ENSG00000138050

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378727 ENSG00000138050 HEK293_OSMI2_6hA HEK293_TMG_6hB THUMPD2 protein_coding nonsense_mediated_decay 12.23743 4.95856 21.70295 0.8110042 0.5931065 2.127656 4.6443460 1.9283120 7.9440530 0.42057953 0.50502131 2.0368893 0.38712083 0.38690000 0.367433333 -0.019466667 9.745710e-01 2.394131e-11 TRUE TRUE
ENST00000460072 ENSG00000138050 HEK293_OSMI2_6hA HEK293_TMG_6hB THUMPD2 protein_coding retained_intron 12.23743 4.95856 21.70295 0.8110042 0.5931065 2.127656 1.0420991 0.4676946 2.3416087 0.01968303 0.02014378 2.2994875 0.08538333 0.10026667 0.108066667 0.007800000 9.468298e-01 2.394131e-11 FALSE TRUE
ENST00000505747 ENSG00000138050 HEK293_OSMI2_6hA HEK293_TMG_6hB THUMPD2 protein_coding protein_coding 12.23743 4.95856 21.70295 0.8110042 0.5931065 2.127656 1.1874182 0.8805105 0.5740844 0.15946588 0.57408437 -0.6084559 0.12626250 0.17680000 0.025233333 -0.151566667 1.440287e-01 2.394131e-11 FALSE TRUE
ENST00000527689 ENSG00000138050 HEK293_OSMI2_6hA HEK293_TMG_6hB THUMPD2 protein_coding retained_intron 12.23743 4.95856 21.70295 0.8110042 0.5931065 2.127656 0.7240082 0.3484317 1.5105923 0.17422048 0.12182860 2.0848634 0.06511250 0.08026667 0.069433333 -0.010833333 9.658040e-01 2.394131e-11   FALSE
ENST00000530095 ENSG00000138050 HEK293_OSMI2_6hA HEK293_TMG_6hB THUMPD2 protein_coding retained_intron 12.23743 4.95856 21.70295 0.8110042 0.5931065 2.127656 0.1461019 0.3163310 0.1587228 0.15967965 0.15872281 -0.9516809 0.01576667 0.07110000 0.007666667 -0.063433333 5.062063e-01 2.394131e-11 FALSE FALSE
MSTRG.18272.11 ENSG00000138050 HEK293_OSMI2_6hA HEK293_TMG_6hB THUMPD2 protein_coding   12.23743 4.95856 21.70295 0.8110042 0.5931065 2.127656 0.9091982 0.2756716 1.0339707 0.27567163 0.34172380 1.8696515 0.07362500 0.05090000 0.048033333 -0.002866667 7.049844e-01 2.394131e-11 FALSE TRUE
MSTRG.18272.6 ENSG00000138050 HEK293_OSMI2_6hA HEK293_TMG_6hB THUMPD2 protein_coding   12.23743 4.95856 21.70295 0.8110042 0.5931065 2.127656 2.0848153 0.0000000 4.5430187 0.00000000 0.79282627 8.8306796 0.12396667 0.00000000 0.208066667 0.208066667 2.394131e-11 2.394131e-11 FALSE TRUE
MSTRG.18272.9 ENSG00000138050 HEK293_OSMI2_6hA HEK293_TMG_6hB THUMPD2 protein_coding   12.23743 4.95856 21.70295 0.8110042 0.5931065 2.127656 0.8600005 0.5525970 2.4285021 0.33536758 0.59622952 2.1158214 0.07211667 0.09426667 0.112166667 0.017900000 8.986529e-01 2.394131e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138050 E001 0.2735028 0.0258546664 0.340577563   2 39736060 39736060 1 - 0.067 0.210 1.886
ENSG00000138050 E002 2.7350256 0.0744892304 0.300305794 0.54074020 2 39736061 39736306 246 - 0.476 0.671 0.891
ENSG00000138050 E003 77.2063237 0.0168631810 0.023013472 0.10598977 2 39736307 39736597 291 - 1.763 1.939 0.592
