ENSG00000136709

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000322313 ENSG00000136709 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR33 protein_coding protein_coding 23.11934 17.96791 30.62252 3.62778 0.9828244 0.768839 4.987440 5.4377674 3.924901 0.6846793 0.47693134 -0.4693377 0.25577500 0.31560000 0.1288333 -0.18676667 0.004053003 0.001885781 FALSE TRUE
ENST00000409658 ENSG00000136709 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR33 protein_coding protein_coding 23.11934 17.96791 30.62252 3.62778 0.9828244 0.768839 1.612994 0.9344029 3.068370 0.1932471 0.03578572 1.7046923 0.06633750 0.05190000 0.1004000 0.04850000 0.012596446 0.001885781 FALSE TRUE
ENST00000436787 ENSG00000136709 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR33 protein_coding protein_coding 23.11934 17.96791 30.62252 3.62778 0.9828244 0.768839 1.960376 0.2238104 4.378126 0.1505520 0.41681241 4.2301940 0.06732917 0.01026667 0.1425000 0.13223333 0.001885781 0.001885781 FALSE FALSE
MSTRG.19174.1 ENSG00000136709 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR33 protein_coding   23.11934 17.96791 30.62252 3.62778 0.9828244 0.768839 1.494297 1.1283836 4.867968 0.1880426 3.00837257 2.0992935 0.05804167 0.06726667 0.1646333 0.09736667 0.848323376 0.001885781 TRUE TRUE
MSTRG.19174.6 ENSG00000136709 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR33 protein_coding   23.11934 17.96791 30.62252 3.62778 0.9828244 0.768839 12.075637 9.3358186 13.672369 2.7006962 3.44519662 0.5499251 0.50285000 0.49413333 0.4405333 -0.05360000 0.933465348 0.001885781 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000136709 E001 2.308289 0.0169121026 6.950853e-01 8.323308e-01 2 127699287 127699319 33 - 0.548 0.506 -0.199
ENSG00000136709 E002 3.610791 0.1185971607 1.455012e-01 3.556442e-01 2 127700609 127700709 101 - 0.510 0.796 1.233
ENSG00000136709 E003 2.968097 0.0086902255 1.306125e-01 3.327433e-01 2 127700710 127700777 68 - 0.474 0.733 1.158
ENSG00000136709 E004 2.850213 0.0083579090 2.445575e-02 1.105237e-01 2 127700778 127700864 87 - 0.382 0.762 1.760
ENSG00000136709 E005 16.784387 0.0035134123 2.663586e-03 2.136189e-02 2 127701027 127701102 76 - 1.100 1.390 1.022
ENSG00000136709 E006 51.435362 0.0113357789 7.761847e-06 1.684524e-04 2 127701103 127701285 183 - 1.532 1.877 1.169
ENSG00000136709 E007 48.951295 0.0105202485 6.216985e-11 4.594374e-09 2 127701286 127701514 229 - 1.408 1.907 1.698
ENSG00000136709 E008 22.068442 0.1261851450 3.142993e-05 5.620813e-04 2 127701515 127701823 309 - 0.850 1.637 2.799
ENSG00000136709 E009 102.748849 1.1394227938 2.497310e-01 4.875694e-01 2 127701824 127702891 1068 - 1.759 2.207 1.505
ENSG00000136709 E010 91.612013 1.1196321084 2.734697e-01 5.133184e-01 2 127702892 127703623 732 - 1.739 2.144 1.362
ENSG00000136709 E011 934.177484 0.0028073901 6.473885e-09 3.162873e-07 2 127703624 127706552 2929 - 2.880 3.060 0.600
ENSG00000136709 E012 393.066868 0.0002104590 3.027569e-21 1.032431e-18 2 127708677 127708892 216 - 2.490 2.701 0.701
