ENSG00000137942

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260506 ENSG00000137942 HEK293_OSMI2_6hA HEK293_TMG_6hB FNBP1L protein_coding protein_coding 5.732121 2.370335 10.12693 0.5296524 0.4676047 2.090385 2.313366 0.9161555 4.778317 0.1811106 0.07204843 2.370192 0.3815625 0.39270000 0.4733000 0.0806 0.595870784 0.002653264 FALSE TRUE
ENST00000370253 ENSG00000137942 HEK293_OSMI2_6hA HEK293_TMG_6hB FNBP1L protein_coding protein_coding 5.732121 2.370335 10.12693 0.5296524 0.4676047 2.090385 2.077830 1.2623939 3.077535 0.2828094 0.20853155 1.278910 0.3875375 0.53233333 0.3033333 -0.2290 0.002653264 0.002653264 FALSE TRUE
MSTRG.1619.1 ENSG00000137942 HEK293_OSMI2_6hA HEK293_TMG_6hB FNBP1L protein_coding   5.732121 2.370335 10.12693 0.5296524 0.4676047 2.090385 1.081312 0.1917850 1.955858 0.1025832 0.14789440 3.284268 0.1689750 0.07493333 0.1930333 0.1181 0.185494115 0.002653264 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000137942 E001 4.2326695 0.005712335 0.706647141 0.83971950 1 93448067 93448117 51 + 0.632 0.651 0.083
ENSG00000137942 E002 5.4466580 0.004855236 0.286555851 0.52724625 1 93448118 93448130 13 + 0.739 0.651 -0.364
ENSG00000137942 E003 28.8669677 0.028508843 0.028149267 0.12169734 1 93448131 93448281 151 + 1.390 1.244 -0.512
ENSG00000137942 E004 22.2769066 0.012713517 0.017950932 0.08887959 1 93448282 93448305 24 + 1.284 1.130 -0.547
ENSG00000137942 E005 33.6881154 0.031447273 0.016928792 0.08519113 1 93499468 93499583 116 + 1.458 1.291 -0.581
ENSG00000137942 E006 26.0632216 0.012367836 0.004781707 0.03343453 1 93522082 93522135 54 + 1.355 1.171 -0.648
ENSG00000137942 E007 41.4757783 0.021999465 0.010971202 0.06224381 1 93523344 93523491 148 + 1.542 1.409 -0.456
ENSG00000137942 E008 31.1408046 0.018708563 0.007588142 0.04743406 1 93524261 93524323 63 + 1.426 1.247 -0.621
ENSG00000137942 E009 31.0774419 0.032204200 0.008258013 0.05051329 1 93529652 93529709 58 + 1.429 1.210 -0.763
ENSG00000137942 E010 31.4650256 0.013979716 0.058303266 0.19897582 1 93529710 93529756 47 + 1.416 1.340 -0.263
ENSG00000137942 E011 47.7872363 0.024569943 0.057849265 0.19797851 1 93530755 93530883 129 + 1.590 1.516 -0.251
ENSG00000137942 E012 51.8881572 0.020220516 0.120778937 0.31709103 1 93532922 93533068 147 + 1.618 1.584 -0.115
ENSG00000137942 E013 56.1167732 0.026843749 0.349973598 0.58719781 1 93534705 93534908 204 + 1.642 1.665 0.079
ENSG00000137942 E014 0.9475002 0.016194520 0.194548555   1 93536332 93536490 159 + 0.278 0.000 -10.836
ENSG00000137942 E015 0.3393995 0.027265619 1.000000000   1 93541042 93541056 15 + 0.114 0.000 -9.253
ENSG00000137942 E016 0.8048655 0.019615055 0.270503881   1 93543826 93544106 281 + 0.242 0.000 -10.573
ENSG00000137942 E017 41.9731351 0.013671228 0.862056701 0.93145864 1 93544107 93544216 110 + 1.505 1.605 0.343
ENSG00000137942 E018 50.3500731 0.006565625 0.757647490 0.87119994 1 93546842 93546974 133 + 1.586 1.670 0.287
ENSG00000137942 E019 46.4068733 0.011437072 0.266585464 0.50607938 1 93547347 93547441 95 + 1.526 1.718 0.653
ENSG00000137942 E020 52.7565187 0.005878011 0.469764279 0.67988055 1 93549278 93549426 149 + 1.609 1.665 0.189
ENSG00000137942 E021 45.5664071 0.001025800 0.061370699 0.20584536 1 93550947 93551045 99 + 1.565 1.546 -0.065
ENSG00000137942 E022 34.1355239 0.005768657 0.948352815 0.97646404 1 93551046 93551105 60 + 1.418 1.519 0.349
ENSG00000137942 E023 85.6874590 0.006354046 0.687258074 0.82734143 1 93551106 93552408 1303 + 1.806 1.923 0.396
ENSG00000137942 E024 241.6188142 1.661511517 0.357163878 0.59340255 1 93552409 93554661 2253 + 2.171 2.558 1.291