ENSG00000136021

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360820 ENSG00000136021 HEK293_OSMI2_6hA HEK293_TMG_6hB SCYL2 protein_coding protein_coding 11.17562 2.453049 21.43761 0.6878025 0.3011408 3.1223 1.8466796 0.3879959 2.38056152 0.11883722 0.30903471 2.586524 0.1392625 0.15793333 0.11090000 -0.04703333 6.584890e-01 2.535516e-11 FALSE TRUE
ENST00000547202 ENSG00000136021 HEK293_OSMI2_6hA HEK293_TMG_6hB SCYL2 protein_coding retained_intron 11.17562 2.453049 21.43761 0.6878025 0.3011408 3.1223 0.2116133 0.1566230 0.33243275 0.09689834 0.11644127 1.039233 0.0385500 0.07706667 0.01543333 -0.06163333 5.176780e-01 2.535516e-11 FALSE FALSE
ENST00000547735 ENSG00000136021 HEK293_OSMI2_6hA HEK293_TMG_6hB SCYL2 protein_coding retained_intron 11.17562 2.453049 21.43761 0.6878025 0.3011408 3.1223 0.3755434 0.2573655 0.02846661 0.25736548 0.02846661 -2.797135 0.1306792 0.08293333 0.00130000 -0.08163333 7.424285e-01 2.535516e-11 FALSE TRUE
ENST00000549687 ENSG00000136021 HEK293_OSMI2_6hA HEK293_TMG_6hB SCYL2 protein_coding protein_coding 11.17562 2.453049 21.43761 0.6878025 0.3011408 3.1223 2.4447675 0.0000000 5.10962340 0.00000000 0.31550855 8.999894 0.1230167 0.00000000 0.23850000 0.23850000 2.535516e-11 2.535516e-11 FALSE TRUE
MSTRG.7866.1 ENSG00000136021 HEK293_OSMI2_6hA HEK293_TMG_6hB SCYL2 protein_coding   11.17562 2.453049 21.43761 0.6878025 0.3011408 3.1223 5.9154197 1.0127516 13.43656145 0.17345105 0.58139999 3.716710 0.4851667 0.45780000 0.62686667 0.16906667 3.795739e-01 2.535516e-11 FALSE TRUE
MSTRG.7866.3 ENSG00000136021 HEK293_OSMI2_6hA HEK293_TMG_6hB SCYL2 protein_coding   11.17562 2.453049 21.43761 0.6878025 0.3011408 3.1223 0.2308392 0.6030835 0.00000000 0.32027418 0.00000000 -5.938012 0.0588000 0.19160000 0.00000000 -0.19160000 2.275388e-02 2.535516e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000136021 E001 1.7799946 0.1819173864 0.073459874 0.23169542 12 100267140 100267176 37 + 0.220 0.697 2.592
ENSG00000136021 E002 10.9992546 0.0867401609 0.263291722 0.50249940 12 100267177 100267245 69 + 0.900 0.758 -0.554
ENSG00000136021 E003 11.4503653 0.0614492044 0.194177245 0.42235890 12 100267246 100267248 3 + 0.917 0.759 -0.611
ENSG00000136021 E004 34.3270865 0.0643962609 0.212345978 0.44450345 12 100267249 100267396 148 + 1.352 1.254 -0.344
ENSG00000136021 E005 16.4089206 0.0030515054 0.211625132 0.44368907 12 100267397 100267792 396 + 1.015 1.260 0.881
ENSG00000136021 E006 73.2836145 0.0233824164 0.007671079 0.04780820 12 100282943 100283131 189 + 1.674 1.513 -0.551
ENSG00000136021 E007 36.2802738 0.0218304397 0.004415787 0.03146355 12 100283132 100283147 16 + 1.385 1.128 -0.902
ENSG00000136021 E008 81.9331539 0.0114233131 0.002799598 0.02218554 12 100291503 100291660 158 + 1.721 1.591 -0.442
