ENSG00000136068

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358537 ENSG00000136068 HEK293_OSMI2_6hA HEK293_TMG_6hB FLNB protein_coding protein_coding 46.98513 66.21811 33.92453 5.249766 0.2828534 -0.9646895 16.299863 17.069655 24.043334 2.616277 0.1117561 0.4939581 0.4220167 0.26640000 0.7089000 0.44250000 4.290436e-05 4.686257e-10 FALSE TRUE
ENST00000484981 ENSG00000136068 HEK293_OSMI2_6hA HEK293_TMG_6hB FLNB protein_coding processed_transcript 46.98513 66.21811 33.92453 5.249766 0.2828534 -0.9646895 6.202513 6.031206 0.000000 3.268948 0.0000000 -9.2386927 0.0973000 0.08406667 0.0000000 -0.08406667 3.626428e-01 4.686257e-10 FALSE TRUE
ENST00000682297 ENSG00000136068 HEK293_OSMI2_6hA HEK293_TMG_6hB FLNB protein_coding processed_transcript 46.98513 66.21811 33.92453 5.249766 0.2828534 -0.9646895 14.382450 28.773467 3.586184 3.609589 0.5472996 -3.0007017 0.2624000 0.43113333 0.1056333 -0.32550000 4.686257e-10 4.686257e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000136068 E001 1.7482769 0.0164464160 9.702011e-01 9.869561e-01 3 58008398 58008399 2 + 0.422 0.443 0.113
ENSG00000136068 E002 2.7410895 0.0178080727 9.711393e-01 9.874173e-01 3 58008400 58008405 6 + 0.540 0.578 0.177
ENSG00000136068 E003 10.4203146 0.0035609806 4.427204e-01 6.605237e-01 3 58008406 58008421 16 + 1.068 1.027 -0.149
ENSG00000136068 E004 49.8876784 0.0289144463 1.823147e-01 4.070189e-01 3 58008422 58008440 19 + 1.739 1.669 -0.240
ENSG00000136068 E005 90.0008402 0.0283641123 1.217190e-01 3.185770e-01 3 58008441 58008486 46 + 1.996 1.915 -0.271
ENSG00000136068 E006 277.8693787 0.0053083887 5.202505e-09 2.606209e-07 3 58008487 58008856 370 + 2.544 2.349 -0.653
ENSG00000136068 E007 237.0998788 0.0048426491 3.418199e-12 3.216933e-10 3 58077046 58077294 249 + 2.498 2.259 -0.799
ENSG00000136068 E008 0.0000000       3 58078329 58078519 191 +      
ENSG00000136068 E009 162.4106699 0.0027789515 8.236227e-13 8.570471e-11 3 58078717 58078814 98 + 2.328 2.103 -0.751
ENSG00000136068 E010 220.1706421 0.0033942776 3.161298e-10 2.016001e-08 3 58081629 58081776 148 + 2.441 2.253 -0.625
ENSG00000136068 E011 222.6497443 0.0059598776 2.924656e-07 9.634798e-06 3 58094836 58094954 119 + 2.443 2.260 -0.610
ENSG00000136068 E012 188.4823939 0.0043541104 4.689289e-14 6.221478e-12 3 58096141 58096218 78 + 2.412 2.147 -0.885
ENSG00000136068 E013 258.8061039 0.0047787444 1.593010e-14 2.273359e-12 3 58097815 58097977 163 + 2.547 2.284 -0.878
ENSG00000136068 E014 283.7267431 0.0098667710 4.218389e-07 1.334786e-05 3 58098711 58098908 198 + 2.565 2.344 -0.736
ENSG00000136068 E015 0.0000000       3 58099638 58099735 98 +      
ENSG00000136068 E016 211.5821506 0.0103221401 2.080976e-05 3.952109e-04 3 58102203 58102340 138 + 2.423 2.233 -0.637
ENSG00000136068 E017 188.9069492 0.0104899527 2.414238e-04 3.125186e-03 3 58103959 58104085 127 + 2.360 2.197 -0.543
ENSG00000136068 E018 176.6983751 0.0026522292 1.018745e-08 4.774724e-07 3 58105080 58105216 137 + 2.332 2.166 -0.555
ENSG00000136068 E019 5.2045624 0.1657584652 2.082884e-01 4.397687e-01 3 58105217 58106354 1138 + 0.880 0.695 -0.737
ENSG00000136068 E020 231.7938457 0.0011081999 1.762648e-13 2.090350e-11 3 58106680 58106873 194 + 2.448 2.285 -0.546
ENSG00000136068 E021 2.5868989 0.0088818740 3.468775e-02 1.407593e-01 3 58106874 58108103 1230 + 0.708 0.402 -1.432
ENSG00000136068 E022 176.7385463 0.0046537754 1.191501e-06 3.305738e-05 3 58108458 58108571 114 + 2.331 2.168 -0.543
ENSG00000136068 E023 237.4433844 0.0009054988 1.790254e-10 1.202924e-08 3 58109179 58109322 144 + 2.440 2.310 -0.435
