ENSG00000136143

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000434484 ENSG00000136143 HEK293_OSMI2_6hA HEK293_TMG_6hB SUCLA2 protein_coding protein_coding 38.08764 25.18824 55.68621 5.242114 1.399001 1.144257 1.734997 0.5162044 3.9830668 0.2583347 1.0010138 2.923802 0.03630000 0.0170000 0.07196667 0.05496667 4.123879e-01 9.91978e-23 FALSE FALSE
ENST00000646932 ENSG00000136143 HEK293_OSMI2_6hA HEK293_TMG_6hB SUCLA2 protein_coding protein_coding 38.08764 25.18824 55.68621 5.242114 1.399001 1.144257 19.659676 5.3588487 38.9346625 0.8889528 0.8522072 2.858741 0.45152083 0.2182667 0.69990000 0.48163333 9.919780e-23 9.91978e-23 FALSE TRUE
MSTRG.8727.27 ENSG00000136143 HEK293_OSMI2_6hA HEK293_TMG_6hB SUCLA2 protein_coding   38.08764 25.18824 55.68621 5.242114 1.399001 1.144257 2.578098 4.6911988 1.3595920 1.0081610 0.2173027 -1.779283 0.08832917 0.1856667 0.02426667 -0.16140000 8.823415e-16 9.91978e-23   FALSE
MSTRG.8727.28 ENSG00000136143 HEK293_OSMI2_6hA HEK293_TMG_6hB SUCLA2 protein_coding   38.08764 25.18824 55.68621 5.242114 1.399001 1.144257 3.240121 4.5725816 1.4732060 1.0017791 0.1186610 -1.627442 0.10950833 0.1807667 0.02653333 -0.15423333 6.583809e-22 9.91978e-23   FALSE
MSTRG.8727.29 ENSG00000136143 HEK293_OSMI2_6hA HEK293_TMG_6hB SUCLA2 protein_coding   38.08764 25.18824 55.68621 5.242114 1.399001 1.144257 2.761340 4.0170283 1.0863228 0.8969344 0.2159242 -1.877043 0.09269583 0.1609333 0.01943333 -0.14150000 5.379461e-11 9.91978e-23   FALSE
MSTRG.8727.30 ENSG00000136143 HEK293_OSMI2_6hA HEK293_TMG_6hB SUCLA2 protein_coding   38.08764 25.18824 55.68621 5.242114 1.399001 1.144257 2.756120 4.4724446 0.5576728 1.2963610 0.3272309 -2.981154 0.09708750 0.1694667 0.01030000 -0.15916667 5.125728e-02 9.91978e-23   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000136143 E001 0.1779838 0.0350556859 1.000000e+00   13 47745736 47746437 702 - 0.058 0.000 -7.577
ENSG00000136143 E002 1.7314215 0.0939772796 7.520579e-01 8.679533e-01 13 47746438 47747424 987 - 0.332 0.499 0.908
ENSG00000136143 E003 0.1614157 0.0335267842 1.000000e+00   13 47797002 47797212 211 - 0.058 0.000 -9.803
ENSG00000136143 E004 0.0000000       13 47798259 47798508 250 -      
ENSG00000136143 E005 0.3150090 0.0292797311 3.398099e-01   13 47807394 47807399 6 - 0.058 0.239 2.367
ENSG00000136143 E006 0.4873834 0.3950957007 1.590011e-01   13 47807400 47807499 100 - 0.057 0.396 3.407
ENSG00000136143 E007 0.4764247 0.0217681645 6.132633e-01   13 47884692 47884761 70 - 0.109 0.239 1.366
ENSG00000136143 E008 0.5540201 0.2410423790 6.940199e-02   13 47905329 47905398 70 - 0.058 0.493 3.889
ENSG00000136143 E009 0.9183577 0.2925999647 1.987053e-01   13 47907018 47907135 118 - 0.155 0.497 2.321
ENSG00000136143 E010 0.0000000       13 47907331 47907452 122 -      
ENSG00000136143 E011 2.1422392 0.0100821628 1.242116e-02 6.813081e-02 13 47932694 47932783 90 - 0.268 0.787 2.585
ENSG00000136143 E012 9.2062272 0.0555441359 1.490347e-01 3.608686e-01 13 47934915 47935821 907 - 0.812 1.159 1.293
ENSG00000136143 E013 4.0302952 0.0085963724 8.425994e-01 9.209127e-01 13 47936491 47936501 11 - 0.584 0.732 0.629
ENSG00000136143 E014 6.2781251 0.0291451840 9.457894e-01 9.752793e-01 13 47936502 47936617 116 - 0.742 0.877 0.533
ENSG00000136143 E015 7.8839779 0.0367719684 8.347439e-01 9.164055e-01 13 47936618 47936773 156 - 0.831 0.918 0.335
ENSG00000136143 E016 1.7337569 0.1335850954 6.449610e-01 8.001725e-01 13 47939267 47939363 97 - 0.326 0.508 0.986
ENSG00000136143 E017 0.9335208 0.0158471574 7.841475e-01   13 47942656 47942660 5 - 0.233 0.238 0.040
ENSG00000136143 E018 12.2909361 0.0036920034 1.321324e-01 3.351882e-01 13 47942661 47942688 28 - 0.938 1.234 1.071
ENSG00000136143 E019 37.6492583 0.0159403777 9.066983e-01 9.554435e-01 13 47942689 47942728 40 - 1.434 1.561 0.435
ENSG00000136143 E020 44.6095225 0.0308875728 5.756543e-01 7.541123e-01 13 47942729 47942780 52 - 1.517 1.590 0.248
