ENSG00000138138

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308448 ENSG00000138138 HEK293_OSMI2_6hA HEK293_TMG_6hB ATAD1 protein_coding protein_coding 35.94016 8.123787 65.67478 1.324563 1.653869 3.01356 4.694437 1.163142 6.434058 0.2033384 0.49249255 2.457592 0.15741250 0.1438000 0.09816667 -0.04563333 0.4624751364 0.0008655451 FALSE TRUE
ENST00000328142 ENSG00000138138 HEK293_OSMI2_6hA HEK293_TMG_6hB ATAD1 protein_coding protein_coding 35.94016 8.123787 65.67478 1.324563 1.653869 3.01356 12.224591 3.147021 24.665784 0.5015944 1.32172044 2.966460 0.38791250 0.3885333 0.37506667 -0.01346667 0.9700029658 0.0008655451 FALSE TRUE
MSTRG.4320.2 ENSG00000138138 HEK293_OSMI2_6hA HEK293_TMG_6hB ATAD1 protein_coding   35.94016 8.123787 65.67478 1.324563 1.653869 3.01356 2.256091 1.331844 3.123993 0.4267946 0.08112839 1.223785 0.05721667 0.1549667 0.04770000 -0.10726667 0.0008655451 0.0008655451 TRUE TRUE
MSTRG.4320.7 ENSG00000138138 HEK293_OSMI2_6hA HEK293_TMG_6hB ATAD1 protein_coding   35.94016 8.123787 65.67478 1.324563 1.653869 3.01356 14.961646 2.049240 28.338919 0.5426513 0.90952001 3.783110 0.33377500 0.2532333 0.43146667 0.17823333 0.1941099781 0.0008655451 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138138 E001 2.7982161 0.3505562090 4.160524e-01 6.406201e-01 10 87746196 87746532 337 - 0.451 0.668 1.000
ENSG00000138138 E002 0.8217936 0.0212033843 1.820548e-01   10 87746686 87746806 121 - 0.149 0.403 1.904
ENSG00000138138 E003 13.8953186 0.0024857539 7.348930e-03 4.630992e-02 10 87751512 87751877 366 - 0.982 1.269 1.031
ENSG00000138138 E004 131.6119061 0.0082417426 7.801866e-01 8.848904e-01 10 87751878 87753116 1239 - 1.984 1.965 -0.066
ENSG00000138138 E005 181.2294093 0.0002553946 9.322223e-01 9.682469e-01 10 87753117 87753451 335 - 2.122 2.129 0.022
ENSG00000138138 E006 547.1007322 0.0001735550 1.072785e-01 2.944903e-01 10 87753452 87754379 928 - 2.594 2.629 0.117
ENSG00000138138 E007 385.8280130 0.0001678013 1.303007e-05 2.640895e-04 10 87754380 87754661 282 - 2.463 2.356 -0.359
ENSG00000138138 E008 228.3743329 0.0002766368 7.912356e-01 8.911718e-01 10 87754662 87754807 146 - 2.220 2.231 0.039
ENSG00000138138 E009 234.1440296 0.0002044367 3.431508e-02 1.397212e-01 10 87756789 87756922 134 - 2.222 2.289 0.226
ENSG00000138138 E010 2.1550011 0.0100944236 4.619766e-01 6.744750e-01 10 87759701 87759813 113 - 0.374 0.518 0.749
ENSG00000138138 E011 3.4825992 0.1406913806 4.049313e-01 6.321986e-01 10 87766220 87766405 186 - 0.505 0.690 0.827
ENSG00000138138 E012 198.6854243 0.0002378133 3.368518e-01 5.752377e-01 10 87767673 87767723 51 - 2.157 2.193 0.120
ENSG00000138138 E013 215.3225422 0.0002223062 4.751218e-01 6.836457e-01 10 87770952 87771041 90 - 2.193 2.220 0.089
ENSG00000138138 E014 266.8104098 0.0003234552 6.762812e-01 8.203795e-01 10 87776321 87776427 107 - 2.292 2.283 -0.030
ENSG00000138138 E015 1.1412444 0.0166734288 3.780084e-01   10 87778521 87778731 211 - 0.226 0.402 1.159
ENSG00000138138 E016 231.9511650 0.0016062284 9.434369e-01 9.740650e-01 10 87784470 87784551 82 - 2.230 2.235 0.019
ENSG00000138138 E017 252.9544451 0.0007776401 8.406029e-01 9.197659e-01 10 87784552 87784670 119 - 2.265 2.275 0.033
ENSG00000138138 E018 4.1128621 0.0066531153 3.931875e-02 1.530305e-01 10 87789040 87789129 90 - 0.521 0.852 1.399
ENSG00000138138 E019 256.7153224 0.0002293886 1.153522e-01 3.080631e-01 10 87790310 87790430 121 - 2.278 2.233 -0.149
ENSG00000138138 E020 280.7367802 0.0015384694 8.368959e-03 5.101919e-02 10 87792657 87792755 99 - 2.322 2.234 -0.294
ENSG00000138138 E021 303.7864116 0.0021829869 4.494541e-01 6.652807e-01 10 87814438 87814612 175 - 2.348 2.324 -0.079
ENSG00000138138 E022 1.4810038 0.0128300534 3.966754e-02 1.538756e-01 10 87814613 87814882 270 - 0.226 0.608 2.163
ENSG00000138138 E023 74.6327267 0.0170364130 1.019268e-06 2.889736e-05 10 87817795 87818160 366 - 1.660 2.038 1.273
ENSG00000138138 E024 62.8288939 0.0086297567 4.528028e-03 3.208693e-02 10 87818167 87818226 60 - 1.696 1.464 -0.791
ENSG00000138138 E025 0.0000000       10 87841187 87841361 175 -