ENSG00000136068 E024 244.9629288 0.0014858118 2.883298e-10 1.854034e-08 3 58109576 58109699 124 + 2.459 2.318 -0.471
ENSG00000136068 E025 249.7895797 0.0043887796 7.256995e-05 1.143763e-03 3 58110010 58110170 161 + 2.452 2.341 -0.369
ENSG00000136068 E026 2.3083839 0.0757267423 6.432384e-01 7.989936e-01 3 58110171 58111467 1297 + 0.424 0.549 0.620
ENSG00000136068 E027 190.4012716 0.0087369763 2.357313e-02 1.077681e-01 3 58111791 58111881 91 + 2.312 2.240 -0.239
ENSG00000136068 E028 248.4765655 0.0029783195 1.368007e-04 1.942861e-03 3 58112149 58112318 170 + 2.438 2.349 -0.295
ENSG00000136068 E029 214.7630831 0.0002604570 1.658651e-06 4.428884e-05 3 58118872 58118989 118 + 2.369 2.290 -0.261
ENSG00000136068 E030 0.5061644 0.2050644342 1.000000e+00   3 58118990 58119487 498 + 0.150 0.180 0.317
ENSG00000136068 E031 338.2771903 0.0008018216 3.351312e-08 1.392537e-06 3 58121241 58121503 263 + 2.571 2.484 -0.288
ENSG00000136068 E032 581.3497103 0.0015088287 6.546809e-03 4.244790e-02 3 58123093 58123690 598 + 2.765 2.745 -0.069
ENSG00000136068 E033 287.5102482 0.0006257389 3.691395e-03 2.743115e-02 3 58124332 58124505 174 + 2.466 2.439 -0.090
ENSG00000136068 E034 319.9235131 0.0001651824 1.325545e-09 7.566657e-08 3 58125581 58125743 163 + 2.542 2.460 -0.274
ENSG00000136068 E035 303.9578752 0.0001802928 2.753493e-04 3.481287e-03 3 58126602 58126762 161 + 2.492 2.457 -0.117
ENSG00000136068 E036 220.2485083 0.0002174325 5.010918e-01 7.015755e-01 3 58130741 58130908 168 + 2.293 2.353 0.200
ENSG00000136068 E037 30.5162688 0.1081825256 6.224236e-01 7.854855e-01 3 58130909 58131926 1018 + 1.473 1.491 0.061
ENSG00000136068 E038 32.8569166 0.0047454350 6.753351e-02 2.195395e-01 3 58131927 58132019 93 + 1.394 1.567 0.594
ENSG00000136068 E039 5.5387097 0.2334912736 7.462216e-01 8.645136e-01 3 58132020 58132077 58 + 0.812 0.798 -0.055
ENSG00000136068 E040 23.0727954 0.0403987180 6.316712e-01 7.914906e-01 3 58132078 58132807 730 + 1.291 1.411 0.415
ENSG00000136068 E041 145.0571155 0.0015208742 9.677759e-01 9.857586e-01 3 58132808 58132836 29 + 2.127 2.168 0.139
ENSG00000136068 E042 238.8566477 0.0011357291 5.366736e-01 7.268252e-01 3 58132837 58132931 95 + 2.351 2.377 0.087
ENSG00000136068 E043 324.8328447 0.0012737812 1.583259e-01 3.742520e-01 3 58134616 58134772 157 + 2.495 2.502 0.021
ENSG00000136068 E044 399.9326284 0.0001919597 2.955843e-02 1.260629e-01 3 58135979 58136168 190 + 2.589 2.591 0.005
ENSG00000136068 E045 463.7051218 0.0001188985 5.980120e-01 7.689440e-01 3 58138282 58138529 248 + 2.633 2.666 0.112
ENSG00000136068 E046 11.8234550 0.1439998057 6.790214e-01 8.221018e-01 3 58138530 58141013 2484 + 1.105 1.086 -0.069
ENSG00000136068 E047 5.0745836 0.0352910791 1.695302e-01 3.899268e-01 3 58141158 58141857 700 + 0.588 0.852 1.090
ENSG00000136068 E048 19.5035651 0.0020070528 1.650588e-05 3.244680e-04 3 58141858 58141896 39 + 0.983 1.417 1.542
ENSG00000136068 E049 14.2812325 0.0097844665 1.845716e-05 3.569176e-04 3 58141897 58141929 33 + 0.773 1.311 1.983
ENSG00000136068 E050 6.0779925 0.1415693186 4.173080e-01 6.416052e-01 3 58141930 58142649 720 + 0.669 0.921 1.002
ENSG00000136068 E051 319.2607533 0.0011641580 9.373212e-02 2.707089e-01 3 58142650 58142752 103 + 2.492 2.491 -0.001
ENSG00000136068 E052 403.1105196 0.0001734779 1.839310e-01 4.090639e-01 3 58143473 58143613 141 + 2.582 2.599 0.059
ENSG00000136068 E053 4.1578280 0.1331060433 8.068360e-01 9.002423e-01 3 58144398 58145920 1523 + 0.632 0.720 0.370
