ENSG00000136603

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000259119 ENSG00000136603 HEK293_OSMI2_6hA HEK293_TMG_6hB SKIL protein_coding protein_coding 4.146598 0.8334022 5.749883 0.1919751 0.1217485 2.771747 1.15662773 0.25311040 2.09950563 0.14053535 1.05134006 3.0031648 0.24100000 0.2627000 0.36076667 0.09806667 0.972347322 0.003257161 FALSE TRUE
ENST00000458537 ENSG00000136603 HEK293_OSMI2_6hA HEK293_TMG_6hB SKIL protein_coding protein_coding 4.146598 0.8334022 5.749883 0.1919751 0.1217485 2.771747 0.50740841 0.20650640 1.01294481 0.11298332 1.01294481 2.2402467 0.13185833 0.3395333 0.18050000 -0.15903333 0.653598296 0.003257161 FALSE TRUE
ENST00000465590 ENSG00000136603 HEK293_OSMI2_6hA HEK293_TMG_6hB SKIL protein_coding processed_transcript 4.146598 0.8334022 5.749883 0.1919751 0.1217485 2.771747 0.61743866 0.00000000 0.69787371 0.00000000 0.18380223 6.1454201 0.10477500 0.0000000 0.12230000 0.12230000 0.031434058 0.003257161   FALSE
ENST00000470571 ENSG00000136603 HEK293_OSMI2_6hA HEK293_TMG_6hB SKIL protein_coding nonsense_mediated_decay 4.146598 0.8334022 5.749883 0.1919751 0.1217485 2.771747 0.72578010 0.00000000 0.80912564 0.00000000 0.09882745 6.3560129 0.11115417 0.0000000 0.14036667 0.14036667 0.003257161 0.003257161 FALSE FALSE
ENST00000477216 ENSG00000136603 HEK293_OSMI2_6hA HEK293_TMG_6hB SKIL protein_coding processed_transcript 4.146598 0.8334022 5.749883 0.1919751 0.1217485 2.771747 0.10059830 0.06197306 0.05392542 0.03112544 0.05392542 -0.1710673 0.03731667 0.0902000 0.00900000 -0.08120000 0.414275675 0.003257161   FALSE
ENST00000490989 ENSG00000136603 HEK293_OSMI2_6hA HEK293_TMG_6hB SKIL protein_coding processed_transcript 4.146598 0.8334022 5.749883 0.1919751 0.1217485 2.771747 0.32445613 0.18660008 0.61495112 0.09376457 0.28650028 1.6684795 0.10069583 0.1859333 0.10516667 -0.08076667 0.839420818 0.003257161   FALSE
MSTRG.24055.1 ENSG00000136603 HEK293_OSMI2_6hA HEK293_TMG_6hB SKIL protein_coding   4.146598 0.8334022 5.749883 0.1919751 0.1217485 2.771747 0.16332675 0.10749971 0.14253679 0.05533776 0.07627265 0.3765000 0.06546250 0.1060333 0.02533333 -0.08070000 0.548912704 0.003257161 FALSE TRUE
MSTRG.24055.3 ENSG00000136603 HEK293_OSMI2_6hA HEK293_TMG_6hB SKIL protein_coding   4.146598 0.8334022 5.749883 0.1919751 0.1217485 2.771747 0.08887188 0.01771254 0.00000000 0.01771254 0.00000000 -1.4705392 0.10305000 0.0156000 0.00000000 -0.01560000 0.419249800 0.003257161 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000136603 E001 2.8555323 0.0102239957 0.0007489657 0.007852303 3 170357658 170357677 20 + 0.367 0.904 2.399
ENSG00000136603 E002 3.0335161 0.0086034511 0.0012315780 0.011661013 3 170357678 170357684 7 + 0.394 0.904 2.247
ENSG00000136603 E003 3.9608799 0.0481538494 0.0169901865 0.085430344 3 170357685 170357714 30 + 0.508 0.933 1.771
ENSG00000136603 E004 4.5750674 0.0058976072 0.0109186068 0.062023438 3 170357715 170357733 19 + 0.564 0.941 1.538
ENSG00000136603 E005 4.5160654 0.0057402956 0.0238519649 0.108639191 3 170357734 170357763 30 + 0.564 0.905 1.402
ENSG00000136603 E006 0.9574634 0.0154670269 0.0086421952   3 170357764 170357856 93 + 0.113 0.581 3.250
ENSG00000136603 E007 5.4330180 0.0048310640 0.0396587401 0.153861198 3 170358509 170358645 137 + 0.644 0.941 1.186
ENSG00000136603 E008 1.5341590 0.4845256437 0.1283705986 0.329272291 3 170359623 170359698 76 + 0.265 0.587 1.767
ENSG00000136603 E009 9.5631541 0.0030617699 0.2603743016 0.499340806 3 170359699 170359774 76 + 0.892 1.035 0.535
ENSG00000136603 E010 14.3533054 0.0030642637 0.2983106340 0.538758037 3 170359775 170359876 102 + 1.061 1.177 0.419
ENSG00000136603 E011 34.1964088 0.0012574738 0.0772088790 0.239214834 3 170359877 170360320 444 + 1.453 1.316 -0.474
ENSG00000136603 E012 12.6683527 0.0025820787 0.1205813443 0.316753583 3 170360321 170360367 47 + 1.061 0.865 -0.729
ENSG00000136603 E013 63.0257723 0.0006998619 0.0264396559 0.116594695 3 170360368 170361211 844 + 1.714 1.591 -0.417
ENSG00000136603 E014 19.6359204 0.0023147501 0.3711286943 0.604795673 3 170361212 170361340 129 + 1.222 1.136 -0.307
ENSG00000136603 E015 19.1323761 0.0023421089 0.3482062264 0.585676624 3 170361341 170361429 89 + 1.206 1.113 -0.334
ENSG00000136603 E016 13.1344837 0.0027464749 0.1026643179 0.286534463 3 170381244 170381275 32 + 1.072 0.866 -0.768
ENSG00000136603 E017 16.8674356 0.0026061589 0.2532348366 0.491464386 3 170381276 170381341 66 + 1.160 1.036 -0.447
ENSG00000136603 E018 21.5138209 0.0023435591 0.5777692073 0.755638448 3 170384533 170384627 95 + 1.248 1.198 -0.176
ENSG00000136603 E019 22.9329963 0.0069424133 0.5530098571 0.738385641 3 170384628 170384765 138 + 1.274 1.217 -0.198
ENSG00000136603 E020 0.1779838 0.0346254114 1.0000000000   3 170384766 170385049 284 + 0.060 0.001 -6.627
ENSG00000136603 E021 30.8926007 0.0016412528 0.0011594641 0.011121988 3 170390223 170390464 242 + 1.430 1.136 -1.031
ENSG00000136603 E022 36.1191760 0.0010684077 0.2956980376 0.536191201 3 170391036 170391260 225 + 1.470 1.397 -0.254
ENSG00000136603 E023 179.0945173 0.0006065867 0.0150716864 0.078358749 3 170392259 170396835 4577 + 2.126 2.198 0.240