ENSG00000135951

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000465216 ENSG00000135951 HEK293_OSMI2_6hA HEK293_TMG_6hB TSGA10 protein_coding processed_transcript 5.933228 5.000521 5.062315 0.9187337 0.4402752 0.01768388 1.4136923 2.21859574 0.5931335 0.79346477 0.30313081 -1.8855857 0.23934167 0.4168000 0.11483333 -0.30196667 4.110664e-01 1.996515e-07   FALSE
ENST00000476849 ENSG00000135951 HEK293_OSMI2_6hA HEK293_TMG_6hB TSGA10 protein_coding processed_transcript 5.933228 5.000521 5.062315 0.9187337 0.4402752 0.01768388 0.1420868 0.05750169 0.3975864 0.05750169 0.16332899 2.5941103 0.02286250 0.0085000 0.07446667 0.06596667 2.383617e-01 1.996515e-07   FALSE
ENST00000483914 ENSG00000135951 HEK293_OSMI2_6hA HEK293_TMG_6hB TSGA10 protein_coding processed_transcript 5.933228 5.000521 5.062315 0.9187337 0.4402752 0.01768388 1.2347926 0.96563891 0.6941581 0.38966456 0.38454757 -0.4704480 0.20152083 0.1777667 0.13140000 -0.04636667 8.722378e-01 1.996515e-07   FALSE
ENST00000489348 ENSG00000135951 HEK293_OSMI2_6hA HEK293_TMG_6hB TSGA10 protein_coding processed_transcript 5.933228 5.000521 5.062315 0.9187337 0.4402752 0.01768388 1.3885091 0.71172812 0.8613917 0.09976476 0.12791191 0.2718659 0.22811667 0.1512667 0.17400000 0.02273333 9.323152e-01 1.996515e-07   FALSE
ENST00000494483 ENSG00000135951 HEK293_OSMI2_6hA HEK293_TMG_6hB TSGA10 protein_coding processed_transcript 5.933228 5.000521 5.062315 0.9187337 0.4402752 0.01768388 0.1212638 0.00000000 0.2470225 0.00000000 0.13215403 4.6838230 0.02313333 0.0000000 0.05286667 0.05286667 3.237182e-01 1.996515e-07   FALSE
ENST00000498097 ENSG00000135951 HEK293_OSMI2_6hA HEK293_TMG_6hB TSGA10 protein_coding processed_transcript 5.933228 5.000521 5.062315 0.9187337 0.4402752 0.01768388 0.1905516 0.10453744 0.5405047 0.06002886 0.33012663 2.2649356 0.03691250 0.0266000 0.11156667 0.08496667 6.687297e-01 1.996515e-07   FALSE
MSTRG.18930.11 ENSG00000135951 HEK293_OSMI2_6hA HEK293_TMG_6hB TSGA10 protein_coding   5.933228 5.000521 5.062315 0.9187337 0.4402752 0.01768388 0.1756967 0.00000000 0.5555076 0.00000000 0.04658803 5.8214746 0.03117083 0.0000000 0.11270000 0.11270000 1.996515e-07 1.996515e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000135951 E001 0.4756169 0.024441170 0.054774880   2 98997261 98997447 187 - 0.000 0.322 10.321
ENSG00000135951 E002 1.3279580 0.019426695 0.751745857   2 98997448 98997885 438 - 0.329 0.393 0.376
ENSG00000135951 E003 3.1594922 0.111567183 0.183702251 0.40873143 2 98997886 98998221 336 - 0.472 0.741 1.201
ENSG00000135951 E004 1.6118719 0.011232083 0.722158906 0.84940188 2 99018200 99018349 150 - 0.384 0.452 0.369
ENSG00000135951 E005 1.8195955 0.011559300 0.502522312 0.70252434 2 99018536 99018640 105 - 0.384 0.505 0.632
ENSG00000135951 E006 1.3746460 0.105464208 0.600181163   2 99020280 99020482 203 - 0.331 0.446 0.647
ENSG00000135951 E007 1.7252442 0.018500478 0.718665354 0.84735896 2 99035230 99035439 210 - 0.384 0.454 0.376
ENSG00000135951 E008 0.0000000       2 99064930 99064938 9 -      
ENSG00000135951 E009 3.2414095 0.016153463 0.471991046 0.68153743 2 99064939 99065124 186 - 0.551 0.670 0.526
ENSG00000135951 E010 2.5209320 0.010659542 0.851970625 0.92619825 2 99068888 99068925 38 - 0.515 0.553 0.177
ENSG00000135951 E011 3.5892651 0.109836977 0.895297277 0.94937939 2 99068926 99068998 73 - 0.672 0.635 -0.160