ENSG00000138050 E004 48.6938417 0.0013152104 0.076441502 0.23761761 2 39736598 39736609 12 - 1.587 1.695 0.367
ENSG00000138050 E005 59.4501550 0.0008307676 0.040323716 0.15554205 2 39736610 39736647 38 - 1.672 1.783 0.376
ENSG00000138050 E006 53.5936935 0.0017159455 0.071473700 0.22775318 2 39736648 39736682 35 - 1.631 1.736 0.357
ENSG00000138050 E007 180.9348310 0.0004983461 0.082997285 0.25074447 2 39736683 39737059 377 - 2.166 2.222 0.189
ENSG00000138050 E008 81.7699260 0.0005707665 0.327422023 0.56648964 2 39744370 39744478 109 - 1.846 1.805 -0.139
ENSG00000138050 E009 0.9798287 0.1017774767 0.519879813   2 39744479 39744654 176 - 0.224 0.350 0.878
ENSG00000138050 E010 74.6862188 0.0005534501 0.460972788 0.67383558 2 39755295 39755409 115 - 1.801 1.770 -0.106
ENSG00000138050 E011 66.0003817 0.0006523056 0.958954581 0.98137640 2 39755889 39755960 72 - 1.743 1.751 0.025
ENSG00000138050 E012 32.6262930 0.0010797923 0.121922305 0.31894899 2 39757248 39757368 121 - 1.419 1.531 0.384
ENSG00000138050 E013 41.9084121 0.0012092895 0.878655630 0.94059696 2 39761331 39761331 1 - 1.552 1.547 -0.017
ENSG00000138050 E014 60.6131280 0.0008955571 0.994550163 0.99887332 2 39761332 39761364 33 - 1.706 1.711 0.015
ENSG00000138050 E015 62.7298860 0.0015472364 0.908749457 0.95644642 2 39761365 39761418 54 - 1.720 1.731 0.038
ENSG00000138050 E016 59.0682811 0.0006949328 0.421083319 0.64448037 2 39766057 39766109 53 - 1.706 1.666 -0.135
ENSG00000138050 E017 3.5920982 0.0072026282 0.114574302 0.30678216 2 39766110 39766212 103 - 0.524 0.777 1.087
ENSG00000138050 E018 67.4747837 0.0025852394 0.042186557 0.16040318 2 39768424 39768501 78 - 1.773 1.661 -0.380
ENSG00000138050 E019 22.1472852 0.0019844818 0.349927378 0.58719324 2 39768502 39768900 399 - 1.299 1.219 -0.283
ENSG00000138050 E020 7.0685315 0.0041670799 0.074954326 0.23471757 2 39768901 39768902 2 - 0.886 0.614 -1.106
ENSG00000138050 E021 19.9459426 0.0016642592 0.027270724 0.11909504 2 39768903 39769093 191 - 1.280 1.063 -0.774
ENSG00000138050 E022 10.8900324 0.0040939839 0.445154859 0.66219706 2 39769094 39769191 98 - 1.016 0.927 -0.332
ENSG00000138050 E023 18.1807577 0.0805639069 0.432074583 0.65279572 2 39769192 39769709 518 - 1.229 1.103 -0.450
ENSG00000138050 E024 40.2625237 0.0010034637 0.094618544 0.27229485 2 39769710 39769757 48 - 1.554 1.443 -0.380
ENSG00000138050 E025 91.9490714 0.0006253114 0.008742159 0.05267598 2 39769758 39770016 259 - 1.908 1.792 -0.393
ENSG00000138050 E026 49.6583348 0.0008411306 0.376652397 0.60959047 2 39770017 39770119 103 - 1.632 1.583 -0.166
ENSG00000138050 E027 17.3752454 0.0028758926 0.655436362 0.80699804 2 39771505 39771514 10 - 1.188 1.148 -0.141
ENSG00000138050 E028 39.5022049 0.0082119024 0.496958337 0.69888251 2 39771515 39771640 126 - 1.531 1.481 -0.169
ENSG00000138050 E029 24.7947974 0.0113565177 0.595997215 0.76775013 2 39779114 39779267 154 - 1.340 1.292 -0.166