ENSG00000136877

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373247 ENSG00000136877 HEK293_OSMI2_6hA HEK293_TMG_6hB FPGS protein_coding protein_coding 81.08989 113.4727 53.07215 19.77684 2.40205 -1.096174 37.606436 64.770622 13.664870 16.413399 0.7690576 -2.2440352 0.4316417 0.55196667 0.2592333 -0.29273333 0.0221271935 0.0002462579 FALSE TRUE
ENST00000475270 ENSG00000136877 HEK293_OSMI2_6hA HEK293_TMG_6hB FPGS protein_coding processed_transcript 81.08989 113.4727 53.07215 19.77684 2.40205 -1.096174 11.098244 11.294598 9.659639 2.474591 0.8801812 -0.2253757 0.1205042 0.10363333 0.1812667 0.07763333 0.3161909732 0.0002462579 FALSE FALSE
ENST00000475765 ENSG00000136877 HEK293_OSMI2_6hA HEK293_TMG_6hB FPGS protein_coding processed_transcript 81.08989 113.4727 53.07215 19.77684 2.40205 -1.096174 7.716967 8.932521 10.401193 1.339715 1.1401867 0.2193819 0.1178625 0.08013333 0.1961000 0.11596667 0.0002462579 0.0002462579 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000136877 E001 14.3147598 0.1931262727 6.381457e-01 7.958131e-01 9 127794597 127794681 85 + 1.083 1.116 0.116
ENSG00000136877 E002 11.8101535 0.1071566484 4.610299e-01 6.738740e-01 9 127794682 127794812 131 + 0.943 1.054 0.408
ENSG00000136877 E003 0.7262068 0.0392728656 2.699343e-01   9 127802858 127802878 21 + 0.000 0.267 10.455
ENSG00000136877 E004 1.9105347 0.0103573067 3.065955e-02 1.293204e-01 9 127802879 127802881 3 + 0.000 0.485 12.296
ENSG00000136877 E005 5.7971433 0.0168972528 1.213289e-03 1.153341e-02 9 127802882 127802892 11 + 0.206 0.861 3.365
ENSG00000136877 E006 23.9418056 0.0410213427 6.955094e-07 2.072530e-05 9 127802893 127802910 18 + 0.534 1.413 3.363
ENSG00000136877 E007 32.5227671 0.0198623270 6.056276e-07 1.833651e-05 9 127802911 127802916 6 + 0.885 1.530 2.300
ENSG00000136877 E008 37.4081577 0.0235118058 6.581021e-07 1.975970e-05 9 127802917 127802917 1 + 0.949 1.588 2.256
ENSG00000136877 E009 62.9288929 0.0144220457 3.169079e-09 1.659520e-07 9 127802918 127802931 14 + 1.224 1.804 1.992
ENSG00000136877 E010 178.7376546 0.0049802663 7.215322e-09 3.493671e-07 9 127802932 127803023 92 + 1.922 2.224 1.013
ENSG00000136877 E011 204.7923272 0.0003102037 2.173068e-05 4.099044e-04 9 127803024 127803062 39 + 2.119 2.263 0.480
ENSG00000136877 E012 2.5536246 0.0175004694 1.615043e-01 3.789910e-01 9 127803063 127803156 94 + 0.668 0.432 -1.098
ENSG00000136877 E013 6.0073717 0.0473252631 6.404297e-01 7.971812e-01 9 127803208 127803251 44 + 0.848 0.769 -0.311
ENSG00000136877 E014 14.2825197 0.0105756684 9.785649e-01 9.910705e-01 9 127803252 127803323 72 + 1.118 1.121 0.009
ENSG00000136877 E015 19.4458499 0.0204808536 7.413317e-01 8.612988e-01 9 127803324 127803404 81 + 1.209 1.250 0.146
ENSG00000136877 E016 164.2043299 0.0002991996 3.658857e-02 1.458245e-01 9 127804285 127804285 1 + 2.077 2.156 0.264
ENSG00000136877 E017 469.9442863 0.0001813640 4.504793e-01 6.660377e-01 9 127804286 127804413 128 + 2.601 2.592 -0.029