ENSG00000136021 E009 0.4929928 0.0313900378 0.317075755   12 100291661 100291989 329 + 0.085 0.292 2.140
ENSG00000136021 E010 0.1779838 0.0800067667 0.811701315   12 100296762 100296807 46 + 0.045 0.000 -9.686
ENSG00000136021 E011 87.9838011 0.0233431238 0.005329173 0.03633874 12 100298031 100298175 145 + 1.753 1.590 -0.554
ENSG00000136021 E012 90.3769093 0.0207455759 0.019612659 0.09458828 12 100311044 100311193 150 + 1.760 1.666 -0.319
ENSG00000136021 E013 129.9459269 0.0280678526 0.065268089 0.21448657 12 100312432 100312653 222 + 1.912 1.854 -0.194
ENSG00000136021 E014 95.9528064 0.0128218853 0.046427300 0.17108437 12 100313422 100313538 117 + 1.780 1.736 -0.151
ENSG00000136021 E015 72.9465537 0.0181370414 0.111567013 0.30165013 12 100314489 100314614 126 + 1.662 1.633 -0.100
ENSG00000136021 E016 82.1171069 0.0100914615 0.086521899 0.25744487 12 100315558 100315734 177 + 1.712 1.696 -0.055
ENSG00000136021 E017 0.1614157 0.0364326733 0.817535951   12 100317681 100317692 12 + 0.045 0.000 -9.682
ENSG00000136021 E018 0.4820342 0.0217328391 1.000000000   12 100317715 100317802 88 + 0.123 0.000 -11.267
ENSG00000136021 E019 70.2525865 0.0136379404 0.911534759 0.95792404 12 100317803 100317925 123 + 1.631 1.743 0.379
ENSG00000136021 E020 0.0000000       12 100319224 100319286 63 +      
ENSG00000136021 E021 58.5871380 0.0064527321 0.339574718 0.57761596 12 100323525 100323597 73 + 1.564 1.604 0.136
ENSG00000136021 E022 46.7271243 0.0227268517 0.296873856 0.53735738 12 100323598 100323638 41 + 1.472 1.470 -0.005
ENSG00000136021 E023 0.1426347 0.0329955173 0.816681691   12 100323639 100323836 198 + 0.045 0.000 -9.680
ENSG00000136021 E024 70.4533555 0.0264118180 0.436847515 0.65633990 12 100326622 100326754 133 + 1.639 1.679 0.133
ENSG00000136021 E025 0.0000000       12 100327185 100327234 50 +      
ENSG00000136021 E026 77.2335584 0.0133792188 0.287324365 0.52810850 12 100329201 100329319 119 + 1.680 1.718 0.127
ENSG00000136021 E027 3.8638833 0.2247391251 0.035538925 0.14301583 12 100333647 100334165 519 + 0.420 1.008 2.497
ENSG00000136021 E028 89.7364863 0.0127682874 0.311049058 0.55142581 12 100334166 100334266 101 + 1.743 1.791 0.162
ENSG00000136021 E029 0.2735028 0.0274424043 0.161128935   12 100335591 100335624 34 + 0.045 0.291 3.138
ENSG00000136021 E030 76.2067048 0.0075913889 0.121982669 0.31901845 12 100335625 100335691 67 + 1.680 1.686 0.023
ENSG00000136021 E031 0.1426347 0.0329955173 0.816681691   12 100335692 100335810 119 + 0.045 0.000 -9.680
ENSG00000136021 E032 82.3913218 0.0006656352 0.394723501 0.62408947 12 100335811 100335906 96 + 1.710 1.773 0.215
ENSG00000136021 E033 79.9532111 0.0147380542 0.409680045 0.63577716 12 100337387 100337506 120 + 1.682 1.842 0.538
ENSG00000136021 E034 488.2988585 1.9457889660 0.396681327 0.62572279 12 100338528 100341715 3188 + 2.415 2.803 1.292