ENSG00000136731

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000259253 ENSG00000136731 HEK293_OSMI2_6hA HEK293_TMG_6hB UGGT1 protein_coding protein_coding 15.51604 9.097885 22.65451 1.662006 0.5859465 1.315247 9.331975 8.1062054 10.729440 1.46610809 0.3787147 0.4040415 0.686225 0.89230000 0.4734667 -0.4188333 6.511910e-23 6.51191e-23 FALSE TRUE
ENST00000376723 ENSG00000136731 HEK293_OSMI2_6hA HEK293_TMG_6hB UGGT1 protein_coding nonsense_mediated_decay 15.51604 9.097885 22.65451 1.662006 0.5859465 1.315247 2.382228 0.0000000 5.297305 0.00000000 0.3563814 9.0518355 0.107650 0.00000000 0.2341667 0.2341667 2.201039e-21 6.51191e-23 FALSE TRUE
MSTRG.19188.1 ENSG00000136731 HEK293_OSMI2_6hA HEK293_TMG_6hB UGGT1 protein_coding   15.51604 9.097885 22.65451 1.662006 0.5859465 1.315247 2.173618 0.1754776 4.356935 0.09271655 0.5203866 4.5573044 0.100200 0.02143333 0.1917333 0.1703000 4.625416e-02 6.51191e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000136731 E001 0.8026527 0.0172195532 8.331896e-02   2 128091195 128091199 5 + 0.334 0.000 -11.187
ENSG00000136731 E002 0.9806365 0.0172671820 5.085324e-02   2 128091200 128091203 4 + 0.378 0.000 -14.133
ENSG00000136731 E003 1.4438896 0.0182364883 1.277974e-02 6.954954e-02 2 128091204 128091207 4 + 0.489 0.000 -14.680
ENSG00000136731 E004 1.7667210 0.0107352863 4.904763e-03 3.412157e-02 2 128091208 128091210 3 + 0.549 0.000 -15.123
ENSG00000136731 E005 9.9542106 0.0031391428 2.574098e-01 4.961423e-01 2 128091211 128091244 34 + 1.057 0.937 -0.441
ENSG00000136731 E006 35.7826547 0.0071157452 5.904181e-02 2.006094e-01 2 128091245 128091382 138 + 1.584 1.447 -0.468
ENSG00000136731 E007 23.2849343 0.0061411259 8.949295e-01 9.491949e-01 2 128091383 128091397 15 + 1.366 1.362 -0.015
ENSG00000136731 E008 23.2376669 0.0055434939 3.311715e-01 5.700376e-01 2 128091398 128091415 18 + 1.391 1.317 -0.256
ENSG00000136731 E009 24.9138004 0.0048401911 8.159951e-05 1.262525e-03 2 128091416 128091596 181 + 1.479 1.148 -1.159
ENSG00000136731 E010 80.2940970 0.0008383426 6.291994e-13 6.699218e-11 2 128097429 128097564 136 + 1.974 1.641 -1.123
ENSG00000136731 E011 0.6246688 0.0192540083 1.402841e-01   2 128103079 128103145 67 + 0.284 0.000 -13.518
ENSG00000136731 E012 72.1573757 0.0023817153 4.034001e-12 3.743531e-10 2 128103932 128104014 83 + 1.936 1.568 -1.245
ENSG00000136731 E013 83.4790739 0.0027550554 1.599944e-12 1.586149e-10 2 128107938 128108068 131 + 2.002 1.644 -1.207
ENSG00000136731 E014 85.6949815 0.0038000221 5.954179e-10 3.611274e-08 2 128109634 128109746 113 + 2.006 1.682 -1.091
ENSG00000136731 E015 100.6672338 0.0012501839 6.416840e-12 5.732388e-10 2 128113084 128113258 175 + 2.066 1.775 -0.980
ENSG00000136731 E016 82.1573395 0.0005339496 3.455631e-08 1.430982e-06 2 128115124 128115213 90 + 1.964 1.727 -0.800
ENSG00000136731 E017 45.4961089 0.0009432291 1.954296e-04 2.624422e-03 2 128115214 128115220 7 + 1.705 1.494 -0.718
ENSG00000136731 E018 77.5587399 0.0004893329 1.087097e-04 1.602443e-03 2 128116265 128116343 79 + 1.922 1.758 -0.551
ENSG00000136731 E019 86.5440285 0.0004830507 6.692114e-03 4.315618e-02 2 128120356 128120456 101 + 1.954 1.850 -0.349
ENSG00000136731 E020 92.7983939 0.0004984620 1.076380e-06 3.030907e-05 2 128121199 128121298 100 + 2.006 1.813 -0.649
ENSG00000136731 E021 93.0518662 0.0004650332 6.568021e-08 2.550729e-06 2 128123186 128123246 61 + 2.011 1.794 -0.727
ENSG00000136731 E022 116.0370614 0.0004239458 1.036784e-10 7.333185e-09 2 128127361 128127452 92 + 2.114 1.880 -0.785
ENSG00000136731 E023 129.8180456 0.0015150495 1.945730e-08 8.549280e-07 2 128129029 128129179 151 + 2.157 1.948 -0.700
ENSG00000136731 E024 102.0902347 0.0092030858 8.405539e-03 5.118157e-02 2 128133141 128133260 120 + 2.035 1.891 -0.483
