ENSG00000135968

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309863 ENSG00000135968 HEK293_OSMI2_6hA HEK293_TMG_6hB GCC2 protein_coding protein_coding 5.648065 2.313814 10.73695 0.3464471 0.2184803 2.20936 3.32532209 0.6925592 6.62148742 0.69255924 0.36080785 3.2386407 0.44772083 0.24800000 0.61643333 0.368433333 3.315022e-01 5.840484e-05 FALSE TRUE
ENST00000409821 ENSG00000135968 HEK293_OSMI2_6hA HEK293_TMG_6hB GCC2 protein_coding protein_coding 5.648065 2.313814 10.73695 0.3464471 0.2184803 2.20936 0.42445362 0.0000000 1.37205232 0.00000000 0.30070736 7.1106684 0.04630417 0.00000000 0.12690000 0.126900000 5.840484e-05 5.840484e-05 FALSE TRUE
ENST00000462897 ENSG00000135968 HEK293_OSMI2_6hA HEK293_TMG_6hB GCC2 protein_coding protein_coding 5.648065 2.313814 10.73695 0.3464471 0.2184803 2.20936 0.22641926 0.2725682 0.33299536 0.08199663 0.04333310 0.2795897 0.05585417 0.11320000 0.03100000 -0.082200000 2.396088e-02 5.840484e-05 FALSE FALSE
ENST00000481729 ENSG00000135968 HEK293_OSMI2_6hA HEK293_TMG_6hB GCC2 protein_coding retained_intron 5.648065 2.313814 10.73695 0.3464471 0.2184803 2.20936 0.55997830 0.1790670 0.78621133 0.10839312 0.14429476 2.0742540 0.10918333 0.06920000 0.07336667 0.004166667 9.804420e-01 5.840484e-05   FALSE
ENST00000685519 ENSG00000135968 HEK293_OSMI2_6hA HEK293_TMG_6hB GCC2 protein_coding protein_coding 5.648065 2.313814 10.73695 0.3464471 0.2184803 2.20936 0.14690308 0.3145343 0.00000000 0.31453430 0.00000000 -5.0202990 0.08571667 0.12540000 0.00000000 -0.125400000 7.035809e-01 5.840484e-05 FALSE TRUE
ENST00000691012 ENSG00000135968 HEK293_OSMI2_6hA HEK293_TMG_6hB GCC2 protein_coding retained_intron 5.648065 2.313814 10.73695 0.3464471 0.2184803 2.20936 0.19465813 0.1114338 0.25074703 0.01676983 0.05808655 1.1024805 0.07154583 0.05116667 0.02346667 -0.027700000 5.437645e-01 5.840484e-05   FALSE
ENST00000692694 ENSG00000135968 HEK293_OSMI2_6hA HEK293_TMG_6hB GCC2 protein_coding protein_coding 5.648065 2.313814 10.73695 0.3464471 0.2184803 2.20936 0.04542249 0.2182079 0.00000000 0.21820786 0.00000000 -4.5122766 0.02402500 0.13300000 0.00000000 -0.133000000 7.678367e-01 5.840484e-05 FALSE TRUE
MSTRG.19000.9 ENSG00000135968 HEK293_OSMI2_6hA HEK293_TMG_6hB GCC2 protein_coding   5.648065 2.313814 10.73695 0.3464471 0.2184803 2.20936 0.06467578 0.1235463 0.04948843 0.12354626 0.04948843 -1.1666587 0.03241667 0.07530000 0.00480000 -0.070500000 9.131446e-01 5.840484e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000135968 E001 0.1308682 0.0326491905 1.177246e-01   2 108449107 108449118 12 + 0.000 0.211 12.138
ENSG00000135968 E002 0.1308682 0.0326491905 1.177246e-01   2 108449119 108449184 66 + 0.000 0.211 14.631
ENSG00000135968 E003 0.6765862 0.2009851167 4.555043e-01   2 108449185 108449205 21 + 0.224 0.000 -14.306
ENSG00000135968 E004 0.6765862 0.2009851167 4.555043e-01   2 108449206 108449212 7 + 0.224 0.000 -14.306
ENSG00000135968 E005 3.2072140 0.0070615177 3.983793e-02 1.543025e-01 2 108449213 108449222 10 + 0.619 0.211 -2.336
