ENSG00000136928

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000259455 ENSG00000136928 HEK293_OSMI2_6hA HEK293_TMG_6hB GABBR2 protein_coding protein_coding 2.560064 2.089768 1.936403 0.1782373 0.1884186 -0.1094191 2.2880703 2.089768 1.5192516 0.1782373 0.2127115 -0.4574038 0.90859167 1 0.7837333 -0.2162667 0.0009292548 0.0009292548 FALSE TRUE
ENST00000637410 ENSG00000136928 HEK293_OSMI2_6hA HEK293_TMG_6hB GABBR2 protein_coding processed_transcript 2.560064 2.089768 1.936403 0.1782373 0.1884186 -0.1094191 0.1679503 0.000000 0.3346729 0.0000000 0.1836865 5.1071561 0.05473333 0 0.1744000 0.1744000 0.2879110857 0.0009292548 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000136928 E001 136.6535921 1.222816853 0.31379158 0.55400769 9 98288109 98290646 2538 - 1.889 2.277 1.300
ENSG00000136928 E002 9.7421025 0.116204000 0.03262758 0.13504871 9 98290647 98290749 103 - 0.751 1.186 1.628
ENSG00000136928 E003 12.0935788 0.003110112 0.42027084 0.64383436 9 98293785 98293902 118 - 1.024 1.193 0.611
ENSG00000136928 E004 14.1174539 0.002188927 0.99663130 0.99999951 9 98299224 98299353 130 - 1.124 1.218 0.336
ENSG00000136928 E005 0.1426347 0.032649190 0.34914632   9 98302843 98302896 54 - 0.128 0.000 -17.964
ENSG00000136928 E006 12.4190870 0.002928295 0.53740742 0.72723939 9 98303241 98303329 89 - 1.113 1.148 0.128
ENSG00000136928 E007 14.1921219 0.031301245 0.28625665 0.52691839 9 98303330 98303423 94 - 1.187 1.163 -0.086
ENSG00000136928 E008 0.3040503 0.024441170 0.12184827   9 98304178 98304289 112 - 0.226 0.000 -18.964
ENSG00000136928 E009 12.9593883 0.003599217 0.04148651 0.15859007 9 98306121 98306213 93 - 1.186 1.089 -0.348
ENSG00000136928 E010 14.7191509 0.012447426 0.53013693 0.72217096 9 98306214 98306345 132 - 1.167 1.204 0.132
ENSG00000136928 E011 0.1614157 0.034108243 0.34709044   9 98306346 98306571 226 - 0.128 0.000 -17.966
ENSG00000136928 E012 13.1413406 0.003312200 0.91656115 0.96045094 9 98311095 98311205 111 - 1.101 1.185 0.301
ENSG00000136928 E013 0.0000000       9 98362555 98362714 160 -      
ENSG00000136928 E014 14.0193149 0.002714420 0.59427989 0.76652584 9 98362715 98362837 123 - 1.156 1.202 0.162
ENSG00000136928 E015 17.1825997 0.002209616 0.70753676 0.84026503 9 98371464 98371571 108 - 1.186 1.312 0.441
ENSG00000136928 E016 0.0000000       9 98375151 98375307 157 -      
ENSG00000136928 E017 17.8814721 0.002622160 0.04021975 0.15526093 9 98385640 98385772 133 - 1.311 1.242 -0.244
ENSG00000136928 E018 18.2432451 0.003143919 0.12989890 0.33167675 9 98388854 98389004 151 - 1.289 1.264 -0.088
ENSG00000136928 E019 12.5649569 0.007163609 0.43034947 0.65135690 9 98394175 98394255 81 - 1.113 1.131 0.066
ENSG00000136928 E020 10.5525722 0.043227229 0.14116401 0.34925461 9 98406081 98406141 61 - 1.102 1.011 -0.332
ENSG00000136928 E021 14.0187256 0.011852244 0.06164143 0.20649157 9 98453981 98454163 183 - 1.223 1.138 -0.302
ENSG00000136928 E022 9.0598044 0.004213484 0.52626320 0.71938295 9 98454164 98454217 54 - 0.995 1.018 0.085
ENSG00000136928 E023 10.6360350 0.013303625 0.05060722 0.18110358 9 98473146 98473229 84 - 1.124 1.006 -0.429
ENSG00000136928 E024 13.7349297 0.021841745 0.19905068 0.42854038 9 98473230 98473335 106 - 1.187 1.149 -0.137
ENSG00000136928 E025 7.3217958 0.027406928 0.86873892 0.93523845 9 98473336 98473346 11 - 0.876 0.950 0.279
ENSG00000136928 E026 11.9181132 0.070777514 0.24482222 0.48200661 9 98480932 98480997 66 - 1.151 1.066 -0.306
ENSG00000136928 E027 0.0000000       9 98495966 98496067 102 -      
ENSG00000136928 E028 12.1334919 0.019942654 0.03118507 0.13089051 9 98496413 98496514 102 - 1.187 1.043 -0.517
ENSG00000136928 E029 0.0000000       9 98515994 98516299 306 -      
ENSG00000136928 E030 4.7554364 0.007983817 0.19860739 0.42792385 9 98541873 98541886 14 - 0.811 0.720 -0.363
ENSG00000136928 E031 11.0934798 0.002941601 0.15454419 0.36879904 9 98541887 98542012 126 - 1.113 1.066 -0.168
ENSG00000136928 E032 6.0579741 0.004680563 0.02057091 0.09793595 9 98542013 98542043 31 - 0.947 0.746 -0.783
ENSG00000136928 E033 0.0000000       9 98552050 98552118 69 -      
ENSG00000136928 E034 0.0000000       9 98555653 98555898 246 -      
ENSG00000136928 E035 11.1082465 0.010664654 0.20916074 0.44089001 9 98577935 98578072 138 - 1.102 1.066 -0.130
ENSG00000136928 E036 0.0000000       9 98581081 98581179 99 -      
ENSG00000136928 E037 0.0000000       9 98607556 98607650 95 -      
ENSG00000136928 E038 0.0000000       9 98707244 98707461 218 -      
ENSG00000136928 E039 7.5283634 0.061807137 0.48697935 0.69185353 9 98708417 98708935 519 - 0.933 0.930 -0.013