ENSG00000138031

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000405392 ENSG00000138031 HEK293_OSMI2_6hA HEK293_TMG_6hB ADCY3 protein_coding protein_coding 38.05882 47.34813 27.3846 1.338844 1.152431 -0.7897207 11.3490732 14.165252 10.833290 1.5401871 0.5979493 -0.3865719 0.30368750 0.30040000 0.39793333 0.097533333 0.5665117987 0.0007862423 FALSE TRUE
ENST00000450524 ENSG00000138031 HEK293_OSMI2_6hA HEK293_TMG_6hB ADCY3 protein_coding processed_transcript 38.05882 47.34813 27.3846 1.338844 1.152431 -0.7897207 0.8154456 2.914665 0.000000 1.2345516 0.0000000 -8.1921277 0.01918333 0.06016667 0.00000000 -0.060166667 0.0007862423 0.0007862423 FALSE FALSE
ENST00000485887 ENSG00000138031 HEK293_OSMI2_6hA HEK293_TMG_6hB ADCY3 protein_coding retained_intron 38.05882 47.34813 27.3846 1.338844 1.152431 -0.7897207 4.0135127 6.557909 2.690579 1.1880615 0.7861166 -1.2821653 0.10264583 0.13793333 0.09633333 -0.041600000 0.7149691614 0.0007862423 FALSE TRUE
ENST00000498288 ENSG00000138031 HEK293_OSMI2_6hA HEK293_TMG_6hB ADCY3 protein_coding protein_coding 38.05882 47.34813 27.3846 1.338844 1.152431 -0.7897207 5.8285079 5.546408 1.696660 0.4785056 0.2827100 -1.7029767 0.14319167 0.11753333 0.06150000 -0.056033333 0.1368049647 0.0007862423 FALSE FALSE
ENST00000606682 ENSG00000138031 HEK293_OSMI2_6hA HEK293_TMG_6hB ADCY3 protein_coding protein_coding 38.05882 47.34813 27.3846 1.338844 1.152431 -0.7897207 4.7503546 6.913026 2.696832 0.8350304 0.6733609 -1.3547974 0.11808750 0.14700000 0.09720000 -0.049800000 0.6193788283 0.0007862423 FALSE TRUE
ENST00000679454 ENSG00000138031 HEK293_OSMI2_6hA HEK293_TMG_6hB ADCY3 protein_coding protein_coding 38.05882 47.34813 27.3846 1.338844 1.152431 -0.7897207 8.2440695 9.205327 5.084423 0.6351170 0.1914125 -0.8551168 0.22415833 0.19410000 0.18686667 -0.007233333 0.9713374051 0.0007862423 FALSE TRUE
MSTRG.18070.12 ENSG00000138031 HEK293_OSMI2_6hA HEK293_TMG_6hB ADCY3 protein_coding   38.05882 47.34813 27.3846 1.338844 1.152431 -0.7897207 1.1756508 0.000000 1.867674 0.0000000 0.9339085 7.5528027 0.03703333 0.00000000 0.07110000 0.071100000 0.2244799846 0.0007862423 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000138031 E001 2.3144259 0.010863521 0.8001524564 0.896402314 2 24819169 24819171 3 - 0.504 0.497 -0.031
ENSG00000138031 E002 9.1346786 0.065324853 0.6150599219 0.780312870 2 24819172 24819187 16 - 0.878 1.023 0.542
ENSG00000138031 E003 105.1008699 0.033686679 0.0549448980 0.191222427 2 24819188 24819368 181 - 1.854 2.069 0.724
ENSG00000138031 E004 654.8129088 1.553585903 0.4194303976 0.643208673 2 24819369 24820114 746 - 2.584 2.876 0.975
ENSG00000138031 E005 20.4003113 0.217172367 0.3211435376 0.560670686 2 24820246 24820383 138 - 1.152 1.376 0.789
ENSG00000138031 E006 32.2259847 0.338331398 0.3096368002 0.550105142 2 24820384 24820451 68 - 1.338 1.568 0.794
ENSG00000138031 E007 54.7119275 0.499975838 0.3514000170 0.588553614 2 24820452 24820723 272 - 1.578 1.787 0.708
ENSG00000138031 E008 253.9015277 1.260356613 0.4515425634 0.666762134 2 24820724 24820848 125 - 2.231 2.449 0.727
ENSG00000138031 E009 10.5074746 0.096611706 0.5034453699 0.703201157 2 24820849 24821516 668 - 0.943 1.089 0.539
ENSG00000138031 E010 266.1430384 1.298031084 0.4873031867 0.692124826 2 24821517 24821640 124 - 2.274 2.462 0.625
ENSG00000138031 E011 3.4217236 0.073998253 0.9513038905 0.977629535 2 24821641 24822510 870 - 0.606 0.658 0.223
ENSG00000138031 E012 261.2574957 0.110583066 0.3301684113 0.569113397 2 24822511 24822630 120 - 2.309 2.439 0.434
ENSG00000138031 E013 300.5577766 0.002420780 0.1900728656 0.417027264 2 24823209 24823355 147 - 2.453 2.461 0.027
ENSG00000138031 E014 1.4572831 0.060254772 0.5512502527 0.737195036 2 24823356 24823363 8 - 0.274 0.424 0.916
ENSG00000138031 E015 321.4656073 0.002341850 0.1646649850 0.383587355 2 24824378 24824536 159 - 2.483 2.490 0.023
ENSG00000138031 E016 14.7396741 0.559815642 0.2719387238 0.511802222 2 24824770 24826044 1275 - 1.494 0.801 -2.503
ENSG00000138031 E017 193.7865857 1.187874882 0.4843037611 0.690056815 2 24826045 24826126 82 - 2.146 2.322 0.586
