ENSG00000137309

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311487 ENSG00000137309 HEK293_OSMI2_6hA HEK293_TMG_6hB HMGA1 protein_coding protein_coding 271.6572 416.0988 139.1895 98.4063 4.854671 -1.579806 147.85064 239.26396 61.6314239 55.705638 3.9582829 -1.9566913 0.54129167 0.57673333 0.442766667 -0.13396667 1.948346e-02 1.446278e-05 FALSE FALSE
ENST00000347617 ENSG00000137309 HEK293_OSMI2_6hA HEK293_TMG_6hB HMGA1 protein_coding protein_coding 271.6572 416.0988 139.1895 98.4063 4.854671 -1.579806 15.39702 24.90421 5.8105774 8.631346 1.5136666 -2.0977345 0.05194167 0.05576667 0.042066667 -0.01370000 8.182770e-01 1.446278e-05   FALSE
ENST00000401473 ENSG00000137309 HEK293_OSMI2_6hA HEK293_TMG_6hB HMGA1 protein_coding protein_coding 271.6572 416.0988 139.1895 98.4063 4.854671 -1.579806 21.20142 37.67545 0.3783036 15.477019 0.3783036 -6.6006788 0.08010833 0.07943333 0.002566667 -0.07686667 3.495243e-02 1.446278e-05   FALSE
ENST00000478214 ENSG00000137309 HEK293_OSMI2_6hA HEK293_TMG_6hB HMGA1 protein_coding processed_transcript 271.6572 416.0988 139.1895 98.4063 4.854671 -1.579806 31.83379 44.68243 30.7159377 3.769893 2.8523984 -0.5405734 0.11595417 0.11970000 0.221100000 0.10140000 2.224805e-01 1.446278e-05 FALSE FALSE
MSTRG.28154.1 ENSG00000137309 HEK293_OSMI2_6hA HEK293_TMG_6hB HMGA1 protein_coding   271.6572 416.0988 139.1895 98.4063 4.854671 -1.579806 37.21898 42.88504 32.6104659 10.014244 3.4912771 -0.3950334 0.14194167 0.10320000 0.233600000 0.13040000 1.446278e-05 1.446278e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000137309 E001 7.359947 2.376156e-02 5.113770e-01 7.090082e-01 6 34236845 34236869 25 + 0.765 0.891 0.490
ENSG00000137309 E002 12.260482 2.980083e-03 2.945936e-01 5.351587e-01 6 34236870 34236872 3 + 0.946 1.086 0.514
ENSG00000137309 E003 478.639897 8.464698e-03 1.470695e-07 5.244810e-06 6 34236873 34236963 91 + 2.357 2.648 0.969
ENSG00000137309 E004 101.423341 4.904317e-04 1.056967e-09 6.142959e-08 6 34236964 34237203 240 + 1.670 1.987 1.069
ENSG00000137309 E005 1013.665873 1.533468e-03 6.558009e-20 1.916869e-17 6 34237204 34237317 114 + 2.731 2.966 0.782
ENSG00000137309 E006 19.980833 5.468398e-02 1.353854e-02 7.251253e-02 6 34238791 34238957 167 + 1.486 1.141 -1.207
ENSG00000137309 E007 2277.851164 1.950621e-04 6.058144e-04 6.628945e-03 6 34240737 34240882 146 + 3.238 3.288 0.164
ENSG00000137309 E008 1230.990117 3.419451e-04 4.326804e-03 3.097377e-02 6 34240883 34240915 33 + 3.033 3.003 -0.100
ENSG00000137309 E009 2.171719 1.766600e-01 5.991570e-01 7.696482e-01 6 34241405 34241449 45 + 0.345 0.465 0.661
ENSG00000137309 E010 1237.925343 2.347709e-04 3.501254e-05 6.155848e-04 6 34242712 34242714 3 + 3.046 3.003 -0.144
ENSG00000137309 E011 2316.357234 5.048521e-05 9.734085e-12 8.374223e-10 6 34242715 34242795 81 + 3.321 3.277 -0.146
ENSG00000137309 E012 1893.091904 5.814315e-05 3.414905e-09 1.775113e-07 6 34243468 34243518 51 + 3.232 3.190 -0.139
ENSG00000137309 E013 22.277099 1.097510e-01 2.093220e-01 4.410739e-01 6 34243616 34243951 336 + 1.451 1.227 -0.780
ENSG00000137309 E014 10216.867010 5.249382e-04 8.196015e-01 9.078719e-01 6 34244831 34246293 1463 + 3.921 3.929 0.025