ENSG00000136731 E025 90.3608519 0.0004375666 1.517757e-03 1.373787e-02 2 128134876 128134961 86 + 1.976 1.856 -0.404
ENSG00000136731 E026 128.2354459 0.0003758143 3.951480e-07 1.259284e-05 2 128138717 128138852 136 + 2.139 1.970 -0.567
ENSG00000136731 E027 146.5130464 0.0003362181 1.490295e-06 4.023632e-05 2 128143094 128143225 132 + 2.190 2.042 -0.497
ENSG00000136731 E028 0.2922838 0.0263203272 6.360496e-01   2 128145652 128145802 151 + 0.090 0.161 0.960
ENSG00000136731 E029 154.6409855 0.0031736418 1.274208e-03 1.196795e-02 2 128145803 128145967 165 + 2.208 2.081 -0.426
ENSG00000136731 E030 116.3402349 0.0026883887 3.300816e-02 1.360785e-01 2 128152784 128152904 121 + 2.073 1.988 -0.284
ENSG00000136731 E031 89.6530348 0.0006401134 4.406762e-01 6.592035e-01 2 128155489 128155587 99 + 1.946 1.923 -0.076
ENSG00000136731 E032 55.4868036 0.0007854983 1.965682e-01 4.252622e-01 2 128156392 128156415 24 + 1.750 1.692 -0.196
ENSG00000136731 E033 92.8015019 0.0005471142 1.020572e-01 2.854600e-01 2 128157252 128157346 95 + 1.971 1.914 -0.190
ENSG00000136731 E034 124.3371781 0.0003463962 2.051760e-02 9.774350e-02 2 128159514 128159720 207 + 2.098 2.027 -0.238
ENSG00000136731 E035 72.4912411 0.0010219474 4.856384e-02 1.763129e-01 2 128160460 128160539 80 + 1.867 1.785 -0.277
ENSG00000136731 E036 75.3002244 0.0039558009 4.041421e-01 6.316506e-01 2 128160540 128160591 52 + 1.867 1.835 -0.108
ENSG00000136731 E037 128.7908929 0.0026186671 2.354645e-01 4.713976e-01 2 128161138 128161268 131 + 2.102 2.062 -0.133
ENSG00000136731 E038 138.2339894 0.0002852821 3.697457e-01 6.038019e-01 2 128164730 128164825 96 + 2.127 2.107 -0.067
ENSG00000136731 E039 142.4679736 0.0004216172 8.797923e-01 9.411343e-01 2 128170288 128170390 103 + 2.131 2.145 0.046
ENSG00000136731 E040 108.1049148 0.0003934309 4.190755e-01 6.429060e-01 2 128171205 128171284 80 + 2.023 2.002 -0.070
ENSG00000136731 E041 0.6648197 0.5295786742 9.059810e-01   2 128171285 128171390 106 + 0.236 0.157 -0.724
ENSG00000136731 E042 142.1680895 0.0002965918 4.337201e-01 6.540309e-01 2 128172573 128172762 190 + 2.139 2.122 -0.054
ENSG00000136731 E043 123.6398235 0.0003661675 8.725866e-01 9.373531e-01 2 128173781 128173939 159 + 2.070 2.072 0.009
ENSG00000136731 E044 86.3838806 0.0005871754 1.273479e-01 3.276581e-01 2 128174773 128174858 86 + 1.937 1.882 -0.185
ENSG00000136731 E045 111.0950948 0.0004961172 5.777084e-02 1.978306e-01 2 128176814 128176898 85 + 2.048 1.987 -0.205
ENSG00000136731 E046 124.9777387 0.0008000076 4.135310e-01 6.386636e-01 2 128177832 128177920 89 + 2.086 2.066 -0.069
ENSG00000136731 E047 132.4070889 0.0003548444 7.242603e-01 8.506979e-01 2 128178468 128178569 102 + 2.094 2.114 0.066
ENSG00000136731 E048 102.8239389 0.0004110574 4.502603e-02 1.676744e-01 2 128179786 128179870 85 + 1.962 2.043 0.274
ENSG00000136731 E049 163.3846028 0.0003209171 3.633386e-01 5.984391e-01 2 128180890 128181072 183 + 2.180 2.215 0.118
ENSG00000136731 E050 169.8670885 0.0020224491 7.818570e-01 8.857162e-01 2 128182130 128182290 161 + 2.201 2.221 0.068
ENSG00000136731 E051 146.3728415 0.0006395850 9.735263e-01 9.886806e-01 2 128183675 128183789 115 + 2.140 2.148 0.027
ENSG00000136731 E052 160.4913519 0.0024438449 1.465171e-01 3.571977e-01 2 128186683 128186799 117 + 2.161 2.226 0.219
ENSG00000136731 E053 0.0000000       2 128187237 128187319 83 +      
ENSG00000136731 E054 173.8459786 0.0004750932 1.562432e-03 1.405684e-02 2 128187449 128187614 166 + 2.182 2.282 0.336
ENSG00000136731 E055 654.8241044 0.0009935886 5.157201e-13 5.574866e-11 2 128189717 128191582 1866 + 2.737 2.885 0.490
ENSG00000136731 E056 523.8533634 0.0007109179 8.627406e-41 1.526179e-37 2 128191583 128193536 1954 + 2.587 2.850 0.875
ENSG00000136731 E057 524.4544479 0.0002034422 4.450839e-78 5.814268e-74 2 128193537 128195677 2141 + 2.565 2.874 1.028