ENSG00000136492

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000577598 ENSG00000136492 HEK293_OSMI2_6hA HEK293_TMG_6hB BRIP1 protein_coding protein_coding 8.452111 2.229773 14.0815 0.3536475 0.7255054 2.653401 0.85824110 0.1317914 2.099652 0.06285636 0.5529523 3.895163 0.08913333 0.07330000 0.1461333 0.07283333 0.6625815910 0.0003984877 FALSE TRUE
ENST00000682453 ENSG00000136492 HEK293_OSMI2_6hA HEK293_TMG_6hB BRIP1 protein_coding protein_coding 8.452111 2.229773 14.0815 0.3536475 0.7255054 2.653401 1.65939528 0.5966306 1.653018 0.31747915 0.8265458 1.454914 0.20571667 0.23510000 0.1129333 -0.12216667 0.9345409767 0.0003984877 FALSE TRUE
ENST00000683235 ENSG00000136492 HEK293_OSMI2_6hA HEK293_TMG_6hB BRIP1 protein_coding nonsense_mediated_decay 8.452111 2.229773 14.0815 0.3536475 0.7255054 2.653401 0.88252833 0.1225653 1.974155 0.12256529 0.2587809 3.903750 0.09458750 0.04516667 0.1424333 0.09726667 0.4386604609 0.0003984877 TRUE TRUE
ENST00000683535 ENSG00000136492 HEK293_OSMI2_6hA HEK293_TMG_6hB BRIP1 protein_coding processed_transcript 8.452111 2.229773 14.0815 0.3536475 0.7255054 2.653401 0.22849914 0.1820821 0.000000 0.09418459 0.0000000 -4.263651 0.10253333 0.08193333 0.0000000 -0.08193333 0.0003984877 0.0003984877 FALSE TRUE
MSTRG.14846.10 ENSG00000136492 HEK293_OSMI2_6hA HEK293_TMG_6hB BRIP1 protein_coding   8.452111 2.229773 14.0815 0.3536475 0.7255054 2.653401 1.57034651 0.1711955 3.008230 0.17119551 0.4256383 4.058083 0.13466250 0.11110000 0.2135000 0.10240000 0.4742742915 0.0003984877 FALSE TRUE
MSTRG.14846.12 ENSG00000136492 HEK293_OSMI2_6hA HEK293_TMG_6hB BRIP1 protein_coding   8.452111 2.229773 14.0815 0.3536475 0.7255054 2.653401 0.01560818 0.1248654 0.000000 0.12486543 0.0000000 -3.753449 0.00641250 0.05130000 0.0000000 -0.05130000 0.6306055786 0.0003984877 FALSE TRUE
MSTRG.14846.19 ENSG00000136492 HEK293_OSMI2_6hA HEK293_TMG_6hB BRIP1 protein_coding   8.452111 2.229773 14.0815 0.3536475 0.7255054 2.653401 0.77604006 0.0998994 2.032925 0.09989940 0.6675264 4.216381 0.06220000 0.03680000 0.1490000 0.11220000 0.4264269307 0.0003984877 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000136492 E001 1.6502418 0.0131279097 0.269532310 0.50935053 17 61679139 61681265 2127 - 0.277 0.538 1.458
ENSG00000136492 E002 0.1308682 0.0326491905 0.072186711   17 61681266 61681271 6 - 0.000 0.259 13.812
ENSG00000136492 E003 0.1308682 0.0326491905 0.072186711   17 61681272 61681273 2 - 0.000 0.259 13.812
ENSG00000136492 E004 0.1308682 0.0326491905 0.072186711   17 61681274 61681278 5 - 0.000 0.259 13.812
ENSG00000136492 E005 0.1308682 0.0326491905 0.072186711   17 61681279 61681285 7 - 0.000 0.259 13.812
ENSG00000136492 E006 5.2059474 0.1434260084 0.039466697 0.15338245 17 61681286 61681348 63 - 0.572 1.028 1.823
ENSG00000136492 E007 8.4058754 0.2773783178 0.082529233 0.24976867 17 61681349 61681388 40 - 0.743 1.184 1.657
