ENSG00000136807

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373264 ENSG00000136807 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK9 protein_coding protein_coding 38.58442 53.49867 21.51629 8.123046 0.6071094 -1.313673 20.771075 27.244058 11.166455 4.4379600 0.6427675 -1.2860085 0.52829583 0.50723333 0.52120000 0.01396667 9.756288e-01 1.600421e-11 FALSE TRUE
ENST00000480353 ENSG00000136807 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK9 protein_coding processed_transcript 38.58442 53.49867 21.51629 8.123046 0.6071094 -1.313673 11.795659 14.978866 8.479946 3.5803087 0.8036862 -0.8200639 0.31849583 0.27160000 0.39276667 0.12116667 3.406225e-01 1.600421e-11 FALSE FALSE
ENST00000491521 ENSG00000136807 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK9 protein_coding processed_transcript 38.58442 53.49867 21.51629 8.123046 0.6071094 -1.313673 2.457693 6.923883 0.000000 1.3026276 0.0000000 -9.4375198 0.05708750 0.13670000 0.00000000 -0.13670000 1.600421e-11 1.600421e-11 FALSE FALSE
ENST00000498339 ENSG00000136807 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK9 protein_coding processed_transcript 38.58442 53.49867 21.51629 8.123046 0.6071094 -1.313673 2.858817 3.705110 1.805575 0.4915099 0.4003151 -1.0329784 0.07802917 0.07146667 0.08306667 0.01160000 9.234573e-01 1.600421e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000136807 E001 1.880795 0.0105809036 0.140065529 0.34760625 9 127785679 127785832 154 + 0.192 0.484 1.878
ENSG00000136807 E002 1.243950 0.0137194413 0.384052540   9 127785833 127785917 85 + 0.192 0.363 1.226
ENSG00000136807 E003 3.045909 0.0523391066 0.031201999 0.13093198 9 127785918 127786033 116 + 0.192 0.639 2.590
ENSG00000136807 E004 32.707142 0.0012001463 0.002820583 0.02231747 9 127786034 127786073 40 + 1.288 1.514 0.783
ENSG00000136807 E005 166.330043 0.0021516812 0.548539840 0.73529044 9 127786074 127786240 167 + 2.178 2.154 -0.079
ENSG00000136807 E006 201.497895 0.0016882179 0.033477460 0.13741256 9 127786701 127786782 82 + 2.296 2.225 -0.236
ENSG00000136807 E007 1.094966 0.4520541367 0.236249146   9 127787500 127787517 18 + 0.001 0.340 9.358
ENSG00000136807 E008 243.915879 0.0009575502 0.120067699 0.31596146 9 127787518 127787608 91 + 2.360 2.315 -0.151
ENSG00000136807 E009 335.482829 0.0004111484 0.901510299 0.95263700 9 127787947 127788113 167 + 2.463 2.463 -0.002
ENSG00000136807 E010 327.279557 0.0002236480 0.003627272 0.02708500 9 127788214 127788385 172 + 2.407 2.469 0.207
ENSG00000136807 E011 24.159658 0.0013846735 0.611541374 0.77794850 9 127788386 127788412 27 + 1.312 1.351 0.135
ENSG00000136807 E012 34.474835 0.0013069527 0.733060153 0.85602235 9 127788422 127788543 122 + 1.477 1.499 0.074
ENSG00000136807 E013 295.267265 0.0003951890 0.788254830 0.88951502 9 127788544 127788692 149 + 2.409 2.412 0.011
ENSG00000136807 E014 926.964313 0.0012978080 0.719165069 0.84765942 9 127789178 127790792 1615 + 2.913 2.900 -0.043