ENSG00000137337

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376406 ENSG00000137337 HEK293_OSMI2_6hA HEK293_TMG_6hB MDC1 protein_coding protein_coding 50.87679 70.25734 35.06245 6.416612 1.299691 -1.002516 24.889855 33.391220 20.7722352 4.3374548 0.72093696 -0.6845500 0.50276667 0.47166667 0.59260000 0.12093333 6.613235e-02 4.995087e-11 FALSE TRUE
ENST00000489540 ENSG00000137337 HEK293_OSMI2_6hA HEK293_TMG_6hB MDC1 protein_coding retained_intron 50.87679 70.25734 35.06245 6.416612 1.299691 -1.002516 7.864299 8.591405 1.3146869 0.5050168 0.07194132 -2.6989210 0.13015833 0.12376667 0.03773333 -0.08603333 9.577369e-07 4.995087e-11 TRUE TRUE
MSTRG.27993.12 ENSG00000137337 HEK293_OSMI2_6hA HEK293_TMG_6hB MDC1 protein_coding   50.87679 70.25734 35.06245 6.416612 1.299691 -1.002516 1.697777 2.159627 3.1691633 0.6544255 0.64234580 0.5512001 0.03734583 0.03076667 0.09023333 0.05946667 1.408933e-01 4.995087e-11 FALSE TRUE
MSTRG.27993.31 ENSG00000137337 HEK293_OSMI2_6hA HEK293_TMG_6hB MDC1 protein_coding   50.87679 70.25734 35.06245 6.416612 1.299691 -1.002516 1.754222 4.899507 0.3649112 0.6058774 0.36491124 -3.7109573 0.03096667 0.06933333 0.01006667 -0.05926667 1.572974e-01 4.995087e-11 FALSE TRUE
MSTRG.27993.52 ENSG00000137337 HEK293_OSMI2_6hA HEK293_TMG_6hB MDC1 protein_coding   50.87679 70.25734 35.06245 6.416612 1.299691 -1.002516 2.360118 4.325947 0.0000000 1.2105319 0.00000000 -8.7602032 0.03747500 0.05933333 0.00000000 -0.05933333 1.130922e-10 4.995087e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000137337 E001 349.160923 0.0049694320 4.022677e-04 4.753140e-03 6 30699807 30700058 252 - 2.389 2.558 0.564
ENSG00000137337 E002 289.510854 0.0036874392 1.676850e-07 5.901923e-06 6 30700059 30700149 91 - 2.264 2.490 0.756
ENSG00000137337 E003 134.895248 0.0045402810 2.917208e-06 7.258739e-05 6 30700150 30700150 1 - 1.914 2.167 0.847
ENSG00000137337 E004 153.292565 0.0050271219 4.737965e-06 1.098151e-04 6 30700151 30700173 23 - 1.972 2.219 0.827
ENSG00000137337 E005 146.848071 0.0054538511 2.831477e-07 9.371467e-06 6 30700174 30700185 12 - 1.924 2.207 0.951
ENSG00000137337 E006 143.052934 0.0055159954 3.874536e-05 6.706474e-04 6 30700186 30700210 25 - 1.953 2.186 0.780
ENSG00000137337 E007 111.613060 0.0172268736 9.120275e-02 2.658894e-01 6 30700211 30700211 1 - 1.905 2.061 0.525
ENSG00000137337 E008 143.530765 0.0199308372 3.977591e-02 1.541529e-01 6 30700212 30700256 45 - 1.987 2.178 0.641
ENSG00000137337 E009 146.528835 0.0056863559 1.215784e-04 1.756577e-03 6 30700257 30700293 37 - 1.976 2.194 0.729
ENSG00000137337 E010 107.099605 0.0083062539 3.015152e-04 3.745462e-03 6 30700294 30700296 3 - 1.822 2.065 0.816
ENSG00000137337 E011 111.896670 0.0094620458 1.357933e-03 1.259466e-02 6 30700297 30700297 1 - 1.857 2.080 0.750
ENSG00000137337 E012 111.718066 0.0081961575 5.479573e-04 6.111635e-03 6 30700298 30700298 1 - 1.851 2.081 0.772
ENSG00000137337 E013 136.425383 0.0062573978 6.824338e-04 7.291617e-03 6 30700299 30700311 13 - 1.957 2.160 0.682
