e-12 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138182 E001 2.1087093 0.1495956320 6.722571e-01 8.177461e-01 10 89701590 89701609 20 + 0.371 0.285 -0.545
ENSG00000138182 E002 30.4484747 0.0013350429 1.445970e-03 1.323197e-02 10 89701610 89701678 69 + 1.325 1.015 -1.106
ENSG00000138182 E003 29.3723192 0.0015399266 9.620500e-04 9.605398e-03 10 89701679 89701680 2 + 1.311 0.974 -1.209
ENSG00000138182 E004 0.4279040 0.5839083620 1.000000e+00   10 89701681 89701717 37 + 0.121 0.000 -8.421
ENSG00000138182 E005 64.3649407 0.0006145573 6.394655e-06 1.426079e-04 10 89705294 89705441 148 + 1.640 1.334 -1.050
ENSG00000138182 E006 57.0505445 0.0009407307 4.562193e-04 5.279851e-03 10 89709167 89709253 87 + 1.582 1.352 -0.789
ENSG00000138182 E007 54.6730562 0.0051470393 6.354405e-04 6.887001e-03 10 89709345 89709461 117 + 1.567 1.314 -0.873
ENSG00000138182 E008 67.0876035 0.0021652399 6.662332e-08 2.580552e-06 10 89709927 89710065 139 + 1.662 1.251 -1.419
ENSG00000138182 E009 68.3891215 0.0007445361 1.211374e-08 5.562984e-07 10 89710961 89711145 185 + 1.673 1.251 -1.452
ENSG00000138182 E010 28.3032018 0.0014671518 3.456794e-02 1.404073e-01 10 89714047 89714083 37 + 1.292 1.119 -0.612
ENSG00000138182 E011 55.3484301 0.0065104943 3.371935e-03 2.559917e-02 10 89714955 89715182 228 + 1.572 1.368 -0.700
ENSG00000138182 E012 48.3951425 0.0176736973 5.338460e-03 3.637869e-02 10 89716436 89716547 112 + 1.518 1.269 -0.861
ENSG00000138182 E013 43.5553742 0.0058667998 7.859626e-03 4.867602e-02 10 89717424 89717495 72 + 1.473 1.272 -0.696
ENSG00000138182 E014 78.5989174 0.0547518172 2.314834e-02 1.064133e-01 10 89717576 89717722 147 + 1.719 1.518 -0.682
ENSG00000138182 E015 78.9742767 0.0004747503 3.696136e-03 2.744715e-02 10 89718710 89718872 163 + 1.715 1.584 -0.443
ENSG00000138182 E016 107.6863852 0.0006431288 1.106219e-06 3.100109e-05 10 89719419 89719706 288 + 1.852 1.615 -0.802
ENSG00000138182 E017 2.7649548 0.0718917472 4.439455e-01 6.613406e-01 10 89723576 89723963 388 + 0.446 0.287 -0.933
ENSG00000138182 E018 66.6568327 0.0123039879 2.330315e-02 1.068992e-01 10 89723964 89724103 140 + 1.641 1.490 -0.515
ENSG00000138182 E019 72.0668013 0.0654270062 1.523328e-01 3.657505e-01 10 89725020 89725158 139 + 1.674 1.541 -0.453
ENSG00000138182 E020 4.2568176 0.0777056426 1.788805e-01 4.024646e-01 10 89726293 89726412 120 + 0.582 0.286 -1.601
ENSG00000138182 E021 65.1381320 0.0008555951 1.068186e-03 1.043743e-02 10 89726413 89726521 109 + 1.635 1.449 -0.637
ENSG00000138182 E022 39.3974299 0.0009166372 1.017589e-04 1.517741e-03 10 89727856 89727896 41 + 1.435 1.087 -1.226
ENSG00000138182 E023 58.6709614 0.0070928956 1.033916e-03 1.016645e-02 10 89729128 89729247 120 + 1.595 1.352 -0.836
ENSG00000138182 E024 74.4646102 0.0342919403 2.740114e-01 5.139672e-01 10 89732903 89733056 154 + 1.681 1.623 -0.200
ENSG00000138182 E025 383.4481763 0.0008792160 5.377515e-02 1.885467e-01 10 89737387 89738617 1231 + 2.380 2.385 0.018
ENSG00000138182 E026 96.2926042 0.0004059826 2.228150e-02 1.035331e-01 10 89738958 89739096 139 + 1.764 1.940 0.592
ENSG00000138182 E027 96.2747731 0.0016136158 2.751071e-01 5.151305e-01 10 89743808 89743927 120 + 1.769 1.890 0.407
ENSG00000138182 E028 75.6684599 0.0006163992 5.497784e-01 7.361276e-01 10 89745899 89745959 61 + 1.680 1.704 0.081
ENSG00000138182 E029 98.2909013 0.0037933897 4.267569e-01 6.485702e-01 10 89751346 89751471 126 + 1.793 1.803 0.037
ENSG00000138182 E030 95.0473303 0.0027494507 2.143180e-01 4.467373e-01 10 89752567 89752691 125 + 1.764 1.895 0.443
ENSG00000138182 E031 101.9246638 0.0055876766 5.164540e-02 1.836232e-01 10 89754518 89754673 156 + 1.787 1.961 0.587
ENSG00000138182 E032 104.1263647 0.0005234394 1.504114e-02 7.823612e-02 10 89758706 89758882 177 + 1.796 1.975 0.603
ENSG00000138182 E033 84.2681219 0.0036504814 5.781234e-02 1.979130e-01 10 89760526 89760636 111 + 1.704 1.879 0.590
ENSG00000138182 E034 119.0050804 0.0128181066 9.639918e-03 5.656806e-02 10 89762638 89762835 198 + 1.843 2.075 0.780
ENSG00000138182 E035 86.5304514 0.0016734408 2.523625e-04 3.245510e-03 10 89768290 89768391 102 + 1.704 1.958 0.858
ENSG00000138182 E036 121.4772495 0.0011479608 2.389250e-04 3.098508e-03 10 89768738 89768888 151 + 1.855 2.082 0.760
ENSG00000138182 E037 103.7734790 0.0166428532 8.653848e-04 8.813856e-03 10 89772689 89772831 143 + 1.775 2.076 1.013
ENSG00000138182 E038 147.9043739 1.5539544593 2.359328e-01 4.719016e-01 10 89773971 89774722 752 + 1.853 2.433 1.941
ENSG00000138182 E039 28.2670346 0.7706990079 1.540219e-01 3.680390e-01 10 89774723 89774939 217 + 1.180 1.673 1.705
ENSG00000138182 E040 0.1614157 0.0339819892 7.575764e-01   10 89792839 89792896 58 + 0.046 0.000 -8.119