ENSG00000137822

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260383 ENSG00000137822 HEK293_OSMI2_6hA HEK293_TMG_6hB TUBGCP4 protein_coding protein_coding 15.47602 14.85558 20.63447 3.153623 0.7421173 0.4737797 2.8019760 1.693490 4.69169743 0.3927088 0.31698063 1.4646884 0.17562500 0.11423333 0.228766667 0.11453333 0.01719217 0.01719217 FALSE TRUE
ENST00000564079 ENSG00000137822 HEK293_OSMI2_6hA HEK293_TMG_6hB TUBGCP4 protein_coding protein_coding 15.47602 14.85558 20.63447 3.153623 0.7421173 0.4737797 10.0111038 9.721070 12.67878543 1.7450266 0.75599670 0.3828837 0.65218750 0.66766667 0.613433333 -0.05423333 0.78750679 0.01719217 FALSE TRUE
ENST00000565548 ENSG00000137822 HEK293_OSMI2_6hA HEK293_TMG_6hB TUBGCP4 protein_coding protein_coding 15.47602 14.85558 20.63447 3.153623 0.7421173 0.4737797 0.4365971 1.381474 0.06792114 0.6938738 0.06792114 -4.1584550 0.03160417 0.07843333 0.003533333 -0.07490000 0.48253005 0.01719217 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000137822 E001 0.1779838 0.0769495546 0.486219034   15 43369221 43369411 191 + 0.116 0.000 -8.949
ENSG00000137822 E002 0.0000000       15 43369601 43369702 102 +      
ENSG00000137822 E003 4.1667369 0.0891050142 0.822188810 0.90923433 15 43371073 43371100 28 + 0.696 0.732 0.148
ENSG00000137822 E004 130.4012331 0.0313497443 0.174490118 0.39649923 15 43371101 43371432 332 + 2.142 2.088 -0.179
ENSG00000137822 E005 111.3924597 0.0256509838 0.140902089 0.34889718 15 43376098 43376226 129 + 2.075 2.019 -0.188
ENSG00000137822 E006 1.9484950 0.0107403688 0.580619864 0.75758415 15 43376455 43376502 48 + 0.495 0.433 -0.314
ENSG00000137822 E007 71.9115615 0.0143217372 0.212910320 0.44519638 15 43376503 43376539 37 + 1.870 1.846 -0.081
ENSG00000137822 E008 92.9279450 0.0343716453 0.363951684 0.59899426 15 43376540 43376625 86 + 1.976 1.963 -0.045
ENSG00000137822 E009 94.4053443 0.0458451673 0.416824064 0.64123845 15 43377014 43377067 54 + 1.982 1.972 -0.034
ENSG00000137822 E010 0.1614157 0.0318893227 0.487185983   15 43377598 43377846 249 + 0.115 0.000 -8.945
ENSG00000137822 E011 93.9542115 0.0454019700 0.503805458 0.70343897 15 43377847 43377891 45 + 1.976 1.974 -0.007
ENSG00000137822 E012 66.0730648 0.0389787905 0.440057857 0.65877949 15 43377892 43377903 12 + 1.831 1.815 -0.054
ENSG00000137822 E013 113.9724282 0.0344035847 0.377538132 0.61027439 15 43380084 43380163 80 + 2.065 2.052 -0.046
ENSG00000137822 E014 199.7390195 0.0399201116 0.284308581 0.52481067 15 43383303 43383504 202 + 2.318 2.283 -0.116
ENSG00000137822 E015 1.1306456 0.0139455494 0.717800788   15 43385368 43385508 141 + 0.346 0.307 -0.243
ENSG00000137822 E016 162.6435357 0.0461374779 0.169276686 0.38963235 15 43385791 43385956 166 + 2.250 2.169 -0.270
ENSG00000137822 E017 128.3913400 0.0312045073 0.082590350 0.24988866 15 43386206 43386330 125 + 2.152 2.061 -0.305
ENSG00000137822 E018 1.6781285 0.0129717890 0.521339000 0.71579582 15 43394081 43395106 1026 + 0.346 0.485 0.759
ENSG00000137822 E019 101.6305663 0.0199375180 0.058659206 0.19975931 15 43395107 43395157 51 + 2.047 1.967 -0.268
ENSG00000137822 E020 1.0708357 0.0553923735 0.425855025   15 43395158 43395582 425 + 0.206 0.377 1.186
ENSG00000137822 E021 138.2243077 0.0252058368 0.271531219 0.51138436 15 43395583 43395688 106 + 2.154 2.130 -0.079
ENSG00000137822 E022 1.5865579 0.1118514574 0.666426499 0.81394776 15 43397210 43397213 4 + 0.451 0.374 -0.419
ENSG00000137822 E023 143.5364330 0.0130139728 0.059001750 0.20052542 15 43397214 43397321 108 + 2.182 2.133 -0.167
ENSG00000137822 E024 24.3773087 0.0083223469 0.012656741 0.06907275 15 43398038 43398040 3 + 1.470 1.320 -0.520
ENSG00000137822 E025 106.9915931 0.0009277585 0.004986905 0.03455429 15 43398041 43398129 89 + 2.056 2.005 -0.171
ENSG00000137822 E026 78.7239565 0.0006277566 0.007498156 0.04701866 15 43398130 43398179 50 + 1.929 1.869 -0.200
ENSG00000137822 E027 1.4818116 0.0126107629 0.094330619 0.27178427 15 43398180 43398383 204 + 0.495 0.227 -1.634
ENSG00000137822 E028 5.2338136 0.0055787374 0.591297088 0.76459987 15 43399112 43399174 63 + 0.745 0.855 0.434
ENSG00000137822 E029 121.0955244 0.0003887854 0.266553582 0.50604714 15 43400044 43400221 178 + 2.082 2.094 0.042
ENSG00000137822 E030 105.6207321 0.0009539994 0.006375016 0.04157224 15 43401716 43401805 90 + 1.951 2.099 0.496
ENSG00000137822 E031 70.5323652 0.0092316588 0.035598669 0.14318978 15 43401806 43401817 12 + 1.758 1.937 0.603
ENSG00000137822 E032 83.8558672 0.0397517407 0.197524230 0.42652083 15 43401818 43401850 33 + 1.846 2.004 0.534
ENSG00000137822 E033 26.8556584 0.0396665232 0.188077939 0.41449970 15 43401851 43403682 1832 + 1.492 1.385 -0.367
ENSG00000137822 E034 131.2342119 1.1217735045 0.400031045 0.62826083 15 43403683 43403799 117 + 1.992 2.229 0.795
ENSG00000137822 E035 3.7211648 0.1493991320 0.510263097 0.70817957 15 43403800 43403842 43 + 0.602 0.772 0.714
ENSG00000137822 E036 133.3774167 1.1562637339 0.459966134 0.67311373 15 43404413 43404552 140 + 2.028 2.216 0.630
ENSG00000137822 E037 365.6001004 1.5711214120 0.607499037 0.77523006 15 43405202 43406600 1399 + 2.514 2.612 0.326
ENSG00000137822 E038 873.9093976 0.1106341542 0.115200139 0.30778335 15 43406601 43409771 3171 + 2.834 3.036 0.672