ENSG00000137145

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361024 ENSG00000137145 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND4C protein_coding protein_coding 4.914302 1.826825 9.467172 0.3881638 0.07754506 2.367243 0.5132799 0.778453045 0.4957585 0.234300210 0.49575846 -0.6405763 0.26265000 0.406000000 0.05216667 -0.35383333 0.1083096003 0.0008903627 FALSE TRUE
ENST00000380427 ENSG00000137145 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND4C protein_coding protein_coding 4.914302 1.826825 9.467172 0.3881638 0.07754506 2.367243 0.1256741 0.148115834 0.0000000 0.148115834 0.00000000 -3.9829099 0.04724167 0.064300000 0.00000000 -0.06430000 0.6404373274 0.0008903627 FALSE TRUE
ENST00000434457 ENSG00000137145 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND4C protein_coding protein_coding 4.914302 1.826825 9.467172 0.3881638 0.07754506 2.367243 3.4600908 0.676569181 7.6152397 0.075735001 0.23279605 3.4733057 0.53013750 0.402266667 0.80446667 0.40220000 0.0008903627 0.0008903627 FALSE TRUE
ENST00000602925 ENSG00000137145 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND4C protein_coding protein_coding 4.914302 1.826825 9.467172 0.3881638 0.07754506 2.367243 0.2907505 0.009976249 0.3101654 0.009976249 0.02674926 4.0024597 0.05386667 0.009433333 0.03280000 0.02336667 0.3043846864 0.0008903627 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000137145 E001 0.6356275 0.0244375659 5.756716e-01   9 19230435 19230692 258 + 0.140 0.260 1.099
ENSG00000137145 E002 6.0178776 0.0263156976 4.825718e-01 6.887747e-01 9 19230693 19230796 104 + 0.726 0.630 -0.402
ENSG00000137145 E003 9.9739782 0.0038750767 1.964283e-01 4.250786e-01 9 19230797 19230833 37 + 0.923 0.771 -0.591
ENSG00000137145 E004 43.4164732 0.0012684133 6.193613e-05 9.999221e-04 9 19276158 19276479 322 + 1.525 1.218 -1.064
ENSG00000137145 E005 0.0000000       9 19276480 19276671 192 +      
ENSG00000137145 E006 39.9021893 0.0009871101 3.501149e-07 1.130802e-05 9 19286769 19287021 253 + 1.497 1.034 -1.634
ENSG00000137145 E007 16.5186070 0.0020733906 1.122631e-03 1.083908e-02 9 19288596 19288665 70 + 1.134 0.706 -1.626
ENSG00000137145 E008 14.0358138 0.0028093417 7.048988e-03 4.485463e-02 9 19290704 19290757 54 + 1.064 0.706 -1.374
ENSG00000137145 E009 20.8770329 0.0016575994 2.386335e-02 1.086777e-01 9 19290758 19290876 119 + 1.215 0.999 -0.779
ENSG00000137145 E010 37.1637560 0.0010324377 1.476293e-01 3.588982e-01 9 19296008 19296246 239 + 1.435 1.363 -0.251
ENSG00000137145 E011 29.4951339 0.0037235387 1.277393e-01 3.282552e-01 9 19298056 19298122 67 + 1.341 1.239 -0.356
ENSG00000137145 E012 26.2133451 0.0136403215 6.480767e-02 2.134692e-01 9 19299229 19299287 59 + 1.299 1.123 -0.621
ENSG00000137145 E013 29.7052089 0.0014755722 1.097723e-01 2.986664e-01 9 19300187 19300331 145 + 1.343 1.239 -0.364
ENSG00000137145 E014 28.7558856 0.0032763337 9.299436e-02 2.692925e-01 9 19305352 19305527 176 + 1.337 1.218 -0.417
ENSG00000137145 E015 28.0243730 0.0015287968 3.509598e-01 5.881101e-01 9 19316417 19316517 101 + 1.317 1.278 -0.136
ENSG00000137145 E016 43.6375696 0.0008471023 5.789812e-02 1.980748e-01 9 19316621 19316839 219 + 1.506 1.407 -0.343