ENSG00000136492 E008 23.7661422 0.6473044349 0.257926757 0.49666518 17 61681389 61681479 91 - 1.177 1.511 1.164
ENSG00000136492 E009 273.5970683 1.7413394064 0.394174724 0.62368335 17 61681480 61684140 2661 - 2.208 2.564 1.187
ENSG00000136492 E010 12.3077095 0.0266612571 0.010428495 0.05997894 17 61684772 61685214 443 - 1.020 0.630 -1.536
ENSG00000136492 E011 3.7951623 0.0073899917 0.654187030 0.80620415 17 61685215 61685218 4 - 0.565 0.538 -0.125
ENSG00000136492 E012 3.7763812 0.0069511269 0.653793769 0.80597293 17 61685219 61685230 12 - 0.565 0.538 -0.125
ENSG00000136492 E013 33.3374461 0.0054761946 0.460405153 0.67344048 17 61685231 61685835 605 - 1.377 1.392 0.052
ENSG00000136492 E014 75.4978729 0.0005580677 0.778611493 0.88390891 17 61685836 61686165 330 - 1.718 1.783 0.220
ENSG00000136492 E015 0.3040503 0.0244411696 1.000000000   17 61687113 61687237 125 - 0.099 0.000 -11.010
ENSG00000136492 E016 0.6847684 0.0189581323 0.620401285   17 61688356 61688472 117 - 0.141 0.260 1.098
ENSG00000136492 E017 44.7348817 0.0185791608 0.577131655 0.75519705 17 61693430 61693512 83 - 1.496 1.521 0.085
ENSG00000136492 E018 54.7671580 0.0108969659 0.349965180 0.58719781 17 61715951 61716063 113 - 1.585 1.589 0.012
ENSG00000136492 E019 0.3206185 0.0249364644 1.000000000   17 61716064 61716771 708 - 0.099 0.000 -11.010
ENSG00000136492 E020 0.6071052 0.0193874923 0.009295745   17 61739057 61739116 60 - 0.052 0.538 4.265
ENSG00000136492 E021 2.1922581 0.0103402519 0.074617967 0.23400083 17 61739117 61739410 294 - 0.332 0.706 1.833
ENSG00000136492 E022 59.0141492 0.0039786028 0.445815451 0.66264916 17 61743013 61743134 122 - 1.616 1.646 0.102
ENSG00000136492 E023 59.9143850 0.0056116972 0.486436070 0.69152460 17 61744432 61744591 160 - 1.625 1.661 0.121
ENSG00000136492 E024 0.0000000       17 61758674 61759310 637 -      
ENSG00000136492 E025 0.3453689 0.0294823922 0.222704036   17 61775878 61776147 270 - 0.052 0.260 2.686
ENSG00000136492 E026 41.8985316 0.0016410010 0.843908751 0.92153987 17 61776401 61776502 102 - 1.472 1.537 0.225
ENSG00000136492 E027 23.7206295 0.0019944357 0.196348645 0.42499829 17 61776503 61776562 60 - 1.215 1.406 0.670
ENSG00000136492 E028 0.8206259 0.0326689296 0.206393274   17 61776563 61776898 336 - 0.141 0.420 2.090
ENSG00000136492 E029 3.3500158 0.3022350311 0.991593724 0.99756775 17 61776899 61778119 1221 - 0.512 0.537 0.117
ENSG00000136492 E030 2.5995229 0.0192796618 0.045268359 0.16827424 17 61778120 61778179 60 - 0.357 0.770 1.938
ENSG00000136492 E031 3.9951970 0.2964480111 0.704103384 0.83820257 17 61778180 61778672 493 - 0.574 0.544 -0.138
ENSG00000136492 E032 1.4618628 0.0735639713 0.656860840 0.80788462 17 61778673 61778778 106 - 0.278 0.420 0.861
ENSG00000136492 E033 4.4802340 0.0461117345 0.251830840 0.48987411 17 61778779 61780260 1482 - 0.564 0.830 1.111
ENSG00000136492 E034 40.8563760 0.0010324745 0.290822252 0.53144469 17 61780261 61780401 141 - 1.470 1.471 0.002
