ENSG00000137962

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260526 ENSG00000137962 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP29 protein_coding protein_coding 2.852955 0.3960688 5.931104 0.02895744 0.3039014 3.870935 0.95989462 0.28038091 1.74021600 0.05455272 0.06524609 2.5915145 0.52497917 0.6981667 0.29473333 -0.40343333 8.909722e-03 6.504733e-08 FALSE TRUE
ENST00000546444 ENSG00000137962 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP29 protein_coding retained_intron 2.852955 0.3960688 5.931104 0.02895744 0.3039014 3.870935 0.08401632 0.08659797 0.07867537 0.01692737 0.03152504 -0.1234595 0.10273750 0.2270000 0.01330000 -0.21370000 2.028581e-03 6.504733e-08   FALSE
MSTRG.1636.4 ENSG00000137962 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP29 protein_coding   2.852955 0.3960688 5.931104 0.02895744 0.3039014 3.870935 1.48531363 0.00000000 3.12985836 0.00000000 0.18504432 8.2945557 0.28265417 0.0000000 0.52756667 0.52756667 6.504733e-08 6.504733e-08 FALSE TRUE
MSTRG.1636.6 ENSG00000137962 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGAP29 protein_coding   2.852955 0.3960688 5.931104 0.02895744 0.3039014 3.870935 0.12945337 0.00000000 0.49991334 0.00000000 0.09329059 5.6721802 0.02497917 0.0000000 0.08316667 0.08316667 2.413650e-01 6.504733e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000137962 E001 0.6544085 0.0191656274 2.853376e-01   1 94148988 94149846 859 - 0.112 0.314 1.842
ENSG00000137962 E002 0.1426347 0.0334888857 5.359385e-01   1 94149847 94149883 37 - 0.041 0.000 -6.786
ENSG00000137962 E003 0.3206185 0.0274424043 1.000000e+00   1 94149884 94150351 468 - 0.078 0.000 -7.757
ENSG00000137962 E004 0.4632531 0.0277431691 1.000000e+00   1 94150352 94150515 164 - 0.112 0.000 -8.284
ENSG00000137962 E005 0.3040503 0.0274424043 1.000000e+00   1 94154551 94154648 98 - 0.078 0.000 -7.757
ENSG00000137962 E006 0.0000000       1 94154649 94154829 181 -      
ENSG00000137962 E007 129.2464572 0.0005479667 2.440678e-19 6.456126e-17 1 94168905 94174234 5330 - 1.827 2.173 1.161
ENSG00000137962 E008 16.2066666 0.0031188712 6.617104e-01 8.109118e-01 1 94174235 94174256 22 - 1.006 1.063 0.209
ENSG00000137962 E009 34.8041005 0.0014292296 2.708932e-03 2.161939e-02 1 94174257 94174466 210 - 1.290 1.542 0.871
ENSG00000137962 E010 20.5585187 0.0016679676 8.955815e-03 5.362091e-02 1 94174467 94174603 137 - 1.069 1.345 0.979
ENSG00000137962 E011 25.1675114 0.0096395874 7.719299e-01 8.797751e-01 1 94174604 94174749 146 - 1.180 1.137 -0.155
ENSG00000137962 E012 0.8086220 0.1471667081 3.790942e-01   1 94176613 94177611 999 - 0.143 0.316 1.455
ENSG00000137962 E013 24.2920159 0.0205432818 7.329532e-01 8.559702e-01 1 94177612 94177720 109 - 1.167 1.104 -0.223
ENSG00000137962 E014 36.5592263 0.0033779012 1.199813e-01 3.158075e-01 1 94177852 94178167 316 - 1.344 1.169 -0.618