ENSG00000137337 E014 141.449261 0.0055996200 1.692100e-03 1.496762e-02 6 30700312 30700314 3 - 1.989 2.171 0.610
ENSG00000137337 E015 741.902782 0.0026758653 2.275648e-07 7.719750e-06 6 30700315 30700632 318 - 2.713 2.886 0.575
ENSG00000137337 E016 463.875467 0.0001474267 3.070469e-30 2.471262e-27 6 30702553 30702663 111 - 2.455 2.701 0.820
ENSG00000137337 E017 478.458666 0.0361051221 1.080164e-03 1.053268e-02 6 30702752 30702877 126 - 2.415 2.724 1.028
ENSG00000137337 E018 507.252068 0.1016815375 2.869904e-02 1.234581e-01 6 30703104 30703286 183 - 2.439 2.749 1.033
ENSG00000137337 E019 451.627159 0.0018740497 3.272102e-09 1.708202e-07 6 30703418 30703537 120 - 2.487 2.675 0.626
ENSG00000137337 E020 7.306252 0.0727000049 5.588045e-01 7.424023e-01 6 30703538 30703620 83 - 0.934 0.862 -0.274
ENSG00000137337 E021 1082.402542 0.0001025334 3.008272e-06 7.450399e-05 6 30703621 30704183 563 - 2.950 3.028 0.261
ENSG00000137337 E022 307.657247 0.0008610273 3.177592e-02 1.325485e-01 6 30704184 30704251 68 - 2.405 2.481 0.253
ENSG00000137337 E023 178.878892 0.0031654916 3.207579e-01 5.603545e-01 6 30704252 30704266 15 - 2.238 2.218 -0.067
ENSG00000137337 E024 327.313553 0.0003557666 7.687450e-02 2.385404e-01 6 30704267 30704374 108 - 2.499 2.480 -0.063
ENSG00000137337 E025 141.365869 0.0008881485 2.318533e-04 3.021798e-03 6 30704375 30704389 15 - 2.194 2.091 -0.343
ENSG00000137337 E026 304.048779 0.0078047918 5.513753e-01 7.372755e-01 6 30704390 30704497 108 - 2.461 2.449 -0.040
ENSG00000137337 E027 230.982830 0.0002808284 1.720942e-05 3.362738e-04 6 30704498 30704568 71 - 2.393 2.306 -0.291
ENSG00000137337 E028 167.199733 0.0032749708 6.988321e-09 3.393702e-07 6 30704569 30704620 52 - 2.324 2.121 -0.678
ENSG00000137337 E029 260.312209 0.0026501076 3.684102e-03 2.738881e-02 6 30704621 30704691 71 - 2.438 2.360 -0.260
ENSG00000137337 E030 274.462496 0.0012688398 1.283986e-02 6.977965e-02 6 30704692 30704766 75 - 2.440 2.392 -0.163
ENSG00000137337 E031 312.627288 0.0029285583 9.101359e-03 5.427990e-02 6 30704767 30704866 100 - 2.508 2.441 -0.224
ENSG00000137337 E032 416.412845 0.0007499359 6.014504e-02 2.031547e-01 6 30704867 30705012 146 - 2.604 2.582 -0.076
ENSG00000137337 E033 315.021392 0.0001658724 8.794259e-03 5.292231e-02 6 30705013 30705112 100 - 2.494 2.458 -0.119
ENSG00000137337 E034 333.895465 0.0014543308 3.492403e-03 2.629529e-02 6 30705113 30705235 123 - 2.535 2.475 -0.200
ENSG00000137337 E035 289.469721 0.0020205874 7.280236e-07 2.155703e-05 6 30705236 30705381 146 - 2.518 2.387 -0.435
ENSG00000137337 E036 190.778776 0.0002546118 8.730408e-08 3.285230e-06 6 30705382 30705447 66 - 2.333 2.208 -0.416
ENSG00000137337 E037 144.097012 0.0013460291 4.384995e-09 2.227559e-07 6 30705448 30705481 34 - 2.246 2.063 -0.611
ENSG00000137337 E038 136.919679 0.0005005398 5.974919e-09 2.935142e-07 6 30705482 30705504 23 - 2.216 2.048 -0.561
