ENSG00000138107

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369905 ENSG00000138107 HEK293_OSMI2_6hA HEK293_TMG_6hB ACTR1A protein_coding protein_coding 155.1771 215.3116 90.90934 33.36873 3.675523 -1.243834 130.65053 188.28556 69.74401 31.723318 3.2358589 -1.432651 0.8122167 0.8698333 0.7668 -0.1030333 0.0519190035 0.0009659925 FALSE TRUE
MSTRG.4552.9 ENSG00000138107 HEK293_OSMI2_6hA HEK293_TMG_6hB ACTR1A protein_coding   155.1771 215.3116 90.90934 33.36873 3.675523 -1.243834 12.77542 15.33682 13.13356 3.323232 0.7573221 -0.223583 0.1020000 0.0702000 0.1448 0.0746000 0.0009659925 0.0009659925 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138107 E001 0.4646582 0.0212851361 0.7155373484   10 102461881 102462060 180 - 0.190 0.140 -0.524
ENSG00000138107 E002 1.3498753 0.6378222383 1.0000000000   10 102472835 102472981 147 - 0.313 0.344 0.192
ENSG00000138107 E003 6.9670252 0.0793850730 0.9004120077 0.952073256 10 102478860 102479074 215 - 0.843 0.847 0.013
ENSG00000138107 E004 12.1759418 0.1359698021 0.3545430608 0.591345010 10 102479075 102479228 154 - 0.874 1.109 0.872
ENSG00000138107 E005 7.5994103 0.0204335429 0.0084437208 0.051351454 10 102479229 102479229 1 - 0.502 0.964 1.912
ENSG00000138107 E006 25.4261413 0.0146073713 0.1483311903 0.359924668 10 102479230 102479236 7 - 1.226 1.410 0.640
ENSG00000138107 E007 4254.8887974 0.0034790552 0.0185260367 0.090805759 10 102479237 102480478 1242 - 3.494 3.592 0.326
ENSG00000138107 E008 244.4132711 0.0045249150 0.0294855986 0.125830644 10 102480479 102480482 4 - 2.230 2.362 0.440
ENSG00000138107 E009 263.8497866 0.0039306030 0.0255907328 0.114030380 10 102480483 102480492 10 - 2.266 2.394 0.427
ENSG00000138107 E010 1479.2898978 0.0035328883 0.7839426805 0.886881782 10 102480493 102480794 302 - 3.089 3.118 0.097
ENSG00000138107 E011 1565.8201188 0.0013354591 0.0843896362 0.253507337 10 102480795 102480965 171 - 3.132 3.136 0.014
ENSG00000138107 E012 926.9616689 0.0019201728 0.0353731678 0.142549476 10 102481132 102481172 41 - 2.917 2.904 -0.042
ENSG00000138107 E013 1039.5432810 0.0009798804 0.0591195300 0.200801135 10 102481837 102481898 62 - 2.956 2.957 0.003
ENSG00000138107 E014 1611.8080363 0.0096554953 0.3128781032 0.553211983 10 102482001 102482175 175 - 3.089 3.166 0.254
ENSG00000138107 E015 61.1471501 0.1672973066 0.3798960287 0.612086033 10 102482176 102483010 835 - 1.799 1.709 -0.305
ENSG00000138107 E016 654.2152043 0.1192791841 0.2306059912 0.465839085 10 102483011 102483013 3 - 2.626 2.793 0.555
ENSG00000138107 E017 1136.9749630 0.2454671690 0.3126430945 0.552970216 10 102483014 102483103 90 - 2.875 3.031 0.517
ENSG00000138107 E018 28.1101466 0.2894436676 0.9277943800 0.965961174 10 102483104 102483680 577 - 1.367 1.419 0.179
ENSG00000138107 E019 10.2005594 0.1172769552 0.1879908852 0.414432460 10 102484074 102484159 86 - 1.133 0.933 -0.734
ENSG00000138107 E020 1696.5109993 0.0078668979 0.8078204310 0.900901877 10 102484160 102484376 217 - 3.140 3.180 0.131
ENSG00000138107 E021 1275.8123175 0.0009783978 0.0006216883 0.006765227 10 102485609 102485733 125 - 3.066 3.040 -0.087
ENSG00000138107 E022 1434.7394272 0.0003676750 0.0001583532 0.002199396 10 102488150 102488272 123 - 3.109 3.093 -0.053
ENSG00000138107 E023 713.6630706 0.0022142446 0.0094723313 0.055839341 10 102488273 102488275 3 - 2.818 2.785 -0.112
ENSG00000138107 E024 1245.8300114 0.0008360636 0.0014067568 0.012947088 10 102489063 102489138 76 - 3.051 3.030 -0.069
ENSG00000138107 E025 931.9033691 0.0014567856 0.0006198277 0.006751828 10 102490549 102490613 65 - 2.941 2.899 -0.139
ENSG00000138107 E026 882.1437755 0.0003505811 0.0003046627 0.003777377 10 102502600 102502834 235 - 2.903 2.879 -0.078