ENSG00000137145 E017 31.7886305 0.0014941838 7.330588e-02 2.314297e-01 9 19324362 19324507 146 + 1.376 1.259 -0.409
ENSG00000137145 E018 19.2638401 0.0022198451 1.778963e-01 4.009802e-01 9 19325939 19325974 36 + 1.172 1.065 -0.386
ENSG00000137145 E019 31.1581663 0.0026841680 2.801994e-01 5.203431e-01 9 19326064 19326194 131 + 1.364 1.314 -0.176
ENSG00000137145 E020 32.1501214 0.0038889806 5.378029e-01 7.275202e-01 9 19328030 19328162 133 + 1.371 1.362 -0.029
ENSG00000137145 E021 35.7854990 0.0024862544 8.954921e-01 9.494912e-01 9 19331978 19332184 207 + 1.400 1.459 0.203
ENSG00000137145 E022 0.0000000       9 19332185 19332188 4 +      
ENSG00000137145 E023 21.7052003 0.0029039381 5.806444e-01 7.576045e-01 9 19334977 19335105 129 + 1.205 1.196 -0.035
ENSG00000137145 E024 34.8434423 0.0019451712 4.770356e-01 6.850008e-01 9 19336270 19336403 134 + 1.404 1.392 -0.040
ENSG00000137145 E025 21.0052892 0.0024816899 3.468335e-01 5.844134e-01 9 19336404 19336414 11 + 1.202 1.148 -0.191
ENSG00000137145 E026 3.1674727 0.0075204698 2.434343e-01 4.804796e-01 9 19336415 19336685 271 + 0.464 0.706 1.097
ENSG00000137145 E027 42.8012598 0.0009129148 5.951400e-01 7.671230e-01 9 19336686 19336832 147 + 1.485 1.494 0.032
ENSG00000137145 E028 1.2397840 0.0163989059 8.723304e-01   9 19337601 19337672 72 + 0.277 0.259 -0.128
ENSG00000137145 E029 42.4008194 0.0008933024 3.385757e-01 5.767212e-01 9 19340992 19341114 123 + 1.483 1.459 -0.084
ENSG00000137145 E030 22.5632734 0.0014799883 4.753582e-01 6.837528e-01 9 19342633 19342668 36 + 1.222 1.196 -0.092
ENSG00000137145 E031 39.1570049 0.0010938559 9.396119e-01 9.720256e-01 9 19342669 19342779 111 + 1.441 1.495 0.184
ENSG00000137145 E032 114.5024367 0.0004046090 4.062249e-02 1.563714e-01 9 19345921 19346555 635 + 1.910 1.863 -0.158
ENSG00000137145 E033 46.2591976 0.0012559760 4.604625e-02 1.701454e-01 9 19346556 19346727 172 + 1.527 1.421 -0.365
ENSG00000137145 E034 66.8940783 0.0006339866 1.182063e-01 3.129007e-01 9 19346728 19347086 359 + 1.678 1.630 -0.162
ENSG00000137145 E035 50.9310386 0.0020872329 8.277164e-01 9.124719e-01 9 19350702 19350879 178 + 1.552 1.586 0.115
ENSG00000137145 E036 40.0556655 0.0009589394 6.288817e-01 7.897483e-01 9 19352073 19352182 110 + 1.443 1.527 0.288
ENSG00000137145 E037 42.6849858 0.0136926546 2.839786e-01 5.244418e-01 9 19352490 19352665 176 + 1.465 1.608 0.490
ENSG00000137145 E038 50.2628666 0.0007814830 8.567949e-02 2.558303e-01 9 19356972 19357154 183 + 1.527 1.685 0.538
ENSG00000137145 E039 3.1953637 0.2404050622 1.519333e-01 3.651487e-01 9 19357155 19357695 541 + 0.441 0.814 1.648
ENSG00000137145 E040 45.9530388 0.0008463444 1.051000e-03 1.030210e-02 9 19357965 19358160 196 + 1.470 1.727 0.874
ENSG00000137145 E041 58.0177707 0.0009074554 4.567243e-02 1.691874e-01 9 19360244 19360489 246 + 1.585 1.753 0.569
ENSG00000137145 E042 41.3701644 0.0012332038 3.153763e-01 5.553981e-01 9 19361846 19361963 118 + 1.447 1.568 0.413
ENSG00000137145 E043 44.1638775 0.0416938752 5.087995e-01 7.070104e-01 9 19369837 19369987 151 + 1.477 1.598 0.413
ENSG00000137145 E044 23.0154461 0.7454034230 3.388491e-01 5.769761e-01 9 19371756 19371820 65 + 1.180 1.445 0.927
ENSG00000137145 E045 252.9079344 0.0168299482 3.914126e-05 6.759977e-04 9 19372037 19374281 2245 + 2.190 2.480 0.970