ENSG00000135968 E006 3.2072140 0.0070615177 3.983793e-02 1.543025e-01 2 108449223 108449224 2 + 0.619 0.211 -2.336
ENSG00000135968 E007 3.7058164 0.0066193219 2.057939e-02 9.795270e-02 2 108449225 108449229 5 + 0.668 0.211 -2.548
ENSG00000135968 E008 3.8672320 0.0062954626 1.643335e-02 8.340339e-02 2 108449230 108449230 1 + 0.684 0.211 -2.612
ENSG00000135968 E009 6.3092380 0.0043878897 1.689111e-02 8.504690e-02 2 108449231 108449239 9 + 0.854 0.459 -1.713
ENSG00000135968 E010 11.7483179 0.0222920882 1.484154e-02 7.747475e-02 2 108449240 108449280 41 + 1.088 0.730 -1.363
ENSG00000135968 E011 1.2846868 0.0130523737 1.041803e-01   2 108449281 108449289 9 + 0.368 0.000 -15.873
ENSG00000135968 E012 18.6388655 0.0143109630 4.202924e-03 3.027842e-02 2 108449633 108449689 57 + 1.272 0.929 -1.241
ENSG00000135968 E013 0.0000000       2 108449690 108449883 194 +      
ENSG00000135968 E014 0.0000000       2 108449884 108449994 111 +      
ENSG00000135968 E015 0.3206185 0.0274424043 1.000000e+00   2 108449995 108451027 1033 + 0.125 0.000 -13.964
ENSG00000135968 E016 22.5742729 0.0016215590 2.259238e-04 2.956543e-03 2 108451028 108451112 85 + 1.351 0.989 -1.293
ENSG00000135968 E017 0.1426347 0.0328219585 1.000000e+00   2 108451866 108451986 121 + 0.067 0.000 -12.964
ENSG00000135968 E018 26.0940041 0.0024001592 2.638650e-04 3.362878e-03 2 108452399 108452466 68 + 1.403 1.066 -1.193
ENSG00000135968 E019 0.0000000       2 108462588 108462685 98 +      
ENSG00000135968 E020 28.9318912 0.0015056343 4.565377e-05 7.699930e-04 2 108468980 108469084 105 + 1.449 1.088 -1.268
ENSG00000135968 E021 0.0000000       2 108469085 108469299 215 +      
ENSG00000135968 E022 0.0000000       2 108469300 108469332 33 +      
ENSG00000135968 E023 0.1779838 0.0363266093 1.000000e+00   2 108469333 108469650 318 + 0.067 0.000 -12.943
ENSG00000135968 E024 100.6488165 0.0015012072 2.890192e-10 1.857061e-08 2 108469651 108470391 741 + 1.972 1.663 -1.044
ENSG00000135968 E025 45.6420772 0.0009307758 7.783055e-03 4.829515e-02 2 108470392 108470709 318 + 1.619 1.455 -0.560
ENSG00000135968 E026 153.2069563 0.0004584188 1.283735e-03 1.203931e-02 2 108470710 108471813 1104 + 2.125 2.025 -0.332
ENSG00000135968 E027 25.3351348 0.0021215006 7.295914e-01 8.539976e-01 2 108471814 108471844 31 + 1.339 1.323 -0.056
ENSG00000135968 E028 58.4227581 0.0008820293 6.709587e-01 8.169514e-01 2 108471845 108472116 272 + 1.682 1.718 0.124
ENSG00000135968 E029 0.3336024 0.0274424043 2.388707e-02   2 108472117 108472826 710 + 0.000 0.353 15.648
ENSG00000135968 E030 28.5904784 0.0013838134 8.088468e-01 9.015068e-01 2 108472827 108472899 73 + 1.397 1.393 -0.013
ENSG00000135968 E031 6.8988722 0.0058614070 5.252341e-03 3.595052e-02 2 108472900 108473979 1080 + 0.726 1.088 1.379
ENSG00000135968 E032 8.2930663 0.0358726715 1.828842e-04 2.481459e-03 2 108474789 108475534 746 + 0.715 1.236 1.955
ENSG00000135968 E033 24.4400159 0.0019593631 9.505676e-01 9.772549e-01 2 108475535 108475561 27 + 1.325 1.335 0.034