ENSG00000136143 E021 296.7109142 0.0013956186 4.969500e-04 5.645809e-03 13 47942781 47943344 564 - 2.338 2.378 0.136
ENSG00000136143 E022 114.9961114 0.0152312757 8.892368e-02 2.617755e-01 13 47943345 47943360 16 - 1.935 1.948 0.041
ENSG00000136143 E023 167.5393550 0.0028671663 1.513278e-02 7.859246e-02 13 47943361 47943445 85 - 2.093 2.136 0.143
ENSG00000136143 E024 0.1426347 0.0320050217 1.000000e+00   13 47945731 47945939 209 - 0.058 0.000 -9.816
ENSG00000136143 E025 192.3657771 0.0003197305 9.903192e-09 4.670341e-07 13 47948940 47949028 89 - 2.169 2.125 -0.145
ENSG00000136143 E026 202.8277053 0.0008225374 1.584075e-08 7.105453e-07 13 47949483 47949603 121 - 2.192 2.145 -0.155
ENSG00000136143 E027 94.2113493 0.0004924114 7.372587e-05 1.159721e-03 13 47954140 47954142 3 - 1.862 1.820 -0.141
ENSG00000136143 E028 212.5888423 0.0002455896 1.348623e-08 6.138493e-07 13 47954143 47954282 140 - 2.209 2.179 -0.099
ENSG00000136143 E029 1.9822669 0.0202645062 3.392671e-02 1.386551e-01 13 47954283 47954395 113 - 0.433 0.000 -13.403
ENSG00000136143 E030 146.9981814 0.0003824708 3.582014e-06 8.648114e-05 13 47954396 47954452 57 - 2.047 2.018 -0.098
ENSG00000136143 E031 188.9984840 0.0002889793 2.100333e-10 1.391127e-08 13 47954453 47954557 105 - 2.164 2.096 -0.227
ENSG00000136143 E032 2.1190318 0.3371566495 7.328517e-01 8.558908e-01 13 47956840 47956872 33 - 0.358 0.602 1.231
ENSG00000136143 E033 1.6260389 0.3071877224 6.701407e-01 8.163880e-01 13 47956873 47956878 6 - 0.300 0.510 1.171
ENSG00000136143 E034 3.7307390 0.0098041734 9.663588e-01 9.850770e-01 13 47965578 47965640 63 - 0.551 0.669 0.520
ENSG00000136143 E035 208.6621142 0.0002609394 5.156869e-08 2.049988e-06 13 47968595 47968733 139 - 2.199 2.175 -0.082
ENSG00000136143 E036 0.9231097 0.0379778862 8.005387e-01   13 47971453 47971680 228 - 0.233 0.239 0.049
ENSG00000136143 E037 2.2447230 0.0098571808 7.750095e-02 2.398659e-01 13 47971681 47971883 203 - 0.330 0.732 1.951
ENSG00000136143 E038 4.0751621 0.0152378430 5.597465e-03 3.772021e-02 13 47971884 47972086 203 - 0.455 0.990 2.247
ENSG00000136143 E039 198.8567777 0.0002566593 9.219374e-09 4.367257e-07 13 47973264 47973392 129 - 2.179 2.139 -0.134
ENSG00000136143 E040 7.3829433 0.0130540877 1.366932e-03 1.266153e-02 13 47987634 47988540 907 - 0.868 0.392 -2.123
ENSG00000136143 E041 232.5807382 0.0009141367 1.044956e-10 7.384831e-09 13 47988541 47988703 163 - 2.250 2.183 -0.224
ENSG00000136143 E042 204.8825694 0.0002979629 6.919662e-13 7.307946e-11 13 47988882 47988981 100 - 2.199 2.108 -0.303
ENSG00000136143 E043 1.6286277 0.0902231431 2.305629e-01 4.657936e-01 13 47991503 47991678 176 - 0.269 0.595 1.775
ENSG00000136143 E044 0.2735028 0.0255119245 3.427087e-01   13 47992047 47992103 57 - 0.058 0.238 2.363
ENSG00000136143 E045 1.3253852 0.0673880186 8.067028e-01   13 47994800 47994896 97 - 0.268 0.393 0.780
ENSG00000136143 E046 136.6378084 0.0003230981 5.900410e-10 3.585064e-08 13 47996843 47996912 70 - 2.028 1.923 -0.353
ENSG00000136143 E047 131.7603470 0.0003371649 4.319042e-08 1.746363e-06 13 47996913 47997023 111 - 2.008 1.930 -0.260
ENSG00000136143 E048 0.4466850 0.0236639526 5.635247e-01   13 48000907 48001179 273 - 0.154 0.000 -11.458
ENSG00000136143 E049 82.8579489 0.0004819728 3.421677e-06 8.317770e-05 13 48001180 48001323 144 - 1.813 1.718 -0.321
ENSG00000136143 E050 19.2052011 0.0922782718 4.870825e-12 4.451981e-10 13 48002248 48002259 12 - 0.594 1.865 4.629
ENSG00000136143 E051 62.3331915 0.4966252170 1.990495e-04 2.664816e-03 13 48002260 48002600 341 - 1.002 2.372 4.695
ENSG00000136143 E052 6.2430385 0.0114287458 1.430845e-13 1.722114e-11 13 48004478 48004700 223 - 0.329 1.386 4.362
ENSG00000136143 E053 36.8134233 0.2340696202 2.160968e-08 9.407384e-07 13 48004701 48005001 301 - 0.681 2.168 5.267
ENSG00000136143 E054 21.5508632 0.0190553765 1.607032e-36 2.148906e-33 13 48015171 48015248 78 - 0.475 1.950 5.475
ENSG00000136143 E055 123.4648942 0.1245289317 8.062953e-16 1.374774e-13 13 48037606 48037968 363 - 1.123 2.693 5.326