ENSG00000136492 E035 2.6997939 0.0100324959 0.168509615 0.38858830 17 61780402 61780839 438 - 0.403 0.706 1.418
ENSG00000136492 E036 55.5692380 0.0155203448 0.323454109 0.56278540 17 61780840 61781005 166 - 1.596 1.593 -0.007
ENSG00000136492 E037 0.1308682 0.0326491905 0.072186711   17 61783819 61783907 89 - 0.000 0.259 13.812
ENSG00000136492 E038 56.8473925 0.0132489139 0.343560343 0.58121262 17 61784270 61784424 155 - 1.604 1.611 0.023
ENSG00000136492 E039 2.0154032 0.1901529283 0.131254522 0.33377936 17 61784425 61784637 213 - 0.409 0.000 -13.283
ENSG00000136492 E040 46.6119752 0.0096238871 0.879191400 0.94090129 17 61793597 61793729 133 - 1.506 1.603 0.331
ENSG00000136492 E041 1.1198745 0.0146797521 0.964927179   17 61795732 61796540 809 - 0.247 0.259 0.097
ENSG00000136492 E042 63.8690632 0.0105531266 0.397363640 0.62622598 17 61799100 61799299 200 - 1.650 1.669 0.064
ENSG00000136492 E043 67.1012891 0.0126456068 0.039654733 0.15385620 17 61801253 61801474 222 - 1.684 1.596 -0.300
ENSG00000136492 E044 0.3337900 0.0298453469 0.223197893   17 61801906 61801990 85 - 0.052 0.260 2.682
ENSG00000136492 E045 85.1666912 0.0005779532 0.001323480 0.01233668 17 61808467 61808757 291 - 1.790 1.692 -0.331
ENSG00000136492 E046 0.0000000       17 61844931 61844935 5 -      
ENSG00000136492 E047 3.0608777 0.0082553446 0.626612380 0.78828092 17 61844936 61845819 884 - 0.482 0.630 0.681
ENSG00000136492 E048 0.9349259 0.0176866536 0.056025303   17 61846882 61847100 219 - 0.141 0.537 2.677
ENSG00000136492 E049 53.7075872 0.0008524071 0.068912110 0.22259117 17 61847101 61847220 120 - 1.590 1.548 -0.146
ENSG00000136492 E050 49.3423687 0.0015719051 0.190034153 0.41698811 17 61849129 61849256 128 - 1.550 1.538 -0.042
ENSG00000136492 E051 63.6599828 0.0273223292 0.191495045 0.41876795 17 61857058 61857231 174 - 1.658 1.616 -0.142
ENSG00000136492 E052 47.2631922 0.0256838647 0.029356898 0.12544604 17 61859796 61859907 112 - 1.544 1.390 -0.529
ENSG00000136492 E053 48.5346397 0.0318637287 0.055007289 0.19136542 17 61861447 61861565 119 - 1.554 1.427 -0.435
ENSG00000136492 E054 14.6947822 0.1037010746 0.079426857 0.24367279 17 61861566 61861569 4 - 1.075 0.817 -0.971
ENSG00000136492 E055 2.2784949 0.0099855455 0.332161145 0.57100011 17 61861570 61861909 340 - 0.424 0.259 -1.020
ENSG00000136492 E056 3.2613442 0.0109079918 0.134432923 0.33878142 17 61861910 61862075 166 - 0.535 0.259 -1.569
ENSG00000136492 E057 6.4929488 0.0208234390 0.007349032 0.04630992 17 61862076 61863280 1205 - 0.777 0.259 -2.609
ENSG00000136492 E058 30.7291758 0.0234558517 0.010408519 0.05989754 17 61863284 61863326 43 - 1.372 1.145 -0.798
ENSG00000136492 E059 32.8172032 0.0144087850 0.004128109 0.02988269 17 61863327 61863473 147 - 1.402 1.170 -0.813
ENSG00000136492 E060 10.2718673 0.0410524507 0.343423683 0.58109142 17 61863474 61863559 86 - 0.921 0.828 -0.358