ENSG00000137337 E039 280.721790 0.0012441911 1.960970e-02 9.458582e-02 6 30705505 30705581 77 - 2.451 2.406 -0.150
ENSG00000137337 E040 180.174086 0.0002592991 6.282336e-12 5.621102e-10 6 30705582 30705627 46 - 2.337 2.168 -0.567
ENSG00000137337 E041 297.949697 0.0043079550 9.827181e-02 2.787415e-01 6 30705628 30705727 100 - 2.475 2.429 -0.154
ENSG00000137337 E042 154.230779 0.0124626686 2.745321e-02 1.196601e-01 6 30705728 30705750 23 - 2.235 2.118 -0.392
ENSG00000137337 E043 338.457250 0.0068765782 1.090384e-01 2.974606e-01 6 30705751 30705937 187 - 2.534 2.482 -0.174
ENSG00000137337 E044 246.244168 0.0055172202 8.123343e-01 9.036355e-01 6 30705938 30706098 161 - 2.353 2.364 0.035
ENSG00000137337 E045 174.242588 0.0024664053 8.333274e-01 9.156300e-01 6 30707384 30707454 71 - 2.202 2.213 0.039
ENSG00000137337 E046 28.662974 0.2402028915 5.183850e-01 7.139508e-01 6 30707455 30707565 111 - 1.445 1.439 -0.020
ENSG00000137337 E047 575.914640 0.0049868752 9.027071e-04 9.115764e-03 6 30707566 30708135 570 - 2.797 2.694 -0.343
ENSG00000137337 E048 383.656229 0.0025769581 1.827812e-06 4.818183e-05 6 30708136 30708357 222 - 2.636 2.509 -0.420
ENSG00000137337 E049 216.732792 0.0003530172 2.750618e-02 1.198108e-01 6 30711412 30711471 60 - 2.332 2.294 -0.127
ENSG00000137337 E050 159.583625 0.0005163547 2.809563e-01 5.212126e-01 6 30711472 30711501 30 - 2.184 2.171 -0.045
ENSG00000137337 E051 87.970567 0.0017136927 6.333625e-01 7.925363e-01 6 30711502 30711504 3 - 1.917 1.916 -0.004
ENSG00000137337 E052 197.307735 0.0005706509 1.379522e-01 3.443846e-01 6 30711667 30711726 60 - 2.280 2.258 -0.073
ENSG00000137337 E053 1394.881427 0.0463154640 9.849786e-01 9.943114e-01 6 30711874 30713354 1481 - 3.119 3.110 -0.030
ENSG00000137337 E054 176.300497 0.0003136258 1.681621e-10 1.140032e-08 6 30713648 30713717 70 - 2.320 2.161 -0.534
ENSG00000137337 E055 148.694717 0.0005279504 1.294489e-07 4.685295e-06 6 30713803 30713832 30 - 2.239 2.093 -0.488
ENSG00000137337 E056 245.444938 0.0033110280 4.436220e-05 7.518685e-04 6 30713833 30713939 107 - 2.443 2.316 -0.425
ENSG00000137337 E057 165.741370 0.0038676122 6.033651e-04 6.608530e-03 6 30713940 30713979 40 - 2.270 2.147 -0.410
ENSG00000137337 E058 315.596125 0.0001877576 3.578006e-13 4.000182e-11 6 30713980 30714183 204 - 2.557 2.424 -0.445
ENSG00000137337 E059 204.316553 0.0004019180 7.031683e-11 5.133884e-09 6 30715040 30715178 139 - 2.384 2.231 -0.512
ENSG00000137337 E060 9.836174 0.2403107872 6.096470e-01 7.766731e-01 6 30716882 30717083 202 - 1.096 0.960 -0.500
ENSG00000137337 E061 19.704776 0.0023799317 2.229098e-02 1.035682e-01 6 30717084 30717244 161 - 1.122 1.346 0.789
ENSG00000137337 E062 62.999180 0.0007197583 2.968400e-05 5.349137e-04 6 30717245 30717248 4 - 1.891 1.719 -0.582
ENSG00000137337 E063 71.928173 0.0008490575 1.959159e-06 5.124926e-05 6 30717249 30717901 653 - 1.957 1.769 -0.634
ENSG00000137337 E064 3.617824 0.0329478033 5.148026e-01 7.115154e-01 6 30720101 30720563 463 - 0.719 0.630 -0.372