ENSG00000138172

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260743 ENSG00000138172 HEK293_OSMI2_6hA HEK293_TMG_6hB CALHM2 protein_coding protein_coding 0.6502313 1.05417 1.213035 0.1395313 1.089798 0.2007366 0.18526850 0.41145268 0.02528283 0.016661698 0.02528283 -3.578332 0.27628750 0.40163333 0.24460000 -0.1570333 0.649951868 0.005552683 FALSE TRUE
ENST00000369788 ENSG00000138172 HEK293_OSMI2_6hA HEK293_TMG_6hB CALHM2 protein_coding protein_coding 0.6502313 1.05417 1.213035 0.1395313 1.089798 0.2007366 0.13911840 0.28848865 0.01008553 0.162413898 0.01008553 -3.893448 0.24566250 0.26063333 0.07043333 -0.1902000 0.766012720 0.005552683 FALSE TRUE
ENST00000461631 ENSG00000138172 HEK293_OSMI2_6hA HEK293_TMG_6hB CALHM2 protein_coding processed_transcript 0.6502313 1.05417 1.213035 0.1395313 1.089798 0.2007366 0.02818436 0.10799516 0.00000000 0.107995164 0.00000000 -3.560656 0.04800000 0.10906667 0.00000000 -0.1090667 0.983369497 0.005552683   FALSE
ENST00000480642 ENSG00000138172 HEK293_OSMI2_6hA HEK293_TMG_6hB CALHM2 protein_coding processed_transcript 0.6502313 1.05417 1.213035 0.1395313 1.089798 0.2007366 0.06816540 0.10068063 0.22654834 0.008232065 0.22654834 1.095732 0.06385417 0.09826667 0.06676667 -0.0315000 0.898590877 0.005552683   FALSE
MSTRG.4587.1 ENSG00000138172 HEK293_OSMI2_6hA HEK293_TMG_6hB CALHM2 protein_coding   0.6502313 1.05417 1.213035 0.1395313 1.089798 0.2007366 0.03721066 0.02467365 0.12366762 0.012618863 0.12366762 1.946739 0.06344583 0.02216667 0.03646667 0.0143000 0.642267037 0.005552683 TRUE TRUE
MSTRG.4587.2 ENSG00000138172 HEK293_OSMI2_6hA HEK293_TMG_6hB CALHM2 protein_coding   0.6502313 1.05417 1.213035 0.1395313 1.089798 0.2007366 0.13747425 0.05781862 0.81732181 0.025460927 0.76243582 3.608695 0.15527083 0.06056667 0.51103333 0.4504667 0.005552683 0.005552683 FALSE TRUE
MSTRG.4587.5 ENSG00000138172 HEK293_OSMI2_6hA HEK293_TMG_6hB CALHM2 protein_coding   0.6502313 1.05417 1.213035 0.1395313 1.089798 0.2007366 0.05480974 0.06306058 0.01012843 0.063060575 0.01012843 -1.859859 0.14750000 0.04773333 0.07073333 0.0230000 1.000000000 0.005552683 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138172 E001 0.0000000       10 103412347 103412402 56 -      
ENSG00000138172 E002 4.2027986 0.011031083 3.787943e-02 1.493005e-01 10 103446786 103446937 152 - 0.874 0.482 -1.674
ENSG00000138172 E003 24.1793735 0.006286163 2.311723e-01 4.664911e-01 10 103446938 103447568 631 - 1.478 1.297 -0.627
ENSG00000138172 E004 13.6212066 0.177521714 8.936484e-04 9.043672e-03 10 103447569 103448228 660 - 1.452 0.488 -3.721
ENSG00000138172 E005 10.1338599 0.465212775 2.584384e-02 1.147919e-01 10 103448229 103449386 1158 - 1.357 0.202 -5.195
ENSG00000138172 E006 2.5040358 0.022703598 4.984279e-03 3.453892e-02 10 103449387 103449399 13 - 0.234 0.704 2.505
ENSG00000138172 E007 9.0282752 0.004328199 2.876074e-06 7.166891e-05 10 103449400 103449624 225 - 0.694 1.148 1.731
ENSG00000138172 E008 4.7581043 0.006801703 1.343973e-03 1.249111e-02 10 103449625 103449698 74 - 0.498 0.886 1.639
ENSG00000138172 E009 6.7773137 0.006307265 4.100475e-02 1.573221e-01 10 103449699 103449934 236 - 0.780 0.947 0.644
ENSG00000138172 E010 3.9049937 0.008784356 2.255609e-01 4.600194e-01 10 103449935 103450024 90 - 0.626 0.729 0.432
ENSG00000138172 E011 3.4174178 0.010864776 3.652774e-01 6.001713e-01 10 103450025 103450099 75 - 0.588 0.653 0.285
ENSG00000138172 E012 1.9242380 0.015378759 3.995459e-01 6.279135e-01 10 103450100 103450295 196 - 0.546 0.336 -1.108
ENSG00000138172 E013 0.9815936 0.205779671 1.013424e-01   10 103450296 103450411 116 - 0.000 0.439 11.635
ENSG00000138172 E014 1.8323191 0.244265349 2.547207e-02 1.136768e-01 10 103450412 103450800 389 - 0.000 0.628 12.369
ENSG00000138172 E015 2.6239453 0.363159178 6.278212e-01 7.890885e-01 10 103451083 103451182 100 - 0.317 0.692 1.865
ENSG00000138172 E016 1.8809826 0.677961094 9.577386e-01 9.807053e-01 10 103451183 103451285 103 - 0.232 0.585 2.011
ENSG00000138172 E017 0.0000000       10 103451286 103451588 303 -      
ENSG00000138172 E018 0.0000000       10 103451879 103452036 158 -      
ENSG00000138172 E019 0.0000000       10 103452037 103452155 119 -      
ENSG00000138172 E020 3.6518467 0.008306050 3.888630e-05 6.724835e-04 10 103452156 103452402 247 - 0.234 0.851 3.092