ENSG00000138031 E018 8.0443869 0.003958175 0.1918141933 0.419143968 2 24826127 24826129 3 - 0.795 1.002 0.786
ENSG00000138031 E019 0.3032425 0.024441170 0.4897342686   2 24826130 24826148 19 - 0.000 0.169 10.317
ENSG00000138031 E020 114.8506805 0.168574996 0.2511498048 0.489223722 2 24827546 24827562 17 - 1.916 2.098 0.610
ENSG00000138031 E021 158.0756454 0.037896663 0.3864093060 0.617623838 2 24827563 24827608 46 - 2.110 2.215 0.351
ENSG00000138031 E022 225.7608844 0.001522191 0.9576402131 0.980672740 2 24827902 24828023 122 - 2.304 2.356 0.174
ENSG00000138031 E023 217.6680243 0.007426902 0.4228454891 0.645741642 2 24828024 24828161 138 - 2.305 2.328 0.075
ENSG00000138031 E024 8.7473588 0.160076477 0.5297123212 0.721853118 2 24828162 24828309 148 - 1.017 0.937 -0.295
ENSG00000138031 E025 51.7179056 0.127832871 0.0887180131 0.261432572 2 24828372 24830433 2062 - 1.840 1.603 -0.802
ENSG00000138031 E026 16.8668499 0.068350841 0.0005631138 0.006247856 2 24830434 24830708 275 - 1.473 1.012 -1.629
ENSG00000138031 E027 203.3228362 0.014048590 0.5784586740 0.756114010 2 24830709 24830825 117 - 2.272 2.298 0.089
ENSG00000138031 E028 181.8319225 0.011911964 0.8749367292 0.938702358 2 24831662 24831749 88 - 2.206 2.259 0.175
ENSG00000138031 E029 0.2922838 0.026444387 0.5923546445   2 24832126 24832185 60 - 0.158 0.093 -0.881
ENSG00000138031 E030 218.2848281 0.017969410 0.6075236752 0.775230064 2 24834485 24834646 162 - 2.302 2.329 0.090
ENSG00000138031 E031 203.1758521 0.016892231 0.4527428948 0.667727551 2 24834794 24834925 132 - 2.282 2.292 0.035
ENSG00000138031 E032 117.0968599 0.001215495 0.2954353662 0.535908141 2 24834926 24834936 11 - 2.043 2.057 0.047
ENSG00000138031 E033 120.3943823 0.001381168 0.0397318842 0.154037819 2 24836917 24836952 36 - 2.079 2.056 -0.077
ENSG00000138031 E034 109.0097610 0.001500877 0.0051804453 0.035565927 2 24836953 24836981 29 - 2.056 2.001 -0.186
ENSG00000138031 E035 139.1008640 0.003695776 0.0144854233 0.076187997 2 24836982 24837045 64 - 2.156 2.108 -0.158
ENSG00000138031 E036 201.7348801 0.007110536 0.0156733789 0.080635591 2 24838445 24838622 178 - 2.321 2.265 -0.188
ENSG00000138031 E037 2.0345760 0.010358429 0.1648627267 0.383832125 2 24838847 24838912 66 - 0.273 0.558 1.582
ENSG00000138031 E038 178.8272596 0.003888988 0.1962061856 0.424819887 2 24839873 24840006 134 - 2.231 2.235 0.015
ENSG00000138031 E039 114.5544172 0.016686115 0.7504586972 0.866996970 2 24840007 24840031 25 - 2.016 2.054 0.127
ENSG00000138031 E040 0.3641499 0.031577636 0.5972693609   2 24840525 24840603 79 - 0.158 0.093 -0.875
ENSG00000138031 E041 141.3007605 0.018554144 0.4402513472 0.658905128 2 24841259 24841324 66 - 2.128 2.133 0.017
ENSG00000138031 E042 137.8991906 0.011703113 0.2181730027 0.451239131 2 24841325 24841386 62 - 2.131 2.117 -0.048
ENSG00000138031 E043 168.9329748 0.013527215 0.2494888672 0.487335495 2 24841556 24841667 112 - 2.216 2.206 -0.035
ENSG00000138031 E044 170.5478690 0.009573194 0.0609910316 0.204988916 2 24842254 24842354 101 - 2.240 2.199 -0.137
ENSG00000138031 E045 100.8884533 0.002026991 0.0064422647 0.041885326 2 24842355 24842384 30 - 2.027 1.968 -0.197
ENSG00000138031 E046 2.2289557 0.220200270 0.4919602760 0.695291093 2 24842385 24842592 208 - 0.565 0.456 -0.525
ENSG00000138031 E047 179.5749322 0.005136028 0.0055829794 0.037641667 2 24872570 24872719 150 - 2.276 2.214 -0.206
ENSG00000138031 E048 0.0000000       2 24877922 24878027 106 -      
ENSG00000138031 E049 0.9714428 0.015880057 0.3879255916   2 24887645 24887669 25 - 0.364 0.234 -0.876
ENSG00000138031 E050 249.5556463 0.014327487 0.0279690003 0.121184266 2 24918313 24918651 339 - 2.424 2.351 -0.246
ENSG00000138031 E051 294.5103316 0.007565248 0.1363371389 0.341900825 2 24918652 24919184 533 - 2.455 2.447 -0.027
ENSG00000138031 E052 0.1779838 0.054132429 0.2359044487   2 24919185 24919473 289 - 0.158 0.000 -11.112
ENSG00000138031 E053 0.0000000       2 24919474 24919682 209 -      
ENSG00000138031 E054 53.6253680 0.009731209 0.3130799858 0.553362331 2 24919683 24920237 555 - 1.629 1.760 0.443