ENSG00000136560

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392749 ENSG00000136560 HEK293_OSMI2_6hA HEK293_TMG_6hB TANK protein_coding protein_coding 14.17386 4.280603 24.65395 0.4788744 2.206756 2.523151 5.6125863 1.38832104 10.7169693 0.40850114 0.2859753 2.9394750 0.37116250 0.31466667 0.44013333 0.12546667 6.629811e-01 7.639963e-13 FALSE TRUE
ENST00000403609 ENSG00000136560 HEK293_OSMI2_6hA HEK293_TMG_6hB TANK protein_coding protein_coding 14.17386 4.280603 24.65395 0.4788744 2.206756 2.523151 1.0366310 0.60076602 1.1314781 0.19245091 0.1733553 0.9022115 0.08754583 0.14116667 0.04556667 -0.09560000 1.883125e-01 7.639963e-13 FALSE TRUE
ENST00000429217 ENSG00000136560 HEK293_OSMI2_6hA HEK293_TMG_6hB TANK protein_coding protein_coding 14.17386 4.280603 24.65395 0.4788744 2.206756 2.523151 0.7324423 0.08840544 1.7400391 0.08840544 0.2635916 4.1525053 0.03580417 0.01700000 0.07116667 0.05416667 3.346001e-01 7.639963e-13 FALSE FALSE
ENST00000440506 ENSG00000136560 HEK293_OSMI2_6hA HEK293_TMG_6hB TANK protein_coding protein_coding 14.17386 4.280603 24.65395 0.4788744 2.206756 2.523151 2.2521095 0.00000000 4.6854656 0.00000000 0.5120407 8.8751244 0.10025833 0.00000000 0.19090000 0.19090000 7.639963e-13 7.639963e-13 FALSE FALSE
ENST00000461338 ENSG00000136560 HEK293_OSMI2_6hA HEK293_TMG_6hB TANK protein_coding processed_transcript 14.17386 4.280603 24.65395 0.4788744 2.206756 2.523151 0.5435236 0.13616939 0.5483135 0.02754749 0.2396916 1.9334342 0.05253750 0.03153333 0.02093333 -0.01060000 7.899591e-01 7.639963e-13   FALSE
ENST00000477952 ENSG00000136560 HEK293_OSMI2_6hA HEK293_TMG_6hB TANK protein_coding retained_intron 14.17386 4.280603 24.65395 0.4788744 2.206756 2.523151 0.7917556 0.43640670 0.4497954 0.21881552 0.2537941 0.0426334 0.09337917 0.09636667 0.01663333 -0.07973333 7.549602e-01 7.639963e-13   FALSE
ENST00000483622 ENSG00000136560 HEK293_OSMI2_6hA HEK293_TMG_6hB TANK protein_coding retained_intron 14.17386 4.280603 24.65395 0.4788744 2.206756 2.523151 0.6402614 0.33805826 1.3380633 0.21673352 0.3154789 1.9534876 0.05926667 0.09126667 0.05770000 -0.03356667 1.000000e+00 7.639963e-13   FALSE
MSTRG.19409.4 ENSG00000136560 HEK293_OSMI2_6hA HEK293_TMG_6hB TANK protein_coding   14.17386 4.280603 24.65395 0.4788744 2.206756 2.523151 0.1445028 0.36242832 0.0000000 0.15362005 0.0000000 -5.2188909 0.02718333 0.07926667 0.00000000 -0.07926667 2.323505e-08 7.639963e-13 FALSE TRUE
MSTRG.19409.6 ENSG00000136560 HEK293_OSMI2_6hA HEK293_TMG_6hB TANK protein_coding   14.17386 4.280603 24.65395 0.4788744 2.206756 2.523151 0.9789057 0.39486493 1.1462679 0.06919928 0.3112675 1.5139631 0.07183750 0.09390000 0.04496667 -0.04893333 3.991858e-01 7.639963e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000136560 E001 0.0000000       2 161136908 161136926 19 +      
ENSG00000136560 E002 0.0000000       2 161136927 161136965 39 +      
ENSG00000136560 E003 0.0000000       2 161136966 161137063 98 +      
ENSG00000136560 E004 0.0000000       2 161160299 161160308 10 +      
ENSG00000136560 E005 1.0713538 0.0153787590 2.330041e-01   2 161160309 161160343 35 + 0.301 0.000 -10.940
ENSG00000136560 E006 1.3636376 0.0132331062 6.277733e-01   2 161160344 161160348 5 + 0.331 0.237 -0.650
ENSG00000136560 E007 5.4051518 0.0056059726 6.449408e-01 0.800164387 2 161160349 161160405 57 + 0.723 0.666 -0.236
ENSG00000136560 E008 6.4508772 0.0041902860 6.597504e-01 0.809832067 2 161160406 161160426 21 + 0.778 0.730 -0.196
ENSG00000136560 E009 6.1987442 0.0051547842 7.588458e-01 0.871846516 2 161160427 161160427 1 + 0.757 0.730 -0.112
ENSG00000136560 E010 6.8719338 0.0047617818 8.702105e-01 0.936038955 2 161160428 161160431 4 + 0.789 0.785 -0.015
ENSG00000136560 E011 6.9840209 0.0047303534 8.716770e-01 0.936868232 2 161160432 161160436 5 + 0.789 0.834 0.177