ENSG00000137962 E015 27.2482725 0.0097600472 3.429530e-02 1.396708e-01 1 94179725 94179957 233 - 1.231 0.924 -1.114
ENSG00000137962 E016 22.1761731 0.0222630704 4.119785e-02 1.578614e-01 1 94184151 94184288 138 - 1.149 0.798 -1.310
ENSG00000137962 E017 29.7176288 0.0047789381 3.161699e-02 1.321079e-01 1 94184872 94185060 189 - 1.264 0.976 -1.036
ENSG00000137962 E018 26.1915911 0.0036323283 7.584604e-02 2.364765e-01 1 94185342 94185481 140 - 1.216 0.976 -0.867
ENSG00000137962 E019 18.7713282 0.0175241659 7.657179e-01 8.760856e-01 1 94186499 94186597 99 - 1.071 1.021 -0.183
ENSG00000137962 E020 16.1740796 0.0022339771 3.253734e-01 5.646128e-01 1 94188837 94188941 105 - 1.019 0.866 -0.573
ENSG00000137962 E021 17.5328100 0.0091050423 4.213022e-01 6.446007e-01 1 94189216 94189328 113 - 1.049 0.924 -0.464
ENSG00000137962 E022 9.3234437 0.0041289925 9.929558e-01 9.981220e-01 1 94189329 94189352 24 - 0.800 0.799 -0.005
ENSG00000137962 E023 20.2017684 0.0021859280 9.574157e-02 2.743262e-01 1 94189926 94190083 158 - 1.114 0.866 -0.919
ENSG00000137962 E024 8.6747231 0.0602730885 1.807483e-01 4.049644e-01 1 94190084 94195940 5857 - 0.742 0.980 0.918
ENSG00000137962 E025 17.1419410 0.0085858715 1.658577e-02 8.392112e-02 1 94201720 94201857 138 - 1.057 0.620 -1.714
ENSG00000137962 E026 4.3458696 0.0064209479 8.446935e-01 9.219410e-01 1 94201895 94202543 649 - 0.539 0.494 -0.217
ENSG00000137962 E027 18.9343874 0.0019535319 2.403479e-02 1.091859e-01 1 94202544 94202732 189 - 1.090 0.719 -1.419
ENSG00000137962 E028 15.1904242 0.0043676676 3.696793e-02 1.468333e-01 1 94202918 94202998 81 - 1.002 0.621 -1.512
ENSG00000137962 E029 18.0991005 0.0070896553 3.024475e-04 3.755670e-03 1 94203100 94203210 111 - 1.086 0.313 -3.404
ENSG00000137962 E030 15.5384726 0.0115790285 8.665988e-03 5.232655e-02 1 94203930 94203994 65 - 1.021 0.493 -2.168
ENSG00000137962 E031 22.3909528 0.0015851846 6.041869e-03 3.992800e-02 1 94205061 94205198 138 - 1.158 0.719 -1.661
ENSG00000137962 E032 16.3957444 0.0052113030 6.968477e-02 2.241494e-01 1 94205635 94205683 49 - 1.028 0.718 -1.192
ENSG00000137962 E033 13.6859490 0.0040610316 1.776074e-01 4.005821e-01 1 94208832 94208904 73 - 0.953 0.718 -0.916
ENSG00000137962 E034 13.2265225 0.0026880648 3.996373e-01 6.279734e-01 1 94209254 94209350 97 - 0.938 0.798 -0.538
ENSG00000137962 E035 13.6778757 0.0025887731 8.112674e-01 9.030069e-01 1 94220258 94220392 135 - 0.943 0.976 0.122
ENSG00000137962 E036 13.8344355 0.0025625760 5.853990e-01 7.605563e-01 1 94231407 94231643 237 - 0.953 0.866 -0.330
ENSG00000137962 E037 4.4316136 0.0061417645 3.040619e-01 5.446268e-01 1 94237415 94237633 219 - 0.563 0.313 -1.329
ENSG00000137962 E038 0.5421338 0.0238440182 1.799765e-01   1 94247565 94247607 43 - 0.078 0.314 2.428
ENSG00000137962 E039 0.0000000       1 94275012 94275068 57 -