ENSG00000137497

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393695 ENSG00000137497 HEK293_OSMI2_6hA HEK293_TMG_6hB NUMA1 protein_coding protein_coding 50.73834 77.32556 36.58685 9.138172 1.298586 -1.079413 7.826567 14.4732995 5.411807 2.4667652 0.2317115 -1.4175446 0.15036667 0.18506667 0.14806667 -0.03700000 0.5074372235 0.0003222491 FALSE TRUE
ENST00000540626 ENSG00000137497 HEK293_OSMI2_6hA HEK293_TMG_6hB NUMA1 protein_coding retained_intron 50.73834 77.32556 36.58685 9.138172 1.298586 -1.079413 7.379770 10.7243063 3.333575 0.4678568 0.2949590 -1.6827654 0.13040417 0.14346667 0.09153333 -0.05193333 0.4305372430 0.0003222491 FALSE TRUE
ENST00000541584 ENSG00000137497 HEK293_OSMI2_6hA HEK293_TMG_6hB NUMA1 protein_coding protein_coding 50.73834 77.32556 36.58685 9.138172 1.298586 -1.079413 4.725058 9.7568411 0.000000 4.4600396 0.0000000 -9.9317482 0.06964167 0.11510000 0.00000000 -0.11510000 0.0003222491 0.0003222491 FALSE TRUE
ENST00000545721 ENSG00000137497 HEK293_OSMI2_6hA HEK293_TMG_6hB NUMA1 protein_coding nonsense_mediated_decay 50.73834 77.32556 36.58685 9.138172 1.298586 -1.079413 3.497194 4.4167506 3.665562 1.3529412 0.3067776 -0.2682833 0.07560833 0.06330000 0.10083333 0.03753333 0.6239601887 0.0003222491 TRUE TRUE
ENST00000620566 ENSG00000137497 HEK293_OSMI2_6hA HEK293_TMG_6hB NUMA1 protein_coding protein_coding 50.73834 77.32556 36.58685 9.138172 1.298586 -1.079413 14.738972 25.2537777 8.334810 3.9771193 2.4776118 -1.5981193 0.28418750 0.32363333 0.22423333 -0.09940000 0.6080991935 0.0003222491 FALSE TRUE
MSTRG.5914.1 ENSG00000137497 HEK293_OSMI2_6hA HEK293_TMG_6hB NUMA1 protein_coding   50.73834 77.32556 36.58685 9.138172 1.298586 -1.079413 2.551086 3.3133315 2.101465 0.3406087 1.0618299 -0.6543856 0.05293750 0.04403333 0.05930000 0.01526667 0.9819029193 0.0003222491 FALSE TRUE
MSTRG.5914.7 ENSG00000137497 HEK293_OSMI2_6hA HEK293_TMG_6hB NUMA1 protein_coding   50.73834 77.32556 36.58685 9.138172 1.298586 -1.079413 3.263005 0.6898375 6.324159 0.6898375 0.8555252 3.1780612 0.08999583 0.01153333 0.17450000 0.16296667 0.0679615082 0.0003222491 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000137497 E001 1.3455559 0.0134189501 5.146098e-02   11 72002864 72002864 1 - 0.000 0.430 11.807
ENSG00000137497 E002 520.3828450 1.2760106666 3.159071e-01 5.559178e-01 11 72002865 72003263 399 - 2.381 2.759 1.259
ENSG00000137497 E003 739.5891422 1.3987403963 3.323453e-01 5.711294e-01 11 72003264 72003538 275 - 2.534 2.911 1.257
ENSG00000137497 E004 642.7815120 0.0032496421 1.127133e-08 5.221309e-07 11 72003887 72004099 213 - 2.579 2.831 0.838
ENSG00000137497 E005 445.6363473 0.0131181426 3.670175e-01 6.015230e-01 11 72004225 72004341 117 - 2.512 2.646 0.444
ENSG00000137497 E006 501.6102176 0.0171052874 9.640464e-01 9.839063e-01 11 72004640 72004816 177 - 2.605 2.683 0.259
ENSG00000137497 E007 201.5004603 0.0128517289 9.823126e-01 9.929020e-01 11 72005233 72005242 10 - 2.210 2.290 0.268
ENSG00000137497 E008 274.6443466 0.0123426077 4.570369e-01 6.710549e-01 11 72005243 72005285 43 - 2.310 2.435 0.415
ENSG00000137497 E009 320.2624013 0.0167311854 5.924883e-01 7.652500e-01 11 72005286 72005369 84 - 2.382 2.499 0.391
ENSG00000137497 E010 574.4966306 0.0246673177 9.687846e-01 9.862230e-01 11 72006035 72006263 229 - 2.663 2.742 0.263
ENSG00000137497 E011 602.7041941 0.0253805773 8.721350e-01 9.370876e-01 11 72007189 72007435 247 - 2.691 2.760 0.232
ENSG00000137497 E012 137.0431294 0.1154529860 1.289026e-01 3.300558e-01 11 72007436 72007925 490 - 2.202 2.049 -0.511