ENSG00000136560 E012 26.6596034 0.0015263616 3.107962e-01 0.551253795 2 161160437 161160456 20 + 1.304 1.411 0.370
ENSG00000136560 E013 41.5269230 0.0015158319 6.566513e-01 0.807718994 2 161160457 161160484 28 + 1.501 1.555 0.186
ENSG00000136560 E014 32.1208610 0.0015327392 6.985430e-01 0.834654894 2 161160485 161160486 2 + 1.393 1.446 0.184
ENSG00000136560 E015 3.5247728 0.3314736889 2.072243e-01 0.438493713 2 161160726 161160822 97 + 0.455 0.880 1.831
ENSG00000136560 E016 7.8747047 0.1906526595 3.700238e-01 0.603973173 2 161160949 161161104 156 + 0.782 1.030 0.943
ENSG00000136560 E017 17.5938708 0.0102224310 4.817163e-04 0.005510340 2 161161285 161161412 128 + 1.063 1.424 1.272
ENSG00000136560 E018 5.5082081 0.0074447251 1.304213e-02 0.070619971 2 161161413 161161666 254 + 0.617 0.989 1.476
ENSG00000136560 E019 3.0058465 0.0199251756 1.425065e-04 0.002010207 2 161161813 161161907 95 + 0.331 0.954 2.804
ENSG00000136560 E020 3.1526129 0.2344593203 4.593923e-02 0.169886703 2 161162533 161163113 581 + 0.383 0.916 2.359
ENSG00000136560 E021 4.8780720 0.0398355028 2.540136e-01 0.492394984 2 161163114 161163518 405 + 0.631 0.834 0.831
ENSG00000136560 E022 0.5233527 0.0216414531 4.670123e-01   2 161179483 161179613 131 + 0.109 0.238 1.352
ENSG00000136560 E023 36.5319262 0.0011131278 5.000740e-01 0.700807963 2 161179614 161179620 7 + 1.462 1.435 -0.095
ENSG00000136560 E024 46.5756882 0.0009157585 6.968872e-01 0.833542007 2 161179621 161179652 32 + 1.558 1.556 -0.008
ENSG00000136560 E025 75.3260289 0.0042002133 3.598997e-01 0.595686771 2 161179653 161179761 109 + 1.765 1.733 -0.111
ENSG00000136560 E026 0.1308682 0.0326491905 8.117607e-02   2 161179762 161180085 324 + 0.000 0.237 13.068
ENSG00000136560 E027 0.1426347 0.0322024476 1.000000e+00   2 161197337 161197528 192 + 0.058 0.000 -10.205
ENSG00000136560 E028 1.7207730 0.0226455879 4.700710e-01 0.680129690 2 161202863 161202979 117 + 0.385 0.238 -0.965
ENSG00000136560 E029 1.0815047 0.1155204570 1.354990e-01   2 161203484 161203486 3 + 0.195 0.503 1.942
ENSG00000136560 E030 83.8394943 0.0005214773 4.928242e-01 0.695885896 2 161203487 161203595 109 + 1.809 1.799 -0.035
ENSG00000136560 E031 82.4009643 0.0007154166 1.755044e-01 0.397819181 2 161204675 161204793 119 + 1.808 1.762 -0.155
ENSG00000136560 E032 3.9411552 0.0066388095 2.132522e-03 0.017962073 2 161204794 161204979 186 + 0.477 0.955 2.002
ENSG00000136560 E033 0.0000000       2 161216389 161216442 54 +      
ENSG00000136560 E034 0.0000000       2 161219724 161219842 119 +      
ENSG00000136560 E035 0.3206185 0.0274424043 1.000000e+00   2 161223400 161223818 419 + 0.109 0.000 -11.175
ENSG00000136560 E036 33.6986587 0.0074391738 7.864457e-02 0.242064329 2 161223915 161223919 5 + 1.443 1.299 -0.498
ENSG00000136560 E037 54.9997534 0.0011434373 3.413289e-03 0.025840540 2 161223920 161223991 72 + 1.653 1.479 -0.595
ENSG00000136560 E038 69.2322146 0.0006461242 6.934845e-05 0.001100445 2 161224631 161224746 116 + 1.756 1.538 -0.742
ENSG00000136560 E039 78.2562121 0.0005268655 1.237690e-02 0.067936348 2 161230971 161231185 215 + 1.794 1.684 -0.374
ENSG00000136560 E040 135.1306090 0.0047227396 5.968657e-01 0.768222074 2 161231186 161231551 366 + 2.002 2.057 0.183
ENSG00000136560 E041 1.0429489 0.1464075136 1.000000e+00   2 161232733 161232755 23 + 0.236 0.240 0.027
ENSG00000136560 E042 1.1855836 0.0160188345 8.729192e-01   2 161232756 161232794 39 + 0.269 0.238 -0.235
ENSG00000136560 E043 0.8627522 0.0167996721 8.814033e-01   2 161232795 161232809 15 + 0.196 0.238 0.350
ENSG00000136560 E044 1.0879220 0.0154901490 2.323943e-01   2 161232810 161232897 88 + 0.301 0.000 -12.840
ENSG00000136560 E045 106.8447453 0.0287012523 8.280962e-02 0.250342501 2 161235342 161236230 889 + 1.872 2.051 0.603