ENSG00000136169

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317257 ENSG00000136169 HEK293_OSMI2_6hA HEK293_TMG_6hB SETDB2 protein_coding protein_coding 2.403835 1.009623 4.360119 0.178774 0.2517001 2.099636 0.1078946 0.00000000 0.0000000 0.00000000 0.000000000 0.000000 0.07718333 0.00000000 0.00000000 0.00000000   0.001027389 FALSE TRUE
ENST00000354234 ENSG00000136169 HEK293_OSMI2_6hA HEK293_TMG_6hB SETDB2 protein_coding protein_coding 2.403835 1.009623 4.360119 0.178774 0.2517001 2.099636 0.1439972 0.02651438 0.2317254 0.02651438 0.109791814 2.726832 0.05885833 0.01943333 0.05636667 0.03693333 0.786234115 0.001027389 FALSE TRUE
ENST00000481439 ENSG00000136169 HEK293_OSMI2_6hA HEK293_TMG_6hB SETDB2 protein_coding processed_transcript 2.403835 1.009623 4.360119 0.178774 0.2517001 2.099636 0.2253171 0.24656236 0.1157181 0.12367739 0.004522259 -1.029117 0.13574167 0.21863333 0.02666667 -0.19196667 0.003638060 0.001027389   FALSE
ENST00000611815 ENSG00000136169 HEK293_OSMI2_6hA HEK293_TMG_6hB SETDB2 protein_coding protein_coding 2.403835 1.009623 4.360119 0.178774 0.2517001 2.099636 0.8943105 0.50288998 1.5782211 0.02477801 0.299695810 1.630691 0.35567917 0.51866667 0.35683333 -0.16183333 0.539742701 0.001027389 FALSE TRUE
MSTRG.8754.5 ENSG00000136169 HEK293_OSMI2_6hA HEK293_TMG_6hB SETDB2 protein_coding   2.403835 1.009623 4.360119 0.178774 0.2517001 2.099636 0.2382962 0.12013851 0.4175342 0.06635020 0.124207332 1.715992 0.12818750 0.14303333 0.09703333 -0.04600000 0.958846817 0.001027389 FALSE TRUE
MSTRG.8754.7 ENSG00000136169 HEK293_OSMI2_6hA HEK293_TMG_6hB SETDB2 protein_coding   2.403835 1.009623 4.360119 0.178774 0.2517001 2.099636 0.7097206 0.05731519 1.9063784 0.05731519 0.122569211 4.831306 0.19808333 0.04200000 0.43696667 0.39496667 0.001027389 0.001027389 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000136169 E001 0.0000000       13 49444101 49444134 34 +      
ENSG00000136169 E002 2.5000101 0.009792724 4.208617e-01 0.6443271699 13 49444274 49444287 14 + 0.497 0.356 -0.755
ENSG00000136169 E003 6.6041264 0.005833351 8.779018e-01 0.9401907037 13 49444288 49444373 86 + 0.785 0.827 0.163
ENSG00000136169 E004 9.2931493 0.003465309 9.360264e-01 0.9702342002 13 49444374 49444494 121 + 0.924 0.935 0.040
ENSG00000136169 E005 4.8532023 0.013948198 8.090558e-01 0.9016332195 13 49444495 49444538 44 + 0.679 0.736 0.233
ENSG00000136169 E006 7.0268670 0.005760966 5.835199e-01 0.7592840498 13 49444539 49444592 54 + 0.807 0.901 0.363
ENSG00000136169 E007 7.4191321 0.050244059 7.528288e-01 0.8684593652 13 49444593 49444633 41 + 0.865 0.824 -0.160
ENSG00000136169 E008 7.1892104 0.006363549 4.716530e-01 0.6812983290 13 49444634 49444667 34 + 0.818 0.934 0.443
ENSG00000136169 E009 5.4724535 0.005645012 5.241541e-01 0.7179212161 13 49444668 49444683 16 + 0.761 0.681 -0.328
ENSG00000136169 E010 8.9260034 0.009613078 3.016355e-01 0.5421802062 13 49444684 49444725 42 + 0.948 0.825 -0.468
ENSG00000136169 E011 15.7595513 0.006014208 5.592036e-01 0.7427249287 13 49444726 49444857 132 + 1.155 1.115 -0.145
ENSG00000136169 E012 0.3751086 0.027442404 2.408669e-02   13 49445553 49445952 400 + 0.000 0.356 11.655
ENSG00000136169 E013 0.0000000       13 49451552 49451552 1 +      
ENSG00000136169 E014 21.9747928 0.002549452 1.037652e-01 0.2884918917 13 49451553 49451909 357 + 1.302 1.174 -0.453
ENSG00000136169 E015 16.8144026 0.002677289 6.306516e-01 0.7908292518 13 49460107 49460232 126 + 1.180 1.155 -0.090
ENSG00000136169 E016 13.9034184 0.009453814 4.607069e-01 0.6736636631 13 49461097 49461162 66 + 1.108 1.045 -0.230
ENSG00000136169 E017 1.8543474 0.055666983 8.042606e-01 0.8987724478 13 49464021 49464056 36 + 0.395 0.357 -0.222
ENSG00000136169 E018 16.5091864 0.025274807 1.701915e-01 0.3906842701 13 49467864 49467960 97 + 1.191 1.042 -0.537
ENSG00000136169 E019 24.9519177 0.029664077 1.587755e-01 0.3749283266 13 49476476 49476698 223 + 1.358 1.219 -0.484
ENSG00000136169 E020 12.5455779 0.008301716 2.782238e-01 0.5183346861 13 49476699 49476792 94 + 1.074 0.964 -0.404
ENSG00000136169 E021 10.7941020 0.014710507 3.014673e-01 0.5419754386 13 49476793 49476821 29 + 1.016 0.900 -0.433
ENSG00000136169 E022 25.0436381 0.001745228 3.153619e-02 0.1318748802 13 49476822 49477039 218 + 1.359 1.192 -0.587
ENSG00000136169 E023 22.3573603 0.001550508 3.011677e-01 0.5416326443 13 49480219 49480335 117 + 1.295 1.226 -0.243
ENSG00000136169 E024 29.0612077 0.001290190 3.635438e-01 0.5986318524 13 49480947 49481116 170 + 1.401 1.353 -0.166
ENSG00000136169 E025 0.3088520 0.025374913 3.458525e-01   13 49482031 49482092 62 + 0.066 0.213 1.942
ENSG00000136169 E026 34.1036422 0.001578304 8.218295e-01 0.9090256363 13 49482737 49482962 226 + 1.454 1.461 0.023
ENSG00000136169 E027 19.9416980 0.004437029 7.466120e-01 0.8647331552 13 49483464 49483563 100 + 1.221 1.273 0.183
ENSG00000136169 E028 21.1370744 0.010766451 5.922271e-01 0.7651292641 13 49485630 49485723 94 + 1.260 1.227 -0.113
ENSG00000136169 E029 29.3876531 0.002968964 7.549607e-01 0.8696427825 13 49488290 49488501 212 + 1.384 1.431 0.162
ENSG00000136169 E030 21.0549357 0.002270095 7.411780e-01 0.8611732081 13 49488502 49488630 129 + 1.250 1.301 0.180
ENSG00000136169 E031 0.0000000       13 49489520 49489576 57 +      
ENSG00000136169 E032 19.1697103 0.008483696 8.603732e-01 0.9305553594 13 49490822 49490910 89 + 1.204 1.244 0.140
ENSG00000136169 E033 84.5113354 0.013412782 2.544741e-05 0.0004685121 13 49491732 49495003 3272 + 1.768 2.043 0.928