ENSG00000136709 E013 230.768502 0.0002978054 2.290275e-08 9.911861e-07 2 127709490 127709582 93 - 2.279 2.449 0.568
ENSG00000136709 E014 259.066980 0.0017544672 1.876234e-04 2.536643e-03 2 127709693 127709856 164 - 2.341 2.487 0.488
ENSG00000136709 E015 479.929543 0.0001921880 1.669455e-09 9.344492e-08 2 127713583 127714021 439 - 2.615 2.752 0.457
ENSG00000136709 E016 194.086496 0.0007279038 3.547007e-05 6.221867e-04 2 127717155 127717263 109 - 2.217 2.369 0.508
ENSG00000136709 E017 875.946491 0.0010166307 1.801972e-02 8.910434e-02 2 127719265 127720353 1089 - 2.905 2.983 0.261
ENSG00000136709 E018 252.201061 0.0003770982 8.707148e-01 9.363781e-01 2 127721836 127721988 153 - 2.388 2.421 0.110
ENSG00000136709 E019 297.959694 0.0001913009 1.010373e-04 1.508304e-03 2 127722591 127722730 140 - 2.493 2.447 -0.154
ENSG00000136709 E020 263.327016 0.0002729713 1.495586e-07 5.326045e-06 2 127722958 127723044 87 - 2.454 2.369 -0.283
ENSG00000136709 E021 274.849264 0.0004866365 2.389306e-07 8.063575e-06 2 127723253 127723347 95 - 2.474 2.388 -0.284
ENSG00000136709 E022 252.537105 0.0002724773 4.173383e-07 1.322269e-05 2 127724333 127724443 111 - 2.437 2.356 -0.272
ENSG00000136709 E023 191.871564 0.0012693396 2.967117e-03 2.320125e-02 2 127724887 127724965 79 - 2.306 2.251 -0.183
ENSG00000136709 E024 293.649755 0.0006574875 2.079436e-10 1.379438e-08 2 127725061 127725215 155 - 2.514 2.398 -0.387
ENSG00000136709 E025 124.597877 0.0022859495 3.156913e-05 5.642736e-04 2 127726651 127726651 1 - 2.149 2.020 -0.432
ENSG00000136709 E026 272.209463 0.0002033246 1.753435e-14 2.485589e-12 2 127726652 127726777 126 - 2.490 2.354 -0.451
ENSG00000136709 E027 32.100224 0.1174073803 6.779911e-03 4.361306e-02 2 127735388 127738054 2667 - 1.201 1.736 1.846
ENSG00000136709 E028 3.828708 0.0065905402 2.382627e-01 4.746221e-01 2 127762533 127763061 529 - 0.742 0.596 -0.619
ENSG00000136709 E029 258.628143 0.0001988818 5.126313e-14 6.743345e-12 2 127763062 127763159 98 - 2.468 2.331 -0.456
ENSG00000136709 E030 104.587194 0.0005000889 1.507970e-15 2.467129e-13 2 127763160 127764827 1668 - 2.117 1.857 -0.873
ENSG00000136709 E031 316.577575 0.0001793945 1.448575e-12 1.446132e-10 2 127764828 127764979 152 - 2.546 2.436 -0.368
ENSG00000136709 E032 215.484667 0.0002127969 9.837887e-09 4.640832e-07 2 127765174 127765269 96 - 2.379 2.272 -0.356
ENSG00000136709 E033 119.628171 0.0004645386 4.891235e-06 1.129821e-04 2 127768189 127768211 23 - 2.127 2.008 -0.398
ENSG00000136709 E034 191.513366 0.0002647116 2.892743e-08 1.221114e-06 2 127768212 127768293 82 - 2.327 2.215 -0.374
ENSG00000136709 E035 187.688377 0.0003634589 1.695831e-06 4.516799e-05 2 127768933 127769001 69 - 2.312 2.218 -0.316
ENSG00000136709 E036 324.109254 0.0002519932 3.629996e-11 2.816157e-09 2 127770778 127771004 227 - 2.552 2.450 -0.339
ENSG00000136709 E037 1.607070 0.0121989077 7.415769e-01 8.614304e-01 2 127810749 127811011 263 - 0.431 0.393 -0.201
ENSG00000136709 E038 148.922187 0.0003534499 3.628936e-06 8.734082e-05 2 127811012 127811377 366 - 2.219 2.116 -0.345