ENSG00000135968 E034 31.0044007 0.0020918144 4.441760e-01 6.615273e-01 2 108475562 108475635 74 + 1.436 1.393 -0.149
ENSG00000135968 E035 32.6337684 0.0088331364 7.922705e-01 8.917697e-01 2 108475752 108475850 99 + 1.450 1.450 0.001
ENSG00000135968 E036 15.0104456 0.0740213173 5.715605e-01 7.513750e-01 2 108481697 108481709 13 + 1.137 1.111 -0.092
ENSG00000135968 E037 33.5642166 0.0037473627 1.855413e-01 4.112718e-01 2 108481710 108481816 107 + 1.434 1.547 0.388
ENSG00000135968 E038 38.2737349 0.0033318238 1.094234e-01 2.981575e-01 2 108482287 108482451 165 + 1.484 1.606 0.416
ENSG00000135968 E039 26.4210845 0.0020564408 4.380306e-01 6.572411e-01 2 108483062 108483123 62 + 1.341 1.415 0.256
ENSG00000135968 E040 28.3068706 0.0013360118 1.670392e-01 3.865938e-01 2 108483124 108483166 43 + 1.358 1.474 0.401
ENSG00000135968 E041 45.2827859 0.0010563439 2.658398e-01 5.052625e-01 2 108484149 108484311 163 + 1.564 1.645 0.277
ENSG00000135968 E042 2.6226961 0.0195415246 3.604386e-01 5.960559e-01 2 108484312 108484739 428 + 0.523 0.352 -0.901
ENSG00000135968 E043 34.6029460 0.0013314566 1.230279e-01 3.205426e-01 2 108485636 108485736 101 + 1.439 1.557 0.405
ENSG00000135968 E044 26.3271785 0.0015683337 6.941090e-01 8.317672e-01 2 108485831 108485908 78 + 1.348 1.394 0.158
ENSG00000135968 E045 0.7673035 0.0193874923 2.721682e-01   2 108486130 108486434 305 + 0.263 0.000 -15.240
ENSG00000135968 E046 1.7611115 0.0106398335 2.797607e-01 5.198409e-01 2 108486435 108486510 76 + 0.425 0.211 -1.410
ENSG00000135968 E047 34.0168028 0.0010797252 5.073021e-01 7.058711e-01 2 108486511 108486648 138 + 1.449 1.509 0.206
ENSG00000135968 E048 34.3877636 0.0015562631 2.226551e-01 4.566443e-01 2 108487699 108487820 122 + 1.444 1.541 0.335
ENSG00000135968 E049 0.5173834 0.0484563541 5.802019e-01   2 108488028 108489837 1810 + 0.176 0.000 -14.396
ENSG00000135968 E050 54.3619053 0.0009579831 3.866480e-01 6.178097e-01 2 108489838 108490014 177 + 1.646 1.708 0.210
ENSG00000135968 E051 0.1779838 0.0363266093 1.000000e+00   2 108490015 108490135 121 + 0.067 0.000 -12.943
ENSG00000135968 E052 66.1853985 0.0008587095 2.046763e-01 4.355076e-01 2 108492573 108492790 218 + 1.730 1.807 0.261
ENSG00000135968 E053 0.3503582 0.0341660900 3.401880e-01   2 108493301 108495290 1990 + 0.067 0.211 1.911
ENSG00000135968 E054 57.9833605 0.0008865063 5.150417e-02 1.833091e-01 2 108495291 108495485 195 + 1.665 1.781 0.393
ENSG00000135968 E055 1.5333690 0.1845378085 1.306490e-01 3.328114e-01 2 108495486 108496969 1484 + 0.404 0.000 -15.447
ENSG00000135968 E056 39.1719758 0.0012918669 6.786730e-03 4.363874e-02 2 108496970 108497109 140 + 1.481 1.663 0.622
ENSG00000135968 E057 5.4157960 0.0161780768 7.881519e-01 8.894626e-01 2 108498224 108499552 1329 + 0.726 0.778 0.208
ENSG00000135968 E058 38.3835240 0.0477748389 5.148414e-02 1.832685e-01 2 108499553 108499754 202 + 1.461 1.677 0.739
ENSG00000135968 E059 144.2714029 0.0085184520 1.879765e-04 2.540427e-03 2 108507560 108509415 1856 + 2.031 2.221 0.637