ENSG00000136877 E018 462.1152185 0.0001232005 1.393120e-03 1.284804e-02 9 127804499 127804552 54 + 2.629 2.574 -0.183
ENSG00000136877 E019 494.7604247 0.0001307523 6.707827e-03 4.323945e-02 9 127804636 127804700 65 + 2.650 2.605 -0.149
ENSG00000136877 E020 11.6517786 0.0598099758 1.090595e-02 6.197153e-02 9 127804701 127804857 157 + 1.296 0.907 -1.409
ENSG00000136877 E021 34.9023340 0.1003459778 4.465805e-03 3.174801e-02 9 127806497 127806972 476 + 1.789 1.321 -1.603
ENSG00000136877 E022 301.1889698 0.0001690898 7.873533e-01 8.889807e-01 9 127806973 127806991 19 + 2.401 2.401 -0.001
ENSG00000136877 E023 613.5239114 0.0001269471 3.263982e-03 2.497743e-02 9 127806992 127807087 96 + 2.742 2.698 -0.146
ENSG00000136877 E024 532.6056774 0.0003099808 5.735517e-02 1.968438e-01 9 127807209 127807286 78 + 2.670 2.639 -0.104
ENSG00000136877 E025 472.2352900 0.0001807638 9.091698e-06 1.932148e-04 9 127807421 127807482 62 + 2.655 2.575 -0.265
ENSG00000136877 E026 492.2839983 0.0003494004 3.486330e-06 8.459196e-05 9 127807586 127807672 87 + 2.678 2.590 -0.291
ENSG00000136877 E027 313.8907142 0.0006814852 1.165879e-06 3.244724e-05 9 127807673 127807688 16 + 2.506 2.386 -0.400
ENSG00000136877 E028 30.6714006 0.0324922589 2.213165e-05 4.165426e-04 9 127807689 127807775 87 + 1.733 1.275 -1.574
ENSG00000136877 E029 11.0651376 0.1071693093 1.009309e-02 5.854555e-02 9 127807776 127807849 74 + 1.324 0.857 -1.695
ENSG00000136877 E030 18.2973397 0.0553258246 6.069621e-03 4.007158e-02 9 127808147 127808233 87 + 1.469 1.084 -1.356
ENSG00000136877 E031 325.1108070 0.0014934525 2.938120e-03 2.302433e-02 9 127808234 127808263 30 + 2.494 2.410 -0.283
ENSG00000136877 E032 395.3602757 0.0018710030 7.531879e-02 2.354724e-01 9 127808264 127808311 48 + 2.554 2.502 -0.172
ENSG00000136877 E033 515.9709065 0.0012214346 6.555658e-02 2.151390e-01 9 127808558 127808705 148 + 2.591 2.639 0.161
ENSG00000136877 E034 7.3564753 0.0319688332 3.246832e-01 5.639573e-01 9 127808722 127808799 78 + 0.722 0.882 0.633
ENSG00000136877 E035 266.5067013 0.0001863609 1.504128e-13 1.803923e-11 9 127808800 127808889 90 + 2.167 2.387 0.736
ENSG00000136877 E036 226.7500586 0.0033847845 2.356566e-09 1.279892e-07 9 127809684 127809834 151 + 2.057 2.322 0.886
ENSG00000136877 E037 3.1283741 0.1613380096 2.798550e-01 5.199444e-01 9 127809994 127810030 37 + 0.348 0.593 1.247
ENSG00000136877 E038 100.4809505 0.0542345873 1.010405e-03 9.989954e-03 9 127810031 127810106 76 + 1.576 1.985 1.384
ENSG00000136877 E039 159.0627796 0.0020049593 3.778235e-03 2.789944e-02 9 127810945 127811011 67 + 2.026 2.151 0.419
ENSG00000136877 E040 342.4120847 0.0002321282 2.293481e-01 4.643803e-01 9 127813195 127813323 129 + 2.431 2.465 0.116
ENSG00000136877 E041 1293.8434762 0.0008193138 2.481786e-01 4.860098e-01 9 127813324 127814081 758 + 3.011 3.035 0.080
ENSG00000136877 E042 21.5145287 0.0027267190 4.527778e-01 6.677433e-01 9 127814208 127814438 231 + 1.225 1.300 0.263