ENSG00000137497 E013 63.7604545 0.0861609185 4.855938e-02 1.763083e-01 11 72007926 72008091 166 - 1.906 1.701 -0.691
ENSG00000137497 E014 31.1780918 0.1179000156 5.049606e-01 7.042835e-01 11 72008092 72008145 54 - 1.478 1.464 -0.048
ENSG00000137497 E015 60.4366998 0.0980005631 1.719705e-01 3.931815e-01 11 72008146 72008437 292 - 1.827 1.712 -0.387
ENSG00000137497 E016 49.4856532 0.1391170428 1.736296e-01 3.953701e-01 11 72008438 72008687 250 - 1.756 1.619 -0.467
ENSG00000137497 E017 415.4863182 0.0341478252 7.267732e-01 8.522909e-01 11 72008688 72008845 158 - 2.495 2.611 0.385
ENSG00000137497 E018 461.3317544 0.0259824521 5.109242e-01 7.086582e-01 11 72008967 72009185 219 - 2.526 2.661 0.449
ENSG00000137497 E019 314.1058617 0.0293282098 7.972884e-01 8.947610e-01 11 72009268 72009387 120 - 2.383 2.487 0.346
ENSG00000137497 E020 288.6622163 0.0226782064 9.320448e-01 9.681488e-01 11 72010786 72010854 69 - 2.359 2.446 0.292
ENSG00000137497 E021 5.6961161 0.0466576861 2.853599e-01 5.259347e-01 11 72012259 72012400 142 - 0.870 0.753 -0.459
ENSG00000137497 E022 61.3437663 0.0011148428 2.286792e-02 1.055299e-01 11 72012401 72012442 42 - 1.622 1.810 0.637
ENSG00000137497 E023 2469.7144094 0.0005033871 5.566453e-04 6.191052e-03 11 72012895 72014947 2053 - 3.276 3.384 0.359
ENSG00000137497 E024 607.7188529 1.4967566593 5.728840e-01 7.522627e-01 11 72014948 72015428 481 - 2.660 2.776 0.386
ENSG00000137497 E025 886.9767437 1.6206340093 5.802554e-01 7.573414e-01 11 72015429 72016260 832 - 2.817 2.942 0.413
ENSG00000137497 E026 238.5268341 1.1620395163 5.342563e-01 7.251059e-01 11 72016408 72016530 123 - 2.255 2.371 0.388
ENSG00000137497 E027 9.6936101 0.0596884907 7.452650e-02 2.338732e-01 11 72016976 72017279 304 - 1.124 0.918 -0.755
ENSG00000137497 E028 10.6486108 0.3941571585 4.484523e-01 6.645623e-01 11 72017280 72017686 407 - 1.121 0.989 -0.483
ENSG00000137497 E029 266.8299974 1.2174718551 5.618109e-01 7.445697e-01 11 72017687 72017827 141 - 2.318 2.414 0.322
ENSG00000137497 E030 255.2449194 1.2146588091 5.850769e-01 7.603618e-01 11 72018183 72018300 118 - 2.315 2.389 0.248
ENSG00000137497 E031 243.4740271 0.0634111966 7.219788e-01 8.492665e-01 11 72018396 72018513 118 - 2.318 2.361 0.143
ENSG00000137497 E032 196.5936768 0.0694334562 9.417363e-01 9.731147e-01 11 72018823 72018902 80 - 2.254 2.258 0.013
ENSG00000137497 E033 188.3480987 1.1334610259 6.328112e-01 7.921654e-01 11 72018903 72018961 59 - 2.221 2.244 0.079
ENSG00000137497 E034 140.5280187 1.0004957701 5.898105e-01 7.635983e-01 11 72018962 72018980 19 - 2.073 2.126 0.178
ENSG00000137497 E035 188.7741431 0.0180874971 3.208909e-01 5.604832e-01 11 72019494 72019555 62 - 2.266 2.230 -0.121
ENSG00000137497 E036 168.4524302 0.0003195687 5.258791e-07 1.617576e-05 11 72019556 72019598 43 - 2.256 2.171 -0.285
ENSG00000137497 E037 124.7432593 0.0003847667 1.967831e-07 6.790958e-06 11 72019599 72019600 2 - 2.144 2.031 -0.379
ENSG00000137497 E038 138.7101022 0.0003120354 7.815472e-08 2.976557e-06 11 72019601 72019617 17 - 2.187 2.078 -0.366
ENSG00000137497 E039 129.7472594 0.0003133598 7.683723e-11 5.578764e-09 11 72021204 72021225 22 - 2.184 2.033 -0.504
ENSG00000137497 E040 214.2925514 0.0069188298 8.793809e-06 1.877535e-04 11 72021226 72021291 66 - 2.389 2.247 -0.472
ENSG00000137497 E041 1.9694323 0.3701501285 2.469224e-01 4.845946e-01 11 72022202 72022338 137 - 0.607 0.353 -1.276
ENSG00000137497 E042 164.2180317 0.0202335828 1.179707e-02 6.562758e-02 11 72022339 72022382 44 - 2.254 2.142 -0.375
