ENSG00000136682

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000490323 ENSG00000136682 HEK293_OSMI2_6hA HEK293_TMG_6hB CBWD2 protein_coding retained_intron 44.29482 31.76263 60.75123 5.342621 2.054544 0.9353665 11.683207 10.829594 8.777881 1.908965 0.9262104 -0.3027236 0.2922458 0.3421333 0.1438000 -0.198333333 1.041433e-05 1.041433e-05 FALSE TRUE
MSTRG.19088.1 ENSG00000136682 HEK293_OSMI2_6hA HEK293_TMG_6hB CBWD2 protein_coding   44.29482 31.76263 60.75123 5.342621 2.054544 0.9353665 16.156898 11.157253 26.801074 3.703666 1.5716374 1.2635546 0.3337292 0.3265333 0.4405000 0.113966667 6.780696e-01 1.041433e-05 TRUE TRUE
MSTRG.19088.3 ENSG00000136682 HEK293_OSMI2_6hA HEK293_TMG_6hB CBWD2 protein_coding   44.29482 31.76263 60.75123 5.342621 2.054544 0.9353665 5.805128 3.959050 12.879261 1.020461 0.9745748 1.6993037 0.1247792 0.1239000 0.2135000 0.089600000 2.497257e-01 1.041433e-05 TRUE TRUE
MSTRG.19088.5 ENSG00000136682 HEK293_OSMI2_6hA HEK293_TMG_6hB CBWD2 protein_coding   44.29482 31.76263 60.75123 5.342621 2.054544 0.9353665 8.282465 4.327342 8.930960 0.963570 0.7438203 1.0436186 0.1943917 0.1561667 0.1465333 -0.009633333 9.912638e-01 1.041433e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000136682 E001 0.6071052 0.0193874923 0.103183975   2 113437691 113437762 72 + 0.091 0.368 2.513
ENSG00000136682 E002 3.2736772 0.0490117486 0.040865267 0.15695719 2 113437763 113437790 28 + 0.457 0.804 1.529
ENSG00000136682 E003 20.5487520 0.0020816041 0.001676552 0.01485687 2 113437791 113437816 26 + 1.222 1.462 0.838
ENSG00000136682 E004 38.6946928 0.0010072456 0.023960419 0.10897826 2 113437817 113437821 5 + 1.537 1.666 0.440
ENSG00000136682 E005 89.5927640 0.0005124901 0.880308925 0.94141500 2 113437822 113437838 17 + 1.944 1.939 -0.020
ENSG00000136682 E006 138.5322514 0.0003056604 0.628314730 0.78947342 2 113437839 113437878 40 + 2.123 2.137 0.048
ENSG00000136682 E007 210.5659203 0.0002226207 0.010307024 0.05943934 2 113437879 113438022 144 + 2.286 2.348 0.208
ENSG00000136682 E008 4.9818913 0.0051996699 0.620881673 0.78445368 2 113439020 113439117 98 + 0.736 0.802 0.267
ENSG00000136682 E009 100.2236897 0.0005806621 0.234462936 0.47023004 2 113441351 113441437 87 + 1.972 2.016 0.146
ENSG00000136682 E010 0.7201176 0.0556333009 0.711449261   2 113441438 113441729 292 + 0.232 0.160 -0.656
ENSG00000136682 E011 0.2852693 0.2935482658 0.557841751   2 113443762 113443766 5 + 0.164 0.000 -10.446
ENSG00000136682 E012 148.0251446 0.0027954339 0.780748314 0.88517033 2 113443767 113443863 97 + 2.158 2.144 -0.047
ENSG00000136682 E013 6.0379781 0.0055577323 0.356324196 0.59282213 2 113443864 113444375 512 + 0.864 0.737 -0.502
ENSG00000136682 E014 214.2848401 0.0004602503 0.051373794 0.18300902 2 113444964 113445055 92 + 2.331 2.280 -0.172
ENSG00000136682 E015 1.7213702 0.0147733816 0.454636204 0.66924479 2 113445056 113445540 485 + 0.380 0.509 0.668
ENSG00000136682 E016 209.3293418 0.0002546332 0.040668514 0.15647399 2 113453139 113453198 60 + 2.322 2.270 -0.175
ENSG00000136682 E017 168.1670683 0.0003455535 0.103217940 0.28760222 2 113454741 113454778 38 + 2.227 2.180 -0.158
ENSG00000136682 E018 8.2387048 0.0803910155 0.807678878 0.90080813 2 113457065 113457209 145 + 0.944 0.953 0.035
ENSG00000136682 E019 208.6706103 0.0020547556 0.144345630 0.35390979 2 113460673 113460719 47 + 2.322 2.272 -0.165
ENSG00000136682 E020 226.5789891 0.0005912949 0.333396088 0.57196757 2 113462408 113462494 87 + 2.349 2.323 -0.088
ENSG00000136682 E021 0.2735028 0.0274424043 0.635696582   2 113462495 113462834 340 + 0.091 0.160 0.928
ENSG00000136682 E022 113.5756894 0.0003730889 0.520750661 0.71541336 2 113465129 113465173 45 + 2.035 2.057 0.072
ENSG00000136682 E023 19.8089492 0.0223538729 0.398834348 0.62728662 2 113468585 113471032 2448 + 1.269 1.342 0.256
ENSG00000136682 E024 64.9767300 0.0012404387 0.579179751 0.75660130 2 113471033 113471089 57 + 1.797 1.824 0.090
ENSG00000136682 E025 4.0996970 0.1459470384 0.011188616 0.06314115 2 113481518 113482176 659 + 0.423 0.945 2.247
ENSG00000136682 E026 78.5705842 0.0007733727 0.578865114 0.75641748 2 113482177 113482228 52 + 1.897 1.874 -0.078
ENSG00000136682 E027 39.3540089 0.0047379147 0.662498774 0.81144884 2 113493757 113493825 69 + 1.604 1.572 -0.109
ENSG00000136682 E028 12.6589518 0.0141340753 0.285509983 0.52609519 2 113493929 113493994 66 + 1.077 1.194 0.419
ENSG00000136682 E029 1.6646673 0.0184099099 0.623727904 0.78639987 2 113493995 113495119 1125 + 0.457 0.368 -0.486
ENSG00000136682 E030 16.4911493 0.0047106954 0.012728676 0.06936279 2 113495120 113495249 130 + 1.141 1.357 0.761
ENSG00000136682 E031 0.3447487 0.7535858457 0.201525483   2 113495250 113495636 387 + 0.000 0.282 10.680
ENSG00000136682 E032 12.1342320 0.0064333573 0.050119254 0.17997171 2 113495637 113495798 162 + 1.025 1.219 0.698
ENSG00000136682 E033 2.3140163 0.0099818439 0.652426696 0.80501227 2 113495799 113496204 406 + 0.524 0.444 -0.391
ENSG00000136682 E034 0.4820342 0.0213502800 0.248208892   2 113497398 113497582 185 + 0.231 0.000 -11.713