ENSG00000135951 E012 3.6898436 0.419811929 0.953674522 0.97876648 2 99071706 99071874 169 - 0.690 0.656 -0.147
ENSG00000135951 E013 1.0579220 0.996389138 0.893965523   2 99073018 99073073 56 - 0.367 0.244 -0.813
ENSG00000135951 E014 2.8314469 0.009405883 0.642027832 0.79817392 2 99078659 99078813 155 - 0.551 0.633 0.367
ENSG00000135951 E015 0.3337900 0.026575450 0.868211466   2 99078814 99078928 115 - 0.109 0.136 0.370
ENSG00000135951 E016 2.2845841 0.010539795 0.388955094 0.61966229 2 99081282 99081397 116 - 0.584 0.452 -0.634
ENSG00000135951 E017 5.9732440 0.005675683 0.044643608 0.16671553 2 99103967 99104118 152 - 0.924 0.669 -1.010
ENSG00000135951 E018 4.1434096 0.007894005 0.101104444 0.28378856 2 99105359 99105436 78 - 0.786 0.553 -0.989
ENSG00000135951 E019 7.7236890 0.003861391 0.122814362 0.32017782 2 99105527 99105697 171 - 1.004 0.837 -0.632
ENSG00000135951 E020 9.3489927 0.003801911 0.074024831 0.23281143 2 99108833 99108991 159 - 1.082 0.901 -0.670
ENSG00000135951 E021 4.6075203 0.006452119 0.092561509 0.26852945 2 99109389 99109402 14 - 0.825 0.595 -0.952
ENSG00000135951 E022 6.0034864 0.004994572 0.072421257 0.22961792 2 99109403 99109512 110 - 0.923 0.702 -0.872
ENSG00000135951 E023 1.4690496 0.013696863 0.183218720 0.40806857 2 99109513 99109513 1 - 0.268 0.505 1.368
ENSG00000135951 E024 1.4690496 0.013696863 0.183218720 0.40806857 2 99109514 99109556 43 - 0.268 0.505 1.368
ENSG00000135951 E025 3.9709127 0.040697621 0.086806208 0.25788417 2 99110850 99110915 66 - 0.789 0.505 -1.230
ENSG00000135951 E026 3.0829125 0.008013346 0.109967296 0.29897183 2 99117128 99117246 119 - 0.697 0.453 -1.115
ENSG00000135951 E027 5.8251899 0.005524123 0.424546519 0.64696025 2 99117544 99117566 23 - 0.877 0.787 -0.350
ENSG00000135951 E028 13.3163323 0.003380289 0.106100383 0.29251968 2 99117567 99117759 193 - 1.213 1.079 -0.481
ENSG00000135951 E029 3.7367351 0.006499732 0.116234777 0.30954443 2 99118551 99118686 136 - 0.551 0.788 1.006
ENSG00000135951 E030 1.0121411 0.017618097 0.051528448   2 99118687 99118776 90 - 0.109 0.453 2.694
ENSG00000135951 E031 1.4933675 0.013997633 0.043806544 0.16461672 2 99118777 99118801 25 - 0.195 0.552 2.177
ENSG00000135951 E032 17.7233671 0.017558288 0.579981310 0.75715951 2 99124767 99127047 2281 - 1.237 1.303 0.233
ENSG00000135951 E033 7.8989614 0.062478915 0.143822911 0.35312799 2 99127048 99127176 129 - 1.034 0.807 -0.860
ENSG00000135951 E034 0.4458772 0.022837630 0.443830290   2 99141068 99141082 15 - 0.108 0.239 1.369
ENSG00000135951 E035 0.7852767 0.016766616 0.845388392   2 99141083 99141180 98 - 0.268 0.239 -0.217
ENSG00000135951 E036 0.0000000       2 99141344 99141427 84 -      
ENSG00000135951 E037 1.7327769 0.011789673 0.070160752 0.22511021 2 99141428 99141597 170 - 0.551 0.239 -1.801
ENSG00000135951 E038 0.4514866 0.023106753 0.708295705   2 99148264 99148264 1 - 0.195 0.135 -0.633
ENSG00000135951 E039 4.1184332 0.007228348 0.051034934 0.18215438 2 99148265 99148348 84 - 0.551 0.837 1.201
ENSG00000135951 E040 10.0562603 0.003822312 0.520446410 0.71524490 2 99154291 99154427 137 - 1.004 1.079 0.275
ENSG00000135951 E041 3.0599430 0.090264372 0.596449065 0.76797176 2 99154428 99154692 265 - 0.647 0.550 -0.431
ENSG00000135951 E042 14.7993079 0.004837422 0.001187721 0.01133796 2 99154693 99154836 144 - 1.039 1.333 1.049
ENSG00000135951 E043 11.4831182 0.099627075 0.070096599 0.22498610 2 99154837 99154964 128 - 0.920 1.237 1.151