ENSG00000137497 E043 148.2973938 0.0109581576 6.760803e-04 7.235111e-03 11 72022383 72022419 37 - 2.220 2.094 -0.422
ENSG00000137497 E044 138.5357890 0.0182015540 1.480672e-03 1.347836e-02 11 72023065 72023081 17 - 2.208 2.054 -0.515
ENSG00000137497 E045 143.3708415 0.0172561023 5.325838e-04 5.973120e-03 11 72023082 72023107 26 - 2.232 2.063 -0.567
ENSG00000137497 E046 125.0275568 0.0159103105 4.522077e-04 5.241691e-03 11 72023108 72023129 22 - 2.173 2.004 -0.567
ENSG00000137497 E047 115.4350320 0.0178060674 6.138878e-05 9.925007e-04 11 72023130 72023137 8 - 2.168 1.951 -0.727
ENSG00000137497 E048 117.8223204 0.0121185037 5.034023e-05 8.368176e-04 11 72023138 72023147 10 - 2.155 1.974 -0.605
ENSG00000137497 E049 0.3751086 0.0298955191 6.629948e-01   11 72024071 72024273 203 - 0.000 0.153 11.876
ENSG00000137497 E050 120.9807162 0.0089832993 1.937387e-06 5.075792e-05 11 72024274 72024298 25 - 2.177 1.979 -0.663
ENSG00000137497 E051 104.6441173 0.0043669842 3.526346e-11 2.742008e-09 11 72024299 72024304 6 - 2.144 1.897 -0.830
ENSG00000137497 E052 105.2057775 0.0011206725 1.432592e-17 3.079584e-15 11 72024305 72024312 8 - 2.156 1.895 -0.875
ENSG00000137497 E053 167.6918704 0.0049400848 2.493318e-08 1.070331e-06 11 72024313 72024353 41 - 2.306 2.131 -0.585
ENSG00000137497 E054 0.0000000       11 72024354 72024850 497 -      
ENSG00000137497 E055 189.7331667 0.0060875831 6.975923e-06 1.534152e-04 11 72029205 72029290 86 - 2.337 2.199 -0.460
ENSG00000137497 E056 173.9629833 0.0049386927 2.046867e-03 1.737591e-02 11 72035902 72035975 74 - 2.257 2.185 -0.241
ENSG00000137497 E057 0.1426347 0.0310335951 1.732012e-01   11 72035976 72035987 12 - 0.174 0.000 -12.862
ENSG00000137497 E058 0.0000000       11 72039735 72039825 91 -      
ENSG00000137497 E059 0.2922838 0.0258299668 4.635258e-01   11 72040605 72040958 354 - 0.174 0.083 -1.226
ENSG00000137497 E060 13.2819834 0.1174731075 2.429288e-01 4.798979e-01 11 72040959 72041146 188 - 1.221 1.065 -0.558
ENSG00000137497 E061 0.2617363 0.1007235097 7.129933e-01   11 72041428 72041525 98 - 0.000 0.151 11.350
ENSG00000137497 E062 0.0000000       11 72041722 72041822 101 -      
ENSG00000137497 E063 0.3337900 0.0312719169 4.682545e-01   11 72041823 72042142 320 - 0.174 0.083 -1.222
ENSG00000137497 E064 15.3042392 0.0023906877 2.838985e-01 5.243577e-01 11 72049419 72049539 121 - 1.212 1.173 -0.135
ENSG00000137497 E065 0.9214940 0.0737243760 5.766179e-01   11 72050662 72050833 172 - 0.174 0.312 1.097
ENSG00000137497 E066 0.8818932 0.0320516562 5.504697e-01   11 72062589 72062686 98 - 0.298 0.214 -0.628
ENSG00000137497 E067 1.2802947 0.0131217516 1.734029e-01   11 72065199 72068078 2880 - 0.473 0.266 -1.224
ENSG00000137497 E068 0.9103477 0.0161284247 5.657267e-01   11 72068079 72068104 26 - 0.174 0.313 1.097
ENSG00000137497 E069 7.9314583 0.0045090974 8.152646e-01 9.053714e-01 11 72068105 72068231 127 - 0.897 0.924 0.100
ENSG00000137497 E070 1.8275900 0.0108300453 9.838368e-01 9.937261e-01 11 72068496 72068617 122 - 0.394 0.430 0.193
ENSG00000137497 E071 120.7906794 0.0125715290 1.694171e-01 3.898167e-01 11 72069842 72069911 70 - 2.079 2.036 -0.142
ENSG00000137497 E072 0.4054685 0.6140582182 8.360635e-01   11 72069912 72070093 182 - 0.000 0.162 10.795
ENSG00000137497 E073 0.1308682 0.0308074035 1.000000e+00   11 72076568 72076757 190 - 0.000 0.083 10.859
ENSG00000137497 E074 18.1182194 0.1561004125 4.220647e-01 6.451977e-01 11 72080320 72080457 138 - 1.151 1.277 0.448
ENSG00000137497 E075 87.5692922 0.6167374502 5.840511e-01 7.596972e-01 11 72080458 72080693 236 - 1.891 1.915 0.082