ENSG00000136111

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377625 ENSG00000136111 HEK293_OSMI2_6hA HEK293_TMG_6hB TBC1D4 protein_coding protein_coding 21.46876 12.50404 37.21385 3.47919 1.068126 1.57268 16.579063 11.3393407 27.530204 2.9609126 1.9199607 1.278931 0.8294250 0.9215667 0.7407333 -0.1808333 1.616605e-01 8.143862e-05 FALSE TRUE
ENST00000413735 ENSG00000136111 HEK293_OSMI2_6hA HEK293_TMG_6hB TBC1D4 protein_coding protein_coding 21.46876 12.50404 37.21385 3.47919 1.068126 1.57268 2.474999 0.0000000 4.586951 0.0000000 1.9261116 8.844533 0.0754875 0.0000000 0.1226000 0.1226000 8.143862e-05 8.143862e-05 FALSE FALSE
MSTRG.8883.5 ENSG00000136111 HEK293_OSMI2_6hA HEK293_TMG_6hB TBC1D4 protein_coding   21.46876 12.50404 37.21385 3.47919 1.068126 1.57268 1.917289 0.9476155 4.159963 0.5209889 0.4951751 2.122516 0.0679875 0.0589000 0.1116000 0.0527000 7.291946e-01 8.143862e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000136111 E001 4.5940724 0.1344504185 0.4230828119 0.645910914 13 75283503 75284664 1162 - 0.641 0.838 0.805
ENSG00000136111 E002 63.4323588 0.7744466006 0.1740582788 0.395947961 13 75284665 75284844 180 - 1.532 2.076 1.840
ENSG00000136111 E003 205.0089110 1.4321646776 0.3227320185 0.562097529 13 75284845 75285020 176 - 2.087 2.539 1.510
ENSG00000136111 E004 983.5648044 1.9990221080 0.4580193705 0.671758547 13 75285021 75286615 1595 - 2.820 3.165 1.147
ENSG00000136111 E005 275.0625257 1.6116109752 0.5191587501 0.714460145 13 75286616 75287025 410 - 2.317 2.549 0.776
ENSG00000136111 E006 224.3686511 0.0062907264 0.0383710488 0.150547237 13 75288934 75289110 177 - 2.253 2.427 0.580
ENSG00000136111 E007 213.0629990 0.0039392560 0.7630896899 0.874486675 13 75292102 75292254 153 - 2.262 2.343 0.268
ENSG00000136111 E008 84.7593930 0.0009218815 0.3413812486 0.579309770 13 75292255 75292271 17 - 1.878 1.931 0.181
ENSG00000136111 E009 86.1066154 0.0054883849 0.1788861172 0.402471842 13 75294854 75294864 11 - 1.890 1.912 0.071
ENSG00000136111 E010 196.2883235 0.0094528877 0.1120654207 0.302524231 13 75294865 75295013 149 - 2.249 2.258 0.030
ENSG00000136111 E011 232.8234411 0.0151770775 0.1919956265 0.419355180 13 75299330 75299574 245 - 2.322 2.336 0.045
ENSG00000136111 E012 201.3567330 0.0092085295 0.0781324813 0.241084586 13 75302243 75302401 159 - 2.262 2.265 0.008
ENSG00000136111 E013 0.4880035 0.1295617812 1.0000000000   13 75302616 75302821 206 - 0.146 0.183 0.395
ENSG00000136111 E014 231.6366255 0.0124049123 0.0335185388 0.137516460 13 75306313 75306465 153 - 2.333 2.295 -0.125
ENSG00000136111 E015 111.7644410 0.0144319944 0.0702206086 0.225213870 13 75306466 75306471 6 - 2.019 1.981 -0.130
ENSG00000136111 E016 187.4911555 0.0120832128 0.0235940849 0.107829013 13 75309942 75310034 93 - 2.244 2.198 -0.152
ENSG00000136111 E017 177.1948555 0.0124202447 0.2190983432 0.452337648 13 75310035 75310151 117 - 2.202 2.217 0.050
ENSG00000136111 E018 111.0147474 0.0199339485 0.2819602192 0.522287634 13 75312738 75312781 44 - 2.003 2.010 0.024
ENSG00000136111 E019 157.3054502 0.0143110287 0.1016420178 0.284724736 13 75312782 75312898 117 - 2.161 2.142 -0.064
ENSG00000136111 E020 0.1426347 0.0325890508 1.0000000000   13 75316472 75316552 81 - 0.079 0.000 -8.480
ENSG00000136111 E021 0.1723744 0.1550164844 0.2350853727   13 75320014 75320037 24 - 0.000 0.182 11.192
ENSG00000136111 E022 0.7084213 0.0196441776 0.7328339407   13 75324237 75324401 165 - 0.204 0.308 0.782
ENSG00000136111 E023 243.5975100 0.0167873328 0.0265781312 0.117016955 13 75326197 75326423 227 - 2.357 2.310 -0.156
ENSG00000136111 E024 129.1888339 0.0456721314 0.2328102416 0.468386846 13 75327752 75327826 75 - 2.071 2.067 -0.011
ENSG00000136111 E025 160.2207610 0.0286347094 0.0698029790 0.224408438 13 75336921 75337040 120 - 2.178 2.125 -0.177
ENSG00000136111 E026 152.0840869 0.0186271759 0.0005371283 0.006012178 13 75341125 75341235 111 - 2.182 2.021 -0.540
ENSG00000136111 E027 158.2133381 0.0161023386 0.0004380491 0.005109610 13 75341496 75341587 92 - 2.196 2.050 -0.489
ENSG00000136111 E028 161.9901608 0.0208480951 0.0313918055 0.131465990 13 75349170 75349302 133 - 2.183 2.125 -0.194
ENSG00000136111 E029 128.3490533 0.0254511340 0.0080160977 0.049391110 13 75356147 75356251 105 - 2.096 1.984 -0.374
ENSG00000136111 E030 117.4166982 0.0156287928 0.0401006455 0.154975702 13 75359769 75359858 90 - 2.044 1.988 -0.185
ENSG00000136111 E031 334.5171703 0.0130620585 0.0009211542 0.009272311 13 75362026 75362607 582 - 2.509 2.406 -0.342
ENSG00000136111 E032 0.0000000       13 75364601 75364655 55 -      
ENSG00000136111 E033 0.0000000       13 75366914 75367015 102 -      
ENSG00000136111 E034 177.5106798 0.0175874455 0.3970409202 0.625984609 13 75481270 75482169 900 - 2.196 2.242 0.154