ENSG00000136068 E054 370.1977323 0.0001453654 9.777519e-01 9.906722e-01 3 58145921 58146049 129 + 2.528 2.572 0.145
ENSG00000136068 E055 1.3687290 0.0136721413 4.241258e-01   3 58146678 58146819 142 + 0.422 0.304 -0.694
ENSG00000136068 E056 417.5168978 0.0017429360 5.084867e-01 7.068360e-01 3 58146820 58146993 174 + 2.570 2.630 0.200
ENSG00000136068 E057 396.7534436 0.0002069025 6.349804e-02 2.105953e-01 3 58148206 58148364 159 + 2.534 2.613 0.263
ENSG00000136068 E058 511.2535530 0.0030211265 6.624379e-01 8.114105e-01 3 58148649 58148852 204 + 2.659 2.715 0.185
ENSG00000136068 E059 0.5061644 0.2050644342 1.000000e+00   3 58149088 58149231 144 + 0.150 0.180 0.317
ENSG00000136068 E060 1.7498248 0.0919107073 6.858637e-01 8.263833e-01 3 58149232 58149849 618 + 0.482 0.437 -0.231
ENSG00000136068 E061 203.9760479 0.0002551430 4.118024e-01 6.373759e-01 3 58149850 58149865 16 + 2.256 2.321 0.216
ENSG00000136068 E062 380.4650706 0.0019424530 2.259050e-01 4.604326e-01 3 58149866 58149980 115 + 2.518 2.596 0.258
ENSG00000136068 E063 225.6623136 0.0024187030 2.210889e-01 4.548052e-01 3 58149981 58150002 22 + 2.288 2.374 0.288
ENSG00000136068 E064 372.1306584 0.0001635032 6.376150e-06 1.422887e-04 3 58150105 58150227 123 + 2.470 2.604 0.445
ENSG00000136068 E065 2.4536639 0.0090465155 8.395564e-01 9.191453e-01 3 58150228 58151391 1164 + 0.485 0.548 0.305
ENSG00000136068 E066 1.1447270 0.4443737313 4.890195e-01   3 58152708 58152807 100 + 0.150 0.377 1.747
ENSG00000136068 E067 0.9419927 0.2883794887 5.245084e-01   3 58152808 58152854 47 + 0.150 0.316 1.380
ENSG00000136068 E068 2.1859428 0.0148492597 1.063897e-01 2.929787e-01 3 58152855 58153374 520 + 0.260 0.579 1.768
ENSG00000136068 E069 512.0539537 0.0008844449 6.818273e-10 4.098759e-08 3 58153375 58153641 267 + 2.577 2.755 0.593
ENSG00000136068 E070 1.4880183 0.0136968632 6.014120e-01 7.710872e-01 3 58154610 58154790 181 + 0.422 0.356 -0.375
ENSG00000136068 E071 330.8126145 0.0068185193 1.315084e-05 2.661836e-04 3 58154791 58154928 138 + 2.341 2.583 0.809
ENSG00000136068 E072 299.3919804 0.0055137807 2.451352e-04 3.165508e-03 3 58155960 58156026 67 + 2.329 2.529 0.666
ENSG00000136068 E073 295.0957953 0.0036469174 3.092463e-04 3.824713e-03 3 58156027 58156075 49 + 2.340 2.516 0.586
ENSG00000136068 E074 440.2598012 0.0124902563 5.225665e-04 5.879020e-03 3 58159554 58159686 133 + 2.470 2.706 0.786
ENSG00000136068 E075 0.8092192 0.0168577802 7.095339e-02   3 58159687 58159691 5 + 0.000 0.356 13.853
ENSG00000136068 E076 422.2156706 1.4769417763 3.612986e-01 5.967633e-01 3 58163154 58163330 177 + 2.330 2.723 1.308
ENSG00000136068 E077 5.0613831 0.0108154628 7.088754e-03 4.502669e-02 3 58163331 58163512 182 + 0.422 0.882 2.012
ENSG00000136068 E078 7.7879561 0.2018449982 3.689683e-01 6.031971e-01 3 58164573 58165475 903 + 0.762 1.015 0.968
ENSG00000136068 E079 2.1650116 0.1633897280 1.926239e-01 4.202965e-01 3 58165476 58165580 105 + 0.259 0.601 1.872
ENSG00000136068 E080 27.9079881 0.0609092593 2.019261e-01 4.319991e-01 3 58165581 58168439 2859 + 1.283 1.526 0.841
ENSG00000136068 E081 639.6170825 0.0142418497 5.162996e-05 8.553553e-04 3 58168440 58168658 219 + 2.600 2.878 0.926
ENSG00000136068 E082 6.1216196 0.0051718770 6.590061e-01 8.094020e-01 3 58168659 58169589 931 + 0.855 0.835 -0.077
ENSG00000136068 E083 618.6785019 0.0197449098 3.809635e-04 4.547755e-03 3 58169590 58169793 204 + 2.581 2.865 0.946
ENSG00000136068 E084 2092.6514677 0.0041157781 3.798712e-13 4.221915e-11 3 58170575 58172251 1677